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Polycyclic naphthalenediimide-based nanoparticles for NIR-Ⅱ fluorescence imaging guided phototherapy

Science China Chemistry 2020年第7期63卷 946-956页

作者： chuanchao tang Chuanhui Song Zheng Wei Chen Liang Jianchuan Ran Yu Cai Xiaochen Dong Wei Han Central Laboratory'of Stomatology Nanjing Stomatological HospitalMedical School of Nanjing UniversityNanjing 210008China Department of Oral and Maxillofacial Surgery Nanjing Stomatological HospitalMedical School of Nanjing UniversityNanjing 2 J0008China School of Chemistry and Materials Science Nanjing University of Information Science&TechnologyNanjing 210044China

Optical imaging and phototherapy in the second near-infrared window(NIR-Ⅱ, 900–1700 nm) can reduce tissue auto-fluorescence and photon scattering, which facilitates higher spatial resolution and deeper tissue penetration depth for solid tumor theranostics. Herein, a polycyclic naphthalenediimide(NDI) based chromophore 13-amino-4,5-dibromo-2,7-di(dodecan-6-yl)-1 H-isoquinolino[4,5,6-fgh]naphtho[1,8-bc][1,9]phenanthroline-1,3,6,8(2H,7H,9H)-tetraone(NDI-NA) was designed and synthesized. With large polycyclic π-systems, NDI-NA molecule possesses broad near-infrared(NIR) absorption(maximum at777 nm) and emission(maximum at 921 nm). By nanoprecipitation, NDI-NA nanoparticles(NPs) were formed in aqueous solution with J-aggregative state, which showed huge red-shift in both absorption spectrum(maximum at 904 nm) and emission spectrum(maximum at 1,020 nm), endowing NDI-NA NPs efficient NIR-Ⅱ fluorescence imaging capability. Besides, the NPs present effective tumor-targeting capability in vivo based on the enhanced permeation and retention(EPR) effect. More importantly, NDI-NA NPs simultaneously have high photothermal conversion efficiency(30.8%) and efficient reactive oxygen species generation ability, making them remarkably phototoxic to cancer cells. The polycyclic chromophore based multifunctional NDI-NA NPs as NIR-Ⅱ phototheranostic agents possess bright future for clinical NIR-Ⅱ imaging-guided cancer phototherapy.

关键词： second near-infrared window fluorescence imaging phototherapy phototheranostics polycyclic naphthalenediimide

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Peroxidase-mimicking evodiamine/indocyanine green nanoliposomes for multimodal imaging-guided theranostics for oral squamous cell carcinoma

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Bioactive Materials 2021年第7期6卷 2144-2157页

作者： Zheng Wei Huihui Zou Gongyuan Liu Chuanhui Song chuanchao tang Sheng Chen Guorong Zhang Jianchuan Ran Yufeng Wang Xiteng Yin Yu Cai Wei Han Department of Oral and Maxillofacial Surgery Nanjing Stomatological HospitalMedical School of Nanjing University30 Zhongyang Road210008NanjingChina Clinical Research Institute Zhejiang Provincial People’s HospitalPeople’s Hospital of Hangzhou Medical CollegeNo.158 Shangtang RoadHangzhou310014Zhejiang ProvinceChina Pediatric Dentistry Nanjing Stomatology HospitalMedical School of Nanjing UniversityNo 30 Zhongyang RoadNanjing210008China Department of Orthodontics Nanjing Stomatological HospitalMedical School of Nanjing UniversityNo 30 Zhongyang RoadNanjing210008China Central Laboratory of Stomatology Nanjing Stomatological HospitalMedical School of Nanjing University30 Zhongyang Road210008NanjingChina Department of Oral Pathology Nanjing Stomatological HospitalMedical School of Nanjing UniversityNanjingChina Department of Chemistry City University of Hong Kong83 Tat Chee AvenueHong Kong SARChina

Here,evodiamine(EVO)and the photosensitizer indocyanine green(ICG)were integrated into a liposomal nanoplatform for noninvasive diagnostic imaging and combinatorial therapy against oral squamous cell carcinoma(OSCC).EVO,as an active component extracted from traditional Chinese medicine,not only functioned as an antitumor chemotherapeutic agent but was also capable of 68Ga-chelation,thus working as a contrast agent for positron emission tomography/computed tomography(PET/CT)***,EVO could exhibit peroxidase-like catalytic activity,converting endogenous tumor H2O2 into cytotoxic reactive oxygen species(ROS),enabling Chemo catalytic therapy beyond the well-known chemotherapy effect of *** proven by in vitro and in vivo experiments,guided by optical imaging and PET/CT imaging,we show that the theragnostic liposomes have a significant inhibiting effect on in situ tongue tumor through photodynamic therapy combined with chemodynamic chemotherapy.

关键词： Oral squamous cell carcinoma Evodiamine Peroxidase-mimicking Trimodal antitumor therapy

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A novel multifunctional nanoprobe for NIR-Ⅱ imaging and targeting chemo-photothermal therapy in Oral Squamous Cell Carcinoma

A novel multifunctional nanoprobe for NIR-Ⅱ imaging and tar...

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2019第一届全国口腔颌面-头颈肿瘤学术大会——聚合引领、协同发展

作者：王玉凤 YIN Xiteng tang chuanchao CAI Yu WANG Zhiyong HU Qingang HAN Wei Department of Oral and Maxillofacial Surgery Nanjing Stomatological Hospital Medical School of Nanjing University

Object: Current surgical treatment for oral squamous cell carcinoma(OSCC) must be as precise as possible to fully resect the tumors and preserve functional tissues. Thus, it is urgent to develop efficient fluorescent probes to clearly identify tumor delineation, as well as metastatic lymph nodes. Combined photothermal and chemotherapy attracted growing attention to increase anti-tumor effect in various kinds of tumors including OSCC. In the present study, we designed a multimodal NIR-Ⅱ probe involving a combination of photothermal and chemotherapy, imaging OSCC tumors and detecting metastatic lymph nodes. Methods: In this study, we synthesized a novel near infrared(NIR)-Ⅱ probe named TQTPA via Suzuki reaction and prepared multimodal nanoparticles(NPs) loading TQTPA and cis-Dichlorodiammine platinum(CDDP)(HT@CDDP) by hyaluronic acid. The characteristics, photothermal effect, as well as the imaging property were investigated in vitro and in vivo. Their antitumor effect was evaluated using orthotopic tongue tumor-bearing nude mice. Results: The NPs possessed good water-solubility, stability and were pH/hyaluronidase-sensitive. The good tissue penetration quality and active targeting ability made the NPs draw the outline of orthotopic tongue tumors and metastatic lymph nodes as small as 1 mm in nude mice by IR-808 under NIR exposure. In vitro and in vivo experiments validate the biocompatibility and low systematic toxicity of the NPs. At the same time, the NPs acted as multimodal therapy agents in combination with photothermal and chemotherapy. Conclusion: With good imaging property and antitumor effect, our NPs successfully outlined orthotopic tongue tumors and metastatic lymph nodes, as well as combined photothermal and chemotherapy. Our study established a solid foundation for the application of new clinical diagnosis and treatment patterns in the future.

关键词： NIR-Ⅱ imaging photothermal/chemo-therapy active-target metastatic lymph nodes detecting

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四甲基二甲酰型芳环化合物的合成

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江西师范大学学报（自然科学版） 2018年第1期42卷 89-94页

作者：洪慧铭王利云宋琤唐传超姚大林喻国生陈海宋才生江西师范大学化学化工学院江西南昌330022 九江市特种胶业有限公司江西九江332726

双酮酐型聚酰亚胺(PI)具有优异的耐热性能及力学性能,制备此类型聚酰亚胺的重要单体之一是多烷基化合物.通过低温Friedel-Crafts酰基化反应制备1,4-二(3',4'-二甲基苯甲酰基)苯、1,3-二(3',4'-二甲基苯甲酰基)苯、4,4'-二(3',4'-二甲基... 详细信息

双酮酐型聚酰亚胺(PI)具有优异的耐热性能及力学性能,制备此类型聚酰亚胺的重要单体之一是多烷基化合物.通过低温Friedel-Crafts酰基化反应制备1,4-二(3',4'-二甲基苯甲酰基)苯、1,3-二(3',4'-二甲基苯甲酰基)苯、4,4'-二(3',4'-二甲基苯甲酰基)二苯醚、4,4'-二(3',4'-二甲基苯甲酰基)联苯4种四甲基二甲酰型芳环化合物,并且分别对4种化合物的结构进行了红外和核磁分析.结果表明:所得4种化合物与目标产物一致,有望拓展双酮型二酐的种类,进而合成性能更佳的新型双酮酐型聚酰亚胺.

关键词：四甲基二甲酰双酮二酐双酮酐型聚酰亚胺

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联苯型聚芳醚砜醚酮酮共聚物的合成与表征

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江西师范大学学报（自然科学版） 2017年第5期41卷 488-491页

作者：王利云洪慧铭宋琤唐传超姚大林喻国生陈海宋才生江西师范大学化学化工学院江西南昌330022 九江市特种胶业有限公司江西九江332726

以无水Al Cl3/二氯乙烷(DCE)/N,N-二甲基甲酰胺(DMF)为复合溶剂体系,在低温条件下,以4,4'-二苯氧基二苯砜(DPODPS)、对苯二甲酰氯(TPC)、4,4'-联苯二甲酰氯(BPPC)为原料通过亲电共缩聚反应制得一系列聚芳醚砜醚酮酮(PESEKKs),用FT-IR、... 详细信息

以无水Al Cl3/二氯乙烷(DCE)/N,N-二甲基甲酰胺(DMF)为复合溶剂体系,在低温条件下,以4,4'-二苯氧基二苯砜(DPODPS)、对苯二甲酰氯(TPC)、4,4'-联苯二甲酰氯(BPPC)为原料通过亲电共缩聚反应制得一系列聚芳醚砜醚酮酮(PESEKKs),用FT-IR、DSC、TG、WAXD等技术对聚合物做了表征.结果表明:随着BPPC含量的增加,共聚物的Tg从194℃上升到210℃,Tm从223℃增加到238℃,热分解温度均大于550℃,聚合物的耐热性能得到显著提升.经过检测,共聚物的溶解性能良好.

关键词：聚芳醚砜醚酮酮联苯热性能共聚物

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联苯聚芳醚砜醚酮酮及其碳纤维复合材料的制备

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江西师范大学学报（自然科学版） 2018年第5期42卷 473-476页

作者：刘勇军周丽云王利云洪慧铭宋琤唐传超宋才生江西师范大学化学化工学院江西南昌330022 九江市特种胶业有限公司江西九江332726

以4,4'-二苯氧基二苯砜(DPODPS)和4,4'-联苯二甲酰氯(BPPC)为原料,采用亲电缩合反应制备了主链含联苯结构单元的聚芳醚砜醚酮酮(PESEKDK),并用红外(FT-IR)、广角X-射线衍射(WAXD)、示差扫描量热法(DSC)、热重法(TGA)等手段对其进行了表... 详细信息

以4,4'-二苯氧基二苯砜(DPODPS)和4,4'-联苯二甲酰氯(BPPC)为原料,采用亲电缩合反应制备了主链含联苯结构单元的聚芳醚砜醚酮酮(PESEKDK),并用红外(FT-IR)、广角X-射线衍射(WAXD)、示差扫描量热法(DSC)、热重法(TGA)等手段对其进行了表征.结果表明:PESEKDK的玻璃化转变温度(Tg)为207℃,在238℃、264℃、283℃处出现3个熔融峰;热分解温度(Td)为561℃,说明聚合物的耐热性能优良.以质量比为50%的T700短碳纤维和PESEKDK熔融共混制备的复合材料的拉伸强度为286 MPa,拉伸模量为30.9 GPa,表明复合材料具有优良的力学性能.

关键词：短碳纤维聚芳醚砜醚酮酮复合材料力学性能

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交变载荷作用下Ⅰ型裂纹准静态稳定扩展的有限元模拟

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西北工业大学学报 1988年第2期6卷 151-158页

作者：郑传超汤玄春刘元镛西北工业大学西北工业大学博士生副教授

本文用二维弹塑性有限元素法分析了交变载荷作用下Ⅰ型裂纹准静态稳定扩展时裂尖前方应力场、应变场的变化和裂纹面的开闭现象;得到了裂纹扩展过程中的闭合应力和张开应力;裂尖塑性区和裂尖反向塑性区与裂纹长度的关系。在文献[1]的基础... 详细信息

本文用二维弹塑性有限元素法分析了交变载荷作用下Ⅰ型裂纹准静态稳定扩展时裂尖前方应力场、应变场的变化和裂纹面的开闭现象;得到了裂纹扩展过程中的闭合应力和张开应力;裂尖塑性区和裂尖反向塑性区与裂纹长度的关系。在文献[1]的基础上,本文分析了扩展裂纹的开闭行为,进而揭示其与静止裂纹的差异。这种差异是由裂纹扩展时残留在裂纹面上的拉伸变形所致。本文详细地讨论了模拟裂纹扩展时,裂尖节点力释放技巧的重要性及其力学意义;并且利用共线双裂纹模型的概念对裂纹闭合现象作了进一步的分析。文中所得到的裂纹扩展时裂尖张开角的结论与文献[2]的实验结果基本一致。

关键词：有限元模拟释放技巧共线双裂纹

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Identification of endophytic fungi responsive miRNA involved in the regulation of sesquiterpenoid biosynthesis in Atractylodes lancea

Identification of endophytic fungi responsive miRNA involved...

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中国植物学会第十六次全国会员代表大会暨85周年学术年会

作者： Jie Yuan Fei Chen Hurong Yang Piaoxue Chen Wei Zhang Mengjun tang Xia Li chuanchao Dai Jiangsu Key Laboratory for Microbes and Functional Genomics Jiangsu Engineering and Technology Research Center for Industrialization of Microbial ResourcesCollege of Life SciencesNanjing Normal University Jiangsu High-Quality Rice Research and Development Center Nanjing Branch of China National Center for Rice ImprovementInstitute of Food CropsJiangsu Academy of Agricultural Sciences

Endophytes have been considered long-term safe and effective methods for inducing plant secondary metabolite ***,the underlying microRNAs associated with endophyte induced terpenoid biosynthesis are *** elucidate the molecular mechanism at the miRNA level,we identified endophytic fungiresponsive miRNAs in *** shoots and analyzed the function of their targets using a high-throughput platform.A total of 153 known miRNAs and 83 novel miRNAs were differentially expressed in *** after endophytes Gilmaniella ***12 ***,51,570 potential targets were *** ontology(GO) enrichment analyses showed prominent enrichment in signal transduction for the targets of down-regulated ***,novelir5,novelir44,and novelir37 were predicted to be involved in regulating sesquiterpenoid biosynthesis in ***.,Moreover,we proposed that novelir44 may be a hub miRNA functioning in regulating sesquiterpenoids biosynthesis by targeting 1-deoxyD-xylulose 5-phosphate synthase(DXS) and many transcription factors such as WRKY,APETALA2/Ethylene-Response Factors(AP2/ERF),basic Helix-Loop-Helix(bHLH),heat stress,and Nuclear transcription factor Y subunit A(NF-YA).This study provides the first insight into endophytes-induced plant terpenoid biosynthesis at the miRNA expression level and will provide knowledge about beneficial plant-endophyte interactions.

关键词： Endophytes Atractylodes lancea Sesquiterpenoids MicroRNA Transcription factors

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Enhanced Nitrogen and Phosphorus Activation with an Optimized Bacterial Community by Endophytic Fungus Phomopsis liquidambari in Paddy Soil

Enhanced Nitrogen and Phosphorus Activation with an Optimize...

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中国植物学会第十六次全国会员代表大会暨85周年学术年会

作者： Mengjun tang Qiang Zhu Fengmin Zhang Wei Zhang Jie Yuan Kai Sun Fangji Xu chuanchao Dai Jiangsu Key Laboratory for Microbes and Functional Genomics Jiangsu Engineering and Technology Research Center for Industrialization of Microbial ResourcesCollege of Life SciencesNanjing Normal University

The endophytic fungus Phomopsis liquidambari play a key role in habitat adaptation of rice(Oryza sativa L.) with potential multiple ***,our previous published work on this subject remains ***,we performed a soil nutrient(nitrogen and phosphorus) transformation with related functional genes and elucidated how rhizosphere microbiota vary their response to *** interaction throughout the plant’s life cycle under field conditions by Illumina Miseq sequencing platforms in a nutrient-limited paddy *** results showed that *** symbiosis decreased the nitrogen and phosphorus loss by 531.24 mg and 558.12 mg per pot,***,we suggest that the application of *** altered the activation of soil nitrogen and phosphorus functional genes to accelerate nutrient turnover in the rice ***-throughput sequencing with cooccurrence network and species-related network analysis further revealed that *** colonization influenced the patterns of microbiota shift in the rhizosphere,especially during the heading *** led to an optimized microbial community through the promotion and inhibition of indigenous soil microbes with a higher level of available nutrient *** study strongly proposes *** symbiosis as a useful candidate for improving N and P acquisition and utilization.

关键词： rhizosphere microbiota whole developmental stages fungal endophyte network analysis rice soil nutrient

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古代农书中天文及术数内容的来源及流变——以《四时纂要》为中心的考察

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中国科技史杂志 2009年第4期30卷 438-453页

作者：王传超中国科学院自然科学史研究所

传统农书中有大量天文术数内容,在这方面《四时纂要》是一个典型。通过分析,认为该书中的天文术数内容主要来自于月令书、《史记.天官书》等古天文书以及术数书;这些内容在战国至秦汉时期因农家与阴阳五行学说及民间方术之间的互动而进... 详细信息

传统农书中有大量天文术数内容,在这方面《四时纂要》是一个典型。通过分析,认为该书中的天文术数内容主要来自于月令书、《史记.天官书》等古天文书以及术数书;这些内容在战国至秦汉时期因农家与阴阳五行学说及民间方术之间的互动而进入农学领域,并因后世农书所采用的经学注疏方法而得以不断传承和拓展,《四时纂要》对前代农书中的天文术数内容作了系统的整理归纳。至于农书中引入天文术数内容的原因,观象授时的传统为天文术数内容进入农书打开了方便之门,而天文术数内容在农事安排中所起的背景作用使其有必要成为农书的一个组成部分,术数在唐朝社会上的流行则为《四时纂要》归纳整理农学中的天文术数内容提供了现实基础。

关键词：《四时纂要》天文术数韩鄂传统农学

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