检索结果-南通市图书馆

在线全文

学校读者我要写书评

暂无评论

一个玉米矮秆突变体K123d的遗传鉴定

植物遗传资源学报 2017年第1期18卷 155-163页

作者：徐敏石海春余学杰谭义川柯永川赵长云柯永培四川农业大学农学院成都611130 乐山市农业科学研究院乐山614000 四川农大正红生物技术有限责任公司成都610213

矮秆已被广泛用于改良作物的抗倒伏性状,培育理想株型,从而提高作物产量。玉米矮秆突变体K123d由自交系K123自然突变产生。本研究比较该突变体与野生型主要农艺性状差异及其对赤霉素的敏感性;用K123d与株高不同的3个自交系分别构建F1、B... 详细信息

矮秆已被广泛用于改良作物的抗倒伏性状,培育理想株型,从而提高作物产量。玉米矮秆突变体K123d由自交系K123自然突变产生。本研究比较该突变体与野生型主要农艺性状差异及其对赤霉素的敏感性;用K123d与株高不同的3个自交系分别构建F1、BC和F2群体,分析矮秆性状的遗传模式;以K169/K123d-F2为定位群体,采用集团分离分析法(BSA),运用SSR标记定位矮秆基因d123;参照br-2序列信息分段设计特异引物,同源克隆d123。结果表明,与野生型相比K123d株高降低35.59%,穗位高降低、节间缩短、叶片较直立,但结实率差,对赤霉素敏感;在F2群体和BC1群体中,正常植株与矮秆植株分离比例分别符合3∶1和1∶1,说明矮秆性状受1对隐性基因控制;其矮秆基因d123定位于第一条染色体上SSR标记umc1278和bnlg1564之间,遗传距离分别为12.8 c M和7.3 c M;同源克隆显示d123与br-2存在12个碱基替换,其中第4个外显子编码的一个谷氨酸被替换为赖氨酸。由此可见,矮秆突变体K123d为br-2的一个突变类型,对矮化育种具有进一步研究利用价值。

关键词：玉米矮秆基因突变遗传分析 SSR标记基因定位同源克隆

Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第1期20卷 6-20页

作者： Xiu-Yun zhao De-En Xu Ming-Lei Wu Ji-chuan Liu Zi-Ling Shi Quan-Hong Ma Department of Neurology and Clinical Research Center of Neurological Disease the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Neuroscience&Jiangsu key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases Soochow UniversitySuzhouJiangsu ProvinceChina Department of Neurology Jiangnan University Medical CenterWuxiJiangsu ProvinceChina

The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular *** reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role in maintaining endoplasmic reticulum homeostasis by controlling endoplasmic reticulum turnover,remodeling,and *** this review,we briefly describe the endoplasmic reticulum quality control system,and subsequently focus on the role of endoplasmic reticulum autophagy,emphasizing the spatial and temporal mechanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular *** also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative *** summary,this review highlights the mechanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve *** review would help researchers to understand the roles and regulatory mechanisms of endoplasmic reticulum-phagy in neurodegenerative disorders.

关键词： autophagy endoplasmic reticulum endoplasmic reticulum autophagy endoplasmic reticulum quality control system endoplasmic reticulum receptors endoplasmic reticulum-associated degradation neurodegeneration neurodegenerative disease selective autophagy unfolded protein response

Highly mass activity electrocatalysts with ultralow Pt loading on carbon black for hydrogen evolution reaction

在线全文

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 182-190页

作者： Shaorou ke Yajing zhao Xin Min Yanghong Li Ruiyu Mi Yangai Liu Xiaowen Wu Minghao Fang zhaohui Huang Engineering Research Center of Ministry of Education for Geological Carbon Storage and Low Carbon Utilization of Resources Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid WastersNational Laboratory of Mineral MaterialsSchool of Materials Science and TechnologyChina University of Geosciences(Beijing)Beijing 100083China

Pt-based nanocatalysts offer excellent prospects for various ***,the low loading of Pt with excellent performance for efficient and stable nanocatalysts still presents a considerable *** this study,nanocatalysts with ultralow Pt content,excellent performance,and carbon black as support were prepared through in-situ ***~2-nm particles uniformly and stably dispersed on carbon black because of the strong s-p-d orbital hybridizations between carbon black and Pt,which suppressed the agglomeration of Pt *** unique structure is beneficial for the hydrogen evolution *** catalysts exhibited remarkable catalytic activity for hydrogen evolution reaction,exhibiting a potential of 100 mV at 100 mA·cm^(-2),which is comparable to those of commercial Pt/C *** activity(1.61 A/mg)was four times that of a commercial Pt/C catalyst(0.37 A/mg).The ultralow Pt loading(6.84wt%)paves the way for the development of next-generation electrocatalysts.

关键词： hydrogen evolution reaction ultralow platinum in-situ synthesis ultrasound

The complex roles of m^(6)A modifications in neural stem cell proliferation, differentiation, and self-renewal and implications for memory and neurodegenerative diseases

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第6期20卷 1582-1598页

作者： Yanxi Li Jing Xue Yuejia Ma ke Ye Xue zhao Fangliang Ge Feifei Zheng Lulu Liu Xu Gao Dayong Wang Qing Xia Department of Biochemistry and Molecular Biology College of Basic Medical SciencesHarbin Medical UniversityHarbinHeilongjiang ProvinceChina College of Basic Medical Sciences Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Basic Medical Institute Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina key Laboratory of Heilongjiang Province for Genetically Modified Animals Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Translational Medicine Research and Cooperation Center of Northern China Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijingChina

N6-methyladenosine(m^(6)A), the most prevalent and conserved RNA modification in eukaryotic cells, profoundly influences virtually all aspects of mRNA metabolism. mRNA plays crucial roles in neural stem cell genesis and neural regeneration, where it is highly concentrated and actively involved in these processes. Changes in m^(6)A modification levels and the expression levels of related enzymatic proteins can lead to neurological dysfunction and contribute to the development of neurological diseases. Furthermore, the proliferation and differentiation of neural stem cells, as well as nerve regeneration, are intimately linked to memory function and neurodegenerative diseases. This paper presents a comprehensive review of the roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, as well as its implications in memory and neurodegenerative diseases. m^(6)A has demonstrated divergent effects on the proliferation and differentiation of neural stem cells. These observed contradictions may arise from the time-specific nature of m^(6)A and its differential impact on neural stem cells across various stages of development. Similarly, the diverse effects of m^(6)A on distinct types of memory could be attributed to the involvement of specific brain regions in memory formation and recall. Inconsistencies in m^(6)A levels across different models of neurodegenerative disease, particularly Alzheimer's disease and Parkinson's disease, suggest that these disparities are linked to variations in the affected brain regions. Notably, the opposing changes in m^(6)A levels observed in Parkinson's disease models exposed to manganese compared to normal Parkinson's disease models further underscore the complexity of m^(6)A's role in neurodegenerative processes. The roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, and its implications in memory and neurodegenerative diseases, appear contradictory. These inconsistencies may be a

关键词： Alzheimer's disease cell self-renewal central nervous system memory microglia nerve regeneration neurodegenerative diseases neurogenesis RNA methylation

Optimal Investment Control of Macroeconomic Systems

在线全文

学校读者我要写书评

暂无评论

Journal of China University of Mining and Technology 2006年第3期16卷 362-366页

作者： zhao ke-jie LIU chuan-zhe School of Management China University of Mining ＆ Technology XuzhouJiangsu 221008 China

Economic growth is always accompanied by economic fluctuation. The target of macroeconomic control is to keep a basic balance of economic growth, accelerate the optimization of economic structures and to lead a rapid, sustainable and healthy development of national economies, in order to propel society forward. In order to realize the above goal, investment control must be regarded as the most important policy for economic stability. Readjustment and control of investment includes not only control of aggregate investment, but also structural control which depends on economic-technology relationships between various industries of a national economy. On the basis of the theory of a generalized system, an optimal investment control model for government has been developed. In order to provide a scientific basis for government to formulate a macroeconomic control policy, the model investigates the balance of total supply and aggregate demand through an adjustment in investment decisions realizes a sustainable and stable growth of the national economy. The optimal investment decision function proposed by this study has a unique and specific expression, high regulating precision and computable characteristics.

关键词： generalized system macroeconomic control optimal investment control

Performance improvement of Ethylene-Vinyl Acetate Copolymer Pour Point Depressant(EVA PPD)by adding small dosages of Laurylamine(LA)

在线全文

学校读者我要写书评

暂无评论

Petroleum Science 2022年第5期19卷 2472-2482页

作者： Xue Xia chuan-Xian Li Guang-Yu Sun ke-ke zhao Jie Zhang Bo Yao Fei Yang College of Pipeline and Civil Engineering China University of PetroleumQingdaoShandong266580PR China Shandong Provincial key Laboratory of Oil&Gas Storage and Transportation Safety QingdaoShandong266580PR China China Petroleum Engineering&Construction Corp.Beijing Company PR China

Lauramine is widely considered to be an asphaltene flocculant,but its effect on the modification of crude oil by PPDs has been little *** this paper,the effect of LA dosage on the rheology improvement of EVA PPDs(100 ppm)on Qinghai waxy crude oil was investigated through rheological measurement,wax precipitating analysis,granularity test and resins/asphaltenes FTIR *** with pure EVA,the compounding of LA and EVA obviously enhances the agglomeration degree and reduces the number of fine wax crystals,thus further enhancing the rheology of the oil samples,and the best performance is at the LA dosage of 200 *** relatively small LA dosages,the LA facilitates the adsorption of EVA molecules on the asphaltene surfaces,which favors the becoming of EVA/asphaltenes composite particles;but at relatively high LA dosages,the LA makes the asphaltenes more aggregated and disturbs the EVA adsorption on the asphaltenes,which is adverse for the formation of EVA/asphaltenes compound *** compound particles can serve as wax precipitating templates and significantly influence its morphology,thus further improving the crude oil *** consequence,the rheology improvement of EVA PPDs on Qinghai waxy crude oil first increases and then decreases with increasing the LA dosage.

关键词： Waxy crude oil EVA PPD Laurylamine Asphaltenes Synergistic effect

Effect of Cold Deformation on the Friction–Wear Property of a Biomedical Nickel-Free High-Nitrogen Stainless Steel

在线全文

学校读者我要写书评

暂无评论

Acta Metallurgica Sinica(English Letters) 2016年第3期29卷 217-227页

作者： Hao-chuan zhao Yi-Bin Ren Jia-Hui Dong Xin-Min Fan ke Yang Department of Materials Science and Engineering Nanjing University of Science and Technology Institute of Metal Research Chinese Academy of Sciences

The microstructural,mechanical and corrosion properties of different cold-rolled biomedical nickel-free highnitrogen stainless steels（NFHNSSs） were investigated to study the effect of cold deformation on its dry wear resistance as well as corrosion–wear behaviors in distilled water and Hank＇s solution. The results indicated that NFHNSS was characterized by stable austenite and possessed excellent work-hardening capacity; due to increasing cold deformation,the corrosion resistance just decreased very slightly and the dry wear rate decreased initially but subsequently increased,while the corrosion–wear resistance was improved monotonically in both distilled water and Hank＇s solution in spite of the presence of corrosive ions. The friction coefficients for different cold-rolled NFHNSSs were very close under the same lubricating condition,but they were the largest in distilled water compared to that in dry wear tests and Hank＇s solution.

关键词： Nickel-free high-nitrogen stainless steel Cold deformation Friction Wear Lubricating condition

Axial enantiomers with donor-regulated TADF feature for multicolor circularly polarized electroluminescence

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2024年第6期67卷 2039-2045页

作者： Chen-Hao Guo Wen-Long zhao ke-ke Tan Wei-Chen Guo Liheng Feng chuan-Feng Chen Meng Li School of Chemistry and Chemical Engineering Shanxi UniversityTaiyuan030006China Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Molecular Recognition and FunctionInstitute of ChemistryChinese Academy of SciencesBeijing100190China University of Chinese Academy of Sciences Beijing100049China

This study optimized the TADF feature of axial chiral enantiomers through precise donor engineering,and multicolor CP-TADFwas achieved in the axial chiral *** pairs of axial enantiomers with donor-regulated TADF feature,namely(R/S)-TPCBD,(R/S)-DPCBD,and(R/S)-DPACBD,were synthesized by introducing carbazole donors with different substituents onto biphenyl cyanide *** the electron-donating ability of donors increases,the emission of these axial enantiomers ranges from 455,476 to 552 nm,their singlet-triplet energy gaps(ΔE_(ST))gradually decrease from 0.30,0.22 to 0.02 e V,accompanied by an increasement in the transition rate(k_(RISC))of RISC process,and the k_(RISC)of DPACBD could reach up to 7.16×10^(5)s^(-1).These axial enantiomers also exhibit mirror-image CD and circularly polarized luminescence(CPL)***,OLEDs based on TPCBD,DPCBD,and DPACBD as emitter were then fabricated,which displayed blue,green,and orange electroluminescence with EQE_(max)of 13.0%,16.4%,and 25.0%,*** results also exhibited a phenomenon of device efficiency increasing with the enhancement of donor ***,the CP-OLEDs using(R/S)-TPCBD,(R/S)-DPCBD and(R/S)-DPACBD as emitters displayed intense CPEL signals with g_(EL)values of 3.4×10^(-3)/-4.1×10^(-3),3.2×10^(-3)/-3.1×10^(-3)and2.3×10^(-3)/-2.1×10^(-3),*** convenient molecular engineering of donor regulation in the same molecular skeleton,CP-TADF materials with multicolor CPEL and improved device performance could be conveniently achieved.

关键词： axial chirality thermally activated delayed fluorescence circularly polarized luminescence electroluminescence organic light-emitting diodes

Optimal operating policy for a controllable queueing model with a fuzzy environment

在线全文

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第2期10卷 311-318页

作者： Chuen-horng LIN Jau-chuan ke Department of Information Management Department of Applied Statistics National Taichung Institute of Technology

We construct the membership functions of the fuzzy objective values of a controllable queueing model,in which cost elements,arrival rate and service rate are all fuzzy numbers. Based on Zadeh's extension principle,a set of parametric nonlinear programs is developed to find the upper and lower bounds of the minimal average total cost per unit time at the possibility level. The membership functions of the minimal average total cost are further constructed using different values of the possibility level. A numerical example is solved successfully to illustrate the validity of the proposed approach. Because the object value is expressed and governed by the membership functions,the optimization problem in a fuzzy environment for the controllable queueing models is represented more accurately and analytical results are more useful for system designers and practitioners.

关键词： Controllable queue Fuzzy sets Membership function Nonlinear programming