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A quantum-search-based multi-classifier for image recognition

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 21-31页

作者： Lu Liu Xingyu Wu Lufan zhang chuan Wang School of Artificial Intelligence Beijing Normal University Applied Optics Beijing Area Major Laboratory Beijing Normal University

The multi-class classification of images is a pivotal challenge within the realm of image processing. As the volume of visual data continues to expand, there is a burgeoning interest in harnessing the unique capabilities of quantum computation to augment the efficiency of classification tasks. However, many existing methods for training quantum image multi-classifiers parallel classical machine learning techniques, where the requisite circuit measurements increase linearly with the volume of training data. This work introduces a novel approach for training a quantum image multi-classifier based on the quantum search algorithm. We have meticulously conducted rigorous experiments on a handwritten digit dataset, a classic benchmark in the field. The results have been meticulously compared with previous works, and the comparative analysis not only validates the efficiency of our proposed approach, requiring only O(N/b) measurements during training, but also highlights a significant quadratic speedup of the algorithm.

关键词： quantum computation image recognition quantum search algorithm

Immune Responses and Histopathological Changes in Rabbits Immunized with Inactivated SARS Coronavirus

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中国病毒学 2007年第5期22卷 360-365页

作者： chuan-hai zhang Xin-jian LIU Yi-fei WANG Jia-hai LU Huan-ying ZHENG Sheng XIONG Mei-ying zhang Qiu-ying LIU Biomedicine Research ＆ Development Center Jinan University Guangzhou 510630 China Department of Chemistry and Biology West Anhui University Lu-an 237012 China The First People＇s Hospital Shanghai Jiaotong University Shanghai 200080 China School of Public Health Sun Yat-sen University Guangzhou 510080 China Center for Diseases Control and Prevention of Guangdong Province Guangzhou 510300 China

To evaluate the immunogenicity of inactivated SARS coronavirus(SARS-CoV),three groups of rabbits were immunized three times at 2-week intervals with inactivated vaccine + adjuvant,adjuvant,and normal saline *** batchs of serum were sampled from the auricular vein at day 7 to day 51,and specific IgG antibody titers and neutralizing antibody titers were detected by indirect ELISA and micro-cytopathic effect neutralizing *** specificity was identified by proteinchip *** changes were detected by H&E *** results showed that,rabbits in the experimental group immunized with inactivated SARS-CoV all generated specific IgG antibodies with neutralizing activity,which suggested the inactivated SARS-CoV could preserve its antigenicity well and elicit an effective humoral immune *** peak titer value of specific IgG antibody and neutralizing antibody reached 1:40960 and 1:2560 *** the experimental group,no obvious histopathological changes was detected in the H&E stained slides of heart,spleen,kidney and testis samples,but the livers had slight histopathological changes,and the lungs presented remarkable histopathological *** findings are of importance for SARS-CoV inactivated vaccine development.

关键词：免疫反应组织病理学兔急性呼吸综合症冠状病毒 SARS 疫苗

In vitro Anti-viral Activity of the Total Alkaloids from Tripterygium hypoglaucum against Herpes Simplex Virus Type 1

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Virologica Sinica 2010年第2期25卷 107-114页

作者： Zhe REN chuan-hai zhang Lian-jun WANG Yun-xia CUI Ren-bin QI Chong-ren YANG Ying-jun zhang Xiao-yi WEI Da-xiang LU Yi-fei WANG Biomedicine Research and Development Center of Jinan University Guangzhou 510632 China MedicalCollege of Jinan University Guangzhou 510632 China National Engineering Research Center of GeneticMedicine Guangzhou 510632 China Department of Chemistry and Biology West Anhui University Lu＇an 237012 China Kunming Institute of Botany Chinese Academy of Sciences Kunming 650204 China SouthChina Botanical Garden Chinese Academy of Sciences Guangzhou 510000 China

Herpes simplex virus type 1 （HSV-1） is a commonly occurring human pathogen worldwide. There is an urgent need to discover and develop new alternative agents for the management of HSV-1 infection. Tripterygium hypoglaucum （level） Hutch （Celastraceae） is a traditional Chinese medicine plant with many pharmacological activities such as anti-inflammation, anti-tumor and antifertility. The usual medicinal part is the roots which contain about a 1% yield of alkaloids. A crude total alkaloids extract was prepared from the roots of T. hypoglaucum amd its antiviral activity against HSV-1 in Vero cells was evaluated by cytopathic effect （CPE） assay, plaque reduction assay and by RT-PCR analysis. The alkaloids extract presented low cytotoxicity （CC50 = 46.6μg/mL） and potent CPE inhibition activity, the 50% inhibitory concentration （ICs0） was 6.5 μg/mL, noticeably lower than that of Acyclovir （15.4μg /mL）. Plaque formation was significantly reduced by the alkaloids extract at concentrations of 6.25 μg/mL to 12.5 μg/mL, the plaque reduction ratio reached 55% to 75% which was 35% higher than that of Acyclovir at the same concentration. RT-PCR analysis showed that, the transcription of two important delayed early genes UL30 and UL39, and a late gene US6 of HSV-1 genome all were suppressed by the alkaloids extract, the expression inhibiting efficacy compared to the control was 74.6% （UL30）, 70.9% （UL39） and 62.6% （US6） respectively at the working concentration of 12.5μg/mL. The above results suggest a potent anti-HSV-1 activity of the alkaloids extract in vitro.

关键词： Tripterygium hypoglaucum Herpes complex virus Alkaloid Antiviral activity Gene expression

Stability and Stabilization of Sampled-Data Based LFC for Power Systems:A Data-Driven Method

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IEEE/CAA Journal of Automatica Sinica 2025年第1期 291-293页

作者： Yu-Long Fan chuan-Ke zhang Yong He the School of Automation China University of Geosciences the Hubei Key Laboratory of Advanced Control and Intelligent Automation for Complex Systems the Engineering Research Center of Intelligent Technology for Geo-Exploration Ministry of Education IEEE

Dear Editor,This letter is concerned with stability analysis and stabilization design for sampled-data based load frequency control(LFC) systems via a data-driven method. By describing the dynamic behavior of LFC systems based on a data-based representation, a stability criterion is derived to obtain the admissible maximum sampling interval(MSI) for a given controller and a design condition of the PI-type controller is further developed to meet the required MSI. Finally, the effectiveness of the proposed methods is verified by a case study.

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Metastable seed-crystals: epitaxial growth of branched-array organic heterostructure nanowires

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Science China Chemistry 2025年

作者： Jin Feng Zhen-Yu Geng Ting-Yao Song Ying-Xin Ma chuan-Zeng Wang Wei zhang Hong-Tao Lin Jin Zhou Shu-Ping Zhuo Shu-hai Chen Xue-Dong Wang School of Chemistry and Chemical Engineering Shandong University of Technology Institute of Functional Nano & Soft Materials (FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials & DevicesSoochow University College of Chemistry and Chemical Engineering Hunan Normal University

Tunable light–matter interactions are exhibited by organic low-dimensional crystals, making these crystals a promising platform for organic photonics. However, the precise synthesis of organic low-dimensional crystals remains challenging due to the stochastic nature of molecular nucleation processes. Herein, the directed nucleation process is driven by the introduction of metastable seed-crystals as the trunk, which ultimately leads to branched-array organic heterostructures. The successful formation of organic heterostructures with high-density branched arrays is attributed to the highest attachment energy (Eatt（023）=-104.25 kcal mol-1) of the exposed （023） crystal plane during the seed-crystal growth route. Significantly, these as-prepared heterostructures inherently have an ultralow lattice mismatch ratio η of 0.7%between trunk and branch, which contributes to the multi-channel photon transportation. Therefore, this work provides valuable insights into a versatile synthetic strategy for accessing low-dimensional heterostructures for integrated optoelectronics.

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Stable copper boron–imidazolate cage as Cu-riched enzyme for highly efficient electrocatalytic CO2 reduction to ethylene

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Science China Chemistry 2025年

作者： Jun-Qiang Chen Qiao-Hong Li Qin-Long Hong Ping Shao hai-Xia zhang Jian zhang State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences

Single-atom catalyst has garnered widespread attention to mimic mature enzymes due to its well-defined atomic structure and coordination environments. However, since the carbon–carbon（C–C） coupling reactions require synergistic catalysis of multiple sites, single-atom catalysts suffer from insufficient active sites and unclear reaction mechanisms. Controlling the reaction intermediates in a precisely targeted pocket through careful metal–organic cage design is therefore crucial. Here, we prepare a tetrahedral [Cu6L4]-type boron–imidazolate cage integrating highly active Cu sites and optimized cavity, which exhibits enzyme like specific catalytic performance in electrochemical CO2reduction reaction（CO2RR） to enhance the selectivity of *** analyses and computational calculations suggest that the single Cu site together with neighboring boron–imidazolate ligands provides suitably synergistic effects that enable the energetically favorable formation of an *COCHO intermediate, a key step determining selectivity. As a result, the [Cu6L4]-type cage of BIC-145 achieves a Faradaic efficiency of 28% for C2H4maintaining an average current density of -3.54 mA cm-2over a 5-hour electrolysis period. This work represents the first example for studying single-metal site catalysts with ultra-low coordination numbers through the rational design of metal–organic cages.

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Visible-light-responsive homologous heterostructure of oxynitrides constructed to boost charge separation and water splitting

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Science China Chemistry 2025年第01期 186-191页

作者： hai Zou Yunfeng Bao Xueshang Xin Yu Qi Tengfeng Xie Fuxiang zhang State Key Laboratory of Catalysis Dalian National Laboratory for Clean Energy Dalian Institute of Chemical Physics Chinese Academy of Sciences School of Chemistry and Chemical Engineering Liaoning Normal University College of Chemistry Jilin University

Constructing type II heterostructures represents a widely recognized strategy for enhancing charge separation and photocatalytic efficiency,but it remains challenging to fabricate homologous heterostructures based on visible-light-responsive semiconductors,especially for popularly investigated （oxy）nitrides with low thermal ***,we synthesized a homologous heterostructure （denoted as YTON＿H） based on the oxynitrides of YTaO4-xNyand YTa *** heterostructure exhibits type II band structure alignment and intimate interface achieved through a magnesium （Mg） powder-assisted nitridation *** with widely reported heterologous heterostructures,the as-obtained YTON＿H homologous heterostructure could similarly exhibit enhanced charge separation as well as photocatalytic water splitting performance with respect to its counterparts(YTaO4-xNyand YTaON2).Meanwhile,detailed structural characterizations and spectroscopy analysis have been made to confirm the formation of heterostructure and promotion of spatial charge separation.

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Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-Yan Huang Yi-De zhang Jie Chen hai-Di Fan Wan Wang Bin Wang Ju-Yun Ma Peng-Peng Li hai-Wei Pu Xin-Yian Guo Jian-Gang Shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

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不同术式泪囊鼻腔吻合术治疗慢性泪囊炎

国际眼科杂志 2012年第7期12卷 1399-1401页

作者：丛日昌张海川林荣封韩丽川白玉广东医学院附属西乡人民医院眼科中国广东省深圳市518102 广东医学院附属西乡人民医院耳鼻喉科中国广东省深圳市518102

目的:比较改良的传统泪囊鼻腔吻合术和经鼻内镜下泪囊鼻腔吻合术治疗慢性泪囊炎的临床疗效。方法:选取病历资料完整、行手术治疗的慢性泪囊炎患者112例,其中行改良的传统泪囊鼻腔吻合术患者53例,行鼻内镜下泪囊鼻腔吻合术患者59例。结果... 详细信息

目的:比较改良的传统泪囊鼻腔吻合术和经鼻内镜下泪囊鼻腔吻合术治疗慢性泪囊炎的临床疗效。方法:选取病历资料完整、行手术治疗的慢性泪囊炎患者112例,其中行改良的传统泪囊鼻腔吻合术患者53例,行鼻内镜下泪囊鼻腔吻合术患者59例。结果:统计经过6～12mo的随访观察,改良的传统泪囊鼻腔吻合术组有效51例,有效率96.2%,经鼻内镜下泪囊鼻腔吻合组有效55例,有效率93.2%,两组差异比较无统计学意义(P>0.05)。结论:经鼻内镜下泪囊鼻腔吻合术具有较多优点,避免了面部瘢痕,符合现代微创手术要求;掌握手术指征,其手术效果可接近改良的传统泪囊鼻腔吻合术。

关键词：慢性泪囊炎泪囊鼻腔吻合鼻内镜改良术式