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Journal of Contemporary Educational Research 2024年第5期8卷 117-127页

作者： chuan-chin chen Jiann-Sheng Jiang Shaolei Zhou Graduate Institute of Cultural and Creative Design Tung-Fang Design UniversityKaohsiung 83044Taiwan ProvinceChina Department of Art and Design Shaoguan UniversityShaoguan 512000Guangdong ProvinceChina

Ceramic relief mural is a contemporary landscape art that is carefully designed based on human nature,culture,and architectural wall space,combined with social customs,visual sensibility,and *** may also become the main axis of ceramic art in the *** public ceramic relief murals(PCRM)are most distinctive with the PCRM pioneered by Pan-Hsiung Chu of Meinong Kiln in *** addition to breaking through the limitations of traditional public ceramic murals,Chu leveraged local culture and *** theme of art gives PCRM its unique style and innovative value throughout the Taiwan *** study mainly analyzes and understands the design image of public ceramic murals,taking Taiwan PCRM’s design and creation as the scope,and applies STEEP analysis,that is,the social,technological,economic,ecological,and political-legal environments are analyzed as core factors;eight main important factors in the artistic design image of ceramic murals are ***,interpretive structural modeling(ISM)is used to establish five levels,analyze the four main problems in the main core factor area and the four main target results in the affected factor area;and analyze the problem points and target points as well as their causal *** is expected to sort out the relationship between these factors,obtain the hierarchical relationship of each factor,and provide a reference basis and research methods.

关键词： Interpretive structural modeling(ISM) STEEP analysis Public ceramic relief murals(PCRM)

Influence of Film Thickness on Nanofabrication of Graphene Oxide

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Nanomanufacturing and Metrology 2024年第2期7卷 13-25页

作者： chuan Tang Lei chen Linmao Qian Tribology Research Institute The State Key Laboratory of Rail Vehicle SystemSchool of Mechanical EngineeringSouthwest Jiaotong UniversityChengdu 610031China

Nanofabrication of two-dimensional materials through mechanical machining is normally influenced by not only process parameters such as load and velocity but also intrinsic properties such as strength and ***,we examined the effects of graphene oxide(GO)film thickness on nanofabrication on the plane surfaces and at the step edges using scanning probe microscope *** material removal of GO initiates at the load above a critical value,which strongly depends on film thickness and *** the increase in film thickness,the critical load decreases monotonically on the plane surfaces but increases gradually at the step ***,the critical load for the GO monolayer at the step edges is at least 25 times lower than that on the plane surfaces,and the gap decreases to around 3 times when GO thickness increases to four ***,mechanical nanofabrication initiating from the GO step edge allows producing various nanopatterns under extremely low loads around 1 ***,the GO nanostructures are deoxidized by annealing at 800°C in high-purity argon to restore their highly functionalized conjugated structures,which are supported by X-ray diffraction and Raman *** work provides a novel approach to fabricating graphene-like nanostructures by deoxidizing GO after nanofabrication,which holds significant potential for applications in graphene-based devices.

关键词： Graphene oxide Nanofabrication Film thickness step edge Nanopattern Deoxidized treatment

High glucose reduces Nrf2-dependent cRAGE release and enhances inflammasome-dependent IL-1βproduction in monocytes:the modulatory effects of EGCG

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Food Science and Human Wellness 2024年第3期13卷 1531-1542页

作者： Chi-Hao Wu Yin-Hsuan Chang chin-Lin Hsu Sheng-Yi chen Gow-chin Yen Graduate Programs of Nutrition Science School of Life ScienceTaiwan Normal UniversityTaipei 106209TaiwanChina Department of Food Science and Biotechnology Chung Hsing UniversityTaichung 40227TaiwanChina School of Nutrition Chung Shan Medical UniversityTaichung 40201TaiwanChina

Soluble receptor for advanced glycation end products(sRAGE)acts as a decoy sequestering of RAGE ligands,thus preventing the activation of the ligand-RAGE axis linking human ***,the molecular mechanisms underlying sRAGE remain *** this study,THP-1 monocytes were cultured in normal glucose(NG,5.5 mmol/L)and high glucose(HG,15 mmol/L)to investigate the effects of diabetesrelevant glucose concentrations on sRAGE and interleukin-1β(IL-1β)*** modulatory effects of epigallocatechin gallate(EGCG)in response to HG challenge were also *** enhanced intracellular reactive oxygen species(ROS)generation and RAGE *** secretion of sRAGE,including esRAGE and cRAGE,was reduced under HG conditions,together with the downregulation of a disintegrin and metallopeptidase 10(ADAM10)and nuclear factor erythroid 2-related factor 2(Nrf2)nuclear ***,the HG effects were counteracted by siRAGE and exacerbated by *** immunoprecipitation results showed that Nrf2 binding to the ADAM10 promoter and HG interfered with this *** data reinforce the notion that RAGE and Nrf2 might be sRAGE-regulating *** HG conditions,the treatment of EGCG reduced ROS generation and RAGE ***-stimulated cRAGE release was likely caused by the upregulation of the Nrf2-ADAM10 *** inhibited HG-mediated NLRP3 inflammasome activation at least partly by stimulating sRAGE,thereby reducing IL-1βrelease.

关键词： Epigallocatechin gallate(EGCG) Inflammasome Nuclear factor erythroid 2-related factor 2(Nrf2) Receptor for advanced glycation end products(RAGE) Soluble RAGE(sRAGE)

A Dual Closed-Loop Digital Twin Construction Method for Optimizing the Copper Disc Casting Process

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IEEE/CAA Journal of Automatica Sinica 2024年第3期11卷 581-594页

作者： Zhaohui Jiang chuan Xu Jinshi Liu Weichao Luo Zhiwen chen Weihua Gui IEEE the School of Automation Central South UniversityChangsha 410083China the Peng cheng Laboratory Shenzhen 518000China

The copper disc casting machine is core equipment for producing copper anode plates in the copper metallurgy *** copper disc casting machine casting package motion curve(CPMC) is significant for precise casting and efficient ***,the lack of exact casting modeling and real-time simulation information severely restricts dynamic CPMC *** this end,a liquid copper droplet model describes the casting package copper flow pattern in the casting ***,a CPMC optimization model is proposed for the first *** top of this,a digital twin dual closed-loop self-optimization application framework(DT-DCS) is constructed for optimizing the copper disc casting process to achieve self-optimization of the CPMC and closed-loop feedback of manufacturing information during the casting ***,a case study is carried out based on the proposed methods in the industrial field.

关键词： Copper disc casting machine digital twin(DT) mechanism modeling self-optimization

Permeable carbon fiber based thermoelectric film with exceptional EMI shielding performance and sensor capabilities

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Journal of Advanced Ceramics 2024年第8期13卷 1119-1131页

作者： Junjie Zhu chuan Sun Wanlin Feng Mengran chen Peng-An Zong Chunlei Wan College of Materials Science and Engineering Nanjing Tech UniversityNanjing 211800China Nationai Innovation Institute of Defense Technology Academy of Military Sciences of the People's Liberation Army of ChinaBeijing 100089China Institute of Nuclear Physics and Chemistry Innovation Research Team for Advanced CeramicsChina Academy of Engineering PhysicsMianyang 621900China State Key Laboratory of New Ceramics and Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China

Thermoelectric(TE)technologies offer a promising approach for directly converting skin heat into electricity for wearable *** p-type Sb2Tes and n-type BizTes as top-performing materials at room temperature,their rigid inorganic structure,with ultralow moisture permeability,poses challenges in warm and humid conditions,fostering bacterial growth and potential skin *** address this issue,we developed a cross-linked core-shell structure by electrodepositing Sb_(2)Te_(3)(Bi_(2)Te_(3))onto carbon fiber(CF).This architecture significantly improved the electrical conductivity and the Seebeck coefficient,resulting in a remarkable 300-fold increase in the power factor compared to that of pure *** CF/Sb_(2)Te_(3) and CF/Bi2Te films demonstrated optimal power factors of 450 and 121μW·m^(-1)·K^(-2),***,the fabricated films exhibited outstanding moisture permeability,over 3000 g·m^(-2)·d^(-1),exceptional electromagnetic interference shielding efficiency approaching 93 dB,and versatility as sensors for language assistance and respiratory *** attributes underline their broad applicability,emphasizing their suitability for human health protection in diverse scenarios.

关键词： thermoelectric(TE) carbon fiber(CF) Bi_(2)Te_(3) electrodeposition moisture permeability electromagnetic interference shielding

Axial enantiomers with donor-regulated TADF feature for multicolor circularly polarized electroluminescence

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Science china Chemistry 2024年第6期67卷 2039-2045页

作者： chen-Hao Guo Wen-Long Zhao Ke-Ke Tan Wei-chen Guo Liheng Feng chuan-Feng chen Meng Li School of Chemistry and Chemical Engineering Shanxi UniversityTaiyuan030006China Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Molecular Recognition and FunctionInstitute of ChemistryChinese Academy of SciencesBeijing100190China University of chinese Academy of Sciences Beijing100049China

This study optimized the TADF feature of axial chiral enantiomers through precise donor engineering,and multicolor CP-TADFwas achieved in the axial chiral *** pairs of axial enantiomers with donor-regulated TADF feature,namely(R/S)-TPCBD,(R/S)-DPCBD,and(R/S)-DPACBD,were synthesized by introducing carbazole donors with different substituents onto biphenyl cyanide *** the electron-donating ability of donors increases,the emission of these axial enantiomers ranges from 455,476 to 552 nm,their singlet-triplet energy gaps(ΔE_(ST))gradually decrease from 0.30,0.22 to 0.02 e V,accompanied by an increasement in the transition rate(k_(RISC))of RISC process,and the k_(RISC)of DPACBD could reach up to 7.16×10^(5)s^(-1).These axial enantiomers also exhibit mirror-image CD and circularly polarized luminescence(CPL)***,OLEDs based on TPCBD,DPCBD,and DPACBD as emitter were then fabricated,which displayed blue,green,and orange electroluminescence with EQE_(max)of 13.0%,16.4%,and 25.0%,*** results also exhibited a phenomenon of device efficiency increasing with the enhancement of donor ***,the CP-OLEDs using(R/S)-TPCBD,(R/S)-DPCBD and(R/S)-DPACBD as emitters displayed intense CPEL signals with g_(EL)values of 3.4×10^(-3)/-4.1×10^(-3),3.2×10^(-3)/-3.1×10^(-3)and2.3×10^(-3)/-2.1×10^(-3),*** convenient molecular engineering of donor regulation in the same molecular skeleton,CP-TADF materials with multicolor CPEL and improved device performance could be conveniently achieved.

关键词： axial chirality thermally activated delayed fluorescence circularly polarized luminescence electroluminescence organic light-emitting diodes

DGS1 improves rice disease resistance by elevating pathogenassociated molecular pattern-triggered immunity

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aBIOTECH 2024年第1期5卷 46-51页

作者： Yu Wang chuan Zheng You-liang Peng Qian chen MOA Key Lab of Pest Monitoring and Green Management and Frontiers Science Center for Molecular Design Breeding China Agricultural UniversityBeijing 100193China

Rice yield and disease resistance are two crucial factors in determining the suitability of a gene for agricultural *** grain size1(DGS1),encoding an RING-type E3 ligase,has been found to have a positive effect on rice yield by regulating rice grain number and 1000-grain ***,the role of DGS1 in rice blast resistance is still *** this study,we report that DGS1 enhances disease resistance by improving PTI responses,including stronger ROS burst and MAPK activation,and also increased expression of defense-related ***,DGS1 works in conjunction with ubiquitin conjugating enzyme OsUBC45 as an E2-E3 pair to facilitate the ubiquitin-dependent degradation of OsGSK3 and OsPIP2;1,thereby influencing rice yield and immunity,***,the DGS1-OsUBC45 module has the potential in facilitating rice agricultural breeding.

关键词： Rice blast PTI ERAD E2-E3 pair Ubiquitination

Development of small molecule drugs targeting immune checkpoints

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Cancer Biology & Medicine 2024年第5期21卷 382-399页

作者： Luoyi chen Xinchen Zhao Xiaowei Liu Yujie Ouyang chuan Xu Ying Shi Department of Oncology Sichuan Academy of Medical SciencesSichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 610054China Institute for Breast Health Medicine State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China Acupuncture and Massage College Chengdu University of Traditional Chinese MedicineChengdu 611137China

Immune checkpoint inhibitors(ICIs)are used to relieve and refuel anti-tumor immunity by blocking the interaction,transcription,and translation of co-inhibitory immune checkpoints or degrading co-inhibitory immune *** of small molecule drugs or biological materials,especially antibody-based ICIs,are actively being studied and antibodies are currently widely ***,such as anti-tumor efficacy,poor membrane permeability,and unneglected tolerance issues of antibody-based ICIs,remain evident but are thought to be overcome by small molecule *** structural studies have broadened the scope of candidate immune checkpoint molecules,as well as innovative chemical *** way of comparison,small molecule drug-based ICIs represent superior oral bioavailability and favorable pharmacokinetic *** ongoing clinical trials are exploring the synergetic effect of ICIs and other therapeutic strategies based on multiple ICI functions,including immune regulation,anti-angiogenesis,and cell cycle *** this review we summarized the current progression of small molecule ICIs and the mechanism underlying immune checkpoint proteins,which will lay the foundation for further exploration.

关键词： Immune checkpoints small molecule drugs programmed death protein 1 CD47 signal-regulatory proteinα

An Effective Approach for the Preparation of High Performance Thermal Conductive Polymer Composites Containing Liquid Metal

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chinese Journal of Polymer Science 2024年第7期42卷 992-1001,I0010页

作者： Xin chen Xue-Zhong Zhang Yi-Fei Yuan chuan-Liang chen Lian-Hu Xiong Qiang Fu Hua Deng College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu610065China Department of Materials Science and Engineering Sichuan University-Pittsburgh InstituteSichuan UniversityChengdu610065China

The preparation of high-performance thermal conductive composites containing liquid metals(LM)has attracted significant ***,the stable dispersion of LM within polymer solution and effective property contribution of liquid metals remains significant challenges that need to be *** by the properties of the dendritic structure of the tree root system in grasping the soil,“shear-induced precipitation-interfacial reset-reprotonation”processing strategy is proposed to prepare nanocomposites based on aramid micron fibers(AMFs)with hierarchical dendritic *** to the combination of van der Waals force provided by hierarchical dendritic structure,electrostatic interaction between AMFs and LM,coordinative bonding of―NH to LM,together with interfacial re-setting and multi-step protonation,several features can be achieved through such strategy:conducive to the local filler network construction,improvement of interfacial interaction,improvement of the stability of filler dispersion in the solvent,and enhancement of mechanical and thermal properties of the *** resulting AMFsp H=4/LM films demonstrate a thermal conductivity of 10.98 W·m^(-1)·K^(-1)at 70%filler content,improvement of 126.8%compared to ANFs/LM film;while maintaining a strength of~85.88 MPa,improvement of 77%compared to AMFs/LM *** also possess insulation properties,enable heat dissipation for high power *** work provides an effective strategy for the preparation of high performance polymer composites containing liquid metal.

关键词： Shear-induced Reprotonation AMFs LM Filler dispersion

Efficient and selective upcycling of waste polylactic acid into acetate using nickel selenide

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Journal of Energy Chemistry 2024年第10期97卷 575-584,I0012页

作者： Bing Lan Yinfang chen Nantian Xiao Na Liu Chao Juan chuan Xia Fan Zhang National Engineering Laboratory of Eco-Friendly Polymeric Materials College of ChemistrySichuan UniversityChengdu 610064SichuanChina School of Materials and Energy University of Electronic Science and Technology of ChinaChengdu 611731SichuanChina

The conversion of waste polylactic acid(PLA)plastics into high-value-added chemicals through electrochemical methods is a promising and sustainable ***,developing efficient and highly selective catalysts for lactic acid oxidation reaction(LAOR)and understanding the reaction process are ***,we report the electrooxidation of waste PLA to acetate at a high current density of 100 mA cm-2 with high Faraday efficiency(~95%)and excellent stability(>100 h)over a nickel selenide nanosheet *** addition,a total Faraday efficiency of up to 190%was achieved for carboxylic acids,including acetic acid and formic acid,by coupling with the cathodic CO_(2) reduction *** situ experimental results and theoretical simulations revealed that the catalytic activity center of LAOR was dynamically formed NiOOH species,and the surface-adsorbed SeO_(x) species accelerated the formation of Ni~(3+)species,thus promoting catalytic *** mechanism of lactic acid electrooxidation was further *** acid was dehydrogenated to produce pyruvate first and then formed CH_3CO due to preferential C-C bond cleavage,resulting in the presence of *** work demonstrated a sustainable method for recycling waste PLA and CO_(2) into high-value-added products.

关键词： Waste plastic upcycling Poly(lactic acid) Lactic acid electro-oxidation Acetic acid