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Quantification of perfluorinated compounds in atmospheric particulate shows potential connection with environmental event

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Journal of Environmental Sciences 2024年第2期136卷 237-247页

作者： Hua Tang ying Wang Shengling Si Hongli Li David Da Yong Chen National Institute of Metrology 18 BeisanhuandongluChaoyang DistrictBeijing 100029China School of Chemistry and Materials Science Nanjing Normal UniversityNanjing 210023China Si chuan Zhong Ce Biao Wu Technology Co.Ltd. Sichuan 610052China Department of Chemistry University of British ColumbiaVancouver V6T 1Z1BCCanada

A method of quantification of perfluorinated compounds(PFCs)from atmospheric particulate matter(APM)is described.A single step pretreatment method,selective pressurized liquid extraction(SPLE),was developed to reduce the high matrix background and avoid contamination from commonly used multiple sample pretreatment *** effective sorbent was selected to purify the PFCs during SPLE,followed by liquid chromatography-tandem mass spectrometry(LC–MS/MS),for quantification of *** affecting the SPLE efficiency,including temperature,static extraction time,and number of extraction cycles used,were *** optimum conditions were found to be 120℃,10 min,and 3 cycles,***-MS/MS method was developed to obtain the optimal sensitivity specific to *** method detection limits(MDLs)were 0.006 to 0.48 ng/g for the PFCs studied and the linear response range was from 0.1 to 100 ng/*** ensure accurate values were obtained,each step of the experiment was evaluated and controlled to prevent *** optimized method was tested by performing spiking experiments in natural particulate matter matrices and good rates of recovery and reproducibility were obtained for all target ***,the method was successfully used to measure 16 PFCs in the APM samples collected in Beijing over five years from 2015 to *** is observed that some PFCs follow the trend of total PFC changes,and can be attributed to the environment influencing events and policy enforcement,while others don't seem to change as much with time of the year or from year to year.

关键词： Selective pressurized liquid extraction Liquid chromatography-mass spectrometry Perfluorinated compounds Atmospheric particulate matter Pollution control

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含螺旋结构的水下声学覆盖层吸声特性研究

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噪声与振动控制 2024年第3期44卷 50-55页

作者：何川应童陶猛贵州大学机械工程学院贵阳550025

设计一种含圆柱空腔和金属螺旋结构的水下声学覆盖层,该覆盖层在565~5000Hz频率范围内平均吸声系数在0.85以上,具有带宽、吸声性能强的特点。通过有限元法分析该覆盖层的位移变化特点以及结构几何参数对吸声性能的影响,结果表明:金属螺... 详细信息

设计一种含圆柱空腔和金属螺旋结构的水下声学覆盖层,该覆盖层在565~5000Hz频率范围内平均吸声系数在0.85以上,具有带宽、吸声性能强的特点。通过有限元法分析该覆盖层的位移变化特点以及结构几何参数对吸声性能的影响,结果表明:金属螺旋结构的引入使基体橡胶产生反向运动(与入射波引起的基体橡胶位移方向相反),两个方向的运动在一定程度上可以相互抵消,从而消耗入射声波能量并有效提升吸声性能。叶片宽度、空腔半径、螺旋阶数的增加使得吸声峰向低频移动,但整体吸声性能会随之下降。

关键词：声学声学覆盖层螺旋结构吸声特性空腔谐振水下吸声

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沸石咪唑酯骨架材料-8/多壁碳纳米管电化学传感器灵敏检测镉离子(Ⅱ)和铅离子(Ⅱ)

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分析化学 2024年第4期52卷 541-549页

作者：冯小庚孙迪孙婧祎胡盈方雯倩熊英辽宁大学化学院

将沸石咪唑酯骨架材料-8（ZIF-8）与多壁碳纳米管（MWCNT）结合，制备得到ZIF-8/MWCNT复合材料，并基于此构建了一种可用于Cd2+和Pb2+同时测定的电化学传感器。MWCNT的引入增强了复合材料的导电性；同时，ZIF-8与MWCNT之间的协同作用使Z... 详细信息

将沸石咪唑酯骨架材料-8（ZIF-8）与多壁碳纳米管（MWCNT）结合，制备得到ZIF-8/MWCNT复合材料，并基于此构建了一种可用于Cd2+和Pb2+同时测定的电化学传感器。MWCNT的引入增强了复合材料的导电性；同时，ZIF-8与MWCNT之间的协同作用使ZIF-8/MWCNT复合材料表现出优异的电催化活性，将ZIF-8/MWCNT复合材料修饰玻碳电极（GCE），能够实现Cd2+和Pb2+的分别和同时检测。在最优实验条件下，基于ZIF-8/MWCNT/GCE的电化学传感器对Cd2+和Pb2+分别检测的线性范围分别为0.03～8.00μmol/L和0.03～6.00μmol/L，检出限分别为0.019和0.035μmol/L（S/N=3）；对Cd2+和Pb2+同时检测的线性范围分别为0.03～5.00μmol/L和0.03～5.00μmol/L，检出限分别为0.022和0.048μmol/L（S/N=3）。此传感器具有良好的选择性、重现性和稳定性，将其用于实际河水样品中Cd2+和Pb2+的测定，加标回收率分别为98.1%～104.0%和98.3%～102.2%，表明此传感器适用于实际水样中Cd2+和Pb2+的分析检测。

关键词：沸石咪唑酯骨架材料-8 多壁碳纳米管镉离子(Ⅱ) 铅离子(Ⅱ) 电化学传感器水样

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Adenylate kinase phosphate energy shuttle underlies energetic communication in flagellar axonemes

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Science China(Life Sciences) 2024年第8期67卷 1697-1714页

作者： Huan Wu Yanman Zhang Yuqian Li Shuya Sun Jintao Zhang Qingsong Xie Yue Dong Shushu Zhou Xuan Sha Kuokuo Li Jinyi Chen Xin Zhang Yang Gao Qunshan Shen Guanxiong Wang Xiaomin Zha Zongliu Duan Dongdong Tang chuan Xu Hao geng Mingrong Lv Yuping Xu Ping Zhou Zhaolian Wei Rong Hua Yunxia Cao Mingxi Liu Xiaojin He Reproductive Medicine Center Department of Obstetrics and GynecologyThe First Affiliated Hospital of Anhui Medical UniversityHefei 230022China State Key Laboratory of Reproductive Medicine and Offspring Health Department of Histology and EmbryologySchool of Basic Medical SciencesNanjing Medical UniversityNanjing 210029China State Key Laboratory of Reproductive Medicine and Offspring Health The Affiliated Taizhou People’s Hospital of Nanjing Medical UniversityTaizhou School of Clinical MedicineNanjing Medical UniversityNanjing 211166China Reproductive Medicine Center Department of Obstetrics and GynecologyShanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China State Key Laboratory of Reproductive Medicine and Offspring Health Clinical Center of Reproductive MedicineThe First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract(Anhui Medical University) Hefei 230032China Key Laboratory of Population Health Across Life Cycle(Anhui Medical University) Ministry of Education of the People’s Republic of ChinaHefei 230032China Anhui Province Key Laboratory of Reproductive Health and Genetics Hefei 230032China Biopreservation and Artificial Organs Anhui Provincial Engineering Research CenterAnhui Medical UniversityHefei 230032China

The complexities of energy transfer mechanisms in the flagella of mammalian sperm flagella have been intensively investigated and demonstrate significant diversity across *** shuttles,particularly adenylate kinase(AK)and creatine kinase(CK),are pivotal in the efficient transfer of intracellular ATP,showing distinct tissue-and ***,the expression profiles of AK and CK were investigated in mice and found to fall into four subgroups,of which Subgroup III AKs were observed to be unique to the male reproductive system and conserved across *** AK8 and AK9 were found to be indispensable to male reproduction after analysis of an infertile male *** mouse models showed that AK8 and AK9 were central to promoting sperm *** combined with mass spectrometry revealed that AK8 and AK9 interact with the radial spoke(RS)of the *** of various human and mouse sperm samples with substructural damage,including the presence of multiple RS subunits,showed that the head of radial spoke 3 acts as an adapter for AK9 in the flagellar *** an ATP probe together with metabolomic analysis,it was found that AK8 and AK9 cooperatively regulated ATP transfer in the axoneme,and were concentrated at sites associated with energy consumption in the *** findings indicate a novel function for RS beyond its structural role,namely,the regulation of ATP *** conclusion,the results expand the functional spectrum of AK proteins and suggest a fresh model regarding ATP transfer within mammalian flagella.

关键词： adenylate kinase Subgroup III AKs AK8 AK9 male infertility ATP transfer radial spoke

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含硅橡胶复合结构的声学覆盖层吸声特性研究

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噪声与振动控制 2024年第4期44卷 278-282页

作者：应童何川陶猛贵州大学机械工程学院贵阳550025

设计一种在声波入射端与出射端均为半无限大水域工况下使用的,内含空腔硅橡胶单元与金属板的复合结构声学覆盖层。利用仿真软件建立有限元模型,对比硅橡胶单元与域边界距离不同情况下的声学性能,验证嵌入金属板能够有效地提升覆盖层的... 详细信息

设计一种在声波入射端与出射端均为半无限大水域工况下使用的,内含空腔硅橡胶单元与金属板的复合结构声学覆盖层。利用仿真软件建立有限元模型,对比硅橡胶单元与域边界距离不同情况下的声学性能,验证嵌入金属板能够有效地提升覆盖层的声学性能,同时研究金属材料不同情况下对覆盖层声学性能的影响,并通过覆盖层位移云图对其吸声机理进行分析。研究表明,该结构可以实现在3300~8000 Hz频段内保持稳定在0.9以上的吸声系数。

关键词：声学声学覆盖层吸声特性硅橡胶单元复合结构

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饱和吸收体恢复时间对正交偏振耗散孤子的影响

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中国光学（中英文） 2024年第3期17卷 714-723页

作者：何晓颖张川张银东饶岚北京邮电大学电子工程学院天地互联与融合北京市重点实验室北京100876

偏振在脉冲锁模时,对其塑形和稳定起着至关重要的作用。本研究开发了一种用于产生正交偏振耗散孤子的被动锁模石墨烯光纤激光器的正交偏振数值模拟。重点是分析由偏振依赖的石墨烯微光纤饱和吸收体引起的净正常色散双折射腔对正交偏振... 详细信息

偏振在脉冲锁模时,对其塑形和稳定起着至关重要的作用。本研究开发了一种用于产生正交偏振耗散孤子的被动锁模石墨烯光纤激光器的正交偏振数值模拟。重点是分析由偏振依赖的石墨烯微光纤饱和吸收体引起的净正常色散双折射腔对正交偏振孤子的影响。研究结果表明,这种饱和吸收体的恢复时间显著影响正交偏振耗散脉冲的特性,如能量、脉宽、时间带宽乘积和啁啾。结果显示,其恢复时间为120飞秒时最佳,产生两个具有大啁啾的正交偏振的窄耗散孤子脉冲,分别约为7.47 ps和8.06 ps。这对于开发紧凑、高功率、偏振耗散孤子光纤激光系统具有重要意义。

关键词：正交偏振光被动锁模净正常色散腔恢复时间

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Future climate change decreases multi-pathway but increases respiratory human health risks of PAHs across China

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National Science Open 2024年第2期3卷 128-147页

作者： Jiaao Bao Xinghui Xia ying Zhu Bingxiang Zhao Erxue Gu Yanan Liu Xiao Yun Zhenrui Zhang Nannan Xi Yong geng ying Xu Zhifeng Yang Derek C.G.Muir Key Laboratory of Water and Sediment Sciences of Ministry of Education State Key Laboratory of Water Environment SimulationSchool of EnvironmentBeijing Normal UniversityBeijing 100875China State Environmental Protection Key Laboratory of Environmental Health Impact Assessment of Emerging Contaminants School of Environmental Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240China College of Urban and Environmental Sciences Laboratory for Earth Surface ProcessesSino-French Institute for Earth System SciencePeking UniversityBeijing 100871China National Climate Center China Meteorological AdministrationBeijing 100081China Key Laboratory for City Cluster Environmental Safety and Green Development of the Ministry of Education Institute of Environmental and Ecological EngineeringGuangdong University of TechnologyGuangzhou 510006China Aquatic Contaminants Research Division Environment and Climate Change CanadaBurlington L7S 1A1Canada

Future climate change will affect the environmental fate of hydrophobic organic contaminants(HOCs)and associated human health risks,yet the extent of these effects remains ***,we couple a high-resolution environmental multimedia model with a bioaccumulation model to study the multimedia distribution of 16 priority polycyclic aromatic hydrocarbons(PAHs),a group of HOCs,and assess future PAH-related human health risks under varying climate change scenarios over China at a continental *** removing the effects of PAH emission changes,we find that the total PAH concentrations would decrease in the air,freshwater,sediment,soil,and organisms,while the high-molecular-weight PAH would increase in the air with climate warming from 1.5°C to 4°***,the multi-pathway exposure human health risks predominately influenced by dietary ingestion are expected to decrease by 1.7%–20.5%,while the respiratory risks are projected to rise by 0.2%–5.8%in the ***,the persistently high multi-pathway human health risks underscore the need for reducing future PAH emissions by 69%compared with 2009 levels in *** study demonstrates the urgency of limiting PAH emissions under future climate change for public health and highlights the importance of including the contribution of dietary ingestion in human health risk assessment.

关键词： polycyclic aromatic hydrocarbons future climate change human health risks emission reduction

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人口老龄化、医疗卫生支出与就业——基于健康人力资本与技术水平的机制分析

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西北人口 2024年第3期45卷 79-91页

作者：英洁宋佳莹高传胜南京大学政府管理学院南京210023

就业是民生之本,在人口老龄化趋势日益严峻的背景下,增加医疗卫生支出对于提升健康人力资本水平,推动医疗技术创新,促进就业发挥着重要作用。文章基于中国2008~2021年31个省级面板数据,运用双向固定效应模型和中介效应模型等方法,考察... 详细信息

就业是民生之本,在人口老龄化趋势日益严峻的背景下,增加医疗卫生支出对于提升健康人力资本水平,推动医疗技术创新,促进就业发挥着重要作用。文章基于中国2008~2021年31个省级面板数据,运用双向固定效应模型和中介效应模型等方法,考察老龄化、医疗卫生支出与就业之间的关系。研究发现:人口老龄化对就业有显著的负向作用,且在老龄化程度越深的地区,负效应越明显,而医疗卫生支出促进就业,在老龄化程度较深的地区医疗卫生支出对就业表现出更为有利的作用,其中在东部地区的促进作用最大。进一步的影响机制分析证明,医疗卫生支出正向调节了人口老龄化对就业的负效应,即,缓解老龄化带来的负面影响;同时健康人力资本与技术水平在人口老龄化与医疗卫生支出影响就业的过程中起部分中介作用。据此,应充分发挥政府职能,有效利用医疗卫生支出的经济效应,在财力可持续的基础上,扩大医疗卫生支出规模,优化医疗卫生支出结构,并建立地方政府医疗卫生支出绩效考核的指标体系,监测地方政府在医疗卫生领域的支出,提高医疗卫生支出利用效率。同时加强健康教育,开展健康促进活动,深入实施创新驱动发展战略,积极推动技术创新与应用,注重个人健康人力资本和企业技术创新能力的提升,实现高质量充分就业。

关键词：人口老龄化医疗卫生支出就业健康人力资本技术水平

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Gene replacement therapy in Bietti crystalline corneoretinal dystrophy:an open-label,single-arm,exploratory trial

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2275-2284页

作者： Jinyuan Wang Jinlu Zhang Shicheng Yu Hongyan Li Shaohong Chen Jingting Luo Haibo Wang Yuxia Guan Haihan Zhang Shiyi Yin Huili Wang Heping Li Junle Liu Jingyuan Zhu Qiong Yang ying Sha chuan Zhang Yuhang Yang Xuan Yang Xifang Zhang Xiuli Zhao Likun Wang Liping Yang Wenbin Wei Beijing Tongren Eye Center Beijing Key Laboratory of Intraocular Tumor Diagnosis and TreatmentBeijing Ophthalmology&Visual Sciences Key LabMedical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information TechnologyBeijing Tongren HospitalCapital Medical University100730 BeijingChina School of Clinical Medicine Tsinghua University100084 BeijingChina Chigenovo Co. Ltd.102206 BeijingChina Department of Ophthalmology Peking University Third HospitalBeijing Key Laboratory of Restoration of Damaged Ocular NervePeking University Third Hospital100191 BeijingChina Department of Ophthalmology The Third People’s Hospital of Dalian116091 DalianChina Department of Biomedical Informatics School of Basic Medical SciencesPeking University Health Science Center100191 BeijingChina Institute of Systems Biomedicine Department of PathologySchool of Basic Medical SciencesPeking University Health Science Center100191 BeijingChina

Bietti crystalline corneoretinal dystrophy is an inherited retinal disease caused by mutations in CYP4V2,which results in blindness in the working-age population,and there is currently no available ***,we report the results of the first-in-human clinical trial(NCT04722107)of gene therapy for Bietti crystalline corneoretinal dystrophy,including 12 participants who were followed up for 180-365 *** open-label,single-arm exploratory trial aimed to assess the safety and efficacy of a recombinant adeno-associated-virus-serotype-2/8 vector encoding the human CYP4V2 protein(rAAV2/8-hCYP4V2).Participants received a single unilateral subretinal injection of 7.5×10^(10)vector genomes of rAAV2/***,73 treatment-emergent adverse events were reported,with the majority(98.6%)being of mild or moderate intensity and considered to be procedure-or corticosteroid-related;no treatment-related serious adverse events or local/systemic immune toxicities were *** with that measured at baseline,77.8%of the treated eyes showed improvement in best-corrected visual acuity(BCVA)on day 180,with a mean±standard deviation increase of 9.0±10.8 letters in the 9 eyes analyzed(p=0.021).By day 365,80%of the treated eyes showed an increase in BCVA,with a mean increase of 11.0±10.6 letters in the 5 eyes assessed(p=0.125).Importantly,the patients’improvement observed using multifocal electroretinogram,microperimetry,and Visual Function Questionnaire-25 further supported the beneficial effects of the *** conclude that the favorable safety profile and visual improvements identified in this trial encourage the continued development of rAAV2/8-hCYP4V2(named ZVS101e).

关键词： cor dystrophy crystalline

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静电悬浮条件下液态Zr_(60)Ni_(25)Al_(15)合金的热物理性质与快速凝固机制

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物理学报 2024年第8期73卷 287-295页

作者：金英捷耿德路林茂杰胡亮魏炳波西北工业大学物理科学与技术学院西安710072

采用静电悬浮实验技术测定了液态Zr_(60)Ni_(25)Al_(15)合金的热物理性质,并研究了其深过冷快速凝固过程.实验发现,液态合金所获得的最大过冷度可达316 K(0.25TL),其密度和表面张力与温度呈线性关系,而黏度则随温度呈指数变化.当过冷度... 详细信息

采用静电悬浮实验技术测定了液态Zr_(60)Ni_(25)Al_(15)合金的热物理性质,并研究了其深过冷快速凝固过程.实验发现,液态合金所获得的最大过冷度可达316 K(0.25TL),其密度和表面张力与温度呈线性关系,而黏度则随温度呈指数变化.当过冷度小于259 K时,凝固过程中发生两次再辉现象,分别对应着二相(Zr_(6)Al_(2)Ni+Zr_(5)Ni_(4)Al)共晶和三元(Zr_(6)Al_(2)Ni+Zr_(5)Ni_(4)Al+Zr_(2)Ni)共晶的快速生长.若过冷度超过259 K,凝固过程只发生一次再辉,3个化合物相均可从合金熔体中独立形核,形成三元不规则共晶组织.理论计算和实验表明,小过冷时Zr_(6)Al_(2)Ni相优先形核,而当过冷度足够大时,三相能够同时形核.

关键词：静电悬浮液态金属快速凝固共晶生长

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