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Animal models of hepatitis E infection: Advances and challenges

Hepatobiliary & Pancreatic Diseases International 2024年第2期23卷 171-180页

作者： Ze Xiang Xiang-Lin He chuan-wu zhu Jia-Jia Yang Lan Huang Chun Jiang Jian wu Chinese Consortium for the Study of Hepatitis E(CCSHE) Zhejiang University School of Medicine Hangzhou 310030China Department of Infectious Diseases The Fifth People’s Hospital of SuzhouSuzhou 215007China Department of Infection Management The Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhou Municipal HospitalGusu SchoolNanjing Medical UniversitySuzhou 215008China Department of Clinical Laboratory The Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhou Municipal HospitalGusu SchoolNanjing Medical UniversitySuzhou 215008China 不详

Hepatitis E virus(HEV)is one of the leading causes of acute viral hepatitis *** most of HEV infections are asymptomatic,some patients will develop the symptoms,especially pregnant women,the elderly,and patients with preexisting liver diseases,who often experience anorexia,nausea,vom-iting,malaise,abdominal pain,and *** infection may become chronic in immunosuppressed *** addition,HEV infection can also cause several extrahepatic *** exists in a wide range of hosts in nature and can be transmitted across ***,animals susceptible to HEV can be used as *** establishment of animal models is of great significance for studying HEV transmission,clinical symptoms,extrahepatic manifestations,and therapeutic strategies,which will help us understand the pathogenesis,prevention,and treatment of hepatitis *** review summarized the animal models of HEV,including pigs,monkeys,rabbits,mice,rats,and other *** each animal species,we provided a concise summary of the HEV genotypes that they can be infected with,the cross-species transmission pathways,as well as their role in studying extrahepatic manifestations,prevention,and treatment of HEV *** advantages and disadvantages of these animal models were also *** review offers new perspectives to enhance the current understanding of the research landscape surrounding HEV animal models.

关键词： Hepatitis E virus Animal models Pathogenesis Prevention Treatment

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2019年第28届亚太肝病研究学会年会纪要

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世界华人消化杂志 2019年第8期27卷 527-529页

作者：朱传武苏州市第五人民医院肝病科江苏省苏州市215131

本文对2019年第28届亚太肝病研究学会年会的学术活动作一简要报道.

关键词：第28届年会亚太肝病研究学会

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Bacterial infection triggers and complicates acute-on-chronic liver failure in patients with hepatitis B virus-decompensated cirrhosis: A retrospective cohort study

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World Journal of Gastroenterology 2020年第6期26卷 645-656页

作者： zhu-Jun Cao Yu-Han Liu chuan-wu zhu Shan Yin Wei-Jing Wang Wei-Liang Tang Gang-De Zhao Yu-Min Xu Lu Chen Tian-Hui Zhou Ming-Hao Cai Hui Wang Wei Cai Shi-San Bao Hai Li Qing Xie Department of Infectious Diseases Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Department of Infectious Diseases The Affiliated Infectious Diseases Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Gastroenterology Renji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China Department of Infectious Diseases Ruijin Hospital NorthShanghai Jiao Tong University School of MedicineShanghai 201801China Discipline of Pathology School of Medical Sciences and Bosch InstituteUniversity of SydneySydneyNSW 2006Australia

BACKGROUND Reports on bacterial infection(BI)in decompensated cirrhosis(DC)is mainly from alcoholic *** role of BI as a trigger or complication of acute-onchronic liver failure(ACLF)in patients with hepatitis B virus decompensated cirrhosis(HBV-DC)remains to be *** To investigate the impact of BI on the outcomes of the patients with HBV-DC admitted into the hospital with or without *** This retrospective study included patients with HBV-DC admitted to two tertiary centers in ***-hospital overall survival,90-d transplant-free survival,5-year post-discharge survival,and cumulative incidence of ACLF were *** factors for death were analyzed considering liver transplantation as a competing *** A total of 1281 hospitalized HBV-DC patients were included;284 had ACLF at *** overall prevalence of BI was 28.1%.The patients with BI had a significantly lower in-hospital survival and transplant-free 90-d survival than those without,in both the patients admitted with and without *** presence of BI significantly increased the risk of developing ACLF[subdistribution hazard ratio(sHR)=2.52,95%CI:1.75-3.61,P<0.001]in the patients without *** the patients discharged alive,those who had an episode of BI had a significantly lower 5-year transplant-free *** was an independent risk factor for death in the patients admitted without ACLF(sHR=3.28,95%CI:1.93-5.57),while in ACLF admissions,the presence of pneumonia,but not other type of BI,independently increased the risk of death(sHR=1.87,95%CI:1.24-2.82).CONCLUSION BI triggers ACLF in patients with HBV-DC and significantly impairs short-term ***-DC patients should be monitored carefully for the development of BI,especially pneumonia,to avoid an adverse outcome.

关键词： Hepatitis B virus Cirrhosis Decompensation Bacterial infection Acute-onchronic liver failure Survival

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A quantum-search-based multi-classifier for image recognition

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 21-31页

作者： Lu Liu Xingyu wu Lufan Zhang chuan Wang School of Artificial Intelligence Beijing Normal University Applied Optics Beijing Area Major Laboratory Beijing Normal University

The multi-class classification of images is a pivotal challenge within the realm of image processing. As the volume of visual data continues to expand, there is a burgeoning interest in harnessing the unique capabilities of quantum computation to augment the efficiency of classification tasks. However, many existing methods for training quantum image multi-classifiers parallel classical machine learning techniques, where the requisite circuit measurements increase linearly with the volume of training data. This work introduces a novel approach for training a quantum image multi-classifier based on the quantum search algorithm. We have meticulously conducted rigorous experiments on a handwritten digit dataset, a classic benchmark in the field. The results have been meticulously compared with previous works, and the comparative analysis not only validates the efficiency of our proposed approach, requiring only O(N/b) measurements during training, but also highlights a significant quadratic speedup of the algorithm.

关键词： quantum computation image recognition quantum search algorithm

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乙型肝炎表面抗原泛素化修饰的研究进展

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世界华人消化杂志 2024年第5期32卷 333-338页

作者：牛安行刘锦朱传武苏州市第五人民医院苏州大学附属传染病医院感染、肝病科江苏省苏州市215131

慢性乙型肝炎(chronic hepatitis B,CHB)患者体内存在的大量亚病毒颗粒可以诱导免疫耐受,导致乙型肝炎病毒(hepatitis B virus,HBV)的持续感染.患者要实现功能性治愈的目标,则需要获得血清乙型肝炎表面抗原(hepatitis B surface antigen... 详细信息

慢性乙型肝炎(chronic hepatitis B,CHB)患者体内存在的大量亚病毒颗粒可以诱导免疫耐受,导致乙型肝炎病毒(hepatitis B virus,HBV)的持续感染.患者要实现功能性治愈的目标,则需要获得血清乙型肝炎表面抗原(hepatitis B surface antigen,HBsAg)的消失,但目前临床上尚缺乏有效抑制HBV共价闭合环状DNA的有效药物,因此HBsAg很难被清除.蛋白质的泛素化修饰是HBsAg降解的一条潜在路径,这将有可能改变HBV的生存和免疫环境.本文重点对有关HBsAg的泛素化,包括类泛素化和去泛素化的研究进行综述,以期为CHB抗病毒治疗探索新的途径提供参考.

关键词：乙型肝炎表面抗原泛素化类泛素化去泛素化

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EZH2在肝脏疾病中的研究进展

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世界华人消化杂志 2018年第16期26卷 951-956页

作者：朱莉李明朱传武苏州市第五人民医院肝病科江苏省苏州市215000

Zeste基因增强子同源物2(enhancer of zeste homolog2,EZH2)在一些恶性肿瘤组织中呈现过度表达,与肿瘤的生长、发展、预后有着密切的关系.最新研究表明,EZH2在肝脏疾病领域除了与肝癌的发生、进展相关,在免疫方面也发挥着不可忽视的作用... 详细信息

Zeste基因增强子同源物2(enhancer of zeste homolog2,EZH2)在一些恶性肿瘤组织中呈现过度表达,与肿瘤的生长、发展、预后有着密切的关系.最新研究表明,EZH2在肝脏疾病领域除了与肝癌的发生、进展相关,在免疫方面也发挥着不可忽视的作用,其参与许多肝脏疾病的发生、发展,与慢性乙型肝炎的病毒复制、非酒精性脂肪性肝病的炎性反应、慢性肝炎肝纤维化的进展均有着密切的关系,可能成为今后肝病研究领域的重要方向.本文就最近十年来对EZH2在肝脏疾病中的研究进展及其在治疗中的潜在应用价值进行综述.

关键词： EZH2 肝癌慢性乙型肝炎非酒精性脂肪肝肝纤维化

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Observation of acoustic hybrid topological phases induced by the p-d orbital interactions

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 132-139页

作者： Xiao Xiang Feng Gao Yu-Gui Peng Peng wu Zong-Lin Li Xue-Feng zhu School of Physics and Innovation Institute Huazhong University of Science and Technology

In spinless systems,growing attention has recently been attracted to synthetic gauge fields,which redefine the fundamental crystal symmetries by utilizing the projective algebraic ***,synthetic gauge fields have been commonly investigated in single orbital systems,and explorations on hybrid orbitals remain elusive in ***,we report the experimental observation of hybrid topological phases induced by hybrid synthetic gauge flux,which is formed by the interaction between p and d orbitals embedded in acoustic *** breaking the translation symmetries of Lxand/or Ly,we unambiguously demonstrate the first-order M?bius edge states and higher-order corner *** work establishes a platform for seeking exotic topological phases induced by hybrid-orbitals interactions and initializing the framework of hybrid-orbitalsrelated topological *** applications can be anticipated in scenarios such as high-quality sensing and robust wave trapping due to the stepwise energy distribution of the hybrid topological phase.

关键词： topological insulator synthetic gauge field projective symmetry corner states

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日照市民间组织发展的现状、问题与对策

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山东行政学院山东省经济管理干部学院学报 2006年第4期 16-18页

作者：武传竹山东省日照市民政局山东日照276826

日照市各类民间组织蓬勃发展,成为推动经济发展的重要力量。但受限于经济发展水平,民间组织发展良莠不齐,发展不规范,自律机制不健全。加强和培育发展民间组织,应明确发展目标,突出发展重点,优化组织结构,并坚持分类指导,重点加强民间... 详细信息

日照市各类民间组织蓬勃发展,成为推动经济发展的重要力量。但受限于经济发展水平,民间组织发展良莠不齐,发展不规范,自律机制不健全。加强和培育发展民间组织,应明确发展目标,突出发展重点,优化组织结构,并坚持分类指导,重点加强民间组织自身能力与诚信建设。

关键词：民间组织社会团体民办非企业单位经济发展

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A new horizon for neuroscience:terahertz biotechnology in brain research

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Neural Regeneration Research 2025年第2期20卷 309-325页

作者： Zhengping Pu Yu wu Zhongjie zhu Hongwei Zhao Donghong Cui Shanghai Key Laboratory of Psychotic Disorders Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Department of Psychiatry Kangci Hospital of JiaxingTongxiangZhejiang ProvinceChina Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghaiChina Key Laboratory of Interfacial Physics and Technology Shanghai Institute of Applied PhysicsChinese Academy of ScienceShanghaiChina National Facility for Protein Science in Shanghai Shanghai Advanced Research InstituteChinese Academy of SciencesShanghaiChina

Terahertz biotechnology has been increasingly applied in various biomedical fields and has especially shown great potential for application in brain *** this article,we review the development of terahertz biotechnology and its applications in the field of *** evidence indicates promising prospects for the use of terahertz spectroscopy and terahertz imaging techniques in the diagnosis of amyloid disease,cerebrovascular disease,glioma,psychiatric disease,traumatic brain injury,and myelin *** vitro and animal experiments have also demonstrated the potential therapeutic value of terahertz technology in some neuropsychiatric *** the precise underlying mechanism of the interactions between terahertz electromagnetic waves and the biosystem is not yet fully understood,the research progress in this field shows great potential for biomedical noninvasive diagnostic and therapeutic ***,the biosafety of terahertz radiation requires further exploration regarding its two-sided efficacy in practical *** review demonstrates that terahertz biotechnology has the potential to be a promising method in the field of neuropsychiatry based on its unique advantages.

关键词： biological effect brain neuron neuropsychiatry neuroscience non-thermal effect terahertz imaging terahertz radiation terahertz spectroscopy terahertz technology

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有效白蛋白浓度在慢性肝病治疗中应用的认识

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世界华人消化杂志 2023年第6期31卷 214-220页

作者：王银玲刘昱含朱传武苏州市第五人民医院肝病科江苏省苏州市215000 武田(中国)投资有限公司上海市200124

白蛋白是一种非糖基化血浆蛋白,除了增加血容量和维持血浆胶体渗透压外,还具有转运、抗氧化、抗炎、免疫调节等多种生物学功能.随着对白蛋白结构和功能的深入研究,有效白蛋白浓度概念引入,发现在慢性肝病患者中由于白蛋白的翻译后修饰,... 详细信息

白蛋白是一种非糖基化血浆蛋白,除了增加血容量和维持血浆胶体渗透压外,还具有转运、抗氧化、抗炎、免疫调节等多种生物学功能.随着对白蛋白结构和功能的深入研究,有效白蛋白浓度概念引入,发现在慢性肝病患者中由于白蛋白的翻译后修饰,引起了结构上的改变从而使有效白蛋白浓度下降,且有效白蛋白浓度比总白蛋白更能准确地反映疾病进展,并为人血白蛋白输注提供更为准确的新指征.本文概述了白蛋白翻译后修饰与肝脏及相关疾病的临床关联性,并提供了有效白蛋白在临床实践中应用的循证证据,以期更好指导慢性肝病的临床治疗管理.

关键词：人血白蛋白有效白蛋白浓度翻译后修饰缺血修饰白蛋白

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