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Assessing gray matter volume in patients with idiopathic rapid eye movement sleep behavior disorder

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Neural Regeneration Research 2019年第5期14卷 868-875页

作者： Xian-Hua Han Xiu-Ming Li Wei-Jun Tang Huan Yu Ping Wu Jing-Jie Ge Jian Wang chuan-tao zuo Kuang-Yu Shi PET Center Huashan Hospital Fudan University Department of Radiology Huashan Hospital Fudan University Department of Neurology Huashan Hospital Fudan University Department of Nuclear Medicine Technical University Munich

Idiopathic rapid eye movement sleep behavior disorder(iRBD) is often a precursor to neurodegenerative disease. However, voxel-based morphological studies evaluating structural abnormalities in the brains of iRBD patients are relatively rare. This study aimed to explore cerebral structural alterations using magnetic resonance imaging and to determine their association with clinical parameters in iRBD patients. Brain structural T1-weighted MRI scans were acquired from 19 polysomnogram-confirmed iRBD patients(male:female 16:3; mean age 66.6 ± 7.0 years) and 20 age-matched healthy controls(male:female 5:15; mean age 63.7 ± 5.9 years). Gray matter volume(GMV) data were analyzed based on Statistical Parametric Mapping 8, using a voxel-based morphometry method and two-sample t-test and multiple regression analysis. Compared with controls, iRBD patients had increased GMV in the middle temporal gyrus and cerebellar posterior lobe, but decreased GMV in the Rolandic operculum, postcentral gyrus, insular lobe, cingulate gyrus, precuneus, rectus gyrus, and superior frontal gyrus. iRBD duration was positively correlated with GMV in the precuneus, cuneus, superior parietal gyrus, postcentral gyrus, posterior cingulate gyrus, hippocampus, lingual gyrus, middle occipital gyrus, middle temporal gyrus, and cerebellum posterior lobe. Furthermore, phasic chin electromyographic activity was positively correlated with GMV in the hippocampus, precuneus, fusiform gyrus, precentral gyrus, superior frontal gyrus, cuneus, inferior parietal lobule, angular gyrus, superior parietal gyrus, paracentral lobule, and cerebellar posterior lobe. There were no significant negative correlations of brain GMV with disease duration or electromyographic activity in iRBD patients. These findings expand the spectrum of known gray matter modifications in iRBD patients and provide evidence of a correlation between brain dysfunction and clinical manifestations in such patients. The protocol was approved by the Et

关键词： nerve regeneration idiopathic rapid eye movement sleep behavior disorder synucleinopathies magnetic resonance imaging gray matter volume statistic parametric mapping voxel-based morphometry structure Parkinson’s disease neurodegenerative diseases neural regeneration

Forniceal deep brain stimulation in severe Alzheimer's disease:A case report

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World Journal of Clinical Cases 2020年第20期8卷 4938-4945页

作者： Wei Lin Wei-Qi Bao Jing-Jie Ge Li-Kun Yang Zhi-Pei Ling Xin Xu Jie-Hui Jiang chuan-tao zuo Yu-Hai Wang Department of Neurosurgery Joint Logistics Support Unit No.904 HospitalWuxi 214044Jiangsu ProvinceChina PET Center Huashan HospitalFudan UniversityShanghai 200235China Department of Neurosurgery PLA General HospitalPLA Postgraduate Medical SchoolBeijing 100039China School of Communication and Information Technology Institute of Biomedical EngineeringShanghai UniversityShanghai 200444China

BACKGROUND Forniceal deep brain stimulation(DBS)has been proposed as an alternative treatment for Alzheimer's disease(AD).Previous studies on mild to moderate AD patients demonstrated improvements in cognitive functions brought about by forniceal ***,we report our longitudinal findings in one severe AD patient for whom the activities of daily living(ADL)rather than cognitive function significantly improved after 3 mo of continuous *** SUMMARY In 2011,a 62-year-old Chinese male with no previous history of brain injury or other neuropsychological diseases and no family history of dementia developed early symptoms of memory decline and cognitive *** years later,the symptoms had increased to the extent that they affected his daily *** lost the ability to work as a businessman and to take care of *** patient was given a clinical diagnosis of probable AD and was prescribed donepezil and subsequently memantine,but no improvement in symptoms was *** patient then received DBS *** 3 mo of continuous stimulation,the patient's ADL score decreased from 65 points to 47 points,indicating the quality of the patient's daily living improved *** scores remained unchanged,suggesting no significant improvement in cognitive function.A follow-up positron emission tomography scan demonstrated perceivable increased glucose metabolism in the classical AD-related brain *** Based on this case we hypothesize that forniceal DBS may improve ADL through elevating regional glucose metabolism in the brain.

关键词： Deep brain stimulation Alzheimer's disease Fluorodeoxy glucose Positron emission tomography Activities of daily living Case report

Dopaminergic Dysfunction and Glucose Metabolism Characteristics in Parkin-Induced Early-Onset Parkinson’s Disease Compared to Genetically Undetermined Early-Onset Parkinson’s Disease

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Phenomics 2023年第1期3卷 22-33页

作者： Feng-tao Liu Jia-Ying Lu Yi-Min Sun Ling Li Yu-Jie Yang Jue Zhao Jing-Jie Ge Ping Wu Jie-Hui Jiang Jian-Jun Wu chuan-tao zuo Jian Wang Department of Neurology National Clinical Research Center for Aging and Medicine&National Center for Neurological DisordersHuashan HospitalFudan University12 Wulumuqi Middle RoadShanghai 200040China Department of Nuclear Medicine&PET Center National Clinical Research Center for Aging and Medicine&National Center for Neurological DisordersHuashan HospitalFudan University518 East Wuzhong RoadShanghai 200235China Institute of Biomedical Engineering School of Life SciencesShanghai UniversityShanghai 200444China Human Phenome Institute Fudan UniversityShanghai 200433China

While early-onset Parkinson’s disease(EOPD)caused by mutations in the parkin gene(PRKN)tends to have a relatively benign course compared to genetically undetermined(GU)-EOPD,the exact underlying mechanisms remain *** aimed to search for the differences between PRKN-EOPD and GU-EOPD by dopamine transporter(DAT)and glucose metabolism positron-emission-tomography(PET)*** patients with PRKN-EOPD and 16 with GU-EOPD who accepted both ^(11)C-2b-carbomethoxy-3b-(4-trimethylstannylphenyl)tropane(^(11)C-CFT)and ^(18)F-fluorodeoxyglucose PET were *** ^(11)C-CFT uptake was analyzed on both regional and voxel levels,whereas glucose metabolism was assessed in a voxel-wise *** between DAT and glucose metabolism imaging,DAT imaging and clinical severity,as well as glucose metabolism imaging and clinical severity were *** clinical symptoms and DAT-binding pat-terns in the posterior putamen were highly symmetrical in patients with PRKN-EOPD,and dopaminergic dysfunction in the ipsilateral putamen was severer in patients with PRKN-EOPD than ***,the DAT binding was associ-ated with the severity of motor dysfunction in patients with GU-EOPD *** with PRKN-EOPD showed increased glucose metabolism in the contralateral medial frontal gyrus(supplementary motor area(SMA)),contralateral substantia nigra,contralateral thalamus,and contralateral ***,glucose metabolic activity in the contralateral medial frontal gyrus was inversely associated with regional DAT binding in the bilateral *** with PRKN-EOPD showed enhanced metabolic connectivity within the bilateral putamen,ipsilateral paracentral and precentral lobules,and the ipsilateral ***,compared to GU-EOPD,PRKN-EOPD is characterized by symmetrical,more severe dopaminergic dysfunction and relative increased glucose ***,SMA with elevated glucose metabolism and enhanced connectivity may act as compensatory mechan

关键词： Early-onset Parkinson’s disease Parkin Dopamine transporter ^(18)F-fluorodeoxyglucose Supplementary motor area

针刺镇痛相关受体及正电子配基研究进展(英文)

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中西医结合学报 2009年第6期7卷 575-581页

作者：王慧春左传涛管一晖复旦大学华山医院PET中心上海200235

As a traditional treatment method, acupuncture can be widely used to regulate physiological function as well as ameliorate pathologic processes, and the capital application is analgesia.

关键词：针刺镇痛电针受体正电子发射断层扫描放射性配基

基于卡尔加里-剑桥指南的沙龙培训模式提升全科规培医师医患沟通技能的对照研究

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中国全科医学 2025年第1期28卷 71-76页

作者：彭涛邹川曾欣张焱沈静四川省成都市第五人民医院全科医学科 611130

背景医患沟通技能是全科医生的核心岗位胜任力之一,高水平的医患沟通能力是创建和谐医患关系的基石,有助于提高患者就医获得感和满意度。而我国全科医生沟通能力普遍偏低,有待探索出一种适应我国国情、满足我国全科医生沟通需求的医患... 详细信息

背景医患沟通技能是全科医生的核心岗位胜任力之一,高水平的医患沟通能力是创建和谐医患关系的基石,有助于提高患者就医获得感和满意度。而我国全科医生沟通能力普遍偏低,有待探索出一种适应我国国情、满足我国全科医生沟通需求的医患沟通培训模式来提高其医患沟通能力。目的探索基于卡尔加里-剑桥指南的沙龙培训模式在全科规培医师医患沟通技能培训中的应用效果,为构建适合我国国情的医患沟通培训体系提供参考依据。方法选取成都市第五人民医院2019—2020年度全科规培医师40名作为研究对象,按照随机数字表法分为沙龙组和对照组,每组20名,其中沙龙组使用基于卡尔加里-剑桥指南的沙龙培训模式进行医患沟通培训,对照组设置为空白对照,培训前、培训后1周分别对两组学员采用标准化病人(SP)模式进行接诊,使用医患沟通评价量表(SEGUE量表)进行现场观察评分,比较两组学员的医患沟通培训效果。结果最终纳入28名,其中沙龙组15名,对照组13名,培训后沙龙组规培医师SEGUE量表评分从(11.80±4.36)分提高至(18.07±4.11)分,对照组规培医师SEGUE量表评分从(12.15±4.63)分提高至(14.46±3.71)分。沙龙组培训后的SEGUE量表评分与培训前的比较,差异有统计学意义(t=3.250,P<0.001);对照组培训后的SEGUE量表评分与培训前比较,差异无统计学意义(t=2.582,P=0.624);培训后对SEGUE量表中的25个项目进行分析,沙龙组与对照组SEGUE量表评分比较,差异有统计学意义(P<0.05)。沙龙组以下5个项目结果优于对照组,准备阶段中的“建立个人信任关系”(93.3%比7.7%)、“保护患者的隐私/尊重患者选择权”(53.3%比15.4%);理解患者阶段中的“认同患者为疾病所付出的努力、改变及其遇到的困难”(33.3%比23.1%)、“表达关心,使患者感到温暖/树立信心”(100.0%比69.2%);结束问诊阶段中的“询问患者是否还有其他的问题需要探讨”(66.7%比23.1%)。结论基于卡尔加里-剑桥指南的沙龙培训模式对全科规培医师进行医患沟通技能培训可增强学员主动参加培训的兴趣和积极性,对于医患沟通能力的提升具有较好的培训效果,值得借鉴和推广。

关键词：全科医学全科医师规范化培训医患沟通沟通培训卡尔加里-剑桥指南

Seasonal size composition and abundance distribution of Euphausia pacifica in relation to environmental factors in the southern Yellow Sea

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Acta Oceanologica Sinica 2019年第2期38卷 70-77页

作者： tao zuo Hui Liu Yellow Sea Fisheries Research Institute Chinese Academy of Fishery Sciences Laboratory for Marine Ecology and Environmental Science Pilot National Laboratory for Marine Science and Technology (Qingdao) Department of Marine Biology Texas A&M University at Galveston

The seasonal size structure and spatial abundance distributions of Euphausia pacifica populations were investigated in the central part of southern Yellow Sea from August 2009 to May *** abundance and biomass of *** were higher in spring and summer,and lower in autumn and *** mean abundance and biomass(calculated by carbon)were 74.94 ind./m^3 and 8.23 mg/m^3,*** with total length(TL)ranging between 10 and 19 mm in summer had a substantial contribution to the population biomass,whereas larvae of TL of 3–7 mm in spring were the main contributor to the population *** sex ratio(female:male)showed a female bias in four *** value peaked in summer,and then decreased in autumn,spring,and winter *** analysis revealed that the length-frequency distribution of *** could be characterized as one group with large animals(mean TL>12 mm)accompanied by one or two subgroups of small individuals(mean TL32),whereas its larvae showed more abundance in inshore water with rich chlorophyll a,low salinity(11℃),especially in summer and *** changed seasonally between stage-specific abundance and environmental factors.

关键词： spatial distribution size composition biomass Euphausia pacifica Yellow Sea

Different strategies in biomass allocation across elevation in two Gentiana plants on the Yunnan-Guizhou Plateau, China

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Journal of Mountain Science 2020年第11期17卷 2750-2757页

作者： ZHANG Ji WANG Yuan-zhong GAO Hong-kai zuo Zhi-tian YANG Shao-bing CAI chuan-tao CAS Key Laboratory of Tropical Plant Resources and Sustainable Use Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesMenglaYunnan 666303China Medicinal Plants Research Institute Yunnan Academy of Agricultural SciencesKunming 650200China College of Life Sciences University of Chinese Academy of SciencesBeijing 100049China Key Laboratory of Geographic Information Science(Ministry of Education) East China Normal UniversityShanghai 200241China School of Geographic Sciences East China Normal UniversityShanghai 200241China Center of Economic Botany Core Botanical GardensChinese Academy of SciencesMenglaYunnan 666303China

Patterns of biomass allocation among organs in plants are important because they influence many growth *** Yunnan-Guizhou Plateau(YGP)is considered to be one of the most sensitive areas in China to climate changes,but we know little about how current climatic gradients on the plateau influence plant biomass *** rigescens and ***,on the YGP,are important species because they are used in traditional Chinese *** therefore analyzed the biomass allocation patterns of the two species across an elevation gradient(1000–2810 m a.s.l.)on the YGP to understand and predict the impact of climate change on these plant *** found that the total biomass,reproductive biomass,vegetative biomass,aboveground biomass,and belowground biomass in *** were all significantly larger than those in ***(p<0.05).However,for both species the aboveground biomass was nearly isometrically related to belowground biomass,regardless of elevation,mean annual temperature(MAT)ranging from 8.4℃t to 18.8℃t,and mean annual precipitation(MAP)ranging from 681 to 1327 mm,while the reproductive biomass was allometrically related to vegetative ***,there was a significant positive relationship(p<0.05)between the slope of the allometric scaling of reproductive and vegetative biomass and elevation among *** populations,*** growing at high elevationsallocate proportionately more biomass to reproduction at larger sizes and less at smaller sizes than plants growing at lower ***,for *** the reproductive allocation was negatively correlated with *** results suggested different strategies in reproductive allocation in the two Gentiana plants on the *** studies are needed to investigate other environmental factors,such as nutrients and light,and genetic factors,in order to understand the trend of reproductive allometry along the environmental *** study has implications for the ma

关键词： Allometry Reproductive investment Climate Environment Herbaceous plant

Hyponymy Graph Model for Word Semantic Similarity Measurement

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Chinese Journal of Electronics 2015年第1期24卷 96-101页

作者： WANG Junhua zuo Wanli PENG tao College of Computer Science and Technology Jilin University Key Laboratory of Symbol Computation and Knowledge Engineering attached to the Ministry of Education

Measuring word semantic similarity is a generic problem with a broad range of applications such as ontology mapping, computational linguistics and artificial intelligence. Previous approaches to computing word semantic similarity did not consider concept occurrence frequency and word’s sense number. This paper introduced Hyponymy graph, and based on which proposed a novel word semantic similarity model. For two words to be compared, we first retrieve their related concepts; then produce lowest common ancestor matrix and distance matrix between concepts; finally calculate distance-based similarity and information-based similarity, which are integrated to get final semantic similarity. The main contribution of our method is that both concept occurrence frequency and word’s sense number are taken into account. This similarity measurement more closely fits with human rating and effectively simulates human thinking process. Our experimental results on benchmark dataset M&C and R&G with Word Net2.1 as platform demonstrate roughly 0.9%–1.2%improvements over existing best approaches.

关键词： Word semantic similarity Concept semantic similarity Semantic similarity Hyponymy graph model Word Net.

A Large-Scale Study of Failures on Petascale Supercomputers

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Journal of Computer Science & Technology 2018年第1期33卷 24-41页

作者： Rui-tao Liu zuo-Ning Chen State Key Laboratory of Mathematical Engineering and Advanced Computing Wuxi 213215 China National Research Center of Parallel Computer Engineering and Technology Beijing 100190 China

With the rapid development of supercomputers, the scale and complexity are ever increasing, and the reliability and resilience are faced with larger challenges. There are many important technologies in fault tolerance, such as proacrive failure avoidance technologies based on fault prediction, reactive fault tolerance based on checkpoint, and scheduling technologies to improve reliability. Both qualitative and quantitative descriptions on characteristics of system faults are very critical for these technologies, This study analyzes the source of failures on two typical petascale supercomputers called Sunway BlueLight （based on multi-core CPUs） and Sunway TaihuLight （based on heterogeneous manycore CPUs）. It uncovers some interesting fault characteristics and finds unknown correlation relationship among main components＇ faults. Finally the paper analyzes the failure time of the two supercomputers in various grains of resource and different time spans, and builds a uniform multi-dimensional failure time model for petascale supereomputers.

关键词： petascale supercomputer fault characteristic correlation relationship multi-dimension failure time model