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Hydrogel loaded with bone marrow stromal cell-derived exosomes promotes bone regeneration by inhibiting inflammatory responses and angiogenesis

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World Journal of Stem Cells 2024年第5期16卷 499-511页

作者： Shuai Zhang chuan Lu sheng Zheng Guang Hong Division for International Collaborative and Innovative Dentistry Tohoku University Graduate School of DentistrySendai 980-8575MiyagiJapan School of Stomatology Zhejiang Chinese Medical UniversityHangzhou 310053Zhejiang ProvinceChina

BACKGROUND Bone healing is a complex process involving early inflammatory immune regu-lation,angiogenesis,osteogenic differentiation,and biomineralization.Fracture repair poses challenges for orthopedic surgeons,necessitating the search for efficient healing methods.AIM To investigate the underlying mechanism by which hydrogel-loaded exosomes derived from bone marrow mesenchymal stem cells(BMSCs)facilitate the process of fracture healing.METHODS Hydrogels and loaded BMSC-derived exosome(BMSC-exo)gels were charac-terized to validate their properties.In vitro evaluations were conducted to assess the impact of hydrogels on various stages of the healing process.Hydrogels could recruit macrophages and inhibit inflammatory responses,enhance of human umbilical vein endothelial cell angiogenesis,and promote the osteogenic differen-tiation of primary cranial osteoblasts.Furthermore,the effect of hydrogel on fracture healing was confirmed using a mouse fracture model.RESULTS The hydrogel effectively attenuated the inflammatory response during the initial repair stage and subsequently facilitated vascular migration,promoted the formation of large vessels,and enabled functional vascularization during bone repair.These effects were further validated in fracture models.CONCLUSION We successfully fabricated a hydrogel loaded with BMSC-exo that modulates macrophage polarization and angiogenesis to influence bone regeneration.

关键词： Hydrogel Bone marrow mesenchymal stem cells Macrophage polarization Angiogenesis Bone regeneration

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Development of small molecule drugs targeting immune checkpoints

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Cancer Biology & Medicine 2024年第5期21卷 382-399页

作者： Luoyi Chen Xinchen zhao Xiaowei Liu Yujie Ouyang chuan Xu Ying Shi Department of Oncology Sichuan Academy of Medical Sciences Sichuan Provincial People's Hospital School of MedicineUniversity of Electronic Science and Technology of China Institute for Breast Health Medicine State Key Laboratory of Biotherapy West China Hospital Sichuan University Acupuncture and Massage College Chengdu University of Traditional Chinese Medicine

Immune checkpoint inhibitors(ICIs) are used to relieve and refuel anti-tumor immunity by blocking the interaction, transcription, and translation of co-inhibitory immune checkpoints or degrading co-inhibitory immune checkpoints. Thousands of small molecule drugs or biological materials, especially antibody-based ICIs, are actively being studied and antibodies are currently widely used. Limitations, such as anti-tumor efficacy, poor membrane permeability, and unneglected tolerance issues of antibody-based ICIs, remain evident but are thought to be overcome by small molecule drugs. Recent structural studies have broadened the scope of candidate immune checkpoint molecules, as well as innovative chemical inhibitors. By way of comparison, small molecule drug-based ICIs represent superior oral bioavailability and favorable pharmacokinetic features. Several ongoing clinical trials are exploring the synergetic effect of ICIs and other therapeutic strategies based on multiple ICI functions, including immune regulation, anti-angiogenesis, and cell cycle regulation. In this review we summarized the current progression of small molecule ICIs and the mechanism underlying immune checkpoint proteins, which will lay the foundation for further exploration.

关键词： CD47 Immune checkpoints programmed death protein 1 signal-regulatory protein α small molecule drugs

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Endoscopic band ligation or endoscopic tissue adhesive injection in the treatment of gastric varices:Which is better?

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World Journal of Gastroenterology 2024年第21期30卷 2827-2828页

作者： Li-Zhi Yi sheng-Bing zhao Department of Gastroenterology The People’s Hospital of LeshanLeshan 614000Sichuan ProvinceChina Department of Gastroenterology Changhai HospitalThe Second Military Medical University/Naval Medical UniversityShanghai 200433China

The combination of endoscopic ultrasound with endoscopic treatment of type 1 gastric variceal hemorrhage may improve the robustness and generalizability of the findings in future studies.Moreover,the esophageal varices should also be included in the evaluation of treatment efficacy in subsequent studies to reach a more convincing conclusion.

关键词： Gastric varices Esophageal varices Endoscopic band ligation Endoscopic tissue adhesive injection Endoscopic ultrasound

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Causal role of immune cells in obstructive sleep apnea hypopnea syndrome:Mendelian randomization study

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World Journal of Clinical Cases 2024年第7期12卷 1227-1234页

作者： Huang-Hong zhao Zhen Ma Dong-sheng Guan Department of Encephalopathy Henan Provincial Hospital of Traditional Chinese MedicineZhengzhou 450000Henan ProvinceChina Department of Personnel The First Affiliated Hospital of Henan University of Traditional Chinese MedicineZhengzhou 450000Henan ProvinceChina Department of Neurology Henan Provincial Hospital of Traditional Chinese MedicineZhengzhou 450000Henan ProvinceChina

BACKGROUND Despite being one of the most prevalent sleep disorders,obstructive sleep apnea hypoventilation syndrome(OSAHS)has limited information on its immunologic foundation.The immunological underpinnings of certain major psychiatric diseases have been uncovered in recent years thanks to the extensive use of genome-wide association studies(GWAS)and genotyping techniques using highdensity genetic markers(e.g.,SNP or CNVs).But this tactic hasn't yet been applied to OSAHS.Using a Mendelian randomization analysis,we analyzed the causal link between immune cells and the illness in order to comprehend the immunological bases of OSAHS.AIM To investigate the immune cells'association with OSAHS via genetic methods,guiding future clinical research.METHODS A comprehensive two-sample mendelian randomization study was conducted to investigate the causal relationship between immune cell characteristics and OSAHS.Summary statistics for each immune cell feature were obtained from the GWAS catalog.Information on 731 immune cell properties,such as morphologic parameters,median fluorescence intensity,absolute cellular,and relative cellular,was compiled using publicly available genetic databases.The results'robustness,heterogeneity,and horizontal pleiotropy were confirmed using extensive sensitivity examination.RESULTS Following false discovery rate(FDR)correction,no statistically significant effect of OSAHS on immunophenotypes was observed.However,two lymphocyte subsets were found to have a significant association with the risk of OSAHS:Basophil%CD33dim HLA DR-CD66b-(OR=1.03,95%CI=1.01-1.03,P<0.001);CD38 on IgD+CD24-B cell(OR=1.04,95%CI=1.02-1.04,P=0.019).CONCLUSION This study shows a strong link between immune cells and OSAHS through a gene approach,thus offering direction for potential future medical research.

关键词： Obstructive sleep apnea hypopnea syndrome Immunity Causal inference MR analysis Sensitivity

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The significance of resource recycling for coking wastewater treatment:based on environmental and economic life cycle assessment

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Green Chemical Engineering 2024年第1期5卷 50-59页

作者： Di Zhang He zhao Wenfang Gao Yuxing sheng Hongbin Cao Institute of Process Engineering Innovation Academy for Green ManufactureChinese Academy of SciencesBeijing100190China University of Chinese Academy of Sciences Beijing100049China Chemistry&Chemical Engineering Data Center Chinese Academy of SciencesBeijing100190China Tianjin Key Laboratory of Clean Energy and Pollutant Control School of Energy and Environmental EngineeringHebei University of TechnologyTianjin300401China

The sustainability of the coking industry is supported by reasonable production profit and environmental quality requirements.The traditional measures substantially increased the related costs for enterprises to reach standards.This paper aims to develop a comprehensive cost combined environmental impact assessment method that is necessary for the analysis of wastewater treatment systems.Typical three coking wastewater treatment processes in China were evaluated.Results showed that eutrophication dominantly contributed to the overall environmental effect.Improving effluent quality could significantly reduce the total environmental impact.In terms of an economic perspective,the price of raw materials was the main factor that affected the operating cost of comprehensive treatment.Based on subsystem analysis,the pretreatment stage accounted for the majority of environmental and cost burdens,respectively reaching 64%-78%and 64%-86%.Optimizing the pretreatment process by enhancing the efficiency of high concentration raw material recovery and substituting toxic raw materials for extractant could reduce the environmental impact and economic cost by 43.8%and 57%,respectively,which was an effective way to improve the potential performance of coking wastewater treatment plants(WWTPs).

关键词： Life cycle assessment Environmental impact Economic evaluation Coking wastewater treatment Resource recycling Comprehensive benefits

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Environmentally persistent free radicals in PM_(2.5)from a typical Chinese industrial city during COVID-19 lockdown:The unexpected contamination level variation

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Journal of Environmental Sciences 2024年第1期135卷 424-432页

作者： Lingyun Wang Wuduo zhao Peiru Luo Qingyun He Wenfen Zhang chuan Dong Yanhao Zhang College of Chemistry Zhengzhou UniversityZhengzhou 450001China Center of Advanced Analysis and Gene Sequencing Key Laboratory of Molecular Sensing and Harmful Substances Detection TechnologyZhengzhou UniversityZhengzhou 450001China State Key Laboratory of Environmental and Biological Analysis Department of ChemistryHong Kong Baptist UniversityHong Kong 999077China Institute of Environmental Science Shanxi UniversityTaiyuan 030006China

The outbreak of COVID-19 has caused concerns globally.To reduce the rapid transmission of the virus,strict city lockdown measures were conducted in different regions.China is the country that takes the earliest home-based quarantine for people.Although normal industrial and social activities were suspended,the spread of virus was efficiently controlled.Simultaneously,another merit of the city lockdown measure was noticed,which is the improvement of the air quality.Contamination levels of multiple atmospheric pollutants were decreased.However,in this work,24 and 14 air fine particulate matter(PM_(2.5))samples were continuously collected before and during COVID-19 city lockdown in Linfen(a typical heavy industrial city in China),and intriguingly,the unreduced concentration was found for environmentally persistent free radicals(EPFRs)in PM_(2.5)after normal life suspension.The primary non-stopped coal combustion source and secondary Cu-related atmospheric reaction may have impacts on this phenomenon.The cigarette-based assessment model also indicated possible exposure risks of PM_(2.5)-bound EPFRs during lockdown of Linfen.This study revealed not all the contaminants in the atmosphere had an apparent concentration decrease during city lockdown,suggesting the pollutants with complicated sources and formation mechanisms,like EPFRs in PM_(2.5),still should not be ignored.

关键词： PM_(2.5) EPFRs COVID-19 City lockdown Health risks

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Multimodal Nature of the Single-cell Primate Brain Atlas:Morphology,Transcriptome,Electrophysiology,and Connectivity

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Neuroscience Bulletin 2024年第4期40卷 517-532页

作者： Yuhui Shen Mingting Shao zhao-Zhe Hao Mengyao Huang Nana Xu sheng Liu State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangzhou510060China Guangdong Province Key Laboratory of Brain Function and Disease Guangzhou510080China

Primates exhibit complex brain structures that augment cognitive function.The neocortex fulfills high-cognitive functions through billions of connected neurons.These neurons have distinct transcriptomic,morphological,and electrophysiological properties,and their connectivity principles vary.These features endow the primate brain atlas with a multimodal nature.The recent integration of next-generation sequencing with modified patch-clamp techniques is revolutionizing the way to census the primate neocortex,enabling a multimodal neuronal atlas to be established in great detail:(1)single-cell/single-nucleus RNA-seq technology establishes high-throughput transcriptomic references,covering all major transcriptomic cell types;(2)patch-seq links the morphological and electrophysiological features to the transcriptomic reference;(3)multicell patch-clamp delineates the principles of local connectivity.Here,we review the applications of these technologies in the primate neocortex and discuss the current advances and tentative gaps for a comprehensive understanding of the primate neocortex.

关键词： Neuron Brain atlas Patch-seq Connectivity Primate

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2D DOA Estimation of Coherent Signals with a Separated Linear Acoustic Vector-Sensor Array

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China Communications 2024年第2期21卷 155-165页

作者： sheng Liu Jing zhao Decheng Wu Yiwang Huang Kaiwu Luo School of Data Science Tongren UniversityTongren 554300China School of Automation Chongqing University of Posts and TelecommunicationsChongqing 400065China

In this paper, a two-dimensional(2D) DOA estimation algorithm of coherent signals with a separated linear acoustic vector-sensor(AVS) array consisting of two sparse AVS arrays is proposed. Firstly,the partitioned spatial smoothing(PSS) technique is used to construct a block covariance matrix, so as to decorrelate the coherency of signals. Then a signal subspace can be obtained by singular value decomposition(SVD) of the covariance matrix. Using the signal subspace, two extended signal subspaces are constructed to compensate aperture loss caused by PSS.The elevation angles can be estimated by estimation of signal parameter via rotational invariance techniques(ESPRIT) algorithm. At last, the estimated elevation angles can be used to estimate automatically paired azimuth angles. Compared with some other ESPRIT algorithms, the proposed algorithm shows higher estimation accuracy, which can be proved through the simulation results.

关键词： acoustic vector-sensor coherent signals extended signal subspace sparse array

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Development of a prognostic scoring system for hepatic vena cava Budd-Chiari syndrome with hepatocellular carcinoma

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Hepatobiliary & Pancreatic Diseases International 2024年第4期23卷 370-375页

作者： sheng-Yan Liu Lu-Hao Li zhao-Chen Liu Su-Xin Li Xiao-Wei Dang Department of Hepatopancreatobiliary Surgery the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Budd-Chiari Syndrome Diagnosis and Treatment Center of Henan Province Zhengzhou 450052China

Background:Hepatocellular carcinoma(HCC)is a serious complication of hepatic vena cava Budd-Chiari syndrome(HVC-BCS)that significantly reduces the survival time of patients.Our study aimed to analyze the prognostic factors influencing the survival of HVC-BCS patients with HCC and to develop a prognostic scoring system.Methods:The clinical and follow-up data of 64 HVC-BCS patients with HCC who received invasive treatment at the First Affiliated Hospital of Zhengzhou University between January 2015 and December 2019 were retrospectively analyzed.Kaplan-Meier curves and log-rank tests were used to analyze the survival curve of patients and the difference in prognoses between the groups.Univariate and multivariate Cox regression analyses were performed to analyze the influence of biochemical,tumor,and etiological characteristics on the total survival time of patients,and a new prognostic scoring system was developed according to the regression coefficients of the independent predictors in the statistical model.The prediction efficiency was evaluated using the time-dependent receiver operating characteristics curve and concordance index.Results:Multivariate analysis showed that serum albumin level7 cm(HR=8.623,95%CI:3.771-19.715,P<0.001),and inferior vena cava stenosis(HR=3.612,95%CI:1.646-7.928,P=0.001)were independent predictors of survival.A prognostic scoring system was developed according to the above-mentioned independent predictors,and patients were classified into grades A,B,C and D.Significant differences in survival were found among the four groups.Conclusions:This study successfully developed a prognostic scoring system for HVC-BCS patients with HCC,which is helpful for clinical evaluation of patient prognosis.

关键词： Budd-Chiari syndrome Hepatocellular carcinoma Prognostic factors Inferior vena cava stenosis Prognostic scoring system

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Unbalanced private set intersection with linear communication complexity

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Science China(Information Sciences) 2024年第3期67卷 79-93页

作者： Quanyu zhao Bingbing JIANG Yuan ZHANG Heng WANG Yunlong MAO sheng ZHONG Department of Computer Science and Technology Nanjing University Purple Mountain Lab

The private set intersection(PSI) protocol allows two parties holding a set of integers to compute the intersection of their sets without revealing any additional information to each other. The unbalanced PSI schemes consider a specific setting where a client holds a small set of the size n and a server holds a much larger set of the size m(n ■ m). The communication overhead of state-of-the-art balanced PSI schemes is O(m + n) and the unbalanced PSI schemes are O(nlogm). In this paper, we propose a novel secure unbalanced PSI protocol based on a hash proof system. The communication complexity of our protocol grows only linearly with the size of the small set. In other words, our protocol achieves communication overhead of O(n). We test the performance on a personal computer(PC) machine with a local area network(LAN)setting for the network. The experimental results demonstrate that the client only takes 2.01 s of online computation, 4.27 MB of round trip communication to intersect 1600 pieces of 32-bit integers with 220pieces of 32-bit integers with the security parameter λ = 512. Our protocol is efficient and can be applied to resource-constrained devices, such as cell phones.

关键词： unbalanced private set intersection Hash proof system linear communication complexity small set resource-constrained devices

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