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Elimination of methicillin‑resistant Staphylococcus aureus biofilms on titanium implants via photothermally‑triggered nitric oxide and immunotherapy for enhanced osseointegration

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Military Medical Research 2024年第2期11卷 157-179页

作者： Yong‑lin Yu Jun‑Jie Wu chuan‑chuan lin Xian Qin Franklin R.Tay Li Miao Bai‑long Tao Yang Jiao Department of Pathology Affiliated Hospital of Zunyi Medical UniversityZunyi 563003GuizhouChina Laboratory Research Center the First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Blood Transfusion Laboratory of Radiation Biologythe Second Affiliated HospitalArmy Military Medical UniversityChongqing 400037China Department of Reproductive Endocrinology Chongqing Health Center for Women and ChildrenChongqing 401147China The Graduate School Augusta UniversityAugustaGA 30912USA Department of Stomatology the Seventh Medical Center of PLA General HospitalBeijing 100700China

Background:Treatment of methicillin-resistant Staphylococcus aureus(MRSA)biofilm infections in implant placement surgery is limited by the lack of antimicrobial activity of titanium(Ti)*** is a need to explore more effective approaches for the treatment of MRSA biofilm ***:Herein,an interfacial functionalization strategy is proposed by the integration of mesoporous polydopamine nanoparticles(PDA),nitric oxide(NO)release donor sodium nitroprusside(SNP)and osteogenic growth peptide(OGP)onto Ti implants,denoted as Ti-PDA@*** physical and chemical properties of Ti-PDA@SNP-OGP were assessed by scanning electron microscopy,X-ray photoelectron spectroscope,water contact angle,photothermal property and NO release *** synergistic antibacterial effect and elimination of the MRSA biofilms were evaluated by 2′,7′-dichlorofluorescein diacetate probe,1-N-phenylnaphthylamine assay,adenosine triphosphate intensity,O-nitrophenyl-β-D-galactopyranoside hydrolysis activity,bicinchoninic acid *** staining,assays for alkaline phosphatase activity,collagen secretion and extracellular matrix mineralization,quantitative real‑time reverse transcription‑polymerase chain reaction,and enzyme-linked immunosorbent assay(ELISA)were used to evaluate the inflammatory response and osteogenic ability in bone marrow stromal cells(MSCs),RAW264.7 cells and their co-culture *** staining,ELISA,micro-CT,hematoxylin and eosin,Masson's trichrome and immunohistochemistry staining were used to evaluate the eradication of MRSA biofilms,inhibition of inflammatory response,and promotion of osseointegration of Ti-PDA@SNP-OGP in ***:Ti-PDA@SNP-OGP displayed a synergistic photothermal and NO-dependent antibacterial effect against MRSA following near-infrared light(NIR)irradiation,and effectively eliminated the formed MRSA biofilms by inducing reactive oxygen species(ROS)-mediated oxidative stress,destroying bacterial membrane integrity and

关键词： Polydopamine nanoparticles Methicillin-resistant Staphylococcus aureus Nitric oxide Osseointegration Osteo-immunomodulation Photothermal effect Titanium implants

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Phase transitions in bismuth under rapid compression

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Chinese Physics B 2019年第3期28卷 300-303页

作者： Dong-Liang Yang Jing Liu chuan-long lin Qiu-Min Jing Yi Zhang Yu Gong Yan-Chun Li Xiao-Dong Li Beijing Synchrotron Radiation Facility Institute of High Energy PhysicsChinese Academy of Science Center for High Pressure Science and Technology Advanced Research National Key Laboratory for Shock Wave and Detonation Physics Institute of Fluid PhysicsChinese Academy of Engineering Physics

The structural phase transitions of bismuth under rapid compression has been investigated in a dynamic diamond anvil cell using time-resolved synchrotron x-ray diffraction. As the pressure increases, the transformations from phase I,to phase II, to phase III, and then to phase V have been observed under different compression rates at 300 K. Compared with static compression results, no new phase transition sequence appears under rapid compression at compression rate from 0.20 GPa/s to 183.8 GPa/s. However, during the process across the transition from phase III to phase V, the volume fraction of product phase as a function of pressure can be well fitted by a compression-rate-dependent sigmoidal *** resulting parameters indicate that the activation energy related to this phase transition, as well as the onset transition pressure, shows a compression-rate-dependent performance. A strong dependence of over-pressurization on compression rate occurs under rapid compression. A formula for over-pressure has been proposed, which can be used to quantify the over-pressurization.

关键词： bismuth high pressure rapid compression over-pressurization

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Immune checkpoint inhibition mediated with liposomal nanomedicine for cancer therapy

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Military Medical Research 2024年第1期11卷 98-114页

作者： Guang-long Ma Wei-Feng lin Faculty of Medicine Centre for Cancer ImmunologyUniversity of SouthamptonSouthampton SO166YDUK Department of Molecular Chemistry and Materials Science Weizmann Institute of Science76100 RehovotIsrael Key Laboratory of Bio-Inspired Smart Interfacial Science and Technology of Ministry of Education School of ChemistryBeihang UniversityBeijing 100191China

Immune checkpoint blockade(ICB)therapy for cancer has achieved great success both in clinical results and on the *** the same time,success drives more attention from scientists to improve ***,only a small portion of patients are responsive to this therapy,and it comes with a unique spectrum of side effects termed immunerelated adverse events(irAEs).The use of nanotechnology could improve ICBs’delivery to the tumor,assist them in penetrating deeper into tumor tissues and alleviate their *** nanomedicine has been investigated and used for decades,and is well-recognized as the most successful nano-drug delivery *** successful combination of ICB with liposomal nanomedicine could help improve the efficacy of ICB *** this review,we highlighted recent studies using liposomal nanomedicine(including new emerging exosomes and their inspired nanovesicles)in associating ICB therapy.

关键词： Liposome Exosome Immune checkpoint blockade(ICB)

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Mechanism study of Cu(Ⅱ) adsorption from acidic wastewater by ultrasonic-modified municipal solid waste incineration fly ash

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Chinese Journal of Chemical Engineering 2024年第3期67卷 157-165页

作者： Shunda lin Yang Lu lin Zheng ling long Xuguang Jiang Jianhua Yan State Key Laboratory of Clean Energy Utilization Institute for Thermal Power EngineeringZhejiang UniversityHangzhou 310027China Zhejiang University Qingshanhu Energy Research Center Hangzhou 310027China Hangzhou Xiaoshan Jinjiang Green Energy Co. Ltd.XiaoshanHangzhou 310000China

High concentrations of copper ions(Cu(Ⅱ)) in water will pose health risks to humans and the ecological environment. Therefore, this study aims to utilize ultrasonic-cured modified municipal solid waste incineration(MSWI) fly ash for Cu(Ⅱ) adsorption to achieve the purpose of “treating waste by waste.” The effects of p H, adsorption time, initial concentration, and temperature on the modified MSWI fly ash’s adsorption efficiency were systematically studied in this article. The adsorption performance of the modified MSWI fly ash can be enhanced by the ultrasonic modification. At pH = 2, 3 and 4, the adsorption capacity of the modified MSWI fly ash for Cu(Ⅱ) increased by 2.7, 1.9 and 1.2 times, respectively. Furthermore, it was suggested that the adsorption process of the modified MSWI fly ash can be better simulated by the pseudo-second-order kinetic model, with a maximum adsorption capacity calculated by the Langmuir model of 24.196 mg.g-1. Additionally, the adsorption process is spontaneous,endothermic, and chemisorption-dominated from the thermodynamic studies(ΔH and ΔS > 0, ΔG < 0).Finally, the enhanced adsorption performance of the modified MSWI fly ash for Cu(Ⅱ) may be attributed to electrostatic interaction and chelation effects.

关键词： Ultrasound MSWI fly ash Cu(Ⅱ) Wastewater Adsorption

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Component modeling and updating method of integrated energy systems based on knowledge distillation

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Energy and AI 2024年第2期16卷 184-199页

作者： Xueru lin Wei Zhong Xiaojie lin Yi Zhou long Jiang Liuliu Du-Ikonen long Huang Shanghai Institute for Advanced Study Zhejiang UniversityShanghaiChina College of Energy Engineering Zhejiang UniversityHangzhouChina Jiaxing Research Institute Zhejiang UniversityJiaxingChina Department of Sustainability Science LUT UniversityLappeenrantaFinland School of Intelligent Manufacturing Ecosystem Xi'an Jiaotong-Liverpool UniversitySuzhouChina

Amid the backdrop of carbon neutrality, traditional energy production is transitioning towards integrated energy systems (IES), where model-based scheduling is key in scenarios with multiple uncertainties on both supply and demand sides. The development of artificial intelligence algorithms, has resolved issues related to model accuracy. However, under conditions of high proportion renewable energy integration, component load adjustments require increased flexibility, so the mathematical model of the component must adapt to constantly changing operating conditions. Therefore, the identification of operating condition changes and rapid model updating are pressing issues. This study proposes a modeling and updating method for IES components based on knowledge distillation. The core of this modeling method is the light weighting of the model, which is achieved through a knowledge distillation method, using a teacher-student mode to compress complex neural network models. The triggering of model updates is achieved through principal component analysis. The study also analyzes the impact of model errors caused by delayed model updates on the overall scheduling of IES. Case studies are conducted on critical components in IES, including coal-fired boilers and turbines. The results show that the time consumption for model updating is reduced by 76.67 % using the proposed method. Under changing conditions, compared with two traditional models, the average deviation of this method is reduced by 12.61 % and 3.49 %, respectively, thereby improving the model's adaptability. The necessity of updating the component model is further analyzed, as a 1.00 % mean squared error in the component model may lead to a power deviation of 0.075 MW. This method provides real-time, adaptable support for IES data modeling and updates.

关键词： Component modeling Adaptive update Knowledge distillation Variable operating conditions Integrated energy system Data-driven

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Algorithms and statistical analysis for linear structured weighted total least squares problem

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Geodesy and Geodynamics 2024年第2期15卷 177-188页

作者： Jian Xie Tianwei Qiu Cui Zhou Dongfang lin Sichun long School of Earth Science and Spatial Information Engineering Hunan University of Science and TechnologyXiangtan 411201China College of Science Central South University of Forestry and TechnologyChangsha 410018China National-Local Joint Engineering Laboratory of Geo-spatial Information Technology Hunan University of Science and TechnologyXiangtan 411201China

Weighted total least squares(WTLS)have been regarded as the standard tool for the errors-in-variables(EIV)model in which all the elements in the observation vector and the coefficient matrix are contaminated with random ***,in many geodetic applications,some elements are error-free and some random observations appear repeatedly in different positions in the augmented coefficient *** is called the linear structured EIV(LSEIV)*** kinds of methods are proposed for the LSEIV model from functional and stochastic *** the one hand,the functional part of the LSEIV model is modified into the errors-in-observations(EIO)*** the other hand,the stochastic model is modified by applying the Moore-Penrose inverse of the cofactor *** algorithms are derived through the Lagrange multipliers method and linear *** estimation principles and iterative formula of the parameters are proven to be *** first-order approximate variance-covariance matrix(VCM)of the parameters is also derived.A numerical example is given to compare the performances of our proposed three algorithms with the STLS ***,the least squares(LS),total least squares(TLS)and linear structured weighted total least squares(LSWTLS)solutions are compared and the accuracy evaluation formula is proven to be feasible and ***,the LSWTLS is applied to the field of deformation analysis,which yields a better result than the traditional LS and TLS estimations.

关键词： linear structured weighted total least squares Errors-in-variables Errors-in-observations Functional modelmodification Stochastic model modification Accuracyevaluation

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Experimental study on the compression-shear performance of a new-type circumferential joint of shield tunnel

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Underground Space 2024年第1期14卷 138-155页

作者： Ziyang Zhou Kun Feng Yiteng Liu Bohan Wu Chunfang Lu Gang lin chuan He Key Laboratory of Transportation Tunnel Engineering of Ministry of Education Southwest Jiaotong UniversityChengdu 610031China China Academy of Railway Sciences Corporation Limited Beijing 100081China China Railway Eryuan Engineering Group Co. Ltd.Chengdu 610031China

To investigate the compression-shear behavior of a new circumferential joint based on the sleeve-straight bolt combination type connection of large-diameter shield tunnels,a series of full-scale joint experiments was carried *** the process of the experiment,more attention was paid to the specimen displacement,bolt stress and joint damage *** the basis of these experiment phenomena,this study discussed the compression-shear bearing process of the new connector,analyzed the damage mode of the joint structure,and finally evaluated the performance of the new *** is found that the bearing process of the joint can be divided into four stages:the transitional stage for overcoming the friction of the concrete,the sleeve bearing stage for the sleeve bearing shear loads alone,the combined bearing stage for bearing shear loads by the connector system,and the structural damage stage for structural instability and *** speaking,affected by connector position and hand hole,the positive compression-shear stiffness of the joint is less than the negative compression-shear stiffness,and the positive shear strength of the joint is greater than the negative shear *** increase of longitudinal axial force will improve the compression-shear performance of the *** relationship between longitudinal axial force and joint stiffness is a logarithmic *** use of new type of connector can effectively improve the compression-shear stiffness of joints under low shear loads,but the application of straight bolts will lose part of the strength performance.

关键词： Shield tunnel New type of connector Shear resistance Full-scale experiment Circumferential joint

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Durable dual-state duplex Si-HfO_(2)with excellent oxidation and cracking resistance

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Journal of Advanced Ceramics 2024年第3期13卷 388-401页

作者： lin Chen Jing-chuan Luo Wen-Qi Yang Chang-Jiu Li Guan-Jun Yang State Key Laboratory for Mechanical Behavior of Materials School of Materials Science and EngineeringXi’an Jiaotong UniversityXi’an 710049China Xi’an Aerospace Engine Company Limited in CASC Xi’an 710065China

The lifetime of Si bond coatings in environmental barrier coatings is constrained by phase-transition-induced cracking of the SiO_(2)*** this study,Si-HfO_(2)dual-state duplex composite materials are proposed to address this issue by partially forming HfSiO_(4)and minimizing the SiO_(2)*** as-prepared composite exhibited a structure comprising discrete HfO_(2)“bricks”embedded in a continuous Si“mortar”,while the oxidized state transformed into discrete HfSiO_(4)“bricks”within continuous thin SiO_(2)“mortars”.The results indicate that continuous thin SiO_(2)contributes to reducing the oxidation rate to a level comparable to that of pure Si,and discrete HfSiO_(4)particles aid in relieving phase transition-induced stress and inhibiting crack propagation,thereby enhancing oxidation and cracking resistance ***,the composite with 20 mol%HfO_(2)and a mean particle size of~500 nm at 1370℃exhibited a service lifetime 10 times greater than that of pure *** research provides valuable insights for designing Si-based bond coatings with improved service lifetime.

关键词： oxidation environmental barrier coatings(EBCs) phase transition cracking bond coatings

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Assembly of highly efficient aqueous light-harvesting system from sequence-defined peptoids for cytosolic microRNA detection

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Nano Research 2024年第2期17卷 788-796页

作者： Yang Song Xiaoli Cai Mingming Wang Dan Du Yuehe lin Chun-long Chen Department of Mechanical and Materials Engineering Washington State UniversityPullmanWA 99164USA Division of Physical Sciences Pacific Northwest National LaboratoryRichlandWA 99352USA Department of Chemical Engineering University of WashingtonSeattleWA 98195USA

Precisely controlled spatial distributions of artificial light-harvesting systems in aqueous media are of significant importance for mimicking natural light-harvesting systems;however,they are often restrained by the solubility and the aggregation-caused quenching effect of the hydrophobic ***,we report one highly efficient artificial light-harvesting system based on peptoid nanotubes that mimic the hierarchical cylindrical structure of natural *** high crystallinity of these nanotubes enabled the organization of arrays of donor chromophores with precisely controlled spatial distributions,favoring an efficient Förster resonance energy transfer(FRET)process in aqueous *** FRET system exhibits an extremely high efficiency of 98.6%with a fluorescence quantum yield of 40%and an antenna effect of *** further demonstrated the use of this artificial light-harvesting system for quantifying miR-210 within cancer *** fluorescence intensity ratio of donor to acceptor is linearly related to the concentration of intercellular miR-210 in the range of 3.3–156 copies/*** high sensitivity in intracellular detection of miR-210 using this artificial light-harvesting system offers a great opportunity and pathways for biological imaging and detection,and for the further creation of microRNA(miRNA)toolbox for quantitative epigenetics and personalized medicine.

关键词： light-harvesting peptoid nanotube Förster resonance energy transfer intracellular RNA detection

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Accumulated-state-error-based event-triggered sampling scheme and its application to H∞ control of sampled-data systems

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Science China(Information Sciences) 2024年第6期67卷 328-341页

作者： Xian-Ming ZHANG Qing-long HAN Bao-lin ZHANG Xiaohua GE Dawei ZHANG School of Science Computingand Engineering TechnologiesSwinburne University of Technology College of Automation and Electronic Engineering Qingdao University of Science & Technology School of Mathematics Shandong University

This paper is concerned with event-triggered H∞control of sampled-data systems. Its novelties lie in three aspects:（i） A novel accumulated-state-error-based event-triggered scheme is introduced by comparing the integral of the state error from tk to t with the system state sampled at tk. This condition works well due to the fact that the so-called Zeno behaviour does not occur.（ii） A novel Lyapunov functional is constructed to establish a criterion to ensure some certain H∞performance of the closed-loop system. This Lyapunov functional is dependent on the integral of the state error involved in the event-triggered scheme.（iii） Under the event-triggered sampling scheme, suitable state-feedback controllers can be designed rather than be given a priori. Moreover, a self-triggered implementation of the proposed event-triggered sampling scheme is presented as well. Finally, a batch reactor model and an inverted pendulum system are given to demonstrate the effectiveness of the proposed method.

关键词： event-triggered sampling self-triggered implementation H ∞ control looped-functional

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