检索结果-南通市图书馆

World Journal of Stem Cells 2022年第1期14卷 41-53页

作者： chuan-jing dai Yu-Ting Cao Fang Huang Yi-Gang Wang College of Life Sciences and Medicine Zhejiang Sci-Tech UniversityHangzhou 310018Zhejiang ProvinceChina Department of Pathology Zhejiang Provincial People’s Hospital of Hangzhou Medical UniversityHangzhou 310014Zhejiang ProvinceChina

The transforming growth factor(TGF)-βsignaling pathway controls many cellular processes,including proliferation,differentiation,and *** in the TGF-βsignaling pathway and its components are closely related to the occurrence of many human diseases,including *** against decapentaplegic homolog 4(Smad4),also known as deleted in pancreatic cancer locus 4,is a typical tumor suppressor candidate gene locating at q21.1 of human chromosome 18 and the common mediator of the TGF-β/Smad and bone morphogenetic protein/Smad signaling *** is believed that Smad4 inactivation correlates with the development of tumors and stem cell fate ***4 also interacts with cytokines,miRNAs,and other signaling pathways,jointly regulating cell ***,the regulatory function of Smad4 in tumorigenesis,stem cells,and drug resistance is currently *** addition,Smad4 represents an attractive therapeutic target for *** the specific role of Smad4 is important for understanding the mechanism of tumorigenesis and cancer ***,we review the identification and characterization of Smad4,the canonical TGF-β/Smad pathway,as well as the multiple roles of Smad4 in tumorigenesis,stem cells,and drug ***,we provide novel insights into the prospects of Smad4-targeted cancer therapy and the challenges that it will face in the future.

关键词： Cancer therapy Drug resistance Mothers against decapentaplegic homolog 4 Stemness Transforming growth factor-β Tumorigenesis

MET receptor tyrosine kinase promotes the generation of functional synapses in adult cortical circuits

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第5期20卷 1431-1444页

作者： Yuehua Cui Xiaokuang Ma jing Wei Chang Chen Neha Shakir Hitesch Guirram Zhiyu dai Trent Anderson Deveroux Ferguson Shenfeng Qiu Basic Medical Sciences University of Arizona College of Medicine-PhoenixPhoenixAZUSA Department of Medicine University of Arizona College of Medicine-PhoenixPhoenixAZUSA

Loss of synapse and functional connectivity in brain circuits is associated with aging and neurodegeneration,however,few molecular mechanisms are known to intrinsically promote synaptogenesis or enhance synapse *** have previously shown that MET receptor tyrosine kinase in the developing cortical circuits promotes dendritic growth and dendritic spine *** investigate whether enhancing MET in adult cortex has synapse regenerating potential,we created a knockin mouse line,in which the human MET gene expression and signaling can be turned on in adult(10–12 months)cortical neurons through doxycycline-containing *** found that similar to the developing brain,turning on MET signaling in the adult cortex activates small GTPases and increases spine density in prefrontal projection *** findings are further corroborated by increased synaptic activity and transient generation of immature silent *** MET signaling resulted in an increasedα-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid/N-methyl-Daspartate(AMPA/NMDA)receptor current ratio,indicative of enhanced synaptic function and *** data reveal that enhancing MET signaling could be an interventional approach to promote synaptogenesis and preserve functional connectivity in the adult *** findings may have implications for regenerative therapy in aging and neurodegeneration conditions.

关键词： aging circuit connectivity cortical circuits molecular mechanisms neural regeneration neurodegeneration synapses

Is it possible to foot reflexology for infants with sensorineural hearing loss?

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2025年第2期13卷 1-4页

作者： Min Ai Hang-Hang Zhang Jun-Bang Feng chuan-Ming Li Wen-jing Wang Meng-Die Hu Department of Anesthesiology Nanan District People's Hospital of ChongqingChongqing 400060China Department of Breast and Thyroid Surgery Chongqing Bishan District Maternal and Child Health Care HospitalChongqing 402760China Department of Medical Imaging Chongqing University Central HospitalChongqing 400014China

Foot reflexology is a non-invasive and safe complementary therapy that works by massaging the reflex zones of the feet and exerts systemic or whole-body regulation through meridian nerve *** therapy is commonly used in the treatment of various conditions such as autism and Parkinson's ***,there is limited reporting on the use of foot reflexology therapy for infants with sensorineural hearing loss(SNHL).Currently,there is no definitive conclusion on how foot reflexology therapy can influence *** editorial holds some guiding significance regarding this clinical *** aim is to present physiological evidence of how foot reflexology therapy can impact infants with SNHL,thereby enhancing clinician’s awareness of foot reflexology in treating infants with SNHL.

关键词： Foot reflexology Sensorineural Hearing Loss Future perspectives Limitations Neural conduction

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基于仿真方法的共享换电站价值量化分析

北京工业大学学报 2025年第1期51卷 22-31页

作者：沙玲汪静张海峰王岱上海工程技术大学机械与汽车工程学院上海201620 上海蔚来汽车有限公司上海201800

相较于电动汽车充电站,换电站具有补能时间短、空间面积小等优点。多品牌电动汽车高效共享换电站,能够极大程度优化补能结构,减少资源浪费。为了量化共享换电站对电动汽车用户的价值,基于排队理论,利用蔚来汽车品牌的运行数据,搭建一个... 详细信息

相较于电动汽车充电站,换电站具有补能时间短、空间面积小等优点。多品牌电动汽车高效共享换电站,能够极大程度优化补能结构,减少资源浪费。为了量化共享换电站对电动汽车用户的价值,基于排队理论,利用蔚来汽车品牌的运行数据,搭建一个模拟用户换电行为的仿真器,通过量化用户的平均排队时间和换电站数量,评估电动汽车用户在不同电动汽车规模和换电站渗透率下的换电体验。结果表明,电动汽车品牌共享换电站资源,能够显著减少电动汽车用户的排队时间,以及将排队时间保持在期望阈值内所需的换电站数量,从而提高用户的充电体验并节省换电站建设成本。

关键词：电动汽车换电站共享排队论换电体验仿真

基于卡尔加里-剑桥指南的沙龙培训模式提升全科规培医师医患沟通技能的对照研究

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国全科医学 2025年第1期28卷 71-76页

作者：彭涛邹川曾欣张焱沈静四川省成都市第五人民医院全科医学科 611130

背景医患沟通技能是全科医生的核心岗位胜任力之一,高水平的医患沟通能力是创建和谐医患关系的基石,有助于提高患者就医获得感和满意度。而我国全科医生沟通能力普遍偏低,有待探索出一种适应我国国情、满足我国全科医生沟通需求的医患... 详细信息

背景医患沟通技能是全科医生的核心岗位胜任力之一,高水平的医患沟通能力是创建和谐医患关系的基石,有助于提高患者就医获得感和满意度。而我国全科医生沟通能力普遍偏低,有待探索出一种适应我国国情、满足我国全科医生沟通需求的医患沟通培训模式来提高其医患沟通能力。目的探索基于卡尔加里-剑桥指南的沙龙培训模式在全科规培医师医患沟通技能培训中的应用效果,为构建适合我国国情的医患沟通培训体系提供参考依据。方法选取成都市第五人民医院2019—2020年度全科规培医师40名作为研究对象,按照随机数字表法分为沙龙组和对照组,每组20名,其中沙龙组使用基于卡尔加里-剑桥指南的沙龙培训模式进行医患沟通培训,对照组设置为空白对照,培训前、培训后1周分别对两组学员采用标准化病人(SP)模式进行接诊,使用医患沟通评价量表(SEGUE量表)进行现场观察评分,比较两组学员的医患沟通培训效果。结果最终纳入28名,其中沙龙组15名,对照组13名,培训后沙龙组规培医师SEGUE量表评分从(11.80±4.36)分提高至(18.07±4.11)分,对照组规培医师SEGUE量表评分从(12.15±4.63)分提高至(14.46±3.71)分。沙龙组培训后的SEGUE量表评分与培训前的比较,差异有统计学意义(t=3.250,P<0.001);对照组培训后的SEGUE量表评分与培训前比较,差异无统计学意义(t=2.582,P=0.624);培训后对SEGUE量表中的25个项目进行分析,沙龙组与对照组SEGUE量表评分比较,差异有统计学意义(P<0.05)。沙龙组以下5个项目结果优于对照组,准备阶段中的“建立个人信任关系”(93.3%比7.7%)、“保护患者的隐私/尊重患者选择权”(53.3%比15.4%);理解患者阶段中的“认同患者为疾病所付出的努力、改变及其遇到的困难”(33.3%比23.1%)、“表达关心,使患者感到温暖/树立信心”(100.0%比69.2%);结束问诊阶段中的“询问患者是否还有其他的问题需要探讨”(66.7%比23.1%)。结论基于卡尔加里-剑桥指南的沙龙培训模式对全科规培医师进行医患沟通技能培训可增强学员主动参加培训的兴趣和积极性,对于医患沟通能力的提升具有较好的培训效果,值得借鉴和推广。

关键词：全科医学全科医师规范化培训医患沟通沟通培训卡尔加里-剑桥指南

Adaptive ordering and filament polymerization of cell cytoskeleton by tunable nanoarrays

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Nano Research 2021年第3期14卷 620-627页

作者： jing dai Yuan Yao School of Physical Science and Technology ShanghaiTech UniversityShanghai201210China

Matrix adaptation reconstructs the architecture of cell,and has important implication in proper biological ***,how the network of cytoskeleton filament undergoes reconstruction,reordering,and surface adaptation,requires a systematic ***,we show that surface sensing and adaptation occur correspondingly with related reorganization of cytoskeleton filaments(actin,tubulin,and vimentin).The microstructure of filament network is built by adaptive change of chemical polymerization on cytoskeleton *** transition of cellular morphology,from spheroidal architecture on nanoarray to extending structure with stress fibers on flat surface,involves spatial reorganization and polymerization modulation of *** dimension of filaments(diameter,orientation,and density)are changed accordingly to spatiotemporal distribution of cytoskeleton *** addition,our findings elucidate how cell can tune their architecture at nanoscale by matrix adaptation,and provide a novel information on interplay between cytoskeleton and pathophysiology.

关键词： adaptation cytoskeleton polymerization reordering

Inspection interval optimization for aircraft composite structures with dent and delamination damage

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Systems Engineering and Electronics 2021年第1期32卷 252-260页

作者： CAI jing dai Dingqiang College of Civil Aviation Nanjing University of Aeronautics and AstronauticsNanjing 211106China

The optimization of inspection intervals for composite structures has been proposed,but only one damage type,dent damage,has been addressed so *** present study focuses on the two main damage types of dent and delamination,and a model for optimizing the inspection interval of composite structures is proposed to minimize the total maintenance cost on the premise that the probability of structure failure will not exceed the acceptable *** order to analyze the damage characteristics and the residual strength of the composite structure,the frequency,energy,size,and depth of the damage are studied,and the situation of missing detection during the inspection is *** structural residual strength and total maintenance cost are quantified corresponding to different inspection *** proposed optimization method relieves the constraints in previous simulation methods,and is more consistent with the actual ***,the outer wing of aircraft is taken as an example,and with the historical cases and experimental data,the optimization method is *** optimal inspection interval is shorter than the actually implemented inspection interval,and the corresponding maintenance cost is reduced by 23.3%.The result shows the feasibility and effectiveness of the proposed optimization method.

关键词： civil aircraft composite structure accidental impact damage failure probability inspection interval

NUMERICAL SIMULATION OF VENTILATED CAVITATING FLOW AROUND A 2D FOIL

在线全文

学校读者我要写书评

暂无评论

Journal of Hydrodynamics 2005年第5期17卷 607-614页

作者： CHEN Xin LU chuan-jing Department of Engineering Mechanics Shanghai Jiaotong University Shanghai 200240 China

By using a pressure-based method and the finite volume method in the framework of the time dependent Reynolds-averaged Navier-Stokes equations, the authors studied the unsteady process of ventilated cavities generated forcing air through an orifice in a 2D hydrofoil without natural cavitation physically. The computation was carried out with the Volume Of Fluid （VOF） technique to track the gas-liquid two-phase interface. The results of simulation indicate that the ventilation rate is an important parameter in determining the morphology of cavity. There exists a critical value to convert sheet cavity into supereavity. A high ventilation rate can induce a two phase interface fluctuation and enable the ventilated eavitating flow to present a characteristic of periodicity.

关键词： ventilated cavity re entrant jet interface fluctuation Volume Of Fluid (VOF) techinique

COLLABORATIVE DESIGN OF RFID SYSTEMS FOR MULTI-PURPOSE SUPPLY CHAIN APPLICATIONS

在线全文

学校读者我要写书评

暂无评论

Journal of Systems Science and Systems Engineering 2013年第2期22卷 152-170页

作者： Hongyan dai jing XU School of Business Central University of Finance and Economics Department of Industrial Engineering Tsinghua University

One of the key challenges for implementing RFID systems in supply chain management is the difficulty in economic justification. Such difficulty is further amplified by its public participation nature as multiple self-interest beneficiaries may receive diverse paybacks, and their incentives to join the system are difficult to align. This paper aims to address these problems by a collaborative design from two aspects. First, we propose to introduce a centralized planning mechanism in the chain to facilitate the participation, so that the cost of the overall system can be minimized. Second, we propose to analyze the multi-facet economic return from multi-purpose applications to achieve the full potential of RFID systems. To illustrate our approach, its application for inventory inaccuracy and product recall in RFID system is presented.

关键词： RFID collaborative design economic justification centralized planning

Inverse Problems for the Dirac Operator on a Star Graph

在线全文

学校读者我要写书评

暂无评论

Acta Mathematica Sinica,English Series 2023年第1期39卷 161-175页

作者： dai Quan LIU chuan Fu YANG School of Mathematics and Statistics Nanjing University of Science and TechnologyNanjing 210094P.R.China

Following the previous work,we shall study some inverse problems for the Dirac operator on an equilateral star *** is proven that the so-called Weyl function uniquely determines the ***,we pay attention to the inverse problem of recovering the potentials from the spectral data,which consists of the eigenvalues and weight matrices,and present a constructive *** basic tool in this paper is the method of spectral mappings developed by Yurko.

关键词： Inverse problem Dirac operator on graph Weyl function weight matrix