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Thymoquinone suppresses migration of Lo Vo human colon cancer cells by reducing prostaglandin E2 induced COX-2 activation

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World Journal of Gastroenterology 2017年第7期23卷 1171-1179页

作者： Hsi-Hsien Hsu Ming-Cheng Chen Cecilia Hsuan Day Yueh-Min Lin Shin-Yi Li chuan-chou tu Viswanadha Vijaya Padma Hui-Nung Shih Wei-Wen Kuo Chih-Yang Huang Division of Colorectal Surgery Mackay Memorial Hospital Mackay Medicine Nursing and Management College Division of Colorectal Surgery Taichung Veterans General Hospital Department of Nursing MeiHo University Department of Pathology Changhua Christian Hospital Jen-Teh Junior College of Medicine Nursing and Management Graduate Institute of Basic Medical Science China Medical University Division of Chest Medicine Department of Internal MedicineArmed Force Taichung General Hospital Department of Biotechnology Bharathiar University Graduate Institute of Chinese Medical Science China Medical University Department of Biological Science and Technology China Medical University Department of Health and Nutrition Biotechnology Asia University

AIM To identify potential anti-cancer constituents in natural extracts that inhibit cancer cell growth and migration. METHODS Our experiments used high dose thymoquinone (TQ) as an inhibitor to arrest LoVo (a human colon adenocarcinoma cell line) cancer cell growth, which was detected by cell proliferation assay and immunoblotting assay. Low dose TQ did not significantly reduce LoVo cancer cell growth. Cyclooxygenase 2 (COX-2) is an enzyme that is involved in the conversion of arachidonic acid into prostaglandin E2 (PGE2) in humans. PGE2 can promote COX-2 protein expression and tumor cell proliferation and was used as a control. RESULTS Our results showed that 20 mu mol/L TQ significantly reduced human LoVo colon cancer cell proliferation. TQ treatment reduced the levels of p-PI3K, p-Akt, p-GSK3 beta, and beta-catenin and thereby inhibited the downstream COX-2 expression. Results also showed that the reduction in COX-2 expression resulted in a reduction in PGE2 levels and the suppression of EP2 and EP4 activation. Further analysis showed that TG treatment inhibited the nuclear translocation of beta-catenin in LoVo cancer cells. The levels of the cofactors LEF-1 and TCF-4 were also decreased in the nucleus following TQ treatment in a dose-dependent manner. Treatment with low dose TQ inhibited the COX-2 expression at the transcriptional level and the regulation of COX-2 expression efficiently reduced LoVo cell migration. The results were further verified in vivo by confirming the effects of TQ and/or PGE2 using tumor xenografts in nude mice. CONCLUSION TQ inhibits LoVo cancer cell growth and migration, and this result highlights the therapeutic advantage of using TQ in combination therapy against colorectal cancer.

关键词： Thymoquinone LoVo cell Cyclooxygenase 2 Prostaglandin E2 migration

Intracellular redox potential-driven live-cell synthesis of CdSe quantum dots in Staphylococcus aureus

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Science China Chemistry 2024年第3期67卷 990-999页

作者： Cai-Qin Wu An-An Liu Xu Li Jia-Wei tu Juan Kong Ling-Ling Yang Jian-Hong Jia chuan Wang Bin Hu Zhi-Xiong Xie Dai-Wen Pang The Institute for Advanced Studies College of Chemistry and Molecular SciencesCollege of Life SciencesHubei Key Laboratory of Cell HomeostasisWuhan UniversityWuhan 430072China Research Center for Analytical Sciences College of ChemistryState Key Laboratory of Medicinal Chemical BiologyTianjin Key Laboratory of Biosensing and Molecular RecognitionFrontiers Science Center for New Organic MatterFrontiers Science Center for Cell Responsesand Haihe Laboratory of Sustainable Chemical TransformationsNankai UniversityTianjin 300071China

Biosynthesized semiconductor quantum dots(QDs) have bright fluorescence,adjustable particle sizes,and environmental friendliness,endowing them with convenience and potential for biological *** to the unclear mechanism of the cellular environment on the live-cell synthesis of QDs,it is still difficult to regulate their optical ***,the critical role of the intracellular redox environment in regulating the fluorescence properties of biosynthesized CdSe QDs in Staphylococcus aureus(***) has been *** glutathione peroxidase(GPx) activity directly affects the intracellular H_(2)O_(2) produced in the SeO_(3)^(2-) reduction,which further manipulates the glutathione redox cycle to determine the content of low-valence *** a result,the fluorescence intensity of the synthesized CdSe QDs increases by 60% in the GPx overexpressed *** cellular redox potential that is controlled by the GSH redox cycle provides the driving force for the reduction of SeO_(3)^(2-),facilitating the synthesis of CdSe QDs in *** *** proposed mechanism of the cellular redox state provides a new perspective for regulating the synthesis of semiconductor nanomaterials in live cells.

关键词： redox H_(2)O_(2) peroxidase quantum dot Staphylococcus aureus

Chiral Pair Density Waves with Residual Fermi Arcs in RbV3Sb5

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Chinese Physics Letters 2024年第9期41卷 88-92页

作者： Xiao-Yu Yan Hanbin Deng Tianyu Yang Guowei Liu Wei Song Hu Miao Zhijun tu Hechang Lei Shuo Wang Ben-chuan Lin Hailang Qin Jia-Xin Yin Department of Physics Southern University of Science and TechnologyShenzhen 518055China Materials Science and Technology Division Oak Ridge National LaboratoryOak RidgeTennessee 37831USA Beijing Key Laboratory of Optoelectronic Functional Materials MicroNano Devices Department of PhysicsRenmin University of ChinaBeijing 100872China Key Laboratory of Quantum State Construction and Manipulation(Ministry of Education) Renmin University of ChinaBeijing 100872China Shenzhen Institute for Quantum Science and Engineering Southern University of Science and TechnologyShenzhen 518055China Guangdong Provincial Key Laboratory of Quantum Science and Engineering Southern University of Science and TechnologyShenzhen 518055China Quantum Science Center of Guangdong-Hong Kong-Macao Greater Bay Area Shenzhen 518055China

The chiral 2×2 charge order has been reported and confirmed in the kagome superconductor RbV3Sb5,while its interplay with superconductivity remains elusive owing to its lowest superconducting transition temperature Tc of about 0.85K in the AV3Sb5 family(A=K,Rb,Cs)that severely challenges electronic spectroscopic ***,utilizing dilution-refrigerator-based scanning tunneling microscopy down to 30 mK,we observe chiral 2×2 pair density waves with residual Fermi arcs in *** find a superconducting gap of 150eV with substantial residual in-gap *** spatial distribution of this gap exhibits chiral 2×2 modulations,signaling a chiral pair density wave(PDW).Our quasi-particle interference imaging of the zero-energy residual states further reveals arc-like *** discuss the relation of the gap modulations with the residual Fermi arcs under the space-momentum correspondence between PDW and Bogoliubov Fermi states.

关键词： Fermi chiral utilizing

青年马克思政治批判的哲学叙事——《〈黑格尔法哲学批判〉导言》的再考察

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西北师大学报（社会科学版） 2024年第5期61卷 16-23页

作者：涂良川华南师范大学马克思主义学院广东广州510631

青年马克思对法哲学的批判是马克思思想发展史上的重要事件。青年马克思的政治批判,直指作为世界观与方法论的哲学之现实性、实践性与超越性,不仅为其解决物质利益的困惑找到了正确的道路,而且明确表达了对作为时代精神精华的哲学之全... 详细信息

青年马克思对法哲学的批判是马克思思想发展史上的重要事件。青年马克思的政治批判,直指作为世界观与方法论的哲学之现实性、实践性与超越性,不仅为其解决物质利益的困惑找到了正确的道路,而且明确表达了对作为时代精神精华的哲学之全新看法。青年马克思以“高卢雄鸡”来表征哲学与时代互动的方式,使哲学在“揭露具有非神圣形象的自我异化”中真正“为历史服务”,并真实地“确立此岸世界的真理”。

关键词：青年马克思《〈黑格尔法哲学批判〉导言》政治批判哲学时代

Remote entangling gate between a quantum dot spin and a transmon qubit mediated by microwave photons

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Chinese Physics B 2024年第2期33卷 52-59页

作者：朱行宇朱乐天涂涛李传锋 Key Laboratory of Quantum Information Chinese Academy of SciencesUniversity of Science and Technology of ChinaHefei 230026China School of Mechanical and Electronic Engineering Suzhou UniversitySuzhou 234000China Hefei National Laboratory University of Science and Technology of ChinaChinese Academy of SciencesHefei 230088China

Spin qubits and superconducting qubits are promising candidates for realizing solid-state quantum information *** a hybrid architecture that combines the advantages of different qubits on the same chip is a highly desirable but challenging *** we propose a hybrid architecture that utilizes a high-impedance SQUID array resonator as a quantum bus,thereby coherently coupling different solid-state *** employ a resonant exchange spin qubit hosted in a triple quantum dot and a superconducting transmon *** this hybrid system is highly tunable,it can operate in a dispersive regime,where the interaction between the different qubits is mediated by virtual *** utilizing such interactions,entangling gate operations between different qubits can be realized in a short time of 30 ns with a fidelity of up to 96.5%under realistic parameter *** utilizing this interaction,remote entangled state between different qubits can be prepared and is robust to perturbations of various *** results pave the way for exploring efficient fault-tolerant quantum computation on hybrid quantum architecture platforms.

关键词： hybrid quantum architectures circuit quantum electrodynamics entangling gate

Half-precessional cycle revealed by environment magnetism of stalagmite in Shizhu Cave from southwestern China during the Last Glacial

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Journal of Earth Science 2024年

作者： Huihui Yang Yu-Min chou Xiuyang Jiang Wenyue Xia Hai Li Yi Zhong Jingyu Zhang Yaoqi He Tsai-Luen Yu Qingsong Liu chuan-chou Shen College of Tourism and Air Service， Guizhou Minzu University Research Center for Future Earth， Taiwan University Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou) School of Environment， Harbin Institute of Technology High-Precision Mass Spectrometry and Environment Change Laboratory (HISPEC)， Department of Geosciences， Taiwan University Key Laboratory of Humid Subtropical Eco-Geographical Processes， College of Geography Science， Fujian Normal University Center for Marine Magnetism (CM2)， Department of Ocean Science and Engineering， Southern University of Science and Technology

The environmental magnetic proxies of stalagmites hold significant potential for reconstructing regional hydroclimate changes by revealing the content and grain size of magnetic particles within stalagmites. In this study， we present the contents and grain sizes of magnetic particles within a stalagmite SZ-1， from Shizhu Cave in southwestern China from 70.4 to 22.3 thousand years ago (ka) during the last glacial period. Specifically， the parameters IRMsoft， soil-derived magnetic minerals， and ARM/SIRM (anhysteretic remanent magnetization/saturation isothermal remanent magnetization)， the ratio of fine magnetic particles to total ferrimagnetic particles preserved in stalagmite SZ-1， indicate the fluctuation of regional precipitation. Obvious half-precessional cycles are evident in these two proxies， indicating that hydroclimatic variations in southwestern China may predominantly arise from the heat and moisture transported from tropical oceans. These variations are likely influenced by shifts in the Intertropical Convergence Zone and fluctuations in the Asian summer monsoon.

关键词：

新质生产力“守正创新”历史唯物主义的文明叙事

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华中科技大学学报（社会科学版） 2024年第4期38卷 1-9页

作者：涂良川张宝翠华南师范大学马克思主义学院

新质生产力是新时代中国共产党人领导中国人民实现中华民族伟大复兴的征程中,守正创新历史唯物主义的最新理论成果。它以中国化时代化马克思主义的理论观念、思维逻辑和价值追求哲学地表征了中国创新、中国道路和中国实践的时代性与文... 详细信息

新质生产力是新时代中国共产党人领导中国人民实现中华民族伟大复兴的征程中,守正创新历史唯物主义的最新理论成果。它以中国化时代化马克思主义的理论观念、思维逻辑和价值追求哲学地表征了中国创新、中国道路和中国实践的时代性与文明性。新质生产力,是以其“新概念、新实践、新思维、新追求”而展开的文明叙事,是以“客观的历史”为根基、“实践的智慧”为依托、“理念的更新”为方式、“文明的推进”为追求的新时代历史唯物主义。其以“生产力形态的跃迁”“生产实践的升华”“生产理念的更新”“生产文明的推进”实现对历史唯物主义的守正创新,既是今天中国化时代化马克思主义的实践逻辑与思想智慧,更是以中国方案、中国理论和中国追求对当代人类繁荣的历史推进。因此,新质生产力“守正创新”历史唯物主义,是时代与实践、文明与文化、中国与世界的文明叙事,是中国人以自己的方式贡献给人类的“时代精神”和“文化的活的灵魂”。

关键词：新质生产力历史唯物主义文明叙事守正创新

SATS:一种基于多重特征提取的恒星光谱分类算法

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光谱学与光谱分析 2024年第7期44卷 2029-2036页

作者：屠良平李双川涂东鑫李建喜丁治超闽南师范大学数学与统计学院福建漳州363000 辽宁科技大学理学院辽宁鞍山114051

对恒星光谱进行深入研究,可以了解恒星的化学组成和物理特性。恒星光谱分类是恒星光谱研究领域的一个重要方向,随着海量恒星光谱数据的出现,人工分类手段就无法满足科研的需要。基于此,搭建了SATS(SVD Analysis Transformer SoftMax)算... 详细信息

对恒星光谱进行深入研究,可以了解恒星的化学组成和物理特性。恒星光谱分类是恒星光谱研究领域的一个重要方向,随着海量恒星光谱数据的出现,人工分类手段就无法满足科研的需要。基于此,搭建了SATS(SVD Analysis Transformer SoftMax)算法,该算法实现了对F、G、K型恒星光谱的自动分类。SATS算法,首先以奇异值分解(SVD)的方式,对归一化后的恒星光谱做去噪处理;然后对恒星光谱进行特征提取,特征提取层共有六个模块:增量主成分分析(Incremental PCA)、核主成分分析(Kernel PCA)、稀疏主成分分析(Sparse PCA)、因子分析(Factor Analysis)、独立成分分析(Fast ICA)和Transformer(前五个模块统称为Analysis模块),为保证方差贡献率在0.95以上,IPCA、KPCA、Sparse PCA、Factor Analysis和Fast ICA将恒星光谱特征提取为300维;最后,将恒星光谱输入到SoftMax层进行自动分类。SATS算法将多个Analysis模块结合使用,进一步提高了使用单一Analysis模块的分类正确率。Transformer模块和多个Analysis模块的结合使用,再一次提高了分类正确率。SATS算法最大的优势在于对恒星光谱进行了多重特征提取,以不同的特征提取方式,最大程度地保留了原始恒星光谱信息,将信息损失做到最低。SATS算法的最终分类正确率为0.93,这一分类正确率也高于混合深度学习算法CNN(convolutional neural network)+Bayes、CNN+KNN、CNN+SVM、CNN+Adaboost和CNN+Adaboost0.86、0.88、0.89、0.87、0.89的分类正确率。

关键词： Transformer LAMOST 恒星光谱 SVD CNN

Hybrid Optimization Algorithm for Handwritten Document Enhancement

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Computers, Materials & Continua 2024年第3期78卷 3763-3786页

作者： Shu-chuan Chu Xiaomeng Yang Li Zhang Václav Snášel Jeng-Shyang Pan College of Computer Science and Engineering Shandong University of Science and TechnologyQingdao266590China School of Information and Control Engineering Qingdao University of TechnologyQingdao266520China Faculty of Electrical Engineering and Computer Science VŠB-TU OstravaOstrava70080Czech Republic Department of Information Management Chaoyang University of TechnologyTaichung41349Taiwan

The Gannet Optimization Algorithm (GOA) and the Whale Optimization Algorithm (WOA) demonstrate strong performance;however, there remains room for improvement in convergence and practical applications. This study introduces a hybrid optimization algorithm, named the adaptive inertia weight whale optimization algorithm and gannet optimization algorithm (AIWGOA), which addresses challenges in enhancing handwritten documents. The hybrid strategy integrates the strengths of both algorithms, significantly enhancing their capabilities, whereas the adaptive parameter strategy mitigates the need for manual parameter setting. By amalgamating the hybrid strategy and parameter-adaptive approach, the Gannet Optimization Algorithm was refined to yield the AIWGOA. Through a performance analysis of the CEC2013 benchmark, the AIWGOA demonstrates notable advantages across various metrics. Subsequently, an evaluation index was employed to assess the enhanced handwritten documents and images, affirming the superior practical application of the AIWGOA compared with other algorithms.

关键词： Metaheuristic algorithm gannet optimization algorithm hybrid algorithm handwritten document enhancement