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An Implementation of Multiscale Line Detection and Mathematical Morphology for Efficient and Precise Blood Vessel Segmentation in Fundus Images

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Computers, Materials & Continua 2024年第5期79卷 2565-2583页

作者： Syed Ayaz Ali Shah Aamir Shahzad Musaed Alhussein chuan Meng Goh Khursheed Aurangzeb tong Boon Tang Muhammad Awais Department of Electrical and Computer Engineering COMSATS University IslamabadAbbottabad CampusAbbottabad22060Pakistan Department of Computer Engineering College of Computer and Information SciencesKing Saud UniversityP.O.Box 51178Riyadh11543Saudi Arabia Faculty of Information and Communication Technology University Tunku Abdul RehmanKampar CampusKampar31900Malaysia Centre for Intelligent Signal and Imaging Research University Teknologi PETRONASBandar Seri IskandarPerak32610Malaysia School of Computing Sciences University of East AngliaNorwichNR47TJUK

Diagnosing various diseases such as glaucoma,age-related macular degeneration,cardiovascular conditions,and diabetic retinopathy involves segmenting retinal blood vessels.The task is particularly challenging when dealing with color fundus images due to issues like non-uniformillumination,low contrast,and variations in vessel appearance,especially in the presence of different pathologies.Furthermore,the speed of the retinal vessel segmentation system is of utmost importance.With the surge of now available big data,the speed of the algorithm becomes increasingly important,carrying almost equivalent weightage to the accuracy of the algorithm.To address these challenges,we present a novel approach for retinal vessel segmentation,leveraging efficient and robust techniques based on multiscale line detection and mathematical morphology.Our algorithm’s performance is evaluated on two publicly available datasets,namely the Digital Retinal Images for Vessel Extraction dataset(DRIVE)and the Structure Analysis of Retina(STARE)dataset.The experimental results demonstrate the effectiveness of our method,withmean accuracy values of 0.9467 forDRIVE and 0.9535 for STARE datasets,aswell as sensitivity values of 0.6952 forDRIVE and 0.6809 for STARE datasets.Notably,our algorithmexhibits competitive performance with state-of-the-art methods.Importantly,it operates at an average speed of 3.73 s per image for DRIVE and 3.75 s for STARE datasets.It is worth noting that these results were achieved using Matlab scripts containing multiple loops.This suggests that the processing time can be further reduced by replacing loops with vectorization.Thus the proposed algorithm can be deployed in real time applications.In summary,our proposed system strikes a fine balance between swift computation and accuracy that is on par with the best available methods in the field.

关键词： Line detector vessel detection localization mathematical morphology image processing

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General Psychiatry 2024年第1期37卷 73-82页

作者： Qian Lu Sisi Huang Tianjiao Zhang Jie Song Manyu Dong Yilun Qian Jing Teng tong Wang chuan He Ying Shen Department of Rehabilitation Medicine The Affiliated Jiangsu Shengze Hospital of Nanjing Medical UniversitySuzhouChina Rehabilitation Medicine Center The First Affiliated Hospital of Nanjing Medical UniversityNanjingChina

Background The neurophysiological differences in cortical plasticity and cholinergic system function due to ageing and their correlation with cognitive function remain poorly understood.Aims To reveal the differences in long-term potentiation(LTP)-like plasticity and short-latency afferent inhibition(SAl)between older and younger individuals,alongside their correlation with cognitive function using transcranial magnetic stimulation(TMS).Methods The cross-sectional study involved 31 younger adults aged 18-30 and 46 older adults aged 60-80.All participants underwent comprehensive cognitive assessments and a neurophysiological evaluation based on TMS.Cognitive function assessments included evaluations of global cognitive function,language,memory and executive function.The neurophysiological assessment included LTP-like plasticity and SAl.Results The findings of this study revealed a decline in LTP among the older adults compared with the younger adults(wald χ^(2)=3.98,p=0.046).Subgroup analysis further demonstrated a significant reduction in SAl level among individuals aged 70-80 years in comparison to both the younger adults(SAI(N20)):(t=-3.37,p=0.018);SAl(N20+4):(t=-3.13,p=0.038)and those aged 60-70(SAl(N20)):(t=3.26,p=0.025);SAl(N20+4):(t=-3.69,p=0.006).Conversely,there was no notable difference in SAl level between those aged 60-70 years and the younger group.Furthermore,after employing the Bonferroni correction,the correlation analysis revealed that only the positive correlation between LTP-like plasticity and language function(r=0.61,p<0.001)in the younger group remained statistically significant.Conclusions During the normal ageing process,a decline in synaptic plasticity may precede cholinergic system dysfunction.In individuals over 60 years of age,there is a reduction in LTP-like plasticity,while a decline in cholinergic system function is observed in those over 70.Thus,the cholinergic system may play a vital role in preventing cognitive decline during normal ageing.In younger individuals,LTP-like plasticit

关键词： function younger plasticity

Achieving laparoscopic anatomic resection for hepatocellular carcinoma by fluorescence guided positive staining of hepatic cone unit

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Hepatobiliary & Pancreatic Diseases International 2024年第4期23卷 406-411页

作者： Jun-Fang Deng chuan-Hui Peng Yu Zhang Xiao-Feng Xu Rong-Liang tong Zheng-Long Zhai Di-Yu Chen Cheng Zhang Li-Ming Wu Jian Wu Division of Hepatobiliary Pancreatic Surgery the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

Laparoscopic anatomical liver resection has been increasingly reported worldwide,but how to demarcate the resection planes is technically challenging[1].Positive staining technique with intraoperative indocyanine green(ICG)-fluorescence imaging has been introduced as an effective tool for real-time intraoperative guidance[2].Liver anatomy is complex.Generally,liver is composed of 9 segments,each is composed of two to three subsegments,and each subsegment contains several hepatic cone units.A hepatic cone unit is dominated by a tertiary or quaternary hepatic pedicles[3].

关键词： hepatic resection anatomy

Reciprocal activation of antigen-presenting cells and CAR T cells triggers a widespread endogenous anti-tumor immune response through sustained high-level IFNγproduction

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Cancer Biology & Medicine 2023年第11期20卷 779-782页

作者： Yelei Guo chuan tong Zhiqiang Wu Yuting Lu Yao Wang Weidong Han Department of Bio-therapeutic the First Medical CenterChinese PLA General HospitalBeijing 100853China

Adoptive cell transfer(ACT)using chimeric antigen receptor(CAR)modified T cells and T cell receptor(TCR)engineered T cells has shown therapeutic efficacy in cancer treatment1,2.CAR T cells are widely applicable to tum... 详细信息

关键词： sustained endogenous CAR

PriChain: Efficient Privacy-preserving Finegrained Redactable Blockchains in Decentralized Settings

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Chinese Journal of Electronics 2024年

作者： Hongchen GUO Weilin GAN Mingyang ZHAO chuan ZHANG tong WU Liehuang ZHU Jingfeng XUE School of Computer Science and Technology Beijing Institute of Technology School of Cyberspace Science and Technology Beijing Institute of Technology School of Computer and Communication Engineering University of Science and Technology Beijing

Recently, redactable blockchain has been proposed and leveraged in a wide range of real systems for its unique properties of decentralization, traceability, and transparency while ensuring controllable on-chain data redaction. However, the development of redactable blockchain is now obstructed by three limitations, which are data privacy breaches, high communication overhead, and low searching efficiency, respectively. In this paper, we propose PriC hain, the first efficient privacy-preserving fine-grained redactable blockchain in decentralized settings. PriChain provides data owners with rights to control who can read and redact on-chain data while maintaining downward compatibility, ensuring the one who can redact will be able to read. Specifically, inspired by the concept of multi-authority attribute-based encryption, we utilize the isomorphism of the access control tree, realizing fine-grained redaction mechanism, downward compatibility, and collusion resistance. With the newly designed structure, PriChain can realize O（n） communication and storage overhead compared to prior O（n2） schemes. Furthermore, we integrate multiple access trees into a tree-based dictionary, optimizing searching efficiency. Theoretical analysis proves that PriC hain is secure against the chosen-plaintext attack and has competitive complexity. The experimental evaluations show that PriChain realizes 10× efficiency improvement of searching and 100× lower communication and storage overhead on average compared with existing schemes.

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C-CORE:Clustering by Code Representation to Prioritize Test Cases in Compiler Testing

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Computer Modeling in Engineering & Sciences 2024年第5期139卷 2069-2093页

作者： Wei Zhou Xincong Jiang chuan Qin School of Electronic Information and Electrical Engineering Shanghai Jiao Tong UniversityShanghai200240China Hikvision Research Institute Hangzhou Hikvision Digital Technology Co.Ltd.Hangzhou310051China

Edge devices,due to their limited computational and storage resources,often require the use of compilers for program optimization.Therefore,ensuring the security and reliability of these compilers is of paramount importance in the emerging field of edge AI.One widely used testing method for this purpose is fuzz testing,which detects bugs by inputting random test cases into the target program.However,this process consumes significant time and resources.To improve the efficiency of compiler fuzz testing,it is common practice to utilize test case prioritization techniques.Some researchers use machine learning to predict the code coverage of test cases,aiming to maximize the test capability for the target compiler by increasing the overall predicted coverage of the test cases.Nevertheless,these methods can only forecast the code coverage of the compiler at a specific optimization level,potentially missing many optimization-related bugs.In this paper,we introduce C-CORE(short for Clustering by Code Representation),the first framework to prioritize test cases according to their code representations,which are derived directly from the source codes.This approach avoids being limited to specific compiler states and extends to a broader range of compiler bugs.Specifically,we first train a scaled pre-trained programming language model to capture as many common features as possible from the test cases generated by a fuzzer.Using this pre-trained model,we then train two downstream models:one for predicting the likelihood of triggering a bug and another for identifying code representations associated with bugs.Subsequently,we cluster the test cases according to their code representations and select the highest-scoring test case from each cluster as the high-quality test case.This reduction in redundant testing cases leads to time savings.Comprehensive evaluation results reveal that code representations are better at distinguishing test capabilities,and C-CORE significantly enhances testing efficiency.Across four datasets,C-COR

关键词： Compiler testing test case prioritization code representation

Identification of NOXA as a pivotal regulator of resistance to CAR T-cell therapy in B-cell malignancies

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Signal Transduction and Targeted Therapy 2022年第5期7卷 1634-1643页

作者： Xin Yan Deyun Chen Yao Wang Yelei Guo chuan tong Jianshu Wei Yajing Zhang Zhiqiang Wu Weidong Han School of Medicine Nankai UniversityTianjinChina Department of Bio-therapeutic the First Medical CenterChinese PLA General HospitalBeijingChina National Clinical Research Center for Hematologic Diseases the First Affiliated Hospital of Soochow UniversitySuzhouChina

Despite the remarkable success of chimeric antigen receptor(CAR)T-cell therapy for treating hematologic malignancies,resistance and recurrence still occur,while the markers or mechanisms underlying this resistance remain poorly understood.Here,via an unbiased genome-wide CRISPR/Cas9 screening,we identified loss of NOXA,a B-cell lymphoma 2(BCL2)family protein in B-cell malignancies,as a pivotal regulator of resistance to CAR T-cell therapy by impairing apoptosis of tumor cells both in vitro and in vivo.Notably,low NOXA expression in tumor samples was correlated with worse survival in a tandem CD19/20 CAR T clinical trial in relapsed/refractory B-cell lymphoma.

关键词： CRISPR/Cas9 NOXA malignancies

Assessing environmental impact:Micro-energy network optimization in a Chinese industrial park

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Chinese Journal of Population,Resources and Environment 2024年第1期22卷 68-73页

作者： Guanzhun Cao chuan Feng tong Li Hongjuan Zhang Xiaoyao Guo Wen Li Yanshuang Jia Leping Chen Yuan Xu Qingsong Wang Guifang Chen Xueliang Yuan China Tobacco Shandong Industrial Co. Ltd.Jinan 250104China Shandong Academy of Environmental Sciences Jinan 250109China Shandong Electrical Engineering&Equipment Group Co. Ltd.Jinan 250001China School of Energy and Power Engineering Shandong UniversityJinan 250061China

Micro-energy systems contribute significantly to environmental improvement by reducing dependence on power grids through the utilization of multiple renewable energy sources.This study quantified the environmental impact of a micro-energy network system in an industrial park through a life cycle assessment using the operation of the micro-energy network over a year as the functional unit and“cradle-to-gate”as the system boundary.Based on the baseline scenario,a natural gas generator set was added to replace central heating,and the light pipes were expanded to constitute the optimized scenario.The results showed that the key impact categories for both scenarios were global warming,fine particulate matter formation,human carcinogenic toxicity,and human non-carcinogenic toxicity.The overall environmental impact of the optimized scenario was reduced by 68%compared to the baseline scenario.A sensitivity analysis of the key factors showed that electricity from the power grid was the key impact factor in both scenarios,followed by central heating and natural gas.Therefore,to reduce the environmental impact of network systems,it is necessary to further optimize the grid power structure.The research approach can be used to optimize micro-energy networks and evaluate the environmental impact of different energy systems.

关键词： Micro-energy network Life cycle assessment Optimal operation Environmental impact

湿地甲烷代谢对氮输入响应的复杂性及其机制分析

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生态学报 2024年第4期44卷 1324-1335页

作者：仝川罗敏谭季湿润亚热带生态-地理过程教育部重点实验室福州350117 福建师范大学地理科学学院福州350117 福州大学环境与安全工程学院福州350116

氮素是影响湿地甲烷代谢过程的重要因素之一。氮输入是否影响湿地甲烷排放,增加全球气候变暖的风险,一直受到科学界的高度关注。目前关于氮输入对湿地甲烷排放影响的几篇meta-analysis文章的主要结论均为氮输入促进湿地甲烷排放,但是多... 详细信息

氮素是影响湿地甲烷代谢过程的重要因素之一。氮输入是否影响湿地甲烷排放,增加全球气候变暖的风险,一直受到科学界的高度关注。目前关于氮输入对湿地甲烷排放影响的几篇meta-analysis文章的主要结论均为氮输入促进湿地甲烷排放,但是多篇研究性论文的结果为氮输入抑制或不影响湿地甲烷排放,由此可见氮输入对湿地甲烷排放的影响十分复杂。湿地甲烷代谢包括湿地甲烷产生、氧化和传输过程以及最终的甲烷排放,综述不同形态氮输入对水稻田、内陆湿地和滨海湿地甲烷排放通量影响的复杂性;分析湿地甲烷产生速率和途径、甲烷好氧氧化和硝酸盐/亚硝酸盐型厌氧甲烷氧化对不同形态氮输入的响应及机制。硝态氮输入对湿地甲烷产生具有抑制作用已成共识,然而其它形态氮输入对湿地土壤甲烷产生的影响具有较大的不确定性,氮输入影响湿地甲烷产生的机制主要包括电子受体-底物竞争机制、离子毒性机制、促进植物生长-碳底物供给增加机制以及pH调控机制等。氮输入对湿地好氧甲烷氧化影响的研究多集中在水稻田和泥炭湿地,影响的结果包括促进、抑制或影响不显著;氮输入促进湿地土壤硝酸盐/亚硝酸盐型厌氧甲烷氧化。着重分析氮输入对湿地甲烷代谢影响不确定性的成因,指出湿地甲烷代谢对氮输入的响应是一个生态系统层面的生物地球化学过程,并提出氮输入是最具争议效应的驱动因素之一,其对甲烷代谢的影响很难得出明确的模式,可能需要考虑湿地土壤特征(本底氮含量、有机碳含量、土壤C:N值等)以及植物群落类型和特征,最后提出今后在氮输入对湿地甲烷代谢影响方面应加强的研究领域。

关键词：氮输入甲烷通量甲烷产生和氧化不确定性生态系统特征湿地