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Hydrogel loaded with bone marrow stromal cell-derived exosomes promotes bone regeneration by inhibiting inflammatory responses and angiogenesis

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World Journal of Stem Cells 2024年第5期16卷 499-511页

作者： Shuai Zhang chuan lu Sheng Zheng Guang Hong Division for International Collaborative and Innovative Dentistry Tohoku University Graduate School of DentistrySendai 980-8575MiyagiJapan School of Stomatology Zhejiang Chinese Medical UniversityHangzhou 310053Zhejiang ProvinceChina

BACKGROUND Bone healing is a complex process involving early inflammatory immune regu-lation,angiogenesis,osteogenic differentiation,and biomineralization.Fracture repair poses challenges for orthopedic surgeons,necessitating the search for efficient healing methods.AIM To investigate the underlying mechanism by which hydrogel-loaded exosomes derived from bone marrow mesenchymal stem cells(BMSCs)facilitate the process of fracture healing.METHODS Hydrogels and loaded BMSC-derived exosome(BMSC-exo)gels were charac-terized to validate their properties.In vitro evaluations were conducted to assess the impact of hydrogels on various stages of the healing process.Hydrogels could recruit macrophages and inhibit inflammatory responses,enhance of human umbilical vein endothelial cell angiogenesis,and promote the osteogenic differen-tiation of primary cranial osteoblasts.Furthermore,the effect of hydrogel on fracture healing was confirmed using a mouse fracture model.RESULTS The hydrogel effectively attenuated the inflammatory response during the initial repair stage and subsequently facilitated vascular migration,promoted the formation of large vessels,and enabled functional vascularization during bone repair.These effects were further validated in fracture models.CONCluSION We successfully fabricated a hydrogel loaded with BMSC-exo that modulates macrophage polarization and angiogenesis to influence bone regeneration.

关键词： Hydrogel Bone marrow mesenchymal stem cells Macrophage polarization Angiogenesis Bone regeneration

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Enantioselective Synthesis of Benzimidazole Atropisomers Featuring a N-N Axis

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Chinese Journal of Chemistry 2024年第7期42卷 711-718页

作者： Fang-Bei Ge Qi-Kun Yin chuan-Jun lu Xuan Xuan Jia Feng Ren-Rong Liu College of Chemistry and Chemical Engineering Qingdao UniversityQingdaoShandong 266071China School of Pharmacy Key Laboratory of Mlecular Pharmacoogy and Drug EvaluationMinistry of EducationYantai Universit YantaiShandong 264005China

Atroposelective synthesis of N-N atropisomers is an emerging area but remains underexplored;in particular,the synthesis of N-N benzimidazole atropisomers is still unprecedented.Herein,the first enantioselective synthesis of N-N benzimidazole atropisomers via the palladium-catalyzed de novo construction of benzimidazole skeleton is presented.With readily available palladium catalyst and biphosphine ligand,a broad range of nonbiaryl benzimidazole and indole-benzimidazole atropisomers were conveniently ac-cessed in high yields and with excellent enantioselectivities.Significantly,these N-N benzimidazole atropisomers showed great anti-tumor activity and selectivity to breast cancer MCF-7 cells.The simple catalytic system,broad substrate scope,high enantioselectivi-ty,and good bioactivity make this approach highly attractive.

关键词： Asymmetric synthesis Atropisomerism Palladium Benzimidazole Antitumor

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Bioinformatic analysis of lncRNA-associated competing endogenous RNA regulatory networks in synovial tissue of temporomandibular joint osteoarthritis

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BIOCELL 2023年第6期47卷 1293-1306页

作者： CHUYAO WANG chuan lu luXIANG ZOU DONGMEI HE School of Stomatology Qingdao UniversityQingdao266000China Department of Oral Surgery Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai Key Laboratory of Stomatology&Shanghai Research Institute of StomatologyNational Clinical Research Center of StomatologyShanghai200011China

Background:Temporomandibular joint osteoarthritis(TMJOA)is an end-stage disease that seriously affects the patients’quality of life.Molecular insights in advancing our understanding of TMJOA are the need of the hour.Methods:We performed RNA high-throughput sequencing and bioinformatics analysis of differentially expressed(DE)long non-coding RNA(lncRNAs),microRNAs(miRNAs),and messenger RNA(mRNAs)in human synovial TMJOA tissues.Firstly,synovium samples of TMJOA patients and non-TMJOA controls were collected for highthroughput sequencing of lncRNAs,miRNAs,and mRNAs.We then performed biological function analysis of the top 100 mRNAs with more than 2-fold differential expression,and their upstream regulated miRNAs and lncRNAs were predicted separately.Intersections between predicted miRNAs/lncRNAs and differentially expressed miRNAs/lncRNAs were determined,respectively.Regulatory networks among the selected lncRNAs,miRNAs,and mRNAs were constructed.Finally,Western Blotting and reverse transcription-quantitative polymerase chain reaction(RT-qPCR)were used to explore the function of selected lncRNA and mRNAs.Results:Our analysis showed that the only upregulated lncRNAxist,was involved in intracellular protein degradation,cartilage matrix degradation,and osteoclast differentiation through four regulatory axes:miR-1271-5p/ctsb,miR-365a-3p/mmp3,miR-199a-3p/fos,and miR-27b-3p/miR-1271-5p/grb2.RT-qPCR results showed that xist expression increased in both TMJOA synovial tissue and inflammatory-stimulated synovial cells.Inhibition of xist could promote the proliferation of synovial cells upon inflammatory stimulation,and xist could positively regulate the expression of GRB2.Targeting GRB2 could inhibit the expression of matrix degrading enzymes in synovial cells,thereby attenuating the inflammatory environment.Conclusion:Given the current lack of reports of lncRNA regulation in TMJOA synovitis,our results revealed that xist was significantly differentially expressed in human synovial TMJOA and could regulate the expression of

关键词： TMJOA Non-coding RNAs Osteoarthritis prevention and treatment

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一部夯实中华民族共同体学理论基础的金教材--《中华民族共同体概论》的叙事特色

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中南民族大学学报（人文社会科学版） 2024年第5期44卷 32-35页

作者：朱露川北京师范大学历史学院、史学理论与史学史研究中心

国家统编教材《中华民族共同体概论》(以下简称《概论》)在近期正式出版了。作为首部以中华民族共同体为讲授对象的教材,《概论》具有鲜明的理论指导,用中国历史的客观进程说明了中华民族共同体的形成和发展,阐述了树立正确的中华民族... 详细信息

国家统编教材《中华民族共同体概论》(以下简称《概论》)在近期正式出版了。作为首部以中华民族共同体为讲授对象的教材,《概论》具有鲜明的理论指导,用中国历史的客观进程说明了中华民族共同体的形成和发展,阐述了树立正确的中华民族历史观的具体路径,是新时代开展铸牢中华民族共同体意识教育工作的重要里程碑。《概论》呼应了全社会对教材的迫切需要,反映了中华民族共同体研究的最新成果,展现了中国学人在中华民族共同体问题上的观点、立场和话语,标志着“中华民族共同体学”的学科建设取得了重大进展。

关键词：《概论》叙事特色中华民族共同体中国学人学科建设讲授对象国家统编教材具体路径

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前庭刺激对自闭症谱系障碍儿童语言障碍的疗效分析

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广西科学 2024年第2期31卷 389-394页

作者：卢川龙耀斌广西医科大学第二附属医院广西南宁530007

本研究将前庭刺激与常规语言训练相结合,观察评价其对自闭症谱系障碍(Autism Spectrum Disorder,ASD)儿童语言障碍的影响。研究选取60例ASD且伴有语言障碍的儿童,随机分为对照组(n=30)和实验组(n=30)。对照组给予常规语言训练,实验组在... 详细信息

本研究将前庭刺激与常规语言训练相结合,观察评价其对自闭症谱系障碍(Autism Spectrum Disorder,ASD)儿童语言障碍的影响。研究选取60例ASD且伴有语言障碍的儿童,随机分为对照组(n=30)和实验组(n=30)。对照组给予常规语言训练,实验组在对照组的基础上接受前庭刺激治疗(利用宇航员旋转板及Bobath球),每次训练均在治疗师的指导下进行。分别于治疗前、治疗8周后对2组患儿的自闭症儿童行为量表(Autism Behavior Checklist,ABC)语言障碍评分和儿童语言发育迟缓检查法(Sign-Significant relations,S-S法)评级结果进行评价分析。结果表明:治疗8周后,2组患儿ABC语言障碍评分较治疗前降低,S-S法评级较治疗前提高,实验组疗效明显优于对照组(P<0.05)。综上可知,前庭刺激联合常规语言训练对改善ASD儿童语言障碍的效果较单纯常规语言训练更为显著。

关键词：前庭康复感觉统合训练自闭症谱系障碍语言障碍 Bobath球

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从“社会批判”到“设计批评”——《黑暗时代的设计:阿伦特辞典》评述

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工业工程设计 2024年第1期6卷 11-18页

作者：卢川西安美术学院西安710065 中国艺术研究院北京100029

通过分析《黑暗时代的设计:阿伦特辞典》的体例与内容,对其借用思想家汉娜·阿伦特的哲学与政治学观念,对设计问题进行批判的研究方法与结果进行了评述,并进一步探讨社会批判与设计批评及其实践相结合的研究路径。

关键词：《黑暗时代的设计:阿伦特辞典》设计理论设计批评

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基于铅铋快堆的直流蒸汽发生器稳态与瞬态特性分析

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核动力工程 2024年第2期45卷 103-109页

作者：黄哲梁铁波杨雯卢川李洋何中海沈昕上海交通大学机械与动力工程学院上海200240 中国核动力研究设计院核反应堆系统设计技术重点实验室成都610213

铅铋快堆的安全稳定运行与换热器一二次侧间的散热性能密切相关。本研究通过建立基于铅铋快堆的直流蒸汽发生器(OTSG)稳态与瞬态耦合分布参数模型,分析对比了不同负荷条件下OTSG内部热工水力特性的分布差异,并进一步揭示了铅铋快堆一次... 详细信息

铅铋快堆的安全稳定运行与换热器一二次侧间的散热性能密切相关。本研究通过建立基于铅铋快堆的直流蒸汽发生器(OTSG)稳态与瞬态耦合分布参数模型,分析对比了不同负荷条件下OTSG内部热工水力特性的分布差异,并进一步揭示了铅铋快堆一次侧焓值及流量扰动对换热器动态散热性能的影响。结果表明:稳态传热时铅铋快堆一次侧温降主要集中在过冷沸腾及核态沸腾区,二次侧负荷减小将导致管壁面温度飞升前移;动态调节显示在设计工况下一次侧入口焓值仅下降5%,就可能导致铅铋快堆循环在90 s后进入事故工况。研究结果为铅铋快堆的OTSG动态流动换热特性研究及结构设计优化提供了有价值的建议。

关键词：铅铋快堆直流蒸汽发生器热工水力分析分布参数模型

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Ground-Based Hyperspectral Stereoscopic Remote Sensing Network: A Promising Strategy to Learn Coordinated Control of O_(3) and PM_(2.5) over China

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Engineering 2022年第12期19卷 71-83页

作者： Cheng Liu Chengzhi Xing Qihou Hu Qihua Li Haoran Liu Qianqian Hong Wei Tan Xiangguang Ji Hua Lin chuan lu Jinan Lin Hanyang Liu Shaocong Wei Jian Chen Kunpeng Yang Shuntian Wang Ting Liu Yujia Chen Department of Precision Machinery and Precision Instrumentation University of Science and Technology of ChinaHefei 230026China Center for Excellence in Regional Atmospheric Environment Institute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China Key Lab of Environmental Optics and Technology Anhui Institute of Optics and Fine MechanicsHefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031China Key Laboratory of Precision Scientific Instrumentation of Anhui Higher Education Institutes University of Science and Technology of ChinaHefei 230026China Anhui Province Key Laboratory of Polar Environment and Global Change University of Science and Technology of ChinaHefei 230026China School of Earth and Space Sciences University of Science and Technology of ChinaHefei 230026China School of Environmental Science and Optoelectronic Technology University of Science and Technology of ChinaHefei 230026China Institute of Physical Science and Information Technology Anhui UniversityHefei 230601China School of Environment and Civil Engineering Jiangnan UniversityWuxi 214122China

With the coming of the“14th Five-Year Plan,”the coordinated control of particulate matter with an aerodynamic diameter no greater than 2.5 lm(PM_(2.5))and O_(3) has become a major issue of air pollution prevention and control in China.The stereoscopic monitoring of regional PM_(2.5) and O_(3) and their precursors is crucial to achieve coordinated control.However,current monitoring networks are currently inadequate for monitoring the vertical profiles of both PM_(2.5) and O_(3) simultaneously and support air quality control.The University of Science and Technology of China(USTC)has established a nationwide ground-based hyperspectral stereoscopic remote sensing network based on multi-axis differential optical absorption spectroscopy(MAX-DOAS)since 2015.This monitoring network provides a significant opportunity for the regional coordinated control of PM_(2.5) and O_(3) in China.One-year vertical profiles of aerosol,NO_(2) and HCHO monitored from four MAX-DOAS stations installed in four megacities(Beijing,Shanghai,Shenzhen,and Chongqing)were used to characterize their vertical distribution differences in four key regions,Jing–Jin–Ji(JJJ),Yangtze River Delta(YRD),Pearl River Delta(PRD),and Sichuan Basin(SB),respectively.The normalized and yearly averaged aerosol vertical profiles below 400 m in JJJ and PRD exhibit a box shape and a Gaussian shape,respectively,and both show exponential shapes in YRD and SB.The NO_(2) vertical profiles in four regions all exhibit exponential shapes because of vehicle emissions.The shape of the HCHO vertical profile in JJJ and PRD was Gaussian,whereas an exponential shape was shown in YRD and SB.Moreover,a regional transport event occurred at an altitude of 600–1000 m was monitored in the southwest–northeast pathway of the North China Plain(NCP)by five MAX-DOAS stations(Shijiazhuang(SJZ),Wangdu(WD),Nancheng(NC),Chinese Academy of Meteorological Sciences(CAMS),and University of Chinese Academy of Sciences(UCAS))belonging to the above network.The aerosol optical depths(AOD)in these five st

关键词： MAX-DOAS Stereoscopic monitoring Regional transport Ozone production Control strategy

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Effects of Planting Density of Quinoa on Agronomic Characters and Yield in Chengde

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Meteorological and Environmental Research 2022年第5期13卷 103-105,109页

作者： chuan lu Yueyou LI Qian CUI Yonggang XIANG Wei LV Zhimin WEI Hebei Science and Technology Innovation Service Center Shijiazhuang 050035China Shijiazhuang Botanical Garden Shijiazhuang 050011China Guyuan Beimai Ecological Agriculture Co. Ltd.Guyuan 076500China Institute of Millet Crops Hebei Academy of Agriculture and Forestry SciencesShijiazhuang 050035China

[Objectives]To study the optimum sowing density of quinoa in Chengde region.[Methods]Yanli No.2 cultivated by Institute of Millet Crops,Hebei Academy of Agriculture and Forestry Sciences was taken as test material.In Chengde region,single-factor density test design was used to study the effects of sowing on agronomic characters and yield of quinoa.[Results]Quinoa had the highest comprehensive yield when row spacing was 30 cm and plant spacing was 25 cm.[Conclusions]The research could provide theoretical basis for quinoa planting in Chengde region.

关键词： Quinoa Planting density Chengde Agronomic characters Yield

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Remediation Technologies for Cadmium Contamination in Greenhouse Vegetable Fields

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Meteorological and Environmental Research 2023年第2期14卷 78-84页

作者： Huiwei ZHAO Yiming LIU Wenjun LIU Wei LIU Jing YANG chuan lu Qiaoying ZHANG National Semi-arid Agricultural Engineering and Technology Research Center Shijiazhuang 050051China College of Chemistry and Environmental Science Hebei UniversityBaoding 071002China Shijiazhuang Academy of Agricultural Sciences Shijiazhuang 050061China

Based on the literature and experimental results, three kinds of soil amendments, namely rice biochar, hydroxyapatite and potassium dihydrogen phosphate(KH2PO4), and deeper ploughing were selected to evaluate the field application effect of soil amendments and agronomic measures on the remediation of Cd contamination in greenhouse vegetable fields. Cd-contaminated greenhouse screening was conducted from 2015 to 2017. In September 2017, comparative tests of eight treatments were performed, and a preferred test was performed in September 2018. The screening results of the contaminated areas indicated that the distribution of over-standard sites was uneven, and Cd content was significantly different. Over-standard rate of No.4 greenhouse was 83.33% and was the highest, and the average content of Cd in soil was 0.535 mg/kg. It was used as a comparative test greenhouse for eight treatments. No.1 greenhouse was selected as the preferred test greenhouse, with three over-standard plots having average Cd concentrations of 0.530, 0.568 and 0.792 mg/kg. The comparative test results showed that after 8 months of remediation, the content of available Cd in the treatment of hydroxyapatite+rice biochar+deeper ploughing(T6) was reduced by 32.55% compared with CK(the control) and 24.96% than 2 months of remediation. The content of available Cd using the treatment of potassium dihydrogen phosphate+rice biochar+deeper ploughing(T7) decreased by 47.88% compared with CK and 31.00% than 2 months of remediation. The preferred remediation test results showed that in the treatment of hydroxyapatite+rice biochar+deeper ploughing: the mean Cd content decreased from 0.489 to 0.372 mg/kg, reducing by 23.86%, and the mean did not exceed the standard. Compared with CK, the mean content of available Cd decreased by 10.71% after 8 months, and the lowest content of available Cd in three treatments was 0.133 mg/kg. In addition, the Cd content, bioconcentration factor(BCF) and translocation coefficient(TF) of bean aboveground plants were decreased

关键词： Greenhouse vegetable fields Cd pollution Remediation technology Application study

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