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Incorporating Sulfur Atoms into Palladium Catalysts by Reactive Metal–Support Interaction for Selective Hydrogenation

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CCS Chemistry 2022年第9期4卷 3051-3063页

作者： Zhen-Yu Wu Hang Nan Shan-Cheng Shen Ming-Xi Chen Hai-Wei Liang chuan-Qi huang Tao Yao Sheng-Qi Chu Wei-Xue Li Shu-Hong Yu Division of Nanomaterials and Chemistry Hefei National Laboratory for Physical Sciences at the MicroscaleCAS Center for Excellence in NanoscienceInstitute of EnergyHefei Comprehensive National Science CenterDepartment of ChemistryInstitute of Biomimetic Materials and ChemistryAnhui Engineering Laboratory of Biomimetic MaterialsUniversity of Science and Technology of ChinaHefei 230026 Hangzhou Institute of Advanced Studies Zhejiang Normal UniversityHangzhouZhejiang 311231 National Synchrotron Radiation Laboratory University of Science and Technology of ChinaHefei 230026 Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049 Department of Chemical Physics School of Chemistry and Materials ScienceiCHeMCAS Center for Excellence in NanoscienceHefei National Laboratory for Physical Sciences at the MicroscaleUniversity of Science and Technology of ChinaHefei 230026

Developing highly active and selective catalysts for the hydrogenation of nitroarenes,an environmentally benign process to produce industrially important aniline intermediates,is highly desirable but very *** catalysts are generally recognized as active but nonselective catalysts for this important ***,we report an effective strategy to greatly improve the selectivity of Pd catalysts based on the reactive metal–support interaction.

关键词： incorporating sulfur atoms palladium catalysts reactive metal–support interaction hydrogenation density functional theory calculations

Does a deviation between the rights and obligations of the board and controlling shareholders affect firm value？

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Journal of Modern Accounting and Auditing 2009年第5期5卷 1-18页

作者： huang chuan-chuan Department of Accounting Feng Chia University Taichung 40724 Taiwan

Pre-mental foramen mandibulotomy for resecting tumors of tongue base and parapharyngeal space

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Chinese Medical Journal 2005年第21期118卷 1803-1807页

作者： YU Guang-yan ZHANG Lei GUO chuan-bin huang Min-xian MAO Chi PENG Xin Department of Oral and Maxillofacial Surgery Peking University School and Hospital of Stomatology Beijing 100081 China

Background Resection of tumors arising from the tongue base and the parapharyngeal space is difficult for exposure and manipulation because of their obscure location. The aim of this study was to evaluate the surgical approach of the pre-mental foramen mandibulotomy for resecting the tumors of tongue base and parapharyngeal space. Methods Fifty-one patients with tumors of tongue base and parapharyngeal space were treated using the mandibulotomy approach on the pre-mental foramen. In the present study, this technique was described in detail. The patients were followed up for three months to six years with a mean of 26 months. Results The tumors of tongue base and parapharyngeal space could be exposed clearly and be resected radically by surgical approach of pre-mental foramen mandibulotomy. The surgical complications were reduced. Conclusions Compared to other surgical approaches, such as lateral mandibulotomy, midline mandibulotomy, the suprahyoid parapharyngeal approach, and paramedian mandibulotomy, we found that the pre-mental foramen mandibulotomy is the ideal choice for resecting the tumors of tongue base and parapharyngeal space.

关键词： tumor of the tongue base parapharyngeal tumor pre-mental foramen mandibulotomy surgical approach

P-modified cobalt oxide: A novel and effective catalyst for oxidative dehydrogenation of propane

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Chinese Chemical Letters 2013年第9期24卷 789-792页

作者： Xiao-Zhang Lin Guang-Chao Li chuan-Jing huang Wei-Zheng Weng Hui-Lin Wan State Key Laboratory of Physical Chemistry of Solid Surfaces National Engineering Laboratory for Green Chemical Productions of Alcohols Ethers and Esters and Department of Chemistry College of Chemistry and Chemical Engineering Xiamen University

A series ofnanosized cobalt oxide catalysts modified with phosphorus have been synthesized by the solgel method and investigated in the oxidative dehydrogenation of propane to propene. With the addition of phosphorus, the crystallite size of the catalyst was largely decreased, while the P species in the catalyst were highly dispersed. Compared to pure cobalt oxide, the P-modified samples showed higher propane conversion and enhanced propene selectivity. Over the PCoO catalyst with a P/Co atomic ratio of 0.05, the maximal propene yields of 15.7% with a propane conversion of 28.3% were obtained at 520 ℃.

关键词： Propane Propene Oxidative dehydrogenation Nanosized PCoO catalyst

Distribution of heavy metals in an incineration system of solid wastes in the Three-Gorges region of the Yangtze River

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Chinese Journal Of Geochemistry 2008年第2期27卷 189-193页

作者： huang chuan WANG Li＇ ao CHEN Gangcai LUO Yu ZHANG Jun CUI Zhiqiang Key Laboratory of Southwest Resources Development and Environmental Disaster Control Engineering Ministry of Education Chongqing 400030 China Chongqing General Brigade of Environmental Enforcement Chongqing 400021 China Rubbish Manage Terminal of Bao ＇an Shenzheng 518101 China Chongqing University Chongqing 400030 China

On the basis of investigations on the composition and contents of heavy metals in the domestic refuse in the Three-Gorges region of the Yangtze River, in combination with the experimental results, this paper deals with the distribution rule of heavy metals in the various compartments of an incineration system:leachate pool, fly ash and residue. It is concluded that in the leachate pool heavy metals should not be neglectable since about 30% of Pb and 10% of Cr are leached here; in the incineration system, above 74% of Cr, As and Pb exists in residue; above 96% of Hg exists in fly ash and the contents of Cd in fly ash are close to those of residue. It is also concluded that the physical conditions of incineration have a significant influence on the distribution of heavy metals in the incineration system.

关键词：废物燃烧系统重金属固体废物三峡地区长江

CREBBP/EP300 mutations promoted tumor progression in diffuse large B-cell lymphoma through altering tumorassociated macrophage polarization via FBXW7-N0TCHCCL2/ CSF1 axis

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Signal Transduction and Targeted Therapy 2021年第2期6卷 482-495页

作者： Yao-Hui huang Kun Cai Peng-Peng Xu Li Wang chuan-Xin huang Ying Fang Shu Cheng Xiao Jian Sun Feng Liu Jin-Yan huang Meng-Meng Ji Wei-Li Zhao Shanghai Istitute of Hematology State Key Laboratory of Medical GenomicsNational Research Center for Translational Medicine at ShanghaiRulin Hospital Afliated to Shanghai Jiao Tong University School of MedicineShanghaiChina School of Life Sciences and Biotechnology.Shanghai Jiao Tong Universiy ShanghalChina Department of Immunobiology and Microbiology Shanghai Istitute of ImmunologyShanghai Jiao Tong University School of MedicineShanghaiChina Pole de Recherches Sino Francais en Science du Vivant et Genomique Laboratory of Molecular PathologyShanghalChina

Epigenetic alterations play an important role in tumor progression of diffuse large B-cell lymphoma(DL BCL).However,the biological relevance of epigenetic gene mutations on tumor microenvironment remains to be *** core set of genes relating to histone methylation(KMT2D,KMT2C,EZH2),histone acetylation(CREBBP,EP300),DNA methylation(TET2),and chromatin remodeling(ARID1A)were detected in the training cohort of 316 patients by whole-genome/exome sequencing(WGS/WES)and in the validation cohort of 303 patients with newly diagnosed DL BCL by targeted *** correlation with peripheral blood immune cells and clinical outcomes were *** mechanisms on tumor microenvironment were investigated both in vitro and in *** all 619 DLBCL patients,somatic mutations in KMT2D(19.5%)were most frequently observed,followed by mutations in ARID1A(8.7%),CREBBP(8.4%),KMT2C(8.2%),TET2(7.8%),EP300(6.8%),and EZH2(2.9%).Among them,CREBBP/EP300 mutations were signifcantly associated with decreased peripheral blood absolute lymphocyte-to-monocyte ratios,as well as inferior progression-free and overall *** B-lymphoma cells,the mutation or knockdown of CREBBP or EP300 inhibited H3K27 acetylation,downregulated FBXW7 expression,activated the NOTCH pathway,and downstream CCL2/CSF1 expression,resulting in tumor-associated macrophage polarization to M2 phenotype and tumor cell *** B-lymphoma murine models,xenografted tumors bearing CREBBP/EP300 mutation presented lower H3K27 acetylation,higher M2 macrophage recruitment,and more rapid tumor growth than those with CREBBP/EP300 wild-type control via FBXW7-NOTCH-CCL2/CSF1 *** work thus contributed to the understanding of aberrant histone acetylation regulation on tumor microenvironment as an alternative mechanism of tumor progression in DLBCL.

关键词： FBXW7 P300 macrophage

Therapeutic targeting miR130b counteracts diffuse large B-cell lymphoma progression via OX40/OX40L-mediated interaction with Th17 cells

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Signal Transduction and Targeted Therapy 2022年第4期7卷 1297-1310页

作者： Rui Sun Pei-Pei Zhang Xiang-Qin Weng Xiao-Dong Gao chuan-Xin huang Li Wang Xiao-Xia Hu Peng-Peng Xu Lin Cheng Lu Jiang Di Fu Bin Qu Yan Zhao Yan Feng Hong-Jing Dou Zhong Zheng Wei-Li Zhao Shanghai Institute of Hematology State Key Laboratory of Medical GenomicsNational Research Center for Translational Medicine at ShanghaiRuijin HospitalShanghai Jiao Tong University of MedicineShanghaiChina State Key Laboratory of Metal Matrix Composites School of Materials Science and EngineeringNational Research Center for Translational Medicine at ShanghaiShanghai Jiao Tong UniversityShanghaiChina Department of Immunobiology and Microbiology Shanghai Institute of ImmunologyShanghai Jiao Tong University School of MedicineShanghaiChina Department of Laboratory Medicine Shanghai RuiJin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina State Key Laboratory of Microbial Metabolism School of Life Sciences and BiotechnologyShanghai Jiao Tong UniversityShanghaiChina

MicroRNAs(miRNAs)are involved in lymphoma progression by regulating the tumor *** miR130b is overexpressed in diffuse large B-cell lymphoma(DLBCL),inducing Th17 cell *** further illustrate its biological significance and therapeutic rationale,miR130b was detected by quantitative real-time PCR in the serum samples of 532 newly diagnosed DLBCL *** mechanism of miR130b on lymphoma progression and the tumor microenvironment was investigated both in vitro and in *** targeting miR130b was also evaluated,including OX40 agonistic antibody and lipid nanoparticles(LNPs)-miR130b *** results showed that serum miR130b significantly correlated with tumor miR130b and serum interleukin-17,indicating lymphoma relapse and inferior survival of DLBCL ***130b overexpression altered tumor microenvironment signaling pathways and increased Th17 cell *** mechanism of action,miR130b downregulated tumor OX40L expression by directly targeting IFNAR1/p-STAT1 axis,recruiting Th17 cells via OX40/OX40L interaction,thereby promoting immunosuppressive function of Th17 *** co-culture systems of B-lymphoma cells with immune cells,miR130b inhibited lymphoma cell autophagy,which could be counteracted by OX40 agonistic antibody and LNPs-miR130b *** murine xenograft model established with subcutaneous injection of A20 cells,both OX40 agonistic antibody and LNPs-miR130b antagomir remarkably inhibited Th17 cells and retarded miR130b-overexpressing tumor *** conclusion,as an oncogenic biomarker of DLBCL,miR130b was related to lymphoma progression through modulating OX40/OX40L-mediated lymphoma cell interaction with Th17 cells,attributing to B-cell lymphoma sensitivity towards OX40 agonistic *** miR130b using LNPs-miR130b antagomir could also be a potential immunotherapeutic strategy in treating OX40-altered lymphoid malignancies.

关键词： lymphoma miR130b inhibited

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荔枝转录因子LcMYB8的克隆与表达分析

中国果树 2024年第6期 68-76页

作者：石雨雨卿昊炜桂秋林黎明易晨歆黄川陈艳艳刘红枫郭慧勤彭宏祥丁峰张树伟广西农业科学院广西作物遗传改良生物技术重点开放实验室南宁530007 广西大学农学院广西灵山县农业科学研究所

为探究LcMYB8转录因子在荔枝成花调控中的作用,以妃子笑荔枝为试验材料,克隆LcMYB8转录因子的序列全长,并对其进行生物信息学分析。通过实时荧光定量PCR技术,分析LcMYB8转录因子在不同器官、年周期以及低温处理中的时空表达模式。结果显... 详细信息

为探究LcMYB8转录因子在荔枝成花调控中的作用,以妃子笑荔枝为试验材料,克隆LcMYB8转录因子的序列全长,并对其进行生物信息学分析。通过实时荧光定量PCR技术,分析LcMYB8转录因子在不同器官、年周期以及低温处理中的时空表达模式。结果显示,LcMYB8转录因子全长1749 bp,其中开放阅读框915 bp,共编码304个氨基酸。时空表达模式表明,LcMYB8转录因子可能在荔枝成花和果实发育期起着关键作用。研究结果旨在为荔枝优质新品种培育提供理论指导。

关键词：荔枝 LcMYB8转录因子表达模式成花调控

Influence of sperm morphology on pregnancy outcome and offspring in in vitro fertilization and intracytoplasmic sperm injection:a matched case-control study

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Asian Journal of Andrology 2021年第4期23卷 421-428页

作者： Wen-Jun Zhou chuan huang Su-Hua Jiang Xi-Ren Ji Fei Gong Li-Qing Fan Wen-Bing Zhu Institute of Reproductive and Stem Cell Engineering Basic Medicine CollegeCentral South UniversityChangsha 410008China Reproductive and Genetic Hospital of CITIC-Xiangya Changsha 410008China Clinical Research Center for Reproduction and Genetics in Hunan Province Changsha 410008China

Sperm morphology was once believed as one of the most predictive indicators of pregnancy outcome in assisted reproductive technology(ART).However,the impact of teratozoospermia on in vitro fertilization(IVF)/intracytoplasmic sperm injection(ICSI)outcomes and its offspring remains *** order to evaluate the influence of teratozoospermia on pregnancy outcome and newborn status after IVF and ICSI,a retrospective study was *** was a matched case-control study that included 2202 IVF cycles and 2574 ICSI cycles and was conducted at the Reproductive and Genetic Hospital of CITIC-Xiangya in Changsha,China,from June 2013 to June *** were divided into two groups based on sperm morphology:teratozoospermia and normal sperm *** pregnancy outcome and newborn outcome were *** results indicated that couples with teratozoospermia had a significantly lower optimal embryo rate compared to those with normal sperm morphology in IVF(P=0.007),while there were no statistically significant differences between the two groups in terms of the fertilization rate,cleavage rate,implantation rate,and pregnancy rate(all P>0.05).Additionally,teratozoospermia was associated with lower infant birth weight in multiple births after *** regard to ICSI,there was no significant difference in both pregnancy outcome and newborn outcome between the teratozoospermia and normal groups(both P>0.05).Furthermore,no increase in the risk of birth defects occurred in the teratozoospermia group after IVF/***,we believe that teratozoospermia has limited predictive value for pregnancy outcomes in IVF/ICSI,and has little impact on the resulting offspring if multiple pregnancy is avoided.

关键词： in vitro fertilization intracytoplasmic sperm injection newborn outcome pregnancy outcome teratozoospermia