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BMSC-derived Exosomes Ameliorate Peritoneal Dialysis-associated Peritoneal Fibrosis via the Mir-27a-3p/TP53 Pathway

Current Medical Science 2024年第2期44卷 333-345页

作者： Jun-li zhao Lin zhao qiu-nan ZHAN Miao LIU Ting ZHANG Wen-wen chu Department of Nephrology Shanghai University of Medicine&Health Sciences Affiliated Zhoupu HospitalShanghai 201318China Orthopedic Department Guangming Traditional Chinese Medicine Hospital of Pudong New AreaShanghai 201399China

Objective:Peritoneal fibrosis(PF)is the main cause of declining efficiency and ultrafiltration failure of the peritoneum,which restricts the long-term application of peritoneal dialysis(PD).This study aimed to investigate the therapeutic effects and mechanisms of bone marrow mesenchymal stem cells-derived exosomes(BMSC-Exos)on PF in response to ***:Small RNA sequencing analysis of BMSC-Exos was performed by second-generation sequencing.C57BL/6J mice were infused with 4.25%glucose-based peritoneal dialysis fluid(PDF)for 6 consecutive weeks to establish a PF model.A total of 36 mice were randomly divided into 6 groups:control group,1.5%PDF group,2.5%PDF group,4.25%PDF group,BMSC-Exos treatment group,and BMSC-Exos+TP53 treatment *** transcription quantitative polymerase chain reaction(RT-qPCR)was performed to measure the expression level of miR-27a-3p in BMSC-Exos and peritoneum of mice treated with different concentrations of *** and Masson staining were performed to evaluate the extent of *** therapeutic potential of BMSC-Exos for PF was examined through pathological examination,RT-qPCR,Western blotting,and peritoneal function ***-mesenchymal transition(EMT)of HMrSV5 was induced with 4.25%*** were divided into control group,4.25%PDF group,BMSC-Exos treatment group,and BMSC-Exos+TP53 treatment *** Counting Kit-8 assay was used to measure cell viability,and transwell migration assay was used to verify the capacity of BMSC-Exos to inhibit EMT in HMrSV5 ***:Small RNA sequencing analysis showed that miR-27a-3p was highly expressed in BMSC-derived exosomes compared to *** RT-qPCR results showed that the expression of miR-27a-3p was upregulated in BMSC-Exos,but decreased in PD *** found that PF was glucose concentration-dependently enhanced in the peritoneum of the PD *** with the control mice,the PD mice showed high solute transport and decreased ultrafiltration volume as well as an obvious f

关键词： peritoneal fibrosis bone marrow mesenchymal stem cell-derived exosomes miR-27a-3p TP53 epithelialmesenchymal transition

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Boron nitride silicone rubber composite foam with low dielectric and high thermal conductivity

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Chinese Journal of Chemical Engineering 2024年第4期68卷 224-230页

作者： Shuilai qiu Hang Wu Fukai chu Lei Song College of Safety and Ocean Engineering China University of Petroleum-BeijingBeijing 102249China State Key Laboratory of Fire Science University of Science and Technology of ChinaHefei 230026China

Silicone rubber(SR)is widely used in the field of electronic packaging because of its low dielectric *** this work,the porosity of the SR was improved,and the dielectric constant of the SR foam was reduced by adding expanded microspheres(EM).Then,the thermal conductivity of the system was improved by combining the modified boron nitride(f-BN).The results showed that after the f-BN was added,the dielectric constant and dielectric loss were much lower than those of pure ***-sized modified boron nitride(f-mBN)improved the dielectric and thermal conductivity of the SR foam better than that of nano-sized modified boron nitride(f-nBN),but f-nBN improved the volume resistivity,tensile strength,and thermal stability of the SR better than *** the mass ratio of f-mBN and fnBN is 2:1,the thermal conductivity of the SR foam reaches the maximum value of 0.808 W·m^(-1)·K^(-1),which is 6.5 times that before the *** heat release rate and fire growth index are the lowest,and the improvement in flame retardancy is mainly attributed to the high thermal stability and physical barrier of f-BN.

关键词： Foam Composites Dielectric properties Thermal conductivity Mechanical properties Flame retardant

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An oscillation-free Hermite WENO scheme for hyperbolic conservation laws

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Science China Mathematics 2024年第2期67卷 431-454页

作者： Zhuang zhao Jianxian qiu School of Mathematical Sciences and Institute of Natural Sciences Shanghai Jiao Tong UniversityShanghai 200240China School of Mathematical Sciences and Fujian Provincial Key Laboratory of Mathematical Modeling and High-Performance Scientific Computing Xiamen UniversityXiamen 361005China

In this paper, the sixth-order oscillation-free Hermite weighted essentially non-oscillatory (OFHWENO) scheme is proposed for hyperbolic conservation laws on structured meshes, where the zeroth- andfirst-order moments are the variables for the governing equations. The main difference from other HWENOschemes existing in the literature is that we add high-order numerical damping terms in the first-order momentequations to control spurious oscillations for the OF-HWENO scheme. The OF-HWENO scheme not only canachieve the designed optimal numerical order, but also can be easily implemented as we use only one set ofstencils in the reconstruction procedure and the same reconstructed polynomials are applied for the zeroth- andfirst-order moment equations. In order to obtain the adaptive order resolution when facing discontinuities, atransition polynomial is added in the reconstruction, where the associated linear weights can also be any positivenumbers as long as their summation equals one. In addition, the OF-HWENO scheme still keeps compactnessas only immediate neighbor values are needed in the space discretization. Some benchmark numerical tests areperformed to illustrate the high-order accuracy, high resolution and robustness of the proposed scheme.

关键词： Hermite WENO scheme hyperbolic conservation laws oscillation-free adaptive order discontinuous Galerkin method

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Intuitive Human-Robot-Environment Interaction With EMG Signals:A Review

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IEEE/CAA Journal of Automatica Sinica 2024年第5期11卷 1075-1091页

作者： Dezhen Xiong Daohui Zhang Yaqi chu Yiwen zhao Xingang zhao State Key Laboratory of Robotics Shenyang Institute of AutomationChinese Academy of SciencesShenyang 110016 Institutes for Robotics and Intelligent Manufacturing Chinese Academy of SciencesShenyang 110169 University of Chinese Academy of Sciences Beijing 100049China

A long history has passed since electromyography(EMG)signals have been explored in human-centered robots for intuitive ***,it still has a gap between scientific research and real-life *** studies mainly focused on EMG decoding algorithms,leaving a dynamic relationship between the human,robot,and uncertain environment in real-life scenarios seldomly *** fill this gap,this paper presents a comprehensive review of EMG-based techniques in human-robot-environment interaction(HREI)*** general processing framework is summarized,and three interaction paradigms,including direct control,sensory feedback,and partial autonomous control,are ***-based intention decoding is treated as a module of the proposed *** key issues involving precision,stability,user attention,compliance,and environmental awareness in this field are *** important directions,including EMG decomposition,robust algorithms,HREI dataset,proprioception feedback,reinforcement learning,and embodied intelligence,are proposed to pave the way for future *** the best of what we know,this is the first time that a review of EMG-based methods in the HREI system is *** provides a novel and broader perspective to improve the practicability of current myoelectric interaction systems,in which factors in human-robot interaction,robot-environment interaction,and state perception by human sensations are considered,which has never been done by previous studies.

关键词： robot summarized Robot

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The Multi-parameter Test of Gravitational Wave Dispersion with Principal Component Analysis

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Research in Astronomy and Astrophysics 2024年第5期24卷 140-150页

作者： Zhi-chu Ma Rui Niu Wen zhao CAS Key Laboratory for Research in Galaxies and Cosmology Department of AstronomyUniversity of Science and Technology of ChinaHefei 230026China School of Astronomy and Space Sciences University of Science and Technology of ChinaHefei 230026China

In this work, we consider a conventional test of gravitational wave(GW) propagation which is based on the phenomenological parameterized dispersion relation to describe potential departures from General Relativity(GR)along the propagation of GWs. But different from tests conventionally performed previously, we vary multiple deformation coefficients simultaneously and employ the principal component analysis(PCA) method to remedy the strong degeneracy among deformation coefficients and obtain informative posteriors. The dominant PCA components can be better measured and constrained, and thus are expected to be more sensitive to potential departures from the waveform model. Using this method we analyze ten selected events and get the result that the combined posteriors of the dominant PCA parameters are consistent with GR within 99.7% credible intervals. The standard deviation of the first dominant PCA parameter is three times smaller than that of the original dispersion parameter of the leading order. However, the multi-parameter test with PCA is more sensitive to not only potential deviations from GR but also systematic errors of waveform models. The difference in results obtained by using different waveform templates hints that the demands of waveform accuracy are higher to perform the multiparameter test with PCA. Whereas, it cannot be strictly proven that the deviation is indeed and only induced by systematic errors. It requires more thorough research in the future to exclude other possible reasons in parameter estimation and data processing.

关键词： gravitational waves-gravitation-black hole physics

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An Efficient Local Radial Basis Function Method for Image Segmentation Based on the Chan-Vese Model

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Computer Modeling in Engineering & Sciences 2024年第4期139卷 1119-1134页

作者： Shupeng qiu chujin Lin Wei zhao School of Mathematics and Statistics Guangdong University of TechnologyGuangzhou510520China

In this paper,we consider the Chan–Vese(C-V)model for image segmentation and obtain its numerical solution accurately and *** this purpose,we present a local radial basis function method based on a Gaussian kernel(GA-LRBF)for spatial *** to the standard radial basis functionmethod,this approach consumes less CPU time and maintains good stability because it uses only a small subset of points in the whole computational ***,since the Gaussian function has the property of dimensional separation,the GA-LRBF method is suitable for dealing with isotropic ***,a numerical scheme that couples GA-LRBF with the fourth-order Runge–Kutta method is applied to the C-V model,and a comparison of some numerical results demonstrates that this scheme achieves much more reliable image segmentation.

关键词： Image segmentation Chan–Vese model local radial basis functionmethod Gaussian kernel Runge–Kuttamethod

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Self assembled electron blocking and lithiophilic interface towards dendrite-free solid-state lithium battery

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Chinese Chemical Letters 2024年第4期35卷 220-225页

作者： Caixia Li Yi qiu Yufeng zhao Wuliang Feng Institute for Sustainable Energy&College of Sciences Shanghai UniversityShanghai 200444China Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) Nankai UniversityTianjin 300071China

The poor interfacial contact is one of the biggest challenges that solid-state lithium batteries suffer *** the solid-state electrolyte surface energy by transforming the interface from lithiophobic to lithiophilic is effective to promote the interfacial contact, but electronic conductive interphases usually increase the risk of electron attack, thus leading to uncontrollable Li dendrite growth. Herein, we propose a self-assembled thermodynamic stable Li I interphase to simultaneously improve the interfacial contact between the garnet electrolyte Li_7La_(3)Zr_(2)O_(12)(LLZO) and Li anode, and prohibit the electron attack. The direct contact between LLZO and Li and the high temperature Li melting process was ascribed to Zr4+reduction, which facilitated Li dendrite formation and propagation. With the modification of the high lithiophilic I_(2) thin film, the area specific interfacial resistance of LLZO/Li was reduced from 1525 Ω/cm^(2) to 57 Ω/cm^(2). More importantly, LLZO was protected from being reduced due to the outstanding electronic insulativity of the Li I interphase, which leaded to a high critical current density of 1.2/7.0 m A/cm^(2) in the time/capacity-constant modes, respectively.

关键词： Li_7La_(3)Zr_(2)O_(12) LiI interphase Interfacial contact Li dendrite Thermodynamic stable

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Improved PSO-Extreme Learning Machine Algorithm for Indoor Localization

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China Communications 2024年第5期21卷 113-122页

作者： qiu Wanqing Zhang Qingmiao zhao Junhui Yang Lihua School of Information Engineering East China Jiaotong UniversityNanchang 330013China School of Electronic and Information Engineering Beijing Jiaotong UniversityBeijing 100044China

Wi Fi and fingerprinting localization method have been a hot topic in indoor positioning because of their universality and location-related *** basic assumption of fingerprinting localization is that the received signal strength indication(RSSI)distance is accord with the location ***,how to efficiently match the current RSSI of the user with the RSSI in the fingerprint database is the key to achieve high-accuracy *** this paper,a particle swarm optimization-extreme learning machine(PSO-ELM)algorithm is proposed on the basis of the original fingerprinting ***,we collect the RSSI of the experimental area to construct the fingerprint database,and the ELM algorithm is applied to the online stages to determine the corresponding relation between the location of the terminal and the RSSI it ***,PSO algorithm is used to improve the bias and weight of ELM neural network,and the global optimal results are ***,extensive simulation results are *** is shown that the proposed algorithm can effectively reduce mean error of localization and improve positioning accuracy when compared with K-Nearest Neighbor(KNN),Kmeans and Back-propagation(BP)algorithms.

关键词： extreme learning machine fingerprinting localization indoor localization machine learning particle swarm optimization

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Perception field based imitation learning for unlabeled multi-agent pathfinding

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Science China(Information Sciences) 2024年第5期67卷 115-135页

作者： Wenjie chu Ailun YU Wei ZHANG Haiyan zhao Zhi JIN School of Computer Science Peking University Key Laboratory of High-Confidence Software Technologies (Peking University) Ministry of Education

This paper proposes an imitation learning method to learn a universal agent policy for unlabeled multi-agent pathfinding(unlabeled MAPF) in grid environments. The method transforms the unlabeled MAPF problem into a series of temporal-independent homogeneous classification problems for each *** on this transformation, a neural network is designed to imitate a distance-optimal expert *** neural network consists of two successive modules: perception field learner and field integrating *** former refines and encodes the current system state into a perception field for each agent by combining a set of learnable field-generating functions. The latter takes an agent's perception field as input and decides the agent's next action based on a triplet cross-attention mechanism. We evaluate our method on a diverse set of unlabeled MAPF tasks. Compared with state-of-the-art counterparts, the experimental results manifest the superiority of the proposed method in both generalization ability and scalability.

关键词： unlabeled multi-agent pathfinding perception field triplet cross-attention multi-agent imitation learning learning-based planning

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Wood use and forest management by Neolithic millet farmers at the Xinglong site,northern China

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Science China Earth Sciences 2024年第6期67卷 1910-1921页

作者： Hui SHEN Zhenwei qiu Keliang zhao Xinying ZHOU Xiaoqiang LI Key Laboratory of Vertebrate Evolution and Human Origins Institute of Vertebrate Paleontology and PaleoanthropologyChinese Academy of SciencesBeijing 100044China National Museum of China Beijing 100006China University of Chinese Academy of Sciences Beijing 100049China

The origin and development of agriculture and its relationship with climate change are hotly debated topics among environmental *** this study,we analyzed wood charcoal materials from the Neolithic Xinglong site in northern China in order to understand the woody vegetation around the site and how early millet farmers shaped local *** results suggest that the area around the Xinglong sites during 8700-7000 yr BP was primarily woodlands,including Prunus sibirica shrubs,Ulmus and Acer forests,and Populus stands near *** 8000 to 7000 yr BP,the warm and humid climate probably contributed to the expansion of Acer,Rhamnus,and Juniperus,and may have facilitated the development of early millet *** these ancient wood fragments that we studied,the high percent of Prunus charcoal appears to indicate an abundance of fruit trees,which might have constituted the main component of local ***,the wood taxa illustrate the existence of a variety of ecological habitats,and it is logical to assume that people made full use of the locally available wood ***,Populus and Ulmus were the dominant sources of *** results of tree-ring curvature analyses indicate that people mainly collected trunks or large branches of Ulmus,Populus,Acer,and Juniperus *** interpret the increasing use of Prunus twigs and the declining percentage of Prunus charcoal in the period between 8000-7000 yr BP as indicating that people started to protect and manage wild fruit *** may have started pruning to acquire more food resources as part of the cultural responses and adaptation strategies employed by these early millet cultivators.

关键词： Xinglong site Wood charcoal Wood use Woodland management

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