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Asian Journal of Andrology 2024年第2期26卷 183-188页

作者： Huan jiang chu-Jie Huang Department of Reproductive Endocrinology Longgang District Maternity&Child Healthcare Hospital of Shenzhen City(Longgang Maternity and Child Institute of Shantou University Medical College)Shenzhen 518172China Institute of Reproductive Immunology College of Life Science and TechnologyJinan UniversityGuangzhou 510632China

Aberrant sperm protamination is linked to sperm dysmorphology and nuclear chromatin ***,its effects on sperm cytoplasmic maturation remain largely *** relationships of protamines,sperm morphology,DNA damage,and cytoplasmic remodeling were illustrated in this study to provide fresh perspectives on the mechanisms of male infertility.A total of 205 infertile males were allocated into 5 groups according to the percentage of spermatozoa exhibiting abnormal morphology within their *** concentration,motility,abnormal sperm morphology,cytoplasmic droplets(CDs),and excess residual cytoplasm(ERC)were analyzed according to the World Health Organization manual(2010).Sperm nuclear vacuoles(NVs)were determined by propidium iodide(PI)*** protamine expressions(P1 and P2)were detected by western *** damage was measured by acridine orange test(AOT)to calculate the proportion of sperm with single-strand DNA breaks(SSBs).Our data showed that sperm concentration and motility in infertile males significantly decreased with the severity of abnormal sperm morphology(both P<0.01).P1 level,P1/P2 ratio,and SSB rate increased with the severity of sperm dysmorphology,whilst the P2 level decreased(all P

关键词： abnormal sperm morphology excess residual cytoplasm male infertility protamines sperm DNA damage sperm nuclear vacuoles

Multi-physics multi-scale simulation of unique equiaxed-to-columnar-to-equiaxed transition during the whole solidification process of Al-Li alloy laser welding

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Journal of Materials Science & Technology 2024年第4期171卷 235-251页

作者： chu Han Ping jiang Shaoning Geng Liangyuan Ren School of Mechanical Science and Engineering Huazhong University of Science&Technology(HUST)Wuhan430074China

In this study,a novel multi-physics multi-scale model with the dilute multicomponent phase-field method in three-dimensional(3D)space was developed to investigate the complex microstructure evolu-tion in the molten pool during laser welding of Al-Li *** accurately compute mass data within both two and three-dimensional computational domains,three efficient computing methods,including central processing unit parallel computing,adaptive mesh refinement,and moving-frame algorithm,were *** was placed on the distinctive equiaxed-to-columnar-to-equiaxed transition phenomenon that occurs during the entire solidification process of Al-Li alloy laser *** results indi-cated that the growth distance of columnar grains that epitaxially grew from the base metal(BM)de-creased as the nucleation rate *** the nucleation rate increased,the morphology of the newly formed grains near the fusion boundary(FB)changed from columnar to equiaxed,and newly formed equiaxed grains changed from having high-order dendrites to no obvious dendrite *** the nucleation rate was sufficiently high,non-dendritic equiaxed grains could directly form near the FB,and there was nearly no epitaxial growth from the ***,simulation results illustrated the com-petition among multiple grains with varying orientations that grow in 3D space near the ***,how equiaxed grain bands develop was *** equiaxed band not only hindered the growth of early columnar grains but also some of its grains could grow epitaxially to form new columnar *** predicted results were in good agreement with experimental measurements and observations.

关键词： Laser welding Al-Li alloy Equiaxed-to-columnar-to-equiaxed transition Multi-physics multi-scale model Multicomponent alloys 3D phase-field model

Defect Engineering and Carbon Supporting to Achieve Ni‑Doped CoP_(3) with High Catalytic Activities for Overall Water Splitting

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Nano-Micro Letters 2024年第11期16卷 569-584页

作者： Daowei Zha Ruoxing Wang Shijun Tian Zhong‑Jie jiang Zejun Xu chu Qin Xiaoning Tian Zhongqing jiang Department of Physics Zhejiang Sci-Tech UniversityHangzhou 310018People’s Republic of China Department of Materials and Chemical Engineering Ningbo University of TechnologyNingbo 315211People’s Republic of China Guangzhou Key Laboratory for Surface Chemistry of Energy Materials Guangdong Engineering and Technology Research Center for Surface Chemistry of Energy MaterialsCollege of Environment and EnergySouth China University of TechnologyGuangzhou 510006People’s Republic of China

This work reports the use of defect engineering and carbon supporting to achieve metal-doped phosphides with high activities and stabilities for the hydrogen evolution reaction(HER)and the oxygen evolution reaction(OER)in alkaline ***,the nitrogen-doped carbon nanofiber-supported Ni-doped CoP_(3) with rich P defects(Pv·)on the carbon cloth(p-NiCoP/NCFs@CC)is synthesized through a plasma-assisted phosphorization *** p-NiCoP/NCFs@CC is an efficient and stable catalyst for the HER and the *** only needs overpotentials of 107 and 306 mV to drive 100 mA cm^(-2) for the HER and the OER,*** catalytic activities are higher than those of other catalysts reported *** high activities of the p-NiCoP/NCFs@CC mainly arise from its peculiar structural *** density functional theory calculation indicates that the Pv·richness,the Ni doping,and the carbon supporting can optimize the adsorption of the H atoms at the catalyst surface and promote the strong electronic couplings between the carbon nanofiber-supported p-NiCoP with the surface oxide layer formed during the OER *** gives the p-NiCoP/NCFs@CC with the high activities for the HER and the *** used in alkaline water electrolyzers,the p-NiCoP/NCFs@CC shows the superior activity and excellent stability for overall water splitting.

关键词： Plasma Electrocatalysis Hydrogen evolution reaction Oxygen evolution reaction Water splitting

Hybrid modeling for carbon monoxide gas-phase catalytic coupling to synthesize dimethyl oxalate process

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Chinese Journal of Chemical Engineering 2024年第6期70卷 234-250页

作者： Shida Gao Cuimei Bo Chao jiang Quanling Zhang Genke Yang Jian chu Ningbo Artificial Intelligence Institute Shanghai Jiao Tong UniversityNingbo 315012China Department of Automation Shanghai Jiao Tong UniversityShanghai 200240China Key Laboratory of Industrial Internet+Safety Production of Hazardous Chemical Ministry of Emergency ManagementNanjing Tech UniversityNanjing 211816China

Ethylene glycol(EG)plays a pivotal role as a primary raw material in the polyester industry,and the syngas-to-EG route has become a significant technical route in *** carbon monoxide(CO)gas-phase catalytic coupling to synthesize dimethyl oxalate(DMO)is a crucial process in the syngas-to-EG route,whereby the composition of the reactor outlet exerts influence on the ultimate quality of the EG product and the energy consumption during the subsequent separation ***,measuring product quality in real time or establishing accurate dynamic mechanism models is *** effectively model the DMO synthesis process,this study proposes a hybrid modeling strategy that integrates process mechanisms and data-driven *** CO gas-phase catalytic coupling mechanism model is developed based on intrinsic kinetics and material balance,while a long short-term memory(LSTM)neural network is employed to predict the macroscopic reaction rate by leveraging temporal relationships derived from archived *** proposed model is trained semi-supervised to accommodate limited-label data scenarios,leveraging historical *** integrating these predictions with the mechanism model,the hybrid modeling approach provides reliable and interpretable forecasts of mass *** investigations unequivocally validate the superiority of the proposed hybrid modeling approach over conventional data-driven models(DDMs)and other hybrid modeling techniques.

关键词： Carbon monoxide Dynamic modeling Hybrid model Reaction kinetics Semi-supervised learning

Glycine-β-cyclodextrin-assisted cometabolism of phenanthrene and pyrene by Pseudomonas stutzeri DJP 1 from marine sediment

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Journal of Oceanology and Limnology 2024年第2期42卷 560-569页

作者： Junfeng jiang Weijun TIAN Zhiyang LU Meile chu Huimin CAO Dantong ZHANG College of Environmental Science and Engineering Ocean University of ChinaQingdao 266100China Key Laboratory of Marine Environment and Ecology Ministry of EducationQingdao 266100China

Cometabolic degradation is currently an effective and extensively way to remove high molecular weight polycyclic aromatic hydrocarbons(HMW-PAHs).Unfortunately,due to low bio-accessibility and high biotoxicity,the cometabolic degradation rate of HMW-PAHs is ***-β-cyclodextrin(GCD)was obtained through amino modification ofβ-cyclodextrin(BCD)and added to cometabolic system of phenanthrene(PHE)and pyrene(PYR)to assist PYR *** show that the addition of GCD(100 mg/L)effectively improved the removal rate of PYR(20 mg/L)by 42.3%.GCD appeared to increase the bio-accessibility and reduce the biotoxicity of PHE and PYR,and then promoted the growth of Pseudomonas stutzeri DJP1 and stimulated the elevation of dehydrogenase(DHA)and catechol 12 dioxygenase(C12O)*** phthalate metabolic pathway was accelerated,which improved the cometabolic *** study provided a new reference for the cometabolic degradation of HMW-PAHs.

关键词： cometabolism phenanthrene pyrene glycine-β-cyclodextrin biological accessibility biotoxicity

An Active Deception Defense Model Based on Address Mutation and Fingerprint Camouflage

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China Communications 2024年第7期21卷 212-223页

作者： Wang Shuo chu.jiang Pei Qingqi Shao Feng Yuan Shuai Zhong Xiaoge State Key Laboratory of Astronautic Dynamics Xi’an Satellite Control CenterXi’an 710043China State Key Laboratory of Integrated Services Networks Xidian UniversityXi’an 710071China Shaanxi Key Laboratory of Blockchain and Secure Computing Xidian UniversityXi’an 710071China

The static and predictable characteristics of cyber systems give attackers an asymmetric advantage in gathering useful information and launching *** reverse this asymmetric advantage,a new defense idea,called Moving Target Defense(MTD),has been proposed to provide additional selectable measures to complement traditional ***,MTD is unable to defeat the sophisticated attacker with fingerprint tracking *** overcome this limitation,we go one step beyond and show that the combination of MTD and Deception-based Cyber Defense(DCD)can achieve higher performance than either of *** particular,we first introduce and formalize a novel attacker model named Scan and Foothold Attack(SFA)based on cyber kill ***,we develop probabilistic models for SFA defenses to provide a deeper analysis of the theoretical effect under different defense *** models quantify attack success probability and the probability that the attacker will be deceived under various conditions,such as the size of address space,and the number of hosts,attack analysis ***,the experimental results show that the actual defense effect of each strategy almost perfectly follows its probabilistic ***,the defense strategy of combining address mutation and fingerprint camouflage can achieve a better defense effect than the single address mutation.

关键词： address mutation deception defense fingerprint camouflage moving target defense probabilistic model

Dendrimer-induced synthesis of porous organosilica capsules for enzyme encapsulation

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Frontiers of Chemical Science and Engineering 2024年第4期18卷 41-48页

作者： Ziyi chu Boyu Zhang Zhenhua Wu Jiaxu Zhang Yiran Cheng Xueying Wang Jiafu Shi Zhongyi jiang School of Environmental Science&Engineering Tianjin UniversityTianjin 300072China Collaborative Innovation Center of Chemical Science and Engineering Tianjin 300072China State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China Key Laboratory for Green Chemical Technology of Ministry of Education School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China

Organic matter-induced mineralization is a green and versatile method for synthesizing hybrid nanostructured materials,where the material properties are mainly influenced by the species of natural biomolecules,linear synthetic polymer,or small molecules,limiting their ***,we adopted dendrimer poly(amidoamine)(PAMAM)as the inducer to synthesize organosilica-PAMAM network(OSPN)capsules for mannose isomerase(MIase)encapsulation based on a hard-templating *** structure of OSPN capsules can be precisely regulated by adjusting the molecular weight and concentration of PAMAM,thereby demonstrating a substantial impact on the kinetic behavior of the MIase@OSPN *** MIase@OSPN system was used for catalytic production of mannose from Dfructose.A mannose yield of 22.24% was obtained,which is higher than that of MIase in organosilica network capsules and similar to that of the free *** overall catalytic efficiency(kcat/Km)of the MIase@OSPN system for the substrate D-fructose was up to 0.556 s^(-1)·mmol^(-1)·***,the MIase@OSPN system showed excellent stability and recyclability,maintaining more than 50% of the yield even after 12 cycles.

关键词： enzyme immobilization enzyme catalysis organosilica networks capsules sugar biosynthesis

Effect of Ti contents on interfacial bonding, mechanical and thermal properties of Mo-Cu composites

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Tungsten 2024年第3期6卷 549-554页

作者： Jian-Ru chu Xiao-Song jiang Tian-Yan Liu Key Laboratory of Advanced Technologies of Materials Ministry of Education School of Materials Science and Engineering Southwest Jiaotong University Reactor Engineering Research Sub-Institute Nuclear Power Institute of China

Mo-Cu composites are widely used in electronic packaging, vacuum technology, microwave devices and other fields due to their excellent properties, such as excellent electrical and thermal conductivity, low adjustable ...

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Vinyltrimethylsilane as a novel electrolyte additive for improving interfacial stability of Li-rich cathode working in high voltage

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Chinese Chemical Letters 2024年第2期35卷 534-538页

作者： Bing jiang Hao Li Bi Luo Lehao Liu Lihua chu Qiaobao Zhang Meicheng Li State Key Laboratory of Alternate Electrical Power System with Renewable Energy Sources School of New EnergyNorth China Electric Power UniversityBeijing 102206China State Key Laboratory of Physical Chemistry of Solid Surfaces College of MaterialsXiamen UniversityXiamen 361005China

Boosting the interfacial stability between electrolyte and Li-rich cathode material at high operating voltage is vital important to enhance the cycling stability of Li-rich cathode materials for high-performance Li-ion *** this work,vinyltrimethylsilane as a new type of organic silicon electrolyte additive is studied to address the interfacial instability of Li-rich cathode material at high operating *** cells using vinyltrimethylsilane additive shows the high capacity retention of 73.9%after 300 cycles at 1 C,whereas the cells without this kind of additive only have the capacity retention of 58.9%.The improvement of stability is mainly attributed to the additive helping to form a more stable surface film for Li-rich cathode material,thus avoiding direct contact between the electrolyte and the cathode material,slowing down the dissolution of metal ions and the decomposition of the electrolyte under high operating *** findings in this work shed some light on the design of stable cycling performance of Li-rich cathode toward advanced Li-ion batteries.

关键词： Vinyltrimethylsilane Electrolyte additive Li-rich cathode Interfacial stability Capacity retention

Si-Miao-Yong-An Decoction alleviates thromboangiitis obliterans by regulating miR-548j-5p/IL-17A signaling pathway

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Chinese Journal of Natural Medicines 2024年第6期22卷 541-553页

作者： chu chu SUN Shangwen ZHANG Zhen WU Qi LI Haoyang LIANG Gang MIAO Xiuming jiang Haiqiang GAO Yan ZHANG Yunhong WANG Bin LI Xia Innovative Institute of Chinese Medicine and Pharmacy Shandong University of Traditional Chinese MedicineJinan 250355China National Key Laboratory for Innovation and Transformation of Luobing Theory The Key Laboratory of Cardiovascular Remod-eling and Function ResearchChinese Ministry of EducationChinese National Health Commission and Chinese Academy of Medical SciencesDepartment of CardiologyQilu Hospital of Shandong UniversityJinan 250012China School of Clinical and Basic Medical Sciences Shandong First Medical University&Shandong Academy of Medical SciencesJinan 271016China Affiliated Hospital of Shandong University of Traditional Chinese Medicine Jinan 250014China International Business School Tianjin Foreign Studies UniversityTianjin 300204China Institute of Pharmaceutical Research Shandong University of Traditional Chinese MedicineJinan 250355China

Thromboangiitis obliterans(TAO)is a rare,chronic,progressive,and segmental inflammatory disease characterized by a high rate of amputation,significantly compromising the quality of life of ***-Miao-Yong-An decoction(SMYA),a tradition-al prescription,exhibits anti-inflammatory,anti-thrombotic,and various other pharmacological ***,it was fully proved to be effective for TAO therapy,but the specific therapeutic effect of SMYA on TAO has been ***,deep unveiling the mechanism of SMYA in TAO for identifying clinical therapeutic targets is extremely *** this study,we observed elev-ated levels of IL-17A in the peripheral blood mononuclear cells(PBMCs)of TAO patients,whereas the expression of miR-548j-5p was significantly decreased.A negative correlation between the levels of miR-548j-5p and IL-17A was also *** vitro ex-periments showed that overexpression of miR-548j-5p led to a decrease in IL-17A levels,whereas downregulation of miR-548j-5p showed the opposite *** a dual luciferase assay,we confirmed that miR-548j-5p directly targets ***,serum containing SMYA effectively decreased IL-17A levels by increasing the expression of *** importantly,the results of in vivo tests indicated that SMYA mitigated the development of TAO by inhibiting IL-17A through the upregulation of miR-548j-5p in vascular *** conclusion,SMYA significantly enhances the expression of miR-548j-5p,thereby reducing the levels of the target gene IL-17A and alleviating *** research not only identifies novel targets and pathways for the clinical diagnosis and treatment of TAO but also advances the innovation in traditional Chinese medicine through the elucidation of the SMYA/miR-548j-5p/IL-17A regulatory axis in the pathogenesis of TAO.

关键词： Thromboangiitis obliterans IL-17A Inflammation miR-548j-5p Si-Miao-Yong-An Decoction