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Coexpression of TLR9 and VEGF-C is associated with lymphatic metastasis in prostate cancer

Asian Journal of Andrology 2022年第4期24卷 380-385页

作者： Xian-Zi Zeng Zhan-Sen Huang Hong-Peng Fang Jie-Ying Wu Qun-Xiong Huang chu-bin zhuang Jing Zhou Jin-Ming Di Department of Urology The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China Department of Infertility and Sexual Medicine The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China Department of Pathology The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China

Prostate cancer(PCa)is one of the most frequent cancers in men,and its biomolecular targets have been extensively *** study aimed to analyze the expression of toll-like receptor 9(TLR9)and vascular endothelial growth factor C(VEGF-C)and the clinical value of the coexpression of TLR9 and VEGF-C in *** retrospectively evaluated 55 patients with clinically localized,intermediate-risk,or high-risk PCa who underwent laparoscopic radical prostatectomy(LRP)and extended pelvic lymph node dissection(ePLND)without neoadjuvant hormonal therapy at a single institution from June 2013 to December *** all 55 patients,the median number of lymph nodes(LNs)resected was 23(range:18-31),and a total of 1269 LNs were removed,of which 78 LNs were *** patients had positive LNs,with a positive rate of 30.9%.In addition,the immunohistochemical results in the above patients revealed that high TLR9 expression was correlated with higher Gleason score(GS)(P=0.049),increased LN metastasis(P=0.004),and more perineural invasion(PNI)(P=0.033).Moreover,VEGF-C expression was associated with GS(P=0.040),pathological stage(pT stage)(P=0.022),LN metastasis(P=0.003),and PNI(P=0.001).Furthermore,a significant positive correlation between TLR9 and VEGF-C was found(P<0.001),and the TLR9/VEGF-C phenotype was associated with LN metastasis(P=0.047).Collectively,we propose that TLR9 stimulation may promote LN metastasis in PCa cells through the upregulation of VEGF-C expression,thereby affecting the prognosis of PCa ***,these markers may serve as valuable targets for the treatment of PCa.

关键词： biochemical progression-free survival coexpression lymphatic metastasis prostate cancer toll-like receptor 9 vascular endothelial growth factor C

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Advances in single-cell sequencing technology in microbiome research

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Genes & Diseases 2024年第4期11卷 201-219页

作者： Yinhang Wu Jing zhuang Yifei Song Xinyi Gao Jian chu Shuwen Han Huzhou Central Hospital Affiliated Central Hospital Huzhou UniversityHuzhouZhejiang 313000China Key Laboratory of Multiomics Research and Clinical Transformation of Digestive Cancer of Huzhou HuzhouZhejiang 313000China The Fifth Affiliated Clinical Medical College of Zhejiang Chinese Medical University HangzhouZhejiang 313000China Zhejiang Provincial People's Hospital and Affiliated People's Hospital Hangzhou Medical CollegeHangzhouZhejiang 310000China

With the rapid development of histological techniques and the widespread applica-tion of single-cell sequencing in eukaryotes,researchers desire to explore individual *** and functional expression,which deepens our understanding of *** this review,the history of the development of microbial detection technologies was revealed and the difficulties in the application of single-cell sequencing in microorganisms were dissected as ***,the characteristics of the currently emerging microbial single-cell sequencing(Microbe-seq)technology were summarized,and the prospects of the application of Microbe-seq in microorganisms were distilled based on the current development *** its mature development,the Microbe-seq technology was still in the optimization stage.A retrospective study was conducted,aiming to promote the widespread application of single-cell sequencing in microorganisms and facilitate further improvement in the technol-ogy.

关键词： Bacterialantibiotic resistance Host immunity Host-phage interaction Microbial single-cell sequencing Microorganisms Single cell Single-cell sequencing technology

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Equivariant Tautological Integrals on Flag Varieties

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Chinese Annals of Mathematics,Series B 2024年第3期45卷 463-486页

作者： Xiaobo zhuang Department of Mathematical Sciences Zhejiang Sci-Tech UniversityHangzhou 310018China

The author apples the Atiyah-Bott-Berline-Vergne formula to the equivariant tautological integrals over flag varieties of types A,B,C,D,and recovers the formulas expressing the integrals as iterated residues at infini... 详细信息

关键词： Localization Flag variety Residue

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Functional nanoemulsions: Controllable low-energy nanoemulsification and advanced biomedical application

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Chinese Chemical Letters 2024年第2期35卷 57-69页

作者： Maojie Zhang Qiang Cao Yuming Yuan Xiaohan Guo Dawei Pan Rui Xie Xiaojie Ju zhuang Liu Wei Wang Liangyin chu College of Engineering Sichuan Normal UniversityChengdu 610101China School of Chemical Engineering Sichuan UniversityChengdu 610065China State Key Laboratory of Polymer Materials Engineering Sichuan UniversityChengdu 610065China

Nanoemulsions are widely used as advanced pharmaceutical delivery systems in biomedical field, due to their high encapsulation efficiency and good therapy *** techniques that produce nanoemulsions with controllable sizes and compositions are promising for creating advanced nanoemulsion systems for pharmaceutical *** review summarizes recent advances on low-energy emulsification techniques for producing nanoemulsions, and the use of these nanoemulsions as advanced pharmaceutical delivery systems and as templates to create drug-loaded functional particles for biomedical ***, nanoemulsification techniques that utilize elaborate interfacial physics/chemistry and micro-/nano-fluidics, featured with relatively-low energy input, to produce nanoemulsions with controllable sizes and compositions, are *** of these nanoemulsions to create nanoemulsionincorporated milli-particles, drug-loaded nanoparticles and nanoparticle-incorporated microparticles with sizes ranging from several millimeters to sub-10 nm are *** and efficient use of the nanoemulsions, functional nanoparticles and milli-/micro-particles integrated with nanoemulsions or nanoparticles for advanced pharmaceutical delivery in biomedical field are highlighted, with focus on how the interplay between their sizes and compositions achieve desired pharmaceutical-delivery ***, perspectives on further advances on the controllable production of nanoemulsions are provided.

关键词： Nanoemulsions Interfaces Drug delivery Template synthesis Nanoparticles

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Cesium removal from radioactive wastewater by adsorption and membrane technology

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Frontiers of Environmental Science & Engineering 2024年第3期18卷 161-175页

作者： Shuting zhuang Jianlong Wang School of Environment&Natural Resources Renmin University of ChinaBeijing 100872China Laboratory of Environmental Technology INETTsinghua UniversityBeijing 100084China Beijing Key Laboratory of Radioactive Waste Treatment INETTsinghua UniversityBeijing 100084China

Radiocesium is frequently present in radioactive wastewater,while its removal is still a challenge due to its small hydrated radius,high diffusion coefficient,and similar chemical behavior to other alkali metal elements with high background *** review summarized and analyzed the recent advances in the removal of Cs+from aqueous solutions,with a particular focus on adsorption and membrane separation *** inorganic,organic,and biological adsorbents have undergone assessments to determine their efficacy in the removal of cesium ***,membrane-based separation techniques,including reverse osmosis,forward osmosis,and membrane distillation,have also shown promise in effectively separating cesium ions from radioactive ***,this review summarized the main approaches,including Kurion/SARRY system+desalination system and advanced liquid processing system,implemented after the Fukushima Daiichi nuclear power plant accident in Japan to remove radionuclides from contaminated *** technology and membrane separation technology play a vital role in treatment of contaminated water.

关键词： Cesium Adsorption Membrane separation Advanced liquid processing system Fukushima nuclear accident

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GmSTF accumulation mediated by DELLA protein GmRGAs contributes to coordinating light and gibberellin signaling to reduce plant height in soybean

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The Crop Journal 2024年第2期12卷 432-442页

作者： zhuang Li Qichao Tu Xiangguang Lyu Qican Cheng Ronghuan Ji Chao Qin Jun Liu bin Liu Hongyu Li Tao Zhao State Key Laboratory of Crop Gene Resources and Breeding Institute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China

Plant height influences plant architecture,lodging resistance,and yield *** is modulated by gibberellic acid(GA)metabolism and *** proteins,acting as central repressors of GA signaling,integrate various environmental and hormonal signals to regulate plant growth and development in *** examined the role of two DELLA proteins,GmRGAa and GmRGAb,in soybean plant height *** of these proteins led to longer internodes and increased plant height,primarily by increasing cell *** functioned under different light conditions,including red,blue,and far-red light,to repress plant *** studies revealed that GmRGAs interacted with the blue light receptor *** with this,GmCRY1b partially regulated plant height via ***,DELLA proteins were found to stabilize the protein GmSTF1/2,a key positive regulator of *** stabilization led to increased transcription of GmGA2ox-7b and subsequent reduction in plant *** study enhances our understanding of DELLA-mediated plant height control,offering Gmrgaab mutants for soybean structure and yield optimization.

关键词： DELLA protein GmRGAs GmSTFs Plant height Soybean

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Typhoon-Induced Ocean Waves and Stokes Drift:A Case Study of Typhoon Mangkhut(2018)

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China Ocean Engineering 2024年第4期38卷 711-724页

作者： WU Zhi-yuan GAO Kai CHEN Jie ZHANG Hao-jian DENG bin JIANG Chang-bo LIU Yi-zhuang LYU Zhao YAN Ren School of Hydraulic and Environmental Engineering Changsha University of Science&TechnologyChangsha 410114China Key Laboratory of Water-Sediment Sciences and Water Disaster Prevention of Hunan Province Changsha 410114China State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering Hohai UniversityNanjing 210024China State Key Laboratory of Coastal and Offshore Engineering Dalian University of TechnologyDalian 116024China School of Civil Engineering Hunan University of TechnologyZhuzhou 412007China

Ocean waves and Stokes drift are generated by *** study investigated the characteristics of ocean waves and wave-induced Stokes drift and their effects during Typhoon Mangkhut using European Centre for MediumRange Weather Forecasts(ECMWF)ERA5 datasets and observational *** results revealed that the typhoon generated intense cyclones and huge typhoon waves with a maximum wind speed of 45 m/s,a minimum pressure of955 h Pa,and a maximum significant wave height of 12 *** Stokes drift caused by typhoon waves exceeded 0.6m/s,the Stokes depth scale exceeded 18 m,and the maximum Stokes transport reached 6 m^(2)/*** spatial distribution of 10-m wind speed,typhoon wave height,Stokes drift,Stokes depth,and Stokes transport during the typhoon was highly correlated with the typhoon *** distribution along the typhoon track showed significant zonal asymmetry,with greater intensity on the right side of the typhoon track than on the left *** findings provide important insights into the impact of typhoons on ocean waves and Stokes drift,thus improving our understanding of the interactions between typhoons and the ocean *** study also investigated the contribution of Stokes transport to the total net transport during typhoons using Ekman-Stokes Numbers as a comparative *** results indicated that the ratio of Stokes transport to the total net transport reached up to 50%within the typhoon radius,while it was approximately 30%outside the *** Stokes transport induced by typhoon waves led to divergence in the transport direction,which resulted in upwelling of the lower ocean as a compensation ***,Stokes transport played a crucial role in the vertical mixing of the ocean during *** findings suggested that Stokes transport should be paid more attention to,particularly in high latitude ocean regions,where strong winds can amplify its effects.

关键词： Stokes drift typhoon waves Ekman-Stokes transport vertical mixing Typhoon Mangkhut

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Preparation of Chemically Recyclable Poly(ether-alt-ester) by the Ring Opening Polymerization of Cyclic Monomers Synthesized by Coupling Glycolide and Epoxides

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Chinese Journal of Polymer Science 2024年第2期42卷 168-175,I0006页

作者： Feng Ren zhuang-zhuang Liang Ming-Xin Niu Chen-Yang Hu Xuan Pang Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130022China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei230026China

Polyester and polyether are two key oxygenated polymers, and completely alternative sequence of poly(ester-alt-ether) could efficiently combine the advantages(including flexibility, degradability, etc.) of both segments. Currently, despite their copolymers could be synthesized from one-pot mixture of cyclic esters and epoxides, perfectly alternative microstructure is very challenging to realize and typically restricted to certain monomer pairs. Moving forward, synthesizing poly(ester-alt-ether) from commercially available and largescale monomers would be a significant advance. For example, successfully commercialized poly(glycolic acid)(PGA), which is not easily soluble in polymers due to its high crystallinity and is brittle and difficult to control the degradation cycle, would encounter a new paradigm if engineered into poly(ester-altether). In this work, starting from the design of monomer with hybrid structures, we successfully synthesized a series of 1,4-dioxan-2-one containing different substituents based on glycolide(GA) and epoxides using commercially available Salen-Cr(III) and PPNCl catalytic *** new monomers underwent ring-opening polymerization(ROP) to form a series of poly(ester-alt-ether) with perfectly alternating glycolic acid and propylene glycol repeat units under catalytic system of thiourea/base. The poly(ester-alt-ether) have significantly lower glass-transition temperature than PGA. Additionally, the poly(ester-alt-ether) can be chemically recovered to monomer using Sn(Oct)2 or 1,8-diazabicyclo[5.4.0]undecane-7-ene(DBU) as a catalyst in solution, thus establishing a closed-loop life cycle. From monomers derived from GA and epoxides, this work furnishes a novel strategy for the synthesis of poly(ester-alt-ether) with chemical recyclability.

关键词： Polyester Polyether Alternative copolymer Ring-opening polymerization

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A whole-net cooperative positioning method based on CDGNSS and inter-vehicle ranging

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Chinese Journal of Aeronautics 2024年第2期37卷 401-416页

作者： Shan HU Hongbo ZHAO Chen zhuang School of Electronics and Information Engineering Beihang UniversityBeijing 100191China

Relative positioning is recognized as an important issue for vehicles in urban ***-vehicle Cooperative Positioning(CP)techniques which fuse the Global Navigation Satellite System(GNSS)and inter-vehicle ranging have attracted attention in improving the performance of baseline estimation between ***,current CP methods estimate the baselines separately and ignore the interactions among the positioning information of different *** interactions are called’information coupling’.In this work,we propose a new multivehicle precise CP framework using the coupled information in the network based on the Carrier Differential GNSS(CDGNSS)and inter-vehicle *** demonstrate the benefit of the coupled information by deriving the Cramer-Rao Lower Bound(CRLB)of the float estimation in *** fully use this coupled information,we propose a Whole-Net CP(WN-CP)method which consists of the Whole-Net Extended Kalman Filter(WN-EKF)as the float estimation filter,and the Partial Baseline Fixing(PBF)as the ambiguity resolution *** WN-EKF fuses the measurements of all baselines simultaneously to improve the performance of float estimation,and the PBF strategy fixes the ambiguities of the one baseline to be estimated,instead of full ambiguity resolution,to reduce the computation load of ambiguity *** tests involving four vehicles were conducted in urban *** results show that the proposed WN-CP method can achieve better performance and meanwhile maintain a low computation load compared to the existing methods.

关键词： GNSS Cooperative positioning Baseline Ambiguity resolution Information coupling

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Digital Twin Modeling Enabled Machine Tool Intelligence:A Review

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Chinese Journal of Mechanical Engineering 2024年第2期37卷 29-54页

作者： Lei Zhang Jianhua Liu Cunbo zhuang School of Mechanical Engineering Tianjin University of CommerceTianjin 300134China Laboratory of Digital Manufacturing School of Mechanical EngineeringBeijing Institute of TechnologyBeijing 10081China

Machine tools,often referred to as the“mother machines”of the manufacturing industry,are crucial in developing smart manufacturing and are increasingly becoming more *** twin technology can promote machine tool intelligence and has attracted considerable research ***,there is a lack of clear and systematic analyses on how the digital twin technology enables machine tool ***,digital twin modeling was identified as an enabling technology for machine tool intelligence based on a comparative study of the characteristics of machine tool intelligence and digital *** review then delves into state-of-the-art digital twin modelingenabled machine tool intelligence,examining it from the aspects of data-based modeling and mechanism-data dual-driven ***,it highlights three bottleneck issues facing the *** these problems,the architecture of a digital twin machine tool(DTMT)is proposed,and three key technologies are expounded in detail:Data perception and fusion technology,mechanism-data-knowledge hybrid-driven digital twin modeling and virtual-real synchronization technology,and dynamic optimization and collaborative control technology for multilevel ***,future research directions for the DTMT are *** work can provide a foundation basis for the research and implementation of digital-twin modeling-enabled machine tool intelligence,making it significant for developing intelligent machine tools.

关键词： Machine tool Digital twin Smart manufacturing Synchronization

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