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Comment on “Updated meta-analysis of pancreatic stent placement in preventing post-endoscopic retrograde cholangiopancreatography pancreatitis”

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World Journal of Gastroenterology 2020年第41期26卷 6510-6513页

作者： Jiang-tao chu Department of Endoscopy National Cancer CenterCancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

I read with interest an article "Updated meta-analysis of pancreatic stent placement in preventing post-endoscopic retrograde cholangiopancreatography pancreatitis" by Fan and colleagues in World J Gastroenterol 2015;21(24): 7577-7583. Although I appreciate their work, I have found problems with the data extracted and analyzed by the authors, and will give my comment in this letter. It would be valuable if the authors could provide an accurate estimation of their extracted data.

关键词： Meta-analysis Pancreatic stent Post-endoscopic retrograde cholangiopancreatography Pancreatitis

BF_3·Et_2O promoted conjugate addition of ethanethiol to electron-deficient alkynes

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Chinese Chemical Letters 2012年第6期23卷 639-642页

作者： Qing Fa Zhou Xue Ping chu Shen Zhao tao Lu Wei Fang Tang Department of Organic Chemistry China Pharmaceutical University Nanjing 210009 China

An effective method for the synthesis of vinyl thioethers through the conjugate addition of ethanethiol to electron-deficient alkynes promoted by ***20 has been developed. Electron-deficient internal alkynes react with ethanethiol in this system to yield mainly Z-isomer of vinyl thioether adducts, while electron-deficient terminal alkynes afford mainly E-isomer of vinyl thioether adducts.

关键词： Vinyl thioether Electron-deficient alkyne Conjugate addition Synthesis

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Electrical nonlinearity in silicon modulators based on reversed PN junctions

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Photonics Research 2017年第2期5卷 124-128页

作者： SHENG YU tao chu State Key Laboratory on Integrated Optoelectronics Institute of Semiconductors Chinese Academy of Sciences College of Information Science and Electronic Engineering Zhejiang University

The electrical nonlinearity of silicon modulators based on reversed PN junctions was found to severely limit the linearity of the *** effect,however,was inadvertently neglected in previous *** the electrical nonlinearity in simulation,a 32.2 dB degradation in the CDR3(i.e.,the suppression ratio between the fundamental signal and intermodulation distortion)of the modulator was observed at a modulation speed of 12 GHz,and the spurious free dynamic range was simultaneously degraded by 17.4 *** was also found that the linearity of the silicon modulator could be improved by reducing the series resistance of the PN *** frequency dependence of the linearity due to the electrical nonlinearity was also investigated.

关键词： PN Electrical nonlinearity in silicon modulators based on reversed PN junctions SFDR CDR MZM IMD EN

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Design and Characterization of a Top Cladding for Silicon-on-Insulator Grating Coupler

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Chinese Physics Letters 2012年第11期29卷 105-107页

作者： Nemkova Anastasia XIAO Xi YANG Biao chu tao YU Jin-Zhong YU Yu-De State Key Laboratory on Integrated Optoelectronics Institute of SemiconductorsChinese Academy of SciencesBeijing 100083

An effective top cladding for silicon-on-insulator grating coupler is designed and the validity of the design is confirmed *** proposed double-layer silicon oxide/silicon nitride(SiO_(2)/Si_(3)N_(4))cladding demonstrates antireflection properties and affects a coupling strength of the grating structure.A coupling efficiency of 65%is obtained after cladding layer deposition.

关键词： cladding coupling fir

Development of silicon photonic devices for optical interconnects

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Science China Technological Sciences 2013年第3期56卷 586-593页

作者： XIAO Xi LI ZhiYong chu tao XU Hao LI XianYao NEMKOVA Anastasia KANG Xiong YU YuDe YU JinZhong State Key Laboratory on Integrated Optoelectronics Institute of SemiconductorsChinese Academy of Sciences

Silicon photonic devices based on complementary-metal-oxide-semiconductor(CMOS) compatible technologies have shown attractive performances on very-large-scale monolithic optoelectronic integration,high speed modulation and switching,and efficient off-chip optical *** paper presents the recent progress on fast silicon optical modulation,wavelength-insensitive optical switching and efficient optical coupling techniques in our *** CMOS-compatible silicon optical couplers with different structures have been developed,showing the highest coupling efficiency of 65%.Broadband silicon-based optical switches with sub-nanosecond switching on-off time are experimentally *** modulators with novel PN junctions are demonstrated with the speed up to 50 Gb s-1.

关键词： silicon photonics microresonator optical modulator optical switch

Osteoarthritis:pathogenic signaling pathways and therapeutic targets

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Signal Transduction and Targeted Therapy 2023年第3期8卷 932-962页

作者： Qing Yao Xiaohao Wu chu tao Weiyuan Gong Mingjue Chen Minghao Qu Yiming Zhong Tailin He Sheng Chen Guozhi Xiao Department of Biochemistry School of MedicineShenzhen Key Laboratory of Cell MicroenvironmentGuangdong Provincial Key Laboratory of Cell Microenvironment and Disease ResearchSouthern University of Science and TechnologyShenzhen 518055China Department of Orthopaedics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

Osteoarthritis(OA)is a chronic degenerative joint disorder that leads to disability and affects more than 500 million population *** was believed to be caused by the wearing and tearing of articular cartilage,but it is now more commonly referred to as a chronic whole-joint disorder that is initiated with biochemical and cellular alterations in the synovial joint tissues,which leads to the histological and structural changes of the joint and ends up with the whole tissue ***,there is no cure for OA,partly due to a lack of comprehensive understanding of the pathological mechanism of the initiation and progression of the ***,a better understanding of pathological signaling pathways and key molecules involved in OA pathogenesis is crucial for therapeutic target design and drug *** this review,we first summarize the epidemiology of OA,including its prevalence,incidence and burdens,and OA risk *** then focus on the roles and regulation of the pathological signaling pathways,such as Wnt/β-catenin,NF-κB,focal adhesion,HIFs,TGFβ/ΒΜP and FGF signaling pathways,and key regulators AMPK,mTOR,and RUNX2 in the onset and development of *** addition,the roles of factors associated with OA,including MMPs,ADAMTS/ADAMs,and PRG4,are discussed in ***,we provide updates on the current clinical therapies and clinical trials of biological treatments and drugs for *** advances in basic knowledge of articular cartilage biology and OA pathogenesis will have a significant impact and translational value in developing OA therapeutic strategies.

关键词： therapeutic Osteoarthritis epidemiology

Improving Personal Product Recommendation via Friendships’ Expansion

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Journal of Computer and Communications 2013年第5期1卷 1-8页

作者： chunxia Yin tao chu The First Aircraft Institute Aviation Industry Corporation of China Xi’an China.

The trust as a social relationship captures similarity of tastes or interests in perspective. However, the existent trust information is usually very sparse, which may suppress the accuracy of our personal product recommendation algorithm via a listening and trust preference network. Based on this thinking, we experiment the typical trust inference methods to find out the most excellent friend-recommending index which is used to expand the current trust network. Experimental results demonstrate the expanded friendships via superposed random walk can indeed improve the accuracy of our personal product recommendation.

关键词： Personal Product Recommendation Trust Inference Listening and Trust Preference Network

Improved extinction ratio of Mach-Zehnder based optical modulators on CMOS platform

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Frontiers of Optoelectronics 2012年第1期5卷 90-93页

作者： Zhiyong LI Liang ZHOU Xi XIAO tao chu Yude YU Jinzhong YU State Key Laboratory on Integrated Optoelectronics Institute of Semiconductors(IS)Chinese Academy of Sciences(CAS)Beijing 100083China

Silicon based optical modulators with improved extinction ratio （ER） of 25 dB were demon- strated on complementary metal oxide semiconductor （CMOS） platform. It was proposed that the effect of optical absorption due to free carriers accumulated in silicon should be considered in the analysis of device configuration. Experimental results presented in this study were identical with the proposed analyses. The modulators were operated with the data transmission rate of 3.2 Gbps.

关键词： silicon photonics optical modulator extinction ratio (ER) integration

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Efficient adiabatic silicon-on-insulator waveguide taper

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Photonics Research 2014年第3期2卷 S0041-S0044页

作者： Yunfei Fu Tong Ye Weijie Tang tao chu State Key Laboratory of Integrated Optoelectronics Institute of SemiconductorsChinese Academy of SciencesBeijing 100083China

A silicon-on-insulator-based adiabatic waveguide taper with a high coupling efficiency and small footprint is *** taper was designed to reduce the incidence of mode conversion to higher-order and radiation modes inside the *** connecting a 0.5-μm-wide output waveguide and a 12-μm-wide input waveguide of a grating coupler,a compact 120-μm-long taper was demonstrated,achieving a transmission of 98.3%.Previously,this transmission level could only be achieved using a conventional linear taper with a length of more than 300μm.

关键词： waveguide taper adiabatic