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铸造 2024年第6期73卷 835-842页

作者：董淏侯明君计效园李沁阳吴楚澔李硕宏郄喜望陈强李宁周建新高亮华中科技大学材料成形与模具技术全国重点实验室湖北武汉430074 中国航发北京航空材料研究院北京100095 中国兵器工业第五九研究所重庆710100 华中科技大学机械科学与工程学院湖北武汉430074

随着国防核心装备对零件的要求不断提高,铸件向结构复杂化方向发展,如大壁厚差、多交叉结构等,致使铸件内部缺陷的无损检测更困难。X射线探伤过程中,拍片依赖人工反复调整成像部位和参数,存在探伤部位易漏检、成像质量波动大等问题,亟... 详细信息

随着国防核心装备对零件的要求不断提高,铸件向结构复杂化方向发展,如大壁厚差、多交叉结构等,致使铸件内部缺陷的无损检测更困难。X射线探伤过程中,拍片依赖人工反复调整成像部位和参数,存在探伤部位易漏检、成像质量波动大等问题,亟需发展智能分区调参拍片技术。为此,本文提出了铸件X射线检测虚拟探伤图像生成方法。首先,建立了铸件坐标降维映射模型,实现了铸件三维坐标降维映射到成像板平面二维坐标。其次,建立了仿真成像参数拟合模型,生成了点光源式虚拟射线对铸件三维模型的仿真探伤图像。最后,开发了铸件X射线检测虚拟成像系统。该方法可为实际探伤提供优化的成像姿态和成像参数信息,为智能分区调参拍片技术提供理论支撑。

关键词： X射线探伤铸件三维模型点光源成像虚拟探伤图像

Dendrimer-induced synthesis of porous organosilica capsules for enzyme encapsulation

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Frontiers of Chemical Science and Engineering 2024年第4期18卷 41-48页

作者： Ziyi chu Boyu Zhang Zhenhua wu Jiaxu Zhang Yiran Cheng Xueying Wang Jiafu Shi Zhongyi Jiang School of Environmental Science&Engineering Tianjin UniversityTianjin 300072China Collaborative Innovation Center of Chemical Science and Engineering Tianjin 300072China State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China Key Laboratory for Green Chemical Technology of Ministry of Education School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China

Organic matter-induced mineralization is a green and versatile method for synthesizing hybrid nanostructured materials,where the material properties are mainly influenced by the species of natural biomolecules,linear synthetic polymer,or small molecules,limiting their ***,we adopted dendrimer poly(amidoamine)(PAMAM)as the inducer to synthesize organosilica-PAMAM network(OSPN)capsules for mannose isomerase(MIase)encapsulation based on a hard-templating *** structure of OSPN capsules can be precisely regulated by adjusting the molecular weight and concentration of PAMAM,thereby demonstrating a substantial impact on the kinetic behavior of the MIase@OSPN *** MIase@OSPN system was used for catalytic production of mannose from Dfructose.A mannose yield of 22.24% was obtained,which is higher than that of MIase in organosilica network capsules and similar to that of the free *** overall catalytic efficiency(kcat/Km)of the MIase@OSPN system for the substrate D-fructose was up to 0.556 s^(-1)·mmol^(-1)·***,the MIase@OSPN system showed excellent stability and recyclability,maintaining more than 50% of the yield even after 12 cycles.

关键词： enzyme immobilization enzyme catalysis organosilica networks capsules sugar biosynthesis

基于全局热网络和局部流体动力学建模的全封闭永磁牵引电机热性能优化（英文）

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2018年第11期19卷 878-888页

作者： Wei CHEN Gui-chu wu You-tong FANG Ji-en MA Key Laboratory of Low-Voltage Apparatus Intellectual Technology of Zhejiang Wenzhou University College of Electrical Engineering Zhejiang University

目的:提出一种适用于全封闭冷却结构的电机热性能优化模型,设计一台600 kW的高速列车用永磁牵引电机。创新点:1.通过耦合局部流体动力学模型的方法求解电机复杂冷却风道内的对流传热系数,并在全局热网络模型的框架内得到快速、准确的电... 详细信息

目的:提出一种适用于全封闭冷却结构的电机热性能优化模型,设计一台600 kW的高速列车用永磁牵引电机。创新点:1.通过耦合局部流体动力学模型的方法求解电机复杂冷却风道内的对流传热系数,并在全局热网络模型的框架内得到快速、准确的电机温升结果以用于结构优化;2.在冷却风道中引入栅格结构,采用热性能分析模型优化冷却结构,提升电机热性能;3.通过三维流体动力学模型计算电机局部温升最大值,并提山一种预测特定结构下电机铁损工作阈值的工程方法。方法:1.采用热网络法建立全局热网络模型(图3),并通过耦合局部流体动力学模型计算风道内的热网络参数(图4和6); 2.应用田口设计法对电机风道结构进行优化,并研制样机进行验证(计算与试验结果见表5); 3.假设铁损的谐波附加值与磁密值成正比,通过三维流体动力学模型计算给山端部绕组、永磁体温升值与铁损的预测曲线,并用样机试验进行验证。结论:1.采用全局热网络和局部流体动力学建模的方法可以快速、正确地计算复杂冷却结构下的电机温升分布,且优化后的冷却结构至少可以提升文中电机15%的热性能;2.本文提出的优化模型适用于全封闭风冷或者水冷等冷却结构相对独立且尚无经验公式可参考的电机热性能优化设计;3.铁损工作阈值的预测方法可以为电磁和控制系统设计提供参考。

关键词：热网络模型流体动力学永磁电机全封闭强制风冷

Si-Miao-Yong-An Decoction alleviates thromboangiitis obliterans by regulating miR-548j-5p/IL-17A signaling pathway

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Chinese Journal of Natural Medicines 2024年第6期22卷 541-553页

作者： chu chu SUN Shangwen ZHANG Zhen wu Qi LI Haoyang LIANG Gang MIAO Xiuming JIANG Haiqiang GAO Yan ZHANG Yunhong WANG Bin LI Xia Innovative Institute of Chinese Medicine and Pharmacy Shandong University of Traditional Chinese MedicineJinan 250355China National Key Laboratory for Innovation and Transformation of Luobing Theory The Key Laboratory of Cardiovascular Remod-eling and Function ResearchChinese Ministry of EducationChinese National Health Commission and Chinese Academy of Medical SciencesDepartment of CardiologyQilu Hospital of Shandong UniversityJinan 250012China School of Clinical and Basic Medical Sciences Shandong First Medical University&Shandong Academy of Medical SciencesJinan 271016China Affiliated Hospital of Shandong University of Traditional Chinese Medicine Jinan 250014China International Business School Tianjin Foreign Studies UniversityTianjin 300204China Institute of Pharmaceutical Research Shandong University of Traditional Chinese MedicineJinan 250355China

Thromboangiitis obliterans(TAO)is a rare,chronic,progressive,and segmental inflammatory disease characterized by a high rate of amputation,significantly compromising the quality of life of ***-Miao-Yong-An decoction(SMYA),a tradition-al prescription,exhibits anti-inflammatory,anti-thrombotic,and various other pharmacological ***,it was fully proved to be effective for TAO therapy,but the specific therapeutic effect of SMYA on TAO has been ***,deep unveiling the mechanism of SMYA in TAO for identifying clinical therapeutic targets is extremely *** this study,we observed elev-ated levels of IL-17A in the peripheral blood mononuclear cells(PBMCs)of TAO patients,whereas the expression of miR-548j-5p was significantly decreased.A negative correlation between the levels of miR-548j-5p and IL-17A was also *** vitro ex-periments showed that overexpression of miR-548j-5p led to a decrease in IL-17A levels,whereas downregulation of miR-548j-5p showed the opposite *** a dual luciferase assay,we confirmed that miR-548j-5p directly targets ***,serum containing SMYA effectively decreased IL-17A levels by increasing the expression of *** importantly,the results of in vivo tests indicated that SMYA mitigated the development of TAO by inhibiting IL-17A through the upregulation of miR-548j-5p in vascular *** conclusion,SMYA significantly enhances the expression of miR-548j-5p,thereby reducing the levels of the target gene IL-17A and alleviating *** research not only identifies novel targets and pathways for the clinical diagnosis and treatment of TAO but also advances the innovation in traditional Chinese medicine through the elucidation of the SMYA/miR-548j-5p/IL-17A regulatory axis in the pathogenesis of TAO.

关键词： Thromboangiitis obliterans IL-17A Inflammation miR-548j-5p Si-Miao-Yong-An Decoction

Threshold Stress Intensity of Hydrogen-Induced Cracking and Stress Corrosion Cracking of High Strength Steel

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Journal of Iron and Steel Research International 2001年第2期8卷 42-46页

作者： LI Hui-lu GAO Ke-wei QIAO Li-jie WANG Yan-bing chu wu-yang HUI Wei-jun DONG Han WENG Yu-qing University of Science and Technology Beijing Central Iron & Steel Research Institute

The threshold stress intensity of stress corrosion cracking(SCC) for 40 CrMo steel in 3.5%NaCl solution decreased exponentially with the increase of yield *** threshold stress intensity of hydrogen-induced cracking during dynamical charging for 40 CrMo steel decreased linearly with the logarithm of the concentration of diffusible *** equation was also applicable to SCC of high strength steel in aqueous *** critical hydrogen enrichment concentration necessary for SCC of high strength steel in water decreased exponentially with the increase of yield *** on the results,the relationship between K_(ISCC) and σ_(ys) could be deduced.

关键词： high strength steel stress corrosion hydrogen-induced cracking

Genesis of the Jianbeigou Gold Deposit on the Southern Margin of the North China Craton: Insights from Fluid Inclusions, H-O-S Isotopes, and Pyrite in situ Trace Element Analyses

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Acta Geologica Sinica(English Edition) 2024年第4期98卷 969-991页

作者： LI Fengchun ZENG Qingdong ZHU Rixiang chu Shaoxiong XIE Wei YU Bing wu Jinjian LI Xinghui Key Laboratory of Mineral Resources Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China Innovation Academy for Earth Science Chinese Academy of SciencesBeijing 100029China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China State Key Laboratory of Lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China School of Earth Science and Engineering Hebei University of EngineeringHandanHebei 056038China

The Jianbeigou gold deposit is a typical lode gold deposit in the Qinling metallogenic belt, located on the southern margin of the North China Craton. Three stages of the hydrothermal process can be distinguished, including the quartz ± pyrite, quartz-polymetallic sulfide, and quartz-carbonate ± pyrite stages. From the early to late stages, the homogenization temperatures of primary fluid inclusions are 281–362°C, 227–331°C, and 149–261°C, respectively. The corresponding salinities estimated for these fluids are 3.9–9.9 wt%, 0.4–9.4 wt%, and 0.7–7.2 wt% Na Cl equiv. Combined with laser Raman spectroscopy data, the ore-forming fluid belongs to a H_(2)O-CO_(2)-Na Cl ± CH_4 system with medium–low temperature and salinity. The δ~(18)Ofluid and δD values for the quartz veins are-1.0‰ to 6.0‰ and-105‰ to-84‰, respectively, which indicates that the ore-forming fluid is of mixed source, mainly derived from magma, with a contribution from meteoric water. Pyrite has been identified into three generations based on mineral paragenetic sequencing, including Py1, Py2, and Py3. The pyrites have δ~(34)S sulfur isotopic compositions from three stages between 3.7‰ and 8.4‰, indicating that sulfur mainly originated from magma. Te, Bi, Sb, and Cu contents in pyrite were all high and showed a strong correlation with Au concentrations. Native gold and the Au-Ag-Bi telluride minerals were formed concurrently, and the As concentration was low and decoupled from the Au content. Therefore, Te, Bi, Sb and other low-melting point chalcophile elements play an important role for gold mineralization in arsenic-deficient ore-forming fluid. Combined with the geological setting, evolution of pyrite, and ore-fluids geochemistry, we propose that the Jianbeigou deposit can be classified as a magmatic–hydrothermal lode gold deposit. Gold mineralization on the southern margin of the North China Craton is related to Early Cretaceous magmatism and formed in an extensional setting.

关键词： ore genesis H-O-S isotopes fluid inclusions in-situ trace element Jianbeigou gold deposit

Study on Shear Strength Characteristics of Basalt-Concrete Bonding Interface Based on in-situ Direct Shear Test

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Journal of Earth Science 2024年第2期35卷 553-567页

作者： Peng Xia Xinli Hu chunye Ying Shuangshuang wu chu Xu Xuan Wang Hao Chen Hang Duan College of Harbour and Coastal Engineering Jimei UniversityXiamen361021China Faculty of Engineering China University of GeosciencesWuhan430074China China Three Gorges Construction Group Ltd.Beijing100038China

In rock engineering,the shear strength of the basalt-concrete bonding interface is a key factor affecting the shear performance of hydroelectric dam foundations,embedded rock piles and rock *** this study,30 sets of in-situ direct shear tests were conducted on the basalt-concrete bond interface in the Baihetan dam area to investigate the shear strength characteristics of the basalt-concrete bonding *** bonding interface contains two states,i.e.,the bonding interface is not sheared,termed as se(symbolic meaning see Table 1);the bonding interface is sheared with rupture surface,termed as *** effects of lithology,Joints structure,rock type grade and concrete compressive strength on the shear strength of the concrete-basalt contact surface were *** test results show that the shear strength of the bonding interface(s_(e)&s_(i))of columnar jointed basalt with concrete is greater than that of the bonding interface(s_(e)&s_(i))of non-columnar jointed one with the same rock type *** the rock type grade isⅢ_(2),fcol is 1.22 times higher than fncol and ccol is 1.13 times greater than *** shear strength parameters of the basalt-concrete bonding interface differ significantly for different *** cohesion of the bonding interface(s_(i))of cryptocrystalline basalt with concrete is 2.05 times higher than that of the bonding interface(s_(i))of breccia lava with concrete under the same rock type grade *** type grade has a large influence on the shear strength of the non-columnar jointed basalt-concrete bonding interface(s_(e)&s_(i)).cnol increases by 33%when the grade of rock type rises fromⅢ_(1)toⅡ_(1).the rock type grade has a greater effect on bonding interface(s_(i))cohesion than the coefficient of *** the rock type grade is reduced fromⅢ_(2)toⅢ_(1),f_(ncol)′increases by 2%and c_(ncol)′improves by 44%.The shear strength of the non-columnar jointed basalt-concrete bonding interface(s_(e)&s_(i))increases wit

关键词： direct shear test basalt-concrete bonding interface shear strength parameters engineering geogolgy

一株十二烷基苯磺酸钠降解菌的分离鉴定及降解特性研究

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微生物学报 2006年第6期46卷 988-993页

作者：吴楚温州大学生命与环境科学学院温州325027

从受污染河水中筛选分离得到一株能以十二烷基苯磺酸钠(Sodiumdodecylbenzenesulfonate,SDBS)为唯一碳源和能源生长的菌株WZR-A。经对其形态特征、生理生化、以及16SrDNA序列分析,将WZR-A初步鉴定为人苍白杆菌(Ochrobactrumanthropi)。... 详细信息

从受污染河水中筛选分离得到一株能以十二烷基苯磺酸钠(Sodiumdodecylbenzenesulfonate,SDBS)为唯一碳源和能源生长的菌株WZR-A。经对其形态特征、生理生化、以及16SrDNA序列分析,将WZR-A初步鉴定为人苍白杆菌(Ochrobactrumanthropi)。研究表明该菌株利用SDBS生长的最适温度为30℃,最适pH为7·0。SDBS浓度低于400mg/L时菌株对SDBS的降解率可在80%以上。菌株细胞蛋白SDS-PAGE结果显示,菌株在SDBS诱导前后的细胞蛋白组成有明显差异。酶的定域试验表明,该菌株的相关降解酶为胞内酶。相关降解酶活性及降解底物测试结果表明,该菌株可能通过邻位途径裂解芳环并具有对多种芳香族化合物降解的能力。此外,利用质粒检测和消除试验发现菌株WZR-A中含有大质粒且该菌株的相关降解基因初步定位于该质粒。

关键词：生物降解十二烷基苯磺酸钠人苍白杆菌

Simple and effective method for treating severe adult skeletal class II malocclusion: A case report

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World Journal of Orthopedics 2024年第10期15卷 965-972页

作者： Li-Li Xie Dan-Yang chu Xiao-Feng wu Department of Stomatology Hebei General HospitalShijiazhuang 050057Hebei ProvinceChina Chengde Medical University Chengde 067000Hebei ProvinceChina

BACKGROUND Severe skeletal class II malocclusion is the indication for combined orthodontic and orthognathic *** SUMMARY A woman with a chief complaint of a protruding chin and an inability to close her lips requested orthodontic *** treatment plan consisted of extracting the right upper third molar,right lower third molar,left lower second molar,and left upper third molar and moving the maxillary dentition distally using a convenient method involving microimplant nail anchors,push springs,long arm traction hooks,and elastic traction *** 52 months of treatment,her overbite and overjet were normal,and her facial profile was *** This method can be used for distal movement of the maxillary dentition and to correct severe skeletal class II malocclusion in adults.

关键词： Skeletal class II malocclusion Maxillary dentition Microimplant nail Simple and effective method Case report