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Military Medical Research 2022年第3期9卷 379-381页

作者： Biao Xu Bo tu Fang chu Mohamed Jalloh Jin-Song Mu Jun-Jie Zheng Wei-Wei Chen Chinese Military Medical Expert Group in Sierra Leone the Fifth Medical Center of Chinese PLA General HospitalBeijing100039China The 34Th Military Hospital Wilberforce BarracksFreetownSierra Leone

Despite the widespread use of malaria rapid diagnostic test(RDT)in clinical practice,there are a lot of *** conducted a secondary analysis of 129 malaria RDT data from rounds 5–8 of the World Health Organization(WHO)product testing summary and discuss the causes of false-negative(FN)results with a focus on low parasite density,improper RDT storage,operation and interpretation,and Plasmodium falciparum with a pfhrp2/3 gene *** results demonstrated that the malaria RDTs currently commercially available might cause FN results in practice.

关键词： Malaria Rapid diagnostic tests False-negative results WHO product testing

SET-SEARCH AS AN IF-THEN STRUCtuRE WITH BOOLEAN-ALGEBRAICAL CELLS

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Chinese Science Bulletin 1989年第22期34卷 1935-1936页

作者：涂象初涂承媛 Beijing Polytechnic University Beijing 100007 PRC

From the point of view of problem-solving, Ref. [1] shows that set-search is isomorphic to a Boolean algebra,

关键词： isomorphic algebra Boolean sence heuristic

nvolvement of collagen-binding heat shock protein 47 in scleroderma-associated fibrosis

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Protein & Cell 2015年第8期6卷 589-598页

作者： Haiyan chu Ting Wu Wenyu Wu Wenzhen tu Shuai Jiang Sidi Chen Yanyun Ma Qingmei Liu Xiaodong Zhoua Li Jin Jiucun Wang Ministry of Education Key Laboratory of Contemporary Anthropology and State Key Laboratory of Genetic Engineering Collaborative Innovation Center for Genetics and Development School of Life Sciences and Institutes of Biomedica Sciences Fudan University Shanghai 200438 China Division of Dermatology Huashan Hospital Fudan University Shanghai 200040 China Division of Rheumatology Shanghai TCM-Integrated Hospital Shanghai 200082 China Division of Rheumatology University of Texas Health Science Center at Houston Houston TX 77030 USA Institute of Rheumatology Immunology and Allergy Fudan University Shanghai 20080 China

Uncontrolled fibrosis of skin and internal organs is the main characteristic of scleroderma, and collagen is a major extracellular matrix protein that deposits in the fibrotic organs. As the chaperone of collagen, heat shock protein 47 （HSP47） is closely related with the development of fbrosis. To explore the potential func- tion of HSP47 in the pathogenesis of scleroderma, the clinical, in vivo and in vitro studies were performed. In clinical, the increased mRNA level of HSP47 was observed in the skin fibroblasts and PBMC from scle- roderma patients, and the enhanced protein level of HSP47 was also detected in the skin biopsy and plasma of the above patients. Unexpectedly, the enhanced levels of HSP47 were positively correlated with the presence of anti-centromere antibody in scleroderma patients. Moreover, a high expression of HSP47 was found in the skin lesion of BLM-induced scleroderma mouse model. Further in vitro studies demonstrated that HSP47 knockdown could block the intracellular and extracellular collagen over-productions induced by exogenous TGF-13. Therefore, the results in this study provide direct evidence that HSP47 is involved in the pathogenesis of scleroderma. The high expression of HSP47 can be detected in the circulatory system of scleroderma patients, indicating that HSP47 maybecome a pathological marker to assess the progres- sion of scleroderma, and also explain the systemic fibrosis of scleroderma. Meanwhile, collagen over-ex- pression is blocked by HSP47 knockdown, suggesting the possibility that HSP47 can be a potential therapeutic target for scleroderma.

关键词： systemic sclerosis fibrosis collagenheat shock protein 47 anti-centromere antibody,therapeutic target

Interface engineering of ferroelectric-gated MoS2 phototransistor

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Science China(Information Sciences) 2021年第4期64卷 166-173页

作者： Shuaiqin WU Xudong WANG Wei JIANG Luqi tu Yan CHEN Jingjing LIU Tie LIN Hong SHEN Jun GE Weida HU Xiangjian MENG Jianlu WANG Junhao chu State Key Laboratory of Infrared Physics Shanghai Institute of Technical PhysicsChinese Academy of Sciences University of Chinese Academy of Sciences Hangzhou Institute for Advanced Study University of Chinese Academy of Sciences

Two-dimensional（2D） layered materials have received significant attention owing to their unique crystal structures as well as outstanding optical and electric properties in photoelectric detection. However,most 2D materials are very sensitive to the environment. Adsorbates and traps introduced during the preparation process have a negative effect on the performance of devices based on these materials. Here,we focus on a molybdenum disulfide（MoS2） phototransistor gated by ferroelectrics, and insert a hexagonal boron nitride（h-BN） layer between MoS2and the ferroelectric film to improve the interface. To clarify the role of h-BN in this device, two parallel devices are prepared on the same MoS2flake. One device is covered with h-BN, while the other is in direct contact with the ferroelectric film. The electronic and optoelectronic properties of these two devices are then measured and compared. Experimental results reveal that, compared to device without h-BN, the MoS2phototransistor with h-BN exhibits higher carrier mobility(average value: 85 cm2·V-1·s-1and highest value: 185 cm2·V-1·s-1), larger responsivity(85 A·W-1), and larger detectivity(1.76×1013Jones). Thus, this strategy is significant for the interface engineering and performance improvement of devices based on 2D materials.

关键词： 2D materials ferroelectrics MoS$_{2}$phototransistors h-BN interface engineering

A coarse-grained bonded particle model for large-scale rock simulation

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Rock Mechanics Bulletin

Rock Mechanics Bulletin 2024年第4期3卷 58-69页

作者： Chengshun Shang Liping Li Kaiwei chu Zongqing Zhou Guillermo Casas Wenfeng tu Yuxue Chen Shangqu Sun School of Qilu Transportation Shandong University250061JinanChina International Center for Numerical Methods in Engineering(CIMNE) 08034BarcelonaSpain Universitat Politecnica de Catalunya(UPC) 08034BarcelonaSpain Geotechnical and Structural Engineering Research Center Shandong University250061JinanChina College of Civil Engineering and Architecture Shandong University of Science And Technology266590QingdaoChina

For solving the computationally intensive problem encountered by the discrete element method(DEM)in simulating large-scale engineering problems,it is essential to establish a numerical model that can effectively simulate large-scale *** this study,the coarse-graining effect of a linear-Mindlin with bonding model was studied in the unconfined compression strength(UCS)and Brazilian tensile strength(BTS)*** found that the main reason for the coarse-graining effect of the BTS tests is that the type I fracture toughness is positively correlated with the size of the *** on the results analysis and fracture mechanics,the coarse-grained(CG)modeling theory was combined with a bonded particle model(BPM)for the first time and a coarse-grained bonded particle model(CG-BPM)was developed,which can be effectively used to model the tensile strength of large-scale rocks with different particle *** excavation damage zone(EDZ)in an underground research laboratory(URL)was selected as an application case,which shows that the coarse-grained bonding model presented in this paper is more accurate and reliable than the traditional one in large-scale rock simulation,at least in the scenario where tensile failure is dominant.

关键词： Numerical simulation Discrete element method(DEM) Coarse-grained bonded particle model(CGBPM) Large-scale rock

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土体一维传热方程解析解及热扩散系数测定

岩土工程学报 2008年第5期30卷 652-657页

作者：涂新斌戴福初中国科学院地质与地球物理研究所北京100029

传热方程是一类常见的基本数学物理方程,热导率是土体重要的热物理参数。从基本传热方程出发,详细地推导了利用傅立叶级数求解一维传热方程的方法,以地面温度随时间变化的波动方程得到地下不同深度处土体温度分布的解析解。在此基础上,... 详细信息

传热方程是一类常见的基本数学物理方程,热导率是土体重要的热物理参数。从基本传热方程出发,详细地推导了利用傅立叶级数求解一维传热方程的方法,以地面温度随时间变化的波动方程得到地下不同深度处土体温度分布的解析解。在此基础上,讨论了利用热导率进行土体含水率测量的基本原理,详细地推导了根据地下不同深度的温度计算土体热扩散系数的振幅法、相位法及其应用,介绍了利用传热方程进行数值模拟的计算原理。最后结合实例介绍了该方法的应用效果。

关键词：热导率热扩散系数传热方程地温梯度

Electrochemical Immunosensor for Detection of Atrazine Based on Polyaniline/Graphene

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Journal of Materials Science & Technology 2016年第6期32卷 539-544页

作者： Nguyen Van chu Nguyen Hai Binh Cao Thi Thanh Nguyen Van tu Nguyen Le Huy Nguyen tuan Dzung Phan Ngoc Minh Vu Thi Thu Tran Dai Lam Institute of Materials Science Vietnam Academy of Science and Technology18 Hoang Quoc VietCau Giay.HanoiViet Nam School of Chemical Engineering.Hanoi University of Science and Technology 1 Dai Co VietHanoiViet Ham Institute for Tropical Technology.Vietnam Academy of Science and Technology 18 Hoang Quoc VietHanoiViet Nam Center for High Technology Development Vietnam Academy of Science and Technology18 Hoang Quoc VietHanoiViet Nam University of Science and Technology of Hanoi.18 Hoang Quoc Viet HanoiViet Ham Graduate University of Science and Technology.Vietnam Academy of Science and Technology 18 Hoang Quoc Viet.HanoiViet Nam

In this study, a novel layer-by-layer polyaniline/graphene （PANi/Gr） structure for electrochemical detec- tion of atrazine was developed. Gr film was synthesized by thermal chemical vapor deposition （CVD） method and transferred onto the PANi-predeposited microelectrode. The properties of PANi/Gr film were thoroughly investigated by high-resolution transmission electron microscopy and Raman techniques. The most attractive feature of this system is a suitable microenvironment, which could provide an amplifi- cation of the conductive signal, thus may contribute to enhancing electron transfer and subsequently improve the sensitivity in electrochemical measurements. With low detection limit （- 43 × 10 -12 g/L）, ac-ceptable stability and good reproducibility, the proposed electrochemical immunosensor could be advantageously extended for multiplexed detection of other agents of environmental pollution.

关键词： Electrochemical immunosensor Polyaniline Graphene Atrazine

Electroacupuncture pretreatment exhibits antidepressive effects by regulating hippocampal proteomics in rats with chronic restraint stress

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Neural Regeneration Research 2015年第8期10卷 1298-1304页

作者： Zhuo Guo Ya tu Tian-wei Guo Yun-chu Wu Xue-qin Yang Lan Sun Xin-jing Yang Wen-yue Zhang Yu Wang Xu-hui Zhang Beijing University of Chinese Medicine Shijiazhuang Hospital of Traditional Chinese Medicine Beijing Rehabilitation Hospital of Capital Medical University

The clinical effect of electroacupuncture on depression is widely recognized. However, the signal transduction pathways and target proteins involved remain unclear. In the present study, rat models of chronic restraint stress were used to explore the mechanism by which electroacupuncture alleviates depression. Rats were randomly divided into control, model, and electroacupuncture groups. Chronic restraint stress was induced in the model and electroacupuncture groups by restraining rats for 28 days. In the electroacupuncture group, electroacupuncture pretreatment at Baihui（GV20） and Yintang（GV29） acupoints was performed daily（1 m A, 2 Hz, discontinuous wave, 20 minutes） prior to restraint for 28 days. Open field tests and body weight measurements were carried out to evaluate the depressive symptoms at specific time points. On day 28, the crossing number, rearing number, and body weights of the model group were significantly lower than those in the control group. Behavior test results indicated that rat models of depressive-like symptoms were successfully established by chronic restraint stress combined with solitary raising. On day 28, an isobaric tag for a relative and absolute quantitation-based quantitative proteomic approach was performed to identify differentially expressed proteins in hippocampal samples obtained from the model and electroacupuncture groups. The potential function of these differential proteins was predicted through the use of the Cluster of Orthologous Groups of proteins（COG） database. Twenty-seven differential proteins（uncharacteristic proteins expected） were selected from the model and electroacupuncture groups. In addition to unknown protein functions, COG are mainly concentrated in general prediction function, mechanism of signal transduction, amino acid transport and metabolism groups. This suggests that electroacupuncture improved depressive-like symptoms by regulating differential proteins, and most of these related proteins exist in ne

关键词： nerve regeneration traditional Chinese medicine electroacupuncture depression chronic restraint stress i TRAQ differential protein proteomics multi-target effect neural regeneration

Characteristics of immune and inflammatory responses among different age groups of pediatric patients with COVID-19 in China

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World Journal of Pediatrics 2021年第4期17卷 375-384页

作者： Su-Qiong Ji Min Zhang Yong Zhang Kun Xia Yuan Chen Qian chu Yong-Chang Wei Fu-Ling Zhou Bi-Tao Bu Hong-Lei tu Ya-Yun Cao Li-Ya Hu Department of Neurology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Cardiovascular Medicine Wuhan Children’HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Geriatrics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Oncology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Radiation and Medical Oncology Hubei Key Laboratory of Tumor Biological BehaviorsHubei Cancer Clinical Study CenterZhongnan Hospital of Wuhan UniversityWuhanChina Department of Hematology Zhongnan Hospital of Wuhan UniversityWuhanChina

Background Severe cases of coronavirus disease 2019(COVID-19)among pediatric patients are more common in children less than 1 year of *** aim is to address the underlying role of immunity and inflammation conditions among different age groups of pediatric *** We recruited pediatric patients confirmed of moderate COVID-19 symptoms,admitted to Wuhan Children's Hospital from January 28th to April 1st in *** were divided into four age groups(≤1,1–6,7–10,and 11–15 years).Demographic information,clinical characteristics,laboratory results of lymphocyte subsets test,immune and inflammation related markers were all *** Analysis included 217/241(90.0%)of patients with moderate clinical stage *** recovery time of children more than 6 years old was significantly shorter than of children younger than 6 years(P=0.001).Reduced neutrophils and increased lymphocytes were significantly most observed among patients under 1 year old(Ptumor necrosis factor γ (P=0.007),interleukin(IL)-10(P=0.011),IL-6(P=0.008),lactate dehydrogenase(P<0.001),and procalcitonin(P=0.007).Conclusion The higher rate of severe cases and long course of COVID-19 among children under 1 year old may be due to the lower production of antibodies and serum complements of in this age group.

关键词： Age difference China Coronavirus disease 2019 Immune Inflammation Pediatric

Application of Livelihood Vulnerability Index to Assess Risks from Flood Vulnerability and Climate VariabilitymA Case Study in the Mekong Delta of Vietnam

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Journal of Environmental Science and Engineering(A) 2013年第8期2卷 476-486页

作者： Nguyen Duy Can Vo Hong tu chu Thai Hoanh Department of Rural Socio-Economics College of Rural Development Can Tho University Can Tho Vietnam Southeast Asia Regional Office IWMI (International Water Management Institute) Lao PDR Vientiane

An Giang province in the Mekong Delta is the most vulnerable province the impact of flooding and climate variability. Thousand of households are at risk due to severe annual floods. This study applied the LVI （livelihood vulnerability index） to estimate flood vulnerability of Phu Huu and Ta Danh villages in An Giang province. Data on socio-demographics, livelihoods, health, social networks, physical, financial and natural resources, natural disasters and climate variability were collected from a survey of 120 households in each village. From these data the LVI of each village was calculated. Results show that the overall LV1 of Phu Huu village, located in the early flooded zone, is higher than that of Ta Danh village, located in the late flooded zone. The analysis also indicated that this practical method can be applied for other purposes such as to monitor vulnerability, evaluate development programs or policy effectiveness by incorporating with scenario comparison.

关键词： An Giang province Mekong Delta livelihood vulnerability index flood and climate variability.