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Programmed death 1 (PD-1) and ligand (PD-L1) inhibitors in head and neck squamous cell carcinoma: A meta-analysis

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2022年第3期8卷 177-186页

作者： Dylan A.Levy Jaimin J.Patel Shaun A.Nguyen W.Nicholas Jungbauer David m.Neskey Ezra E.W.Cohen chrystal m.paulos John A.Kaczmar Hannah m.Knochelmann Terry A.Day Department of Otolaryngology-Head and Neck Surgery Medical University of South CarolinaCharlestonSouth CarolinaUSA Department of Cell and molecular Pharmacology and Developmental Therapeutics Medical University of South CarolinaCharlestonSouth CarolinaUSA Department of medicine Division of Hematology-OncologyUniversity of CaliforniaSan DiegoLa JollaCaliforniaUSA Department of microbiology and Immunology Medical University of South CarolinaCharlestonSouth CarolinaUSA SDepartment of Dermatology and Dermatologic Surgery Medical University of South CarolinaCharlestonSouth CarolinaUSA Division of Hematology&Oncology Medical University of South CarolinaCharlestonSouth CarolinaUsA

Background: PD-1 and PD-L1 inhibitors have emerged as promising treatments for patients with head and neck squamous cell carcinoma (HNSCC).methods: Systematic review and meta-analysis of PD-1 and PD-L1 inhibitors in HNSCC. Outcomes: median overall survival (mOS), median progression-free survival (mPFS), Response Evaluation Criteria in Solid Tumors (RECIST) and treatment-related adverse events (TRAEs).Results: Eleven trials reported data on 1088 patients (mean age: 59.9 years, range: 18-90). The total mOS was 7.97 months (range: 6.0-16.5). mean mPFS for all studies was 2.84 months (range: 1.9-6.5). PD-1 inhibitors had a lower rate of RECIST Progressive Disease than PD-L1 inhibitors (42.61%, 95% confidence interval [CI]: 36.29-49.06 vs. 56.79%, 95% CI: 49.18-64.19,P meta-analysis shows the efficacy of PD-1 and PD-L1 inhibitors in HNSCC and suggests a possible difference in certain RECIST criterion between PD-1 and PD-L1 inhibitors. Future work to investigate the clinical significance of these findings is warranted.

关键词： antibodies disease progression head and neck neoplasms humanized meta-analysis monoclonal squamous cell carcinoma of the neck

Effect of age on the standardized ileal amino acid digestibility of soybean meal and canola meal in broilers

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Animal Nutrition 2024年第1期16卷 11-22页

作者： mukti Barua m.Reza Abdollahi Faegheh Zaefarian Timothy J.Wester Channarayapatna K.Girish Peter V.chrystal Velmurugu Ravindran monogastric Research Center School of Agriculture and EnvironmentMassey UniversityPalmerston North 4442New Zealand Department of Animal Science and Nutrition Faculty of Veterinary MedicineChattogram Veterinary and Animal Sciences UniversityKhulshiChattogram 4225Bangladesh Nutrition and Care Animal NutritionEvonik(SEA)Pte.Ltd609927 Singapore Complete Feed Solutions Howick 2145AucklandNew Zealand

Standardized ileal digestibility coefficients(SIDC)of nitrogen(N)and amino acids(AA)in two protein sources(soybean meal[SBm]and canola meal[Cm])were investigated at six broiler ages(d 7,14,21,28,35,and 42).Two assay diets were formulated to contain either SBm(413 g/kg)or Cm(553 g/kg)as the sole dietary AA *** dioxide(5 g/kg)was added as an indigestible marker.A total of 696 male broilers at 1 d old were allotted to 12 replicate cages per age *** assay diet was offered to birds for 4 d prior to the ileal digesta collection on d 7(14 birds/cage),14(12 birds/cage),21(10 birds/cage),28(8 birds/cage),35(8 birds/cage)and 42(6 birds/cage),*** apparent digestibility coefficients were standardized using age-specific basal endogenous AA *** the SBm group,though the SIDC of N tended to be influenced(quadratic;P=0.075)by age,no linear or quadratic response of age effect was observed on the average SIDC of indispensable(IAA)and total AA(TAA).An age effect(quadratic;Pm with the highest value recorded at d 7,followed by a decrease from d 14 to 28,which increased beyond d *** SIDC of some individual AA(Arg,Thr,Trp,Cys,Pro)were affected(Pmanner by *** the Cm,the SIDC of N,average SIDC of IAA,DAA and TAA were influenced(quadratic;Pm d 7 to 14,declined at d 21,and then increased beyond d *** average SIDC of IAA was low between d 7 and 28 and increased *** SIDC of individual AA were affected(linear or quadratic;Pmagnitudes by *** age influence on the SIDC AA was variable,depending on the protein source and *** results demonstrate that age-specific SIDC AA data might need consideration in broiler feed formulations.

关键词： Age Amino acid Broiler Digestibility Protein source

Capping dietary starch:protein ratios in moderately reduced crude protein,wheat-based diets showed promise but further reductions generated inferior growth performance in broiler chickens

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Animal Nutrition 2020年第2期6卷 168-178页

作者： Shiva Greenhalgh Bernard V.mcInerney Leon R.mcQuade Peter V.chrystal Ali Khoddami molly A.m.Zhuang Sonia Y.Liu Peter H.Selle Poultry Research Foundation The University of SydneyCamdenNSWAustralia Australian Proteome Analysis Facility Macquarie UniversitySydneyNSWAustralia Baiada Poultry Pty Limited Pendle HillNSWAustralia School of Life and Environmental Sciences Faculty of ScienceThe University of SydneySydneyNSWAustralia

The hypothesis that capping dietary starch:protein ratios would enhance the performance of broiler chickens offered reduced-crude protein(CP)diets was tested in this experiment.A total of 432 off-sex,male Ross 308 chicks were allocated to 7 dietary treatments from 7 to 35 d *** experimental design consisted of a 3×2 factorial array of treatments with the seventh treatment serving as a positive *** levels of dietary CP(197.5,180.0 and 162.5 g/kg)with either uncapped or capped dietary starch:protein ratios constituted the factorial array of treatments,whilst the positive control diet contained 215.0 g/kg *** positive control diet had an analysed dietary starch:protein ratio of 1.50 as opposed to a ratio of 1.68 in the uncapped 197.5 g/kg CP diet and 1.41 in the corresponding capped diet and the capped 197.5 g/kg CP diet displayed *** growth performance this diet matched the positive control but outperformed the uncapped 197.5 g/kg CP diet by 10.4%(2,161 vs.1,958 g/bird;P=0.009)in weight gain,by 3.10%(3,492 vs.3,387 g/bird;P=0.019)in feed intake on the basis of pairwise comparisons and numerically improved FCR by 4.04%(1.616 vs.12684).However,the growth performance of birds offered the 180.0 and 162.5 g/kg CP dietary treatments was remarkably inferior,irrespective of dietary starch:protein *** inferior growth performance was associated with poor feathering and even feather-pecking and significant linear relationships between feather scores and parameters of growth performance were *** amino acid profile of feathers was determined where cysteine,glutamic acid,glycine,proline and serine were dominant in a crude protein content of 931 g/***,the feathering issues observed were manifestations of amino acid inadequacies or imbalances in the more reduced-CP diets and consideration is given to the implications of these outcomes.

关键词： Amino acid Broiler chicken Crude protein Feathering Starch:protein ratio Wheat

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产蛋母鸡氨基酸需要量

国外畜牧学（猪与禽） 2024年第4期44卷 1-6,7-14,15-18页

作者：冯占雨(译) 张配配(校) macelline S P Toghyani m chrystal P V 不详

本综述的主要目的是整合已发表的有关产蛋母鸡氨基酸需要量的数据,并根据这些数据提出一套新的推荐标准。自1994年以来,产蛋母鸡对赖氨酸、含硫氨基酸、苏氨酸、色氨酸、支链氨基酸和精氨酸需要量的推荐值不尽一致。本综述还发现,试验... 详细信息

本综述的主要目的是整合已发表的有关产蛋母鸡氨基酸需要量的数据,并根据这些数据提出一套新的推荐标准。自1994年以来,产蛋母鸡对赖氨酸、含硫氨基酸、苏氨酸、色氨酸、支链氨基酸和精氨酸需要量的推荐值不尽一致。本综述还发现,试验所用产蛋母鸡的品种、年龄、基础日粮组成和评估方法会影响产蛋母鸡氨基酸需要量的推荐值。目前,由于对可持续生产的需求,产蛋母鸡低粗蛋白(crude protein,CP)日粮的开发正受到越来越多的关注。这涉及到日粮成分的彻底改变,包括非结合氨基酸(nonbound amino acid)、必需氨基酸和非必需氨基酸。在产蛋母鸡日粮中添加更多的非结合氨基酸,会改变蛋白质的消化动力学,并可能会影响产蛋母鸡对氨基酸的需要量。本综述讨论了目前对产蛋母鸡氨基酸需要量的推荐值,并提出了一些未来可更好地满足蛋鸡业需求的改进方案。

关键词：氨基酸需要量产蛋母鸡非结合氨基酸蛋白质消化动力学