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Kidney disease in patients with chronic liver disease:Does sex matter?

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World Journal of Clinical Cases 2023年第17期11卷 3980-3992页

作者： Katherine M cooper Alessandro Colletta Kristen Moulton Kenneth M Ralto Deepika Devuni Department of Medicine UMass Chan Medical SchoolWorcesterMA 01665United States Department of Medicine Division of GastroenterologyUMass Chan Medical SchoolWorcesterMA 01665United States Department of Medicine Division of Renal MedicineUMass Chan Medical SchoolWorcesterMA 01665United States

Kidney disease in patients with liver disease is serious and increases *** to 50%of patients hospitalized experience an episode of acute kidney *** general,men with liver disease are thought to be at increased risk of kidney ***,this association should be considered with caution because most studies use creatinine-based inclusion criteria,which is negatively biased against *** this review,we synthesize data on sex differences in kidney disease in patients with chronic liver disease in the clinical setting and discuss potential physiologic underpinnings.

关键词： Sex differences Renal disease Gender disparity Hepatorenal syndrome Renal replacement therapy

Effects of historically familiar and novel predator odors on the physiology of an introduced prey

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Current Zoology 2016年第1期62卷 53-59页

作者： Valentina S. A. MELLA Christine E. cooper Stephen J. J. F. DAVIES Department of Environment and Agriculture Curtin University Perth WA 6845 Australia

Predator odors can elicit fear responses in prey and predator odor recognition is generally associated with physiological responses. Prey species are often more likely to respond to the odor of familiar ra- ther than alien predators. However, predator na＇ivety in an introduced prey species has rarely been investigated. We examined the physiological response, as shown by changes in ventilatory vari- ables, of an introduced terrestrial herbivore, the European rabbit Oryctolagus cuniculus, in Australia, to the odor of potential predators and to control odors （distilled water and horse）, to explore if res- ponses were limited to historical （cat and fox） predators, or extended to historically novel predators （snake and quoll）. All odors except distilled water elicited a response, with rabbits showing long- term higher respiratory frequencies and lower tidal volumes after introduction of the odors, indi- cating an increase in alertness. However, the intensity of the rabbits＇ reaction could not be directly linked to any pattern of response with respect to the history of predator-prey relationships. Rabbits exhibited significantly stronger reactions in response to both cat and quoll odors than they did to dis- tilled water, but responses to horse, fox, and snake odor were similar to that of water. Our results show that the introduced rabbit can respond to both historical and novel predators in Australia, and suggest that shared evolutionary history is not necessarily a prerequisite to predator odor recognition.

关键词： physiology ventilation predator odor rabbit introduced prey predator naivety.

Stony Brook’s High-Pressure Laboratory Collaborations with French Scientists

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International Journal of Geosciences 2021年第3期12卷 195-212页

作者： Robert cooper Liebermann Mineral Physics Institute and Department of Geosciences Stony Brook University Stony Brook NY USA

For more than a half century, my colleagues and I in the Stony Brook High Pressure Laboratory have profited from collaborations with French scientists in their laboratories in Orsay, Paris, Toulouse, Lille, Lyon, Strasbourg and Rennes. These interactions have included postdoctoral appointments of French colleagues in our laboratory as well as two année sabbatique by me;in 1983-84, in the Laboratoire de Géophysique et Géodynamique Interne at the Université Paris XI in Orsay and in 2020-2003 in the Laboratoire des Méchanismes et Transfert en Géologie at the Université Paul Sabatier in Toulouse. The objective of this report is to relate this history and to illustrate the scientific advances which resulted from these collaborations.

关键词： Mineral Physics High Pressure High Temperature Multi-Anvil Apparatus Atomic Diffusion Mineral Deformation U.S.-France Collaboration Activation Volume for Creep Ultrasonic Interferometry Synchrotron X-Radiation

My Research Collaborations with Chinese Scientists over the Past Three Decades

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International Journal of Geosciences 2021年第10期12卷 960-983页

作者： Robert cooper Liebermann Mineral Physics Institute and Department of Geosciences Stony Brook University Stony Brook NY USA

For more than three decades, I have been fortunate in working with Chinese graduate students and postdoctoral research scientists in our High-Pressure Laboratory at Stony Brook University. These colleagues have conducted a wide variety of experiments at high pressures and temperatures in collaboration with our other students and researchers. These studies utilized transmission electron microscopy, ultrasonic interferometry, X-ray powder diffraction and synchrotron X-radiation to investigate phase transitions, thermal equations of state, sound velocities, atomic diffusion, dislocation dissociation and deviatoric stress in high-pressure apparatus. During this period, I have also visited high-pressure laboratories in the mainland of China and Taiwan on several occasions. The objective of this paper is to relate this history.

关键词： Mineral Physics High Pressure High Temperature Anisotropy and Lateral Heterogeneity of the Earth’s Mantle

My Research Connections with Russian Scientists over the Past Half Century

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International Journal of Geosciences 2022年第3期13卷 155-173页

作者： Robert cooper Liebermann Mineral Physics Institute and Department of Geosciences Stony Brook University Stony Brook NY USA

Over the past half century, I have maintained research connections with Russian scientists during investigations in seismology and mineral physics. These studies have focused on detection and discrimination of underground nuclear explosions and measurements of the physical properties of minerals at high pressures and temperatures. During this period, I have also visited many research laboratories in Russia, including Moscow, Chernogolovka, Novosibirsk and St. Petersburg. The objective of this paper is to relate this history.

关键词： Mineral Physics High Pressure High Temperature Seismology Underground Nuclear Explosions

My Research Connections with English Scientists over the Past Six Decades

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International Journal of Geosciences 2022年第3期13卷 259-267页

作者： Robert cooper Liebermann Mineral Physics Institute and Department of Geosciences Stony Brook University Stony Brook NY USA

Over the past six decades, I have maintained research connections with English scientists while pursuing an academic career focusing on scientific discoveries of the physical properties of minerals at high pressures and temperatures. During this period, I have also visited many research laboratories in England, including University of Cambridge, University College London, University of Oxford and the Atomic Weapons Research Establishment [AWRE] in Aldermaston, England. The objective of this paper is to relate this history.

关键词： Mineral Physics High Pressure High Temperature Synchrotron X-Radiation Facilities

Reminiscences of Days as an Undergraduate at Caltech in the 1960s: Geology, Student Body Politics and Intercollegiate Football

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International Journal of Geosciences 2021年第8期12卷 653-666页

作者： Robert cooper Liebermann Mineral Physics Institute and Department of Geosciences Stony Brook University Stony Brook NY USA

From 1960 to 1964, I was an undergraduate student at the California Institute of Technology [Caltech] in Pasadena, California. During these years, I spent much of my time indulging in student body politics and playing intercollegiate football. However, with the encouragement of a number of faculty in the Division of Geological Sciences [not yet GPS], I saw the light and became a geology major [strictly speaking, geophysics]. This paper is an expansion of a talk I presented at the 90th Anniversary of the Division of Geological and Planetary Sciences in 2017.

关键词： Undergraduate Geology Student Body Politics Intercollegiate Football

Innovative approaches to genome editing in avian species

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Journal of Animal Science and Biotechnology 2018年第2期9卷 278-284页

作者： Caitlin A.cooper Timothy J.Doran Arjun Challagulla Mark L.V.Tizard Kristie A.Jenkins CSIRO Health and Biosecurity Australian Animal Health Laboratory

The tools available for genome engineering have significantly improved over the last 5 years, allowing scientist to make precise edits to the genome. Along with the development of these new genome editing tools has come advancements in technologies used to deliver them. In mammals genome engineering tools are typically delivered into in vitro fertilized single cell embryos which are subsequently cultured and then implanted into a recipient *** avian species this is not possible, so other methods have been developed for genome engineering in birds. The most common involves in vitro culturing of primordial germ cells(PGCs), which are cells that migrate through the embryonic circulatory system to the developing gonad and colonize the gonad, eventually differentiating into the gonadocytes which produce either sperm or ova. While in culture the PGCs can be modified to carry novel transgenes or gene edits, the population can be screened and enriched, and then transferred into a recipient embryo. The largest drawback of PGC culture is that culture methods do not transfer well across avian species, thus there are reliable culture methods for only a few species including the chicken. Two newer technologies that appear to be more easily adapted in a wider range of avian species are direct injection and sperm transfection assisted gene editing(STAGE).The direct injection method involves injecting genome engineering tools into the circulatory system of the developing embryo just prior to the developmental time point when the PGCs are migrating to the gonads. The genome engineering tools are complexed with transfection reagents, allowing for in vivo transfection of the PGCs. STAGE utilizes sperm transfection to deliver genome engineering tools directly to the newly fertilized embryo. Preliminary evidence indicates that both methodologies have the potential to be adapted for use in birds species other than the chicken, however further work is needed in this area.

关键词： Avian CRISPR Genome engineering PGCs Sperm TALEN

Stony Brook’s Collaborations with Czech Scientists

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International Journal of Geosciences 2021年第5期12卷 487-498页

作者： Robert cooper Liebermann Mineral Physics Institute and Department of Geosciences Stony Brook University NY USA

For the past half-century, I have been fortunate in maintaining collaborations with Czech scientists in the Czech Republic [formerly Czechoslovakia] from the Geofyzikální ústav-GFU [Institute of Geophysics] of the ?eskoslovenská Akademie Věd-?SAV [Czechoslovak Academy of Sciences]. These collaborations have included exchange visits by me to Prague [Praha] and convening international workshops in 1976, 1986 and 1996 in castles used by the ?SAV as well as visits by Czech colleagues to Stony Brook University. The objective of this report is to relate this history. This paper is dedicated to the memory of Vladislav Babu?ka.

关键词： Mineral Physics High Pressure High Temperature Anisotropy and Lateral Heterogeneity of the Earth’s Mantle