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The Representation of Soil Moisture−Atmosphere Feedbacks across the Tibetan Plateau in CMIP6

Advances in Atmospheric Sciences 2023年第11期40卷 2063-2081页

作者： Joshua TALIB Omar V.MÜLLER Emma J.BARTON christopher M.taylor Pier Luigi VIDALE U.K.Centre of Ecology and Hydrology WallingfordOX108BBU.K. National Centre for Atmospheric Science ReadingRG66BBU.K. Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET) Centro de Estudios de Variabilidad y Cambio Climático(CEVARCAM)Facultad de Ingeniería y Ciencias HídricasUniversidad Nacional del LitoralSanta FeArgentina National Centre for Earth Observation WallingfordOX108BBU.K. Department of Meteorology University of ReadingReadingRG66BBU.K.

Thermal processes on the Tibetan Plateau(TP)influence atmospheric conditions on regional and global *** this,previous work has shown that soil moisture−driven surface flux variations feed back onto the *** soil moisture is a source of atmospheric predictability,no study has evaluated soil moisture−atmosphere coupling on the TP in general circulation models(GCMs).In this study,we use several analysis techniques to assess soil moisture−atmosphere coupling in CMIP6 simulations including:instantaneous coupling indices;analysis of flux and atmospheric behaviour during dry spells;and a quantification of the preference for convection over drier *** these metrics we partition feedbacks into their atmospheric and terrestrial *** with previous global studies,we conclude substantial inter-model differences in the representation of soil moisture−atmosphere coupling,and that most models underestimate such *** on dry spell analysis,most models underestimate increased sensible heat during periods of rainfall *** example,the model-mean bias in anomalous sensible heat flux is 10 W m−2(≈25%)smaller compared to *** dry-spell sensible heat fluxes lead to a weaker atmospheric *** also find that most GCMs fail to capture the negative feedback between soil moisture and deep *** poor simulation of feedbacks in CMIP6 experiments suggests that forecast models also struggle to exploit soil moisture−driven *** improve the representation of land−atmosphere feedbacks requires developments in not only atmospheric modelling,but also surface processes,as we find weak relationships between rainfall biases and coupling indexes.

关键词： model evaluation land-atmosphere feedbacks Tibetan Plateau precipitation surface energy balance

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Feasibility of confocal endomicroscopy in the diagnosis of pediatric gastrointestinal disorders

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World Journal of Gastroenterology 2009年第18期15卷 2214-2219页

作者： Krishnappa Venkatesh Marta Cohen Clair Evans Peter Delaney Steven Thomas christopher taylor Ashraf Abou-Taleb Ralf Kiesslich Mike Thomson Centre for Pediatric Gastroenterology Sheffield Children's NHS Foundation TrustSheffieldS10 2THUnited Kingdom Department of Histopathology Sheffield Children's NHS Foundation TrustSheffieldS10 2THUnited Kingdom Optiscan PO Box 1066Mt WaverleyMDCVictoriaAustralia 3149Australia I.Med.Klink und Poliklinik Johannes Gutenberg University of MainzMainz 55131Germany

AIM： To evaluate the feasibility and utility of confocal laser endomicroscopy （CLE） in the description of normal gastrointestinal （GI） mucosa and in the diagnosis of GI disorders in children, in comparison to ***： Forty-four patients （19 female） median age 10.9 years （range 0.7-16.6 years） with suspected or known GI pathology underwent esophago-gastro- duodenoscopy （OGD）（n = 36） and/or ileocolonoscopy （IC）（n = 31） with CLE using sodium fluorescein and acriflavine as contrast agents. Histological sections were compared with same site confocal images by two experienced pediatric and GI histopathologists and endoscopists, ***： Duodenum and ileum were intubated in all but one patient undergoing OGD and IC. The median procedure time was 16.4 min （range 7-25 rain） for OGD and 27.9 min （range 15-45 min） for IC. A total of 4798 confocal images were compared with 153 biopsies from the upper GI tract from 36 procedures, and 4661 confocal images were compared with 188 biopsies from the ileocolon from 31 *** images were comparable to conventional histology both in normal and in pathological conditions such as esophagitis, Helicobacter pylori gastritis, celiac disease, inflammatory bowel disease, colonic heterotopia, and graft versus host ***： CLE offers the prospect of targeting biopsies to abnormal mucosa, thereby increasing diagnostic yield, reducing the number of biopsies, decreasing the burden on the histopathological services, and reducing costs.

关键词： Confocal laser endomicroscopy Histology Pediatric Gastrointestinal mucosa Gastrointestinaldisorders

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Atomistic Simulations of Formation of Elementary Zr-I Systems

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Open Journal of Physical Chemistry 2011年第3期1卷 104-108页

作者： Matthew L. Rossi christopher D. taylor 不详

We report results of simulations on the formation of simple zirconium iodide molecules. Previous work by Wimmer et al. [1] explored the relationship between iodine and a zirconium surface. We investigate the reaction schemes through atomistic simulations to better understand the nature of Zr-I interactions through isolated molecules. The computed energy values of varying Zr-I systems suggests a strong binding mechanism between zirconium and iodine, and offer predictions of likely reaction products. The computed results predict condensation of volatile ZrI4 with ZrI2 to form

关键词： Nuclear Chemistry Quantum Chemistry Computational Modelling

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持续工艺验证,生物工艺管理的重要环节

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流程工业 2023年第2期 28-30页

作者： christopher taylor 柯尔柏医药软件有限公司

生物制品的生产过程会随着时间而变化,过程会不断改进,需要企业不断进行回顾——因此监管机构希望企业长期关注如何能确保生产工艺持续始终保持如最初验证过的一样。美国食品药品监督管理局(FDA)对此建议企业开展持续工艺验证(CPV,Conti... 详细信息

生物制品的生产过程会随着时间而变化,过程会不断改进,需要企业不断进行回顾——因此监管机构希望企业长期关注如何能确保生产工艺持续始终保持如最初验证过的一样。美国食品药品监督管理局(FDA)对此建议企业开展持续工艺验证(CPV,Continued Process Verification)。

关键词：生物工艺工艺验证生物制品 CPV 监管机构生产工艺重要环节

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In situ nanoscale mapping of electrical and catalytic properties

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National Science Review 2024年第7期11卷 65-66页

作者： christopher S.Kley Helmholtz Young Investigator Group Nanoscale Operando CO2 Photo-Electrocatalysis Helmholtz-Zentrum Berlin für Materialien und Energie GmbH Department of Interface Science Fritz Haber Institute of the Max Planck Society

By enabling the conversion of sustainably-derived electrical energy into chemical energy, electrocatalytic reactions are vital for closing the anthropogenic carbon cycle. A wide array of electrocatalytic reactions have gained extensive attention, including hydrogen evolution（HER）, oxygen evolution（OER）, and CO2electroreduction（CO2RR）.

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IgE-Mast cell mediated allergy: a sensor of food quality

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Signal Transduction and Targeted Therapy 2024年第1期9卷 8-9页

作者： christopher C.Udoye Rudolf A.Manz Institute for Systemic Inflammation Research University of LübeckLübeckGermany

In two recent studies published in Nature,Florsheim et *** Plum et *** that allergic-specific reactions induced by immunoglobulin(Ig)E mediated mast cell activation is crucial for the timely induction of antigen-avoidance behaviour.1,2 These studies prove the concept that allergic sensitization triggers the formation of avoidance behaviour and define the underlying molecular mechanism.

关键词： allergic mechanism

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Tocotrienol isoforms:The molecular mechanisms underlying their effects in cancer therapy and their implementation in clinical trials

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Journal of Integrative Medicine 2024年第1期22卷 1-11页

作者： Maria Younes Ghady Loubnane christopher Sleiman Sandra Rizk Department of Natural Sciences Lebanese American UniversityByblosLebanon

Tocotrienols are found in a variety of natural sources,like rice bran,annatto seeds and palm oil,and have been shown to have several health-promoting properties,particularly against chronic diseases such as *** incidence of cancer is rapidly increasing around the world,not only a result of continued aging and population growth,but also due to the adoption of aspects of the Western lifestyle,such as high-fat diets and low-physical *** literature provides strong evidence that tocotrienols are able to inhibit the growth of various cancers,including breast,lung,ovarian,prostate,liver,brain,colon,myeloma and pancreatic *** findings,along with the reported safety profile of tocotrienols in healthy human volunteers,encourage further research into these compounds’potential use in cancer prevention and *** current review provided detailed information about the molecular mechanisms of action of different tocotrienol isoforms in various cancer models and evaluated the potential therapeutic effects of different vitamin E analogues on important cancer hallmarks,such as cellular proliferation,apoptosis,angiogenesis and ***/PubMed and Scopus databases were used to identify recently published articles that investigated the anticancer effects of vitamin E derivatives in various types of cancer in vitro and in vivo along with clinical evidence of adjuvant chemopreventive *** an overview of pre-clinical studies,we describe several completed and ongoing clinical trials that are paving the way for the successful implementation of tocotrienols in cancer chemotherapy.

关键词： Vitamin E Tocotrienols Cancer Molecular mechanism Clinical trials

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Application of supervised machine learning to predict the enhanced gas recovery by CO_(2) injection in shale gas reservoirs

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Petroleum 2024年第1期10卷 124-134页

作者： Moataz Mansi Mohamed Almobarak Jamiu Ekundayo christopher Lagat Quan Xie Discipline of Petroleum Engineering WA School of Mines:MineralsEnergy and Chemical EngineeringCurtin UniversityWestern AustraliaAustralia

The technique of Enhanced Gas Recovery by CO_(2) injection(CO_(2)-EGR)into shale reservoirs has brought increasing attention in the recent ***_(2)-EGR is a complex geophysical process that is controlled by several parameters of shale properties and engineering ***,more challenges arise when simulating and predicting CO_(2)/CH4 displacement within the complex pore systems of ***,the petroleum industry is in need of developing a cost-effective tool/approach to evaluate the potential of applying CO_(2) injection to shale *** recent years,machine learning applications have gained enormous interest due to their high-speed performance in handling complex data and efficiently solving practical ***,this work proposes a solution by developing a supervised machine learning(ML)based model to preliminary evaluate CO_(2)-EGR *** used for this work was drawn across a wide range of simulation sensitivity studies and experimental *** this work,linear regression and artificial neural networks(ANNs)implementations were considered for predicting the incremental enhanced *** on the model performance in training and validation sets,our accuracy comparison showed that(ANNs)algorithms gave 15%higher accuracy in predicting the enhanced CH4 compared to the linear regression *** ensure the model is more generalizable,the size of hidden layers of ANNs was adjusted to improve the generalization ability of ANNs *** ANNs models presented,ANNs of 100 hidden layer size gave the best predictive performance with the coefficient of determination(R2)of 0.78 compared to the linear regression model with R2 of *** developed MLbased model presents a powerful,reliable and cost-effective tool which can accurately predict the incremental enhanced CH4 by CO_(2) injection in shale gas reservoirs.

关键词： Artificial intelligence Supervised Machine Learning Shale Gas Enhanced Shale Gas Recovery CO_(2)Injection CO_(2)sequestration

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The semiotics of humor in cultural trauma:a pilot study on digital methodology concerning the evolution and overcoming of trauma through humor on the example of Rick and Morty

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Language and Semiotic Studies 2024年第2期10卷 203-221页

作者： Felix Poschinger christopher Shannon University of Hamburg Hamburg20148Germany Independent TokyoJapan

This pilot study on humor in cultural trauma uses innovative digital methodologies in speech recognition and social media analysis via Postman and Python in the Twitter API v2 to propose different forms to gather and analyze empirical data on semiotics and humor to be used in a broader *** given example of humorous instances on the cultural trauma of 9/11 in the fictional sitcom Rick and Morty is limited but corroborated by a second example that is structurally different from the first:humor about 9/11 in stand-up comedy by Louis *** on the data,humor in trauma seems to undergo a 5-phase-typology related to the Kübler-Ross model of grief,which is mended by the(digital)participation of ***,we argue,both shapes the discourse on humor in trauma and overcomes the traumatic effects through humorous discourse.

关键词： cultural trauma humor theory Kübler-Ross model collective memory

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Comparison of ERA5 turbulent fluxes at the air-sea interface with measurements from a wave-following platform

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Atmospheric and Oceanic Science Letters 2024年第3期17卷 32-36页

作者： Said Benjeddou Denis Bourras christopher Luneau Aix Marseille Universite National Center for Scientific ResearchMediterranean Institute of OceanographyMarseilleFrance Observatory of the Sciences of the Universe Pytheas Institute National Center for Scientific ResearchMarseilleFrance

Turbulent fluxes at the air-sea interface were estimated with data collected in 2011-2020 with a low-profile platform named OCARINA during eight experiments in five regions:2011,2015,and 2016 in the Iroise Sea;2012 in the tropical Atlantic;2014 in the Chilie-Peru upwelling;2017 and 2018 in the Mediterranean Sea,and 2018 and 2020 in *** observations were carried out with moderate winds(2-10 m s^(-1))and average wave heights of 1.5 *** this study,the authors used the fluxes calculated by the bulk method using OCARINA-sampled data as the *** data can validate the fluxes estimated from ERAS reanalysis *** OCARINA and ERA5 data were taken *** do this,the authors established an algorithm to extract the OCARINA data as closely as possible to the reanalysis data in time and *** measurements of the OCARINA platform can conclude on the relevance of the widely used reanalysis data.

关键词： Ocarina ECMWF ERA5 Turbulent fluxes Louis formulation

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