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第36届中国控制会议

作者： Yiyang Chen Bing Chu christopher t.freeman Electronics and Computer Science University of Southampton

ISBN: (纸本)9781538629185

Iterative learning control(ILC) is a high performance control technique for systems operating in a repetitive manner.A novel design methodology is developed in this paper to incorporate optimal tracking time allocation within the point-topoint ILC framework for discrete time systems. this leads to significant performance improvements compared to fixed time points(e.g. energy reduction). An optimization problem is formulated based on the point-to-point tracking requirement and the via-point temporal constraints. A two stage design framework is proposed to solve this problem, yielding an algorithm based on norm optimal ILC and the coordinate descent method, which automatically minimizes control effort while maintaining high performance tracking. the proposed algorithm is implemented on a gantry robot experimental test platform, with results verifying its practical effectiveness in the presence of model uncertainty.

关键词： iterative learning control optimization coordinate descent method

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Rapid, Semi-Automated Fractionation of Freshwater Dissolved Organic Carbon Using DAX 8 (XAD 8) and XAD 4 Resins in tandem

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Natural Science 2016年第11期8卷 487-498页

作者： David D. Hughes Peter J. Holliman timothy Jones Alexander J. Butler christopher freeman Wolfson Carbon Capture Laboratory Bangor University Wales UK

Natural dissolved organic carbon (DOC) consists of different bio-molecular classes of compounds that are currently very difficult and time-consuming to isolate as individual compounds. However, it is possible to separate natural DOC into hydrophobic and hydrophilic fractions. Such characterisation approaches are becoming increasingly important because, over the past 20 years natural DOC concentrations have been rising rapidly in many parts of the world, most likely influenced by climate change. Higher DOC concentrations in drinking water catchments present a serious problem for the water industry because DOC can form disinfection by-products DBPs during water treatment (e.g. chlorination). Hence, there is an urgent need to better characterise natural DOC before, during and after water treatment. However, current DOC fractionation procedures are extremely laborious requiring days and continual manual monitoring to separate sufficient quantities of DOC for subsequent analysis. this seriously limits sample throughput and the parameter space which can be studied. In this paper, we propose a much more rapid semi-automated method (12.5 hours/litre/sample) which utilises readily available equipment, i.e., HPLC pump or similar and sequential columns of Amberlite DAX 8 and XAD 4 resins. the method reduces the manual input from continual attention to minutes. this paper describes the development of the method and its application in the fractionation of natural DOC from reservoir and lake samples fed from upland peat-land catchments. Recoveries are found to be comparable to those using the manual technique, with the dominant component being hydrophobic acid accounting for 35% - 40% of the natural DOC with the second largest, being hydrophilic acid at 20% - 27%.

关键词： Dissolved Organic Carbon Hydrophilic Compounds Hydrophobic Compounds Fulvic Acids Humic Acids Resins

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急性早幼粒细胞白血病中复杂三元易位的细胞遗传学和分子特点(英文)

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北京大学学报（医学版） 2009年第4期41卷 477-479页

作者： christopher E. freeman Danielle D. MERCER Yi YE John VAN BRUNt Ⅲ Marilyn M. LI Human Genetics Program Hayward Genetics Center Tulane University Health Sciences Center 1430 Tulane Avenue New Orleans LA Department of Pediatrics tulane University Health Sciences Center 1430 Tulane Avenue New Orleans LA tulane Cancer Center Tulane University Health Sciences Center 1430 Tulane Avenue New Orleans LA

the most frequent chromosomal rearrangement reported in acute promyelocytic leukemia (APL) is t(15;17)(q22;q21). the t(15;17) generates the PML/RARA fusion gene that blocks the transcription of genes involved in myeloid cell differentiation. A small number of simple and complex variants of the classical t(15;17) have been reported. We report two complex three-way translocation variants,t(3;17;15)(q27;q21;q22) and t(8;17;15)(q24.3;q12;q22) in which the PML/RARA fusion gene has been created on the derivative 15 chromosomes. Many of these variant translocations are suspected by conventional cytogenetics but need to be confirmed with additional molecular testing. We discuss the importance of supplementing conventional cytogenetic testing with FISH and Rt-PCR to accurately diagnose APL variant patients.

关键词：白血病,早幼粒细胞,急性易位,遗传细胞遗传学

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English and Black Walnut Phenolic Antioxidant Activity <i>in Vitro</i>and Following Human Nut Consumption

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Food and Nutrition Sciences 2011年第3期2卷 193-200页

作者： Jacki M Rorabaugh Ajay P Singh Isabel M Sherrell Michelle R freeman Nicholi Vorsa Peter Fitschen christopher Malone Margaret A Maher ted Wilson 不详

Background: Walnut consumption may reduce the risk of cardiovascular disease by providing antioxidant protection to low density lipoproteins (LDL). Aim: this study compared the phenolic profile and antioxidant activity of English ver- sus black walnuts. Methods: Nuts were extracted in methanol or acetone prior to analysis with HPLC/LC-MS-MS for phenolic identification and quantitation. the ability to prevent oxidation of LDL was examined in vitro using walnut extracts and ex vivo after walnut consumption for 28 days. Results: Flavonoids identified/quantified with HPLC/LC- MS-MS included the phenolic acids 5-caffeoylquinic acid, 3-caffeoylquinic acid (black walnut only), 4-caffeoylquinic acid, and the flavonol glycosides quercetin-3-rutinoside, quercetin-3-galactoside, quercetin-3-pentoside, quercetin-3- arabinoside, quercetin-3-rhamnoside, and the aglycone quercetin (English walnut only). total phenolic yield of acetone extracts were 166.1 and 24.2 μg/g for English and black walnut respectively, and yield for methanol extracts were 147.6 and 4.1 μg/g for English and black walnut respectively. In vitro LDL oxidation by Cu++ with English walnut ex- tracts significantly extended oxidation lag-time (A234) in a dose dependent manner at 1.0 and 0.1 μg/ml and reduced tBARS formation (1.0 μg/ml). Black walnut extracts reduced tBARS significantly but had no effect on A234. Human consumption of English or black walnuts (30 g nuts/day) for 28 days resulted in no differences in LDL antioxidant ca- pacity (A234) between groups or within groups. Conclusion: this study suggests that the English walnuts have a pheno- lic profile and in vitro antioxidant capacity that is better than black walnuts, but that walnut consumption for 28 days does not improve LDL resistance to oxidation.

关键词： Walnut Lipoprotein Oxidation Antioxidant Phenolic Flavonol

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2007年ACC／AHA非心脏手术围手术期心血管评估与管理指南：实施概要

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麻醉与镇痛 2010年第6期6卷 1-28页

作者： Lee A Fleisher Joshua A Beckman Kenneth A Brown Hugh Calkins Elliott Chaikof Kirsten E Fleischmann William K freeman James B Froehlich Edward K Kasper Judy R Kersten Barbara Riegel John F Robb Sidney C Smith Alice K Jacobs Cynthia D Adams Jeffrey L Anderson Elliott M Antman christopher E Buller Mark A Creager Steven M Ettinger David P Faxon Valentin Fuster Jonathan L Halperin Loren F Hiratzka Sharon A Hunt Bruce W Lytle Rick Nishimura Joseph P Ornato Richard L Page Lynn G tarkington Clyde W Yancy

美国心脏病学院镁国心脏协会工作组有关实践指南的一份报告（编写委员会对2002年非心脏手术围手术期心血管评估指南的修改）

关键词：非心脏手术管理指南血管评估围手术期 ACC/AHA 美国心脏病学院实践指南心脏协会

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