检索结果-南通市图书馆

Apples to oranges:environmentally derived,dynamic regulation of serotonin neuron subpopulations in adulthood?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第9期20卷 2596-2597页

作者： christopher J.O’Connell Matthew J.Robson Department of Genetics College of MedicineHarvard UniversityBostonMAUSA James l.Winkle College of Pharmacy Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA Neuroscience Graduate Program College of MedicineUniversity of CincinnatiCincinnatiOHUSA

Traumatic brain injury(TBI)is a public health problem with an undue economic burden that impacts nearly every age,ethnic,and gender group across the globe(Capizzi et al.,2020).TBIs are often sustained during a dynamic range of exposures to energetic environmental forces and as such outcomes are typically heterogeneous regarding severity and pathology(Capizzi et al.,2020).

关键词： sustained orange dynamic

A ROADMAP FOR ClIMATE ACTION AT THE UNIVERSITY OF CAlGARY:HIGHER EDUCATION CAMPUSES AS ClIMATE lEADERS

在线全文

学校读者我要写书评

暂无评论

Journal of Green Building 2013年第1期8卷 44-61页

作者： Joanne l.perdue Adam D.Stoker University of Calgary University of Calgary Office of Sustainability

INTRODUCTION As federal and provincial governments debate the viability of absolute emission reduction targets,universities and college across North America are steadfast on a voluntary movement to slash greenhouse gas emissions and model the way forward on climate *** institutions are taking advantage of campus contexts that offer decentralized energy supply opportunities,district energy systems,large building portfolios,and research partnerships to leverage *** education campuses are emerging as innovation hubs for the deployment of new technologies,policy development,best practices in portfolio scale building operating models,public-private partnership models and more.

关键词： North American university and college climate action plans “greening”college campuses high performance campus buildings energy management systems building energy retrofits

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

禽流感病毒是如何突变为高致病性毒株的

中国动物保健 2001年第9期3卷 21-22页

作者： Dr.Michael l.perdue 杨爱梅美国东南家禽研究实验室

AI病毒似乎拥有无穷的机制使自己从温和型无致病性病原突变为高致病性病原.幸运的是这种突变相对于每年鸡群感染禽流感的总次数来说是很少的.

关键词：高致病性禽流感病毒毒株鸡群病原温和型次数突变性病感染

The impact of acetylation and deacetylation on the p53 pathway

在线全文

学校读者我要写书评

暂无评论

Protein & Cell 2011年第6期2卷 456-462页

作者： christopher l.Brooks Wei Gu Stemline Therapeutics Inc.New YorkNY 10128USA Institute for Cancer Genetics and Department of Pathology College of Physicians&SurgeonsColumbia UniversityNew YorkNY 10032USA

The p53 tumor suppressor is a sequence-specific transcription factor that undergoes an abundance of post-translational modifications for its regulation and *** of p53 is an important reversible enzymatic process that occurs in response to DNA damage and genotoxic stress and is indispensible for p53 transcriptional activity.p53 was the first non-histone protein shown to be acetylated by histone acetyl transferases,and a number of more recent in vivo models have underscored the importance of this type of modification for p53 ***,we review the current knowledge and recent findings of p53 acetylation and deacetylation and discuss the implications of these processes for the p53 pathway.

关键词： p53 Mdm2 acetylation deacetylation destabilization ubiquitination transcriptional activation and stability

The application of Fourier transform mid-infrared(FTIR) spectroscopy to identify variation in cell wall composition of Setaria italica ecotypes

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Agriculture 2017年第6期16卷 1256-1267页

作者： christopher Brown Antony P.Martin christopher P.l.Grof Centre for Plant Science School of Environmental and Life Sciences University of Newcastle Newcastle 2308 Australia light Sheet Microscopy Unit Hunter Medical Research Institute Newcastle 2305 Australia

Cell wall composition in monocotyledonous grasses has been identified as a key area of research for developing better feedstocks for forage and biofuel *** viridis and its close domesticated relative Setaria italica have been chosen as suitable monocotyledonous models for plants possessing the C4 pathway of photosynthesis including sorghum,maize,sugarcane,switchgrass and Miscanthus×*** partial least squares regression（PlSR）models to predict *** stem composition have been generated,based upon Fourier transform mid-infrared（FTIR）spectra and calibrated with wet chemistry determinations of ground *** stem material measured using a modified version of the US National Renewable Energy laboratory（NREl）acid hydrolysis *** models facilitated a high-throughput screening analysis for glucan,xylan,Klason lignin and acid soluble lignin（ASl）in a collection of 183 natural *** variants and clustered them into classes,some possessing unique *** predictive models provide a highly efficient screening tool for large scale breeding programs aimed at identifying lines or mutants possessing unique cell wall *** encoding key catalytic enzymes of the lignin biosynthesis pathway exhibit a high level of conservation with matching expression profiles,measured by RT-q PCR,among accessions of ***,which closely mirror profiles observed in the different developmental regions of an elongating internode of *** by RNASeq.

关键词： monocotyledonous C4 grasses lignin biosynthesis Fourier transform mid-infrared spectroscopy Setaria italica

One size does not fit all: Refining zircon provenance interpretations via integrated grain shape, geochronology, and Hf isotope analysis

在线全文

学校读者我要写书评

暂无评论

Geoscience Frontiers 2023年第4期14卷 230-244页

作者： Gisela Gartmair Milo Barham christopher l.Kirkland Timescales of Mineral Systems Group School of Earth and Planetary SciencesCurtin UniversityGPO Box U1987PerthWA 6845Australia

Sediment provenance studies commonly utilize isotopic signatures to resolve detrital mineral sources and ***,non-unique ages and geochemical characteristics across geographically distinct crystalline source regions can lead to significant ambiguities in mineral provenance *** ambiguity is apparent in southern Australia’s Cenozoic Eucla Basin,which hosts world-class heavy mineral sand ***,new Hf isotope data are provided from four heavy mineral prospects(N=8,n=844[N=samples,n=grains]).Zircon grain shape data are also presented for a suite of detrital Eucla Basin samples(N=22,n=35,604)and the basin’s underlying basement,the Coompana Province(N=13,n=824).The data are integrated with published detrital and non-detrital primary zircon data to investigate the efficacy of grain shape analysis to better resolve the basin’s mineral *** Hf isotope compositions indicate a primary Mesoproterozoic juvenile source for zircon melts(~1250-1000 Ma,-2.5~+5)with additional contributions from a range of juvenile to evolved late Archean to Phanerozoic-aged zircon bearing magmas(-28.0+11).U-Pb geochronology and Hf isotopes are incapable of differentiating Mesoproterozoic-aged source rocks bounding the region for the majority of heavy mineral deposits analyzed as potential sources express overlapping crystallization ages and similarities in Hf-isotope ***,distinct zircon grain shapes(i.e.,perimeter,major axis and circularity)facilitate improved differentiation across these Mesoproterozoic *** of U-Pb age,Hf isotope and shape data implicate the underlying Madura and Coompana provinces as dominant sediment sources for Eucla Basin detritus aged~1400-1000 *** lack of direct sediment pathways between the underlying basement provinces and placer sediments analyzed demonstrates the significance of zircon reworking from intermediate sedimentary basins in the formation of the economically significa

关键词： Isotope fingerprinting Grain shape analysis Sediment provenance Sediment routing Heavy mineral sands Eucla Basin

Strategies towards statistically robust interpretations of in situ U-Pb zircon geochronology

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Geoscience Frontiers 2016年第4期7卷 581-589页

作者： christopher J.Spencer christopher l.Kirkland Richard J.M.Taylor The Institute of Geoscience Research(TIGeR) Department of Applied GeologyWestern Australian School of MinesCurtin UniversityWA 6102Australia Centre for Exploration Targeting-Curtin Node Department of Applied GeologyWestern Australian School of MinesCurtin UniversityWA 6102Australia Australian Research Council Centre of Excellence for Core to Crust Fluid SystemsPerthWA 6102Australia

Zircon U-Pb geochronology has become a keystone tool across Earth science, arguably providing the gold standard in resolving deep geological time. The development of rapid in situ analysis of zircon （via laser ablation and secondary ionization mass spectrometry） has allowed for large amounts of data to be generated in a relatively short amount of time and such large volume datasets offer the ability to address a range of geological questions that would otherwise remain intractable （e.g. detrital zircons as a sedi- ment fingerprinting method）. The ease of acquisition, while bringing benefit to the Earth science com- munity, has also led to diverse interpretations of geochronological data. In this work we seek to refocus U -Pb zircon geochronology toward best practice by providing a robust statistically coherent workflow. We discuss a range of data filtering approaches and their inherent limitations （e.g. discordance and the reduced chi-squared; MSWD）. We evaluate appropriate mechanisms to calculate the most geologically appropriate age from both 238U/206pb and 207pb/206pb ratios and demonstrate the cross over position when chronometric power swaps between these ratios. As our in situ analytical techniques become progressively more precise, appropriate statistical handing of U-Pb datasets will become increasingly pertinent.

关键词： Zircon Geochronology U-Pb Geostatistics MSWD

Potential risk factors for constipation in the community

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2021年第21期27卷 2795-2817页

作者： Barry l Werth Sybele-Anne christopher Susan Wakil School of Nursing and Midwifery Faculty of Medicine and HealthUniversity of SydneySydney 2006New South WalesAustralia

Constipation is a common community health *** are many factors that are widely thought to be associated with constipation but real-world evidence of these associations is difficult to *** potential risk factors may be categorised as demographic,lifestyle and health-related *** review presents the available evidence for each factor by an assessment of quantitative data from cross-sectional studies of community-dwelling adults published over the last 30 *** appears that there is evidence of an association between constipation and female gender,residential location,physical activity and some health-related factors such as self-rated health,some surgery,certain medical conditions and certain *** available evidence for most other factors is either conflicting or ***,further research is necessary to determine if each factor is truly associated with constipation and whether it can be regarded as a potential risk *** is recommended that studies investigating a broad range of factors are conducted in populations in community *** analyses should be performed to account for all possible confounding *** this way,valuable evidence can be accumulated for a better understanding of potential risk factors for constipation in the community.

关键词： Adults Constipation Epidemiology Factors Community

Early Paleogene stratigraphic sequences,mammalian evolution and its response to environmental changes in Erlian Basin,Inner Mongolia,China

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Earth Sciences 2010年第12期53卷 1918-1926页

作者： christopher K.BEARD Daniel l.GEBO Section of Vertebrate Paleontology Carnegie Museum of Natural History4400 Forbes AvenuePittsburghPA 15213USA Department of Anthropology Northern Illinois UniversityDeKalbIL 60115USA

Paleogene strata in the Huheboerhe area,Erlian Basin,Inner Mongolia,China have been subdivided into three lithological units:the Nomogen Formation,the Arshanto Formation,and the Irdin Manha *** least 12 mammal-bearing horizons have been recognized in these formations,of which 4 in the Nomogen Formation,6 in the Arshanto Formation,and 2 in the Irdin Manha *** investigation proved that the "Houldjin Formation" recognized in this area by the Central Asiatic Expeditions(CAE) of the American Museum Natural History in the 1920s is actually the Irdin Manha Formation,while the "Irdin Manha Formation" of CAE is the Arshanto Formation.A recent paleomagnetic study suggests that the upper part of the Nomogen Formation is early Eocene in age and the Arshanto Formation is mainly early Eocene rather than middle Eocene as previously *** Gashatan,Bumbanian,and Arshantan land mammal ages are correlated respectively to the Thanetian,the early Ypresian,and the middle Ypresian through earliest lutetian of the Geological Time *** land mammal ages are also correlated with the late Tiffanian through Clarkforkian,the early Wasatchian,and the middle-late Wasatchian and most of the Bridgerian of the North American land Mammal *** the early Paleogene,the mammalian history of the Erlian Basin was dominated by the appearance of new mammalian families and the replacement of a variety of genera and species,corresponding to the gradual climatic changes during this time *** abrupt emergence of several modern mammalian orders at the beginning of the Eocene is probably related to extreme climatic warming in relation to the Paleocene-Eocene Thermal Maximum.

关键词： Erlian Basin Paleogene mammal faunal turnover biochronology environmental response