检索结果-南通市图书馆

A DNA-Binding Bromodomain-Containing Protein Interacts with and Reduces Rx1-Mediated Immune Response to Potato Virus X

引用

Plant Communications 2020年第4期1卷 101-114页

作者： Octavina C.A.Sukarta Philip D.Townsend Alexander Llewelyn christopher h.dixon Erik J.Slootweg Lars-Olof Pålsson Frank L.W.Takken Aska Goverse Martin J.Cann Laboratory of Nematology Department of Plant SciencesWageningen University6708 PB WageningenThe Netherlands Department of Biosciences Durham UniversitySouth RoadDurham DH13LEUK Biophysical Sciences Institute Durham UniversitySouth RoadDurham DH13LEUK Department of Chemistry Durham UniversitySouth RoadDurham DH13LEUK Molecular Plant Pathology Swammerdam Institute for Life SciencesUniversity of AmsterdamScience Park 9041098 XH AmsterdamThe Netherlands

Plant NLR proteins enable the immune systemto recognize and respond to pathogen *** early consequence of immune activation is transcriptional *** have been shownto act in the nucleus and interact with transcription *** Rx1 NLR protein of potato binds and distorts doublestranded ***,the components of the chromatin-localized Rx1 complex are largely ***,we report a physical and functional interaction between Rx1 and NbDBCP,a bromodomaincontaining chromatin-interacting *** accumulates in the nucleoplasmand nucleolus,interacts with chromatin,and redistributes Rx1 tothe nucleolus in a subpopulation of imaged ***1 overexpression reduces the interaction between NbDBCP and *** is a negative regulator of Rx1-mediated immune responses to potato virus X(PVX),and this activity requires an intact ***,Rx1 has been shown to regulate the DNA-binding activity of a Golden2-like transcription factor,***1 and NbDBCP act synergistically to reduce NbGlk1 DNA binding,suggesting a mode of action for NbDBCP’s inhibitory effect on *** study provides new mechanistic insight into the mechanism by which a chromatin-localized NLR complex co-ordinates immune signaling after pathogen perception.

关键词： cellular immune response DNA-binding protein host-pathogen interaction plant biochemistry plant defense plant virus

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A framework for dynamic modelling of railway track switches considering the switch blades,actuators and control systems

引用

Railway Engineering Science 2024年第2期32卷 162-176页

作者： Saikat Dutta Tim harrison christopher Ward Roger dixon Phil Winship Institute of Thermofluids School of Mechanical EngineeringUniversity of LeedsLeedsWest YorkshireUK Wolfson School of Mechanical Electrical and Manufacturing EngineeringLoughborough UniversityLoughboroughLeicestershireUK Birmingham Centre for Railway Research and Education School of EngineeringUniversity of BirminghamBirminghamWest MidlandsUK Network Rail Milton KeynesBuckinghamshireUK

The main contribution of this paper is the development and demonstration of a novel methodology that can be followed to develop a simulation twin of a railway track switch system to test the functionality in a digital *** is important because,globally,railway track switches are used to allow trains to change routes;they are a key part of all railway ***,because track switches are single points of failure and safety-critical,their inability to operate correctly can cause significant delays and concomitant *** order to better understand the dynamic behaviour of switches during operation,this paper has developed a full simulation twin of a complete track switch *** approach fuses finite element for the rail bending and motion,with physics-based models of the electromechanical actuator system and the control ***,it provides researchers and engineers the opportunity to explore and understand the design space around the dynamic operation of new switches and switch machines before they are *** is useful for looking at the modification or monitoring of existing switches,and it becomes even more important when new switch concepts are being considered and *** simulation is capable of running in real time or faster meaning designs can be iterated and checked *** paper describes the modelling approach,demonstrates the methodology by developing the system model for a novel“REPOINT”switch system,and evaluates the system level performance against the dynamic performance requirements for the *** the context of that case study,it is found that the proposed new actuation system as designed can meet(and exceed)the system performance requirements,and that the fault tolerance built into the actuation ensures continued operation after a single actuator failure.

关键词： Railway track switch Mathematical modelling Redundant actuation Finite element analysis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Prehospital transdermal glyceryl trinitrate for ultra- acute ischaemic stroke: data from the RIGhT- 2 randomised sham- controlled ambulance trial

引用

Stroke & Vascular Neurology 2024年第1期9卷 38-49,I0035-I0046页

作者： Jason Philip Appleton Lisa J Woodhouse Craig S Anderson Sandeep Ankolekar Lesley Cala Mark dixon Timothy J England Kailash Krishnan Grant Mair Keith W Muir John Potter christopher I Price Marc Randall Thompson G Robinson Christine Roffe Else C Sandset Jeffrey L Saver Angela Shone Aloysius Niroshan Siriwardena Joanna M Wardlaw Nikola Sprigg Philip M Bath Stroke University Hospitals Birmingham NHS Foundation TrustBirminghamUK Institute of Applied healthResearch University of Birmingham College of Medical and Dental SciencesBirminghamUK Stroke Trials Unit Mental Health and Clinical NeurosciencesUniversity of NottinghamNottinghamUK Faculty of Medicine The George Institute for Global HealthSydneyNew South WalesAustralia The George Institute China at Peking University health Science Center BeijingChina Neurology Royal Prince Alfred HospitalSydney Health PartnersSydneyNew South WalesAustralia Department of Neurology King's College Hospital NHS Foundation TrustLondonUK Faculty of health and Medical Sciences University of Western AustraliaCrawleyWestern AustraliaAustralia East Midlands Ambulance Service NhS Trust NottinghamUK Stroke Queen's Medical CentreNottingham University Hospitals NHS TrustNottinghamUK Centre for Clinical Brain Sciences Dementia Research InstituteUniveristy of EdinburghEdinburghUK Institute of Neurology and Psychology University of GlasgowGlasgowUK Bob Champion Research and Education Building University of East AngliaNorwichUK Institute of Neuroscience Newcastle UniversityNewcastle upon TyneUK Department of Neurology Leeds Teaching Hospitals NHS TrustLeedsUK Department of Cardiovascular Sciences and NIhR Leicester Biomedical Research Centre University of LeicesterLeicesterUK Stroke Research in Stoke Institute for Science and Technology in MedicineKeele UniversityStoke-on TrentUK Department of Neurology Oslo University HospitalOsloNorway Research and Development Norwegian Air Ambulance FoundationOsloNorway Department of Neurology and Comprehensive Stroke Center David Geffen School of MedicineUCLALos AngelesCaliforniaUSA Research and Graduate Services University of NottinghamNottinghamUK Community and health Research Unit University of LincolnLincolnUK

Background The effect of transdermal glyceryl trinitrate(GTN,a nitrovasodilator)on clinical outcome when administered before hospital admission in suspected stroke patients is ***,we assess the safety and efficacy of GTN in the prespecified subgroup of patients who had an ischaemic stroke within the Rapid Intervention with Glyceryl trinitrate in hypertensive stroke Trial-2(RIGhT-2).Methods RIGhT-2 was an ambulance-based multicentre sham-controlled blinded-endpoint study with patients randomised within 4hours of *** primary outcome was a shift in scores on the modified Rankin scale(mRS)at day *** outcomes included death;a global analysis(Wei-Lachin test)containing Barthel Index,EuroQol-5D,mRS,telephone interview for cognitive status-modified and Zung depression scale;and neuroimaging-determined‘brain frailty’*** were reported as n(%),mean(SD),median[IQR],adjusted common OR(acOR),mean difference or Mann-Whitney difference(MWD)with 95%*** 597 of 1149(52%)patients had a final diagnosis of ischaemic stroke;age 75(12)years,premorbid mRS>2107(18%),Glasgow Coma Scale 14(2)and time from onset to randomisation 67[45,108]***‘brain frailty’was common:median score 2[2,3](range 0–3).At day 90,GTN did not influence the primary outcome(acOR for increased disability 1.15,95%CI 0.85 to 1.54),death or global analysis(MWD 0.00,95%CI-0.10 to 0.09).In subgroup analyses,there were non-significant interactions suggesting GTN may be associated with more death and dependency in participants randomised within 1hour of symptom onset and in those with more severe *** In patients who had an ischaemic stroke,ultra-acute administration of transdermal GTN in the ambulance did not improve clinical outcomes in a population with more clinical and radiological frailty than seen in previous in-hospital *** IS ALREADY KNOWN ON ThIS TOPIC⇒Transdermal glyceryl trinitrate(GTN)was associat-ed with less death and dependency in those w

关键词： Glasgow nitrate random

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cerebral microhaemorrhage in COVID-19: a critical illness related phenomenon?

引用

Stroke & Vascular Neurology 2020年第4期5卷 315-322页

作者： Luke dixon Cillian McNamara Pritika Gaur Dermot Mallon christopher Coughlan Francesca Tona Wajanat Jan Mark Wilson Brynmor Jones Department of Neuroradiology Imperial College Healthcare NHS TrustLondonUK Department of Cardiac Intensive Care Imperial College Healthcare NHS TrustLondonUK Department of Neurosurgery Imperial College Healthcare NHS TrustLondonUK

Background Cerebral microhaemorrhages are increasingly being recognised as a complication of *** observational retrospective study aims to further investigate the potential pathophysiology through assessing the pattern of microhaemorrhage and clinical characteristics of patients with COVID-19 and *** comparing with similar patterns of microhaemorrhage in other non-COVID-19 disease,this study aims to propose possible common pathogenic *** A retrospective observational case series was performed identifying all patients with COVID-19 complicated by cerebral microhaemorrhage on *** distribution and number of microhaemorrhages were recorded using the microbleed anatomical scale,and patients’baseline characteristics and salient test results were also *** Cerebral microhaemorrhages were noted to have a predilection for the corpus callosum,the juxtacortical white matter and *** patients had a preceding period of critical illness with respiratory failure and severe hypoxia necessitating intubation and mechanical *** This study demonstrates a pattern of cerebral microhaemorrhage that is similar to the pattern reported in patients with non-COVID-19 related critical illness and other causes of severe *** raises questions regarding whether microhaemorrhage occurs from endothelial dysfunction due the direct effect of SARS-CoV-2 infection or from the secondary effects of critical illness and hypoxia.

关键词： Cerebral pattern critical

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

家猪肌内注射和接触传染感染非洲猪瘟病毒后的带毒及排毒动力学研究

引用

国外畜牧学（猪与禽） 2015年第3期35卷 4-10页

作者：刘新军张涛 Claire Guinat Ana Luisa Reis christopher L.Netherton Lynnette Goatley Dirk U Pfeiffer Linda dixon

非洲猪瘟病毒(African Swine Fever Virus,ASFV)是猪的一种强毒型病原体,从2007年起在东欧流行,目前还没有有效的疫苗或治疗方法。ASF病毒是当前的流行毒株,在猪体内带毒和排毒(shedding and excretion)的动力学机理至今尚不清楚。因此... 详细信息

非洲猪瘟病毒(African Swine Fever Virus,ASFV)是猪的一种强毒型病原体,从2007年起在东欧流行,目前还没有有效的疫苗或治疗方法。ASF病毒是当前的流行毒株,在猪体内带毒和排毒(shedding and excretion)的动力学机理至今尚不清楚。因此,本试验希望通过将易感的家猪与经肌内注射感染ASF病毒格鲁吉亚2007/1毒株的家猪进行接触,以测定ASF病毒在猪栏内和猪栏之间由受感染猪向易感猪进行传播的动力学机理。试验采集了血液、口液、鼻液、肠液(直肠)样本,以通过病毒滴定法和实时定量PCR(q PCR)法检测ASF病毒,利用血清学试验测定ASF病毒特异性抗体。肌内注射和接触传播感染均能造成猪急性发病,不过试验表明因感染途径不同而导致猪的发病机制有所差异。接种感染猪在接种的第3天可在血液中分离到有传染性的ASF病毒,而通过直接接触和间接接触进行感染的猪分别在曝露后第10天和第13天方可从血液中分离到有传染性的ASF病毒。临近出现ASF临床症状时,ASF病毒在血液中的滴度高于在鼻液和肠液中的。口液样本中没有分离到有传染性的ASF病毒,不过ASF病毒的基因组被检测到。只有一头接种感染的猪在接种后第12天检测到ASF病毒特异性抗体。本项试验结果提供了ASF病毒格鲁吉亚2007/1毒株在家猪中带毒和排毒的定量数据,同时表明该毒株引起持续感染的能力有限。

关键词：家猪野猪非洲猪瘟病毒

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：