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采用GC/MSD DRS对残留农药进行全面筛查

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现代科学仪器 2006年第1期23卷 13-17页

作者： Philip L. Wylie Michael J. Szelewski chin-Kai Meng christopher P. Sandy Agilent Technologies Inc.2850Centerville Road WilmingtonDE 19808-1610 USA Agilent

1引言根据农药手册,目前世界上正在使用的农药有700多种[1].大约600种农药是过去使用的,但现在已经禁用或不再销售.有一些农药早已不再使用,但它们仍然存在于环境中,还可能在植物和动物体内生物富集.在食品和饮料、在土壤、水和大气、... 详细信息

1引言根据农药手册,目前世界上正在使用的农药有700多种[1].大约600种农药是过去使用的,但现在已经禁用或不再销售.有一些农药早已不再使用,但它们仍然存在于环境中,还可能在植物和动物体内生物富集.在食品和饮料、在土壤、水和大气、在水生和陆生的动植物、在人类血液、脂肪组织和乳汁中,都能检测到痕量的农药或它们的代谢物.

关键词：残留农药世界卫生组织筛查 GC 急性毒性生物富集动物体内脂肪组织正常使用动植物

用GC/MSD DRS对残留农药进行全面筛查的应用

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农业质量标准 2006年第1期 19-23页

作者： Philip L. Wylie Michael J. Szelewski chin-Kai Meng christopher P. Sandy Agilent Technologies Inc.WilmingtonDE 19808-1610 USA 不详

世界卫生组织根据农药对人的急性毒性将农药分成5类[1],其类别从'有急性毒性'到'正常使用时没有急性毒性',一些农药被归之为持久性有机污染物(POP),致癌、致畸或内分泌干扰物.分析食品和环境样品中的农药,跟踪它们在环境中的分布以保证... 详细信息

世界卫生组织根据农药对人的急性毒性将农药分成5类[1],其类别从'有急性毒性'到'正常使用时没有急性毒性',一些农药被归之为持久性有机污染物(POP),致癌、致畸或内分泌干扰物.分析食品和环境样品中的农药,跟踪它们在环境中的分布以保证食品安全,是一项经常工作.目前,很多分析方法仅针对一部分可能存在的化合物,然而无论是食品还是环境样品,由于其中一些天然产物能够被一起提取出来,致使分析工作变得复杂起来.因此,在分析之前需要进行若干样品净化步骤[2],但即便如此,在残余基质存在的情况下检测痕量的污染物也很困难.

关键词：残留农药持久性有机污染物 DRS 应用筛查急性毒性世界卫生组织内分泌干扰物食品安全环境样品

Anti-inflammatory mechanisms of the novel cytokine interleukin-38 in allergic asthma

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Cellular & Molecular Immunology 2020年第6期17卷 631-646页

作者： Xiaoyu Sun Tianheng Hou Edwin Cheung Tiffany Nga-Teng Iu Victor Wai-Hou Tam Ida Miu-Ting Chu Miranda Sin-Man Tsang Paul Kay-Sheung Chan christopher Wai-Kei Lam Chun-Kwok Wong Department of Chemical Pathology The Chinese University of Hong KongHong KongChina Cancer Centre/Centre of Precision Medicine Research and Training Faculty of Health SciencesUniversity of MacaoMacaoChina Institute of chinese Medicine and State Key Laboratory of Research on Bioactivities and Clinical Applications of Medicinal Plants The Chinese University of Hong KongHong KongChina Department of Microbiology The Chinese University of Hong KongHong KongChina Faculty of Medicine and State Key Laboratory of Quality Research in chinese Medicines Macao University of Science and TechnologyMacaoChina Li Dak Sum Yip Yio chin R&D Centre for chinese Medicine The Chinese University of Hong KongHong KongChina

We elucidated the anti-inflammatory mechanisms of IL-38 in allergic *** bronchial epithelial cells and eosinophils were cocultured upon stimulation with the viral RLR ligand poly(I:C)/LyoVec or infection-related cytokine TNF-αto induce expression of cytokines/chemokines/adhesion *** dust mite(HDM)-induced allergic asthma and humanized allergic asthma NOD/SCID murine models were established to assess anti-inflammatory mechanisms in ***-38 significantly inhibited induced proinflammatory IL-6,IL-1β,CCL5,and CXCL10 production,and antiviral interferon-βand intercellular adhesion molecule-1 expression in the coculture *** cytometry and RNA-sequencing analysis revealed that IL-38 could antagonize the activation of the intracellular STAT1,STAT3,p38 MAPK,ERK1/2,and NF-κB pathways,and upregulate the expression of the host defense-related gene POU2AF1 and anti-allergic response gene *** injection of IL-38 into HDM-induced allergic asthma mice could ameliorate airway hyperreactivity by decreasing the accumulation of eosinophils in the lungs and inhibiting the expression of the Th2-related cytokines IL-4,IL-5,and IL-13 in the bronchoalveolar lavage fluid(BALF)and lung *** examination indicated lung inflammation was alleviated by reductions in cell infiltration and goblet cell hyperplasia,together with reduced Th2,Th17,and innate lymphoid type 2 cell numbers but increased proportions of regulatory T cells in the lungs,spleen,and lymph ***-38 administration suppressed airway hyperreactivity and asthma-related IL-4 and IL-5 expression in humanized mice,together with significantly decreased CCR3^(+) eosinophil numbers in the BALF and lungs,and a reduced percentage of human CD4^(+)CRTH2^(+)Th2 cells in the lungs and mediastinal lymph ***,our results demonstrated the anti-inflammatory mechanisms of IL-38 and provided a basis for the development of a regulatory cytokine-based treatment for allergic

关键词： allergic asthma eosinophils IL-38 ILC2s Tregs

微小按蚊Anopheles minimus Theobald,1910.类型的研究

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昆虫学报 1959年第2期 154-160页

作者：刘连珠方勤娟胡明华第七军医大学寄生虫教研室

1951年作者等随孟庆华教授在贵州册亨进行蚊类调查时,从采得的按蚊标本中,经初步鉴定者有微小按蚊及瓦容按蚊(Anopheles varuna Iyengar,1924)。惟后者一直未采得幼虫,因而对瓦容按蚊的鉴定甚为怀疑,孟教授当时曾主张以纯培养解决,惜因... 详细信息

1951年作者等随孟庆华教授在贵州册亨进行蚊类调查时,从采得的按蚊标本中,经初步鉴定者有微小按蚊及瓦容按蚊(Anopheles varuna Iyengar,1924)。惟后者一直未采得幼虫,因而对瓦容按蚊的鉴定甚为怀疑,孟教授当时曾主张以纯培养解决,惜因时间仓促及实验室的条件所限,未能如愿。

关键词：微小按蚊白斑典型形态标本幼虫按蚊属癌前状态 Anopheles minimus Theobald,1910 子胞

Sub-percent precision measurement of neutrino oscillation parameters with JUNO

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chinese Physics C 2022年第12期46卷 28-49页

作者： Angel Abusleme Thomas Adam Shakeel Ahmad Rizwan Ahmed Sebastiano Aiello Muhammad Akram Abid Aleem 安丰鹏安琪 Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Pedro Athayde Marcondes de André Didier Auguste 白伟东 Nikita Balashov Wander Baldini Andrea Barresi Davide Basilico Eric Baussan Marco Bellato Antonio Bergnoli Thilo Birkenfeld Sylvie Blin David Blum Simon Blyth Anastasia Bolshakova Mathieu Bongrand Clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Jose Busto Ilya Butorov Anatael Cabrera Barbara Caccianiga 蔡浩蔡啸蔡严克蔡志岩 Riccardo Callegari Antonio Cammi Agustin Campeny 曹传亚曹国富曹俊 Rossella Caruso Cédric Cerna Chi Chan 常劲帆 Yun Chang 陈国明陈平平 Po-An Chen 陈少敏 Xurong Chen 陈义学陈羽陈志源陈梓康程捷程雅苹 Yu chin Cheng Alexey Chetverikov Davide Chiesa Pietro Chimenti Artem Chukanov Gérard Claverie Catia Clementi Barbara Clerbaux Selma Conforti Di Lorenzo Daniele Corti Flavio Dal Corso Olivia Dalager Christophe De La Taille 邓智邓子艳 Wilfried Depnering Marco Diaz Xuefeng Ding 丁雅韵 Bayu Dirgantara Sergey Dmitrievsky Tadeas Dohnal Dmitry Dolzhikov Georgy Donchenko 董建蒙 Evgeny Doroshkevich Marcos Dracos Frédéric Druillole 杜然杜书先 Stefano Dusini Martin Dvorak Timo Enqvist Heike Enzmann Andrea Fabbri Donghua Fan 樊磊方建方文兴 Marco Fargetta Dmitry Fedoseev 费政勇 Li-Cheng Feng 冯启春 Richard Ford Amélie Fournier 甘浩男高峰 Alberto Garfagnini Arsenii Gavrikov Marco Giammarchi Nunzio Giudice Maxim Gonchar 龚光华宫辉 Yuri Gornushkin Alexandre Göttel Marco Grassi Vasily Gromov 顾旻皓谷肖飞古宇关梦云管宇铎 Nunzio Guardone 郭聪郭竞渊郭万磊 Xinheng Guo 郭宇航 Paul Hackspacher Caren Hagner 韩然 Yang Han 何苗 Wei He Tobias Heinz Patrick Hellmuth 衡月昆 Rafael Herrera 贺远强侯少静 Yee Hsiung Bei-Zhen Hu 胡航 Jianrun Hu 胡俊胡守扬胡涛胡宇翔胡焯钧黄桂鸿黄翰雄黄凯旋黄文昊 Xin Huang 黄性涛黄永波惠加琪霍雷霍文驹 Cédric Huss Safeer Hussain Ara Ioannisian Roberto Isocrate Beatrice Jelmini Ignacio Jeria 季筱璐贾慧慧贾俊基蹇司玉蒋荻蒋炜江晓山荆小平 Cécile Jollet Jari Joutsenvaara Leonidas Kalousis Philipp Kampmann 康丽 Rebin Karaparambil Narine Kazarian Amina Khatun Yerevan Physics Institute YerevanArmenia UniversiéLibre de Bruxelles BrusselsBelgium Universidade Estadual de Londrina LondrinaBrazil Pontificia Universidade Catolica do Rio de Janeiro Rio de JaneiroBrazil Pontificia Universidad Católica de Chile SantiagoChile Universidad Tecnica Federico Santa Maria ValparaisoChile Beijing Institute of Spacecraft Environment Engineering BeijingChina Beijing Normal University BeijingChina china Institute of Atomic Energy BeijingChina Institute of High Energy Physics BeijingChina North china Electric Power University BeijingChina School of Physics Peking UniversityBeijingChina Tsinghua University BeijingChina University of chinese Academy of Sciences BeijingChina Jilin University ChangchunChina College of Electronic Science and Engineering National University of Defense TechnologyChangshaChina Chongqing University ChongqingChina Dongguan University of Technology DongguanChina Jinan University GuangzhouChina Sun Yat-Sen University GuangzhouChina Harbin Institute of Technology HarbinChina University of Science and Technology of china HefeiChina The Radiochemistry and Nuclear Chemistry Group in University of South china HengyangChina Wuyi University JiangmenChina Shandong University JinanChinaand Key Laboratory of Particle Physics and Particle Irradiation of Ministry of EducationShandong UniversityQingdaoChina Institute of Modern Physics Chinese Academy of SciencesLanzhouChina Nanjing University NanjingChina Guangxi University NanningChina East china University of Science and Technology ShanghaiChina School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghaiChina Tsung-Dao Lee Institute Shanghai Jiao Tong UniversityShanghaiChina Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuangChina Nankai University TianjinChina Wuhan University WuhanChina Xi'an Jiaotong University Xi'anChina Xiamen University XiamenChina School of Physics and Microelectronics Zhengzhou UniversityZhengzhou

JUNO is a multi-purpose neutrino observatory under construction in the south of *** publication presents new sensitivity estimates for the measurement of the △m_(31)^(2),△m_(21)^(2),sin^(2)θ_(12),and sin^(2)θ_(13) oscillation parameters using reactor antineutrinos,which is one of the primary physics goals of the *** sensitivities are obtained using the best knowledge available to date on the location and overburden of the experimental site,the nuclear reactors in the surrounding area and beyond,the detector response uncertainties,and the reactor antineutrino spectral shape constraints expected from the TAO satellite *** is found that the △m_(21)^(2) and sin^(2)θ_(12) oscillation parameters will be determined to 0.5%precision or better in six years of data *** the same period,the △m_(31)^(2) parameter will be determined to about 0.2%precision for each mass ordering *** new precision represents approximately an order of magnitude improvement over existing constraints for these three parameters.

关键词： neutrino oscillation reactor antineutrino precision measurement JUNO