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Bone Research 2015年第4期3卷 226-234页

作者： Longze Zhang martin Chang christopher A Beck Edward m Schwarz Brendan F Boyce Center for musculoskeletal Research School of Medicine and DentistryUniversity of Rochester Medical Center

Histomorphometric analysis of histologic sections of normal and diseased bone samples,such as healing allografts and fractures,is widely used in bone ***,the utility of traditional semi-automated methods is limited because they are labor-intensive and can have high interobserver variability depending upon the parameters being assessed,and primary data cannot be re-analyzed *** histomorphometry has long been recognized as a solution for these issues,and recently has become more feasible with the development of digital whole slide imaging and computerized image analysis systems that can interact with digital ***,we describe the development and validation of an automated application（algorithm）using Visiopharm＇s image analysis system to quantify newly formed bone,cartilage,and fibrous tissue in healing murine femoral allografts in high-quality digital images of H＆E/alcian blue-stained decalcified histologic *** validate this algorithm,we compared the results obtained independently using OsteomeasureTm and Visiopharm image analysis *** intraclass correlation coefficient between Visiopharm and Osteomeasure was very close to one for all tissue elements tested,indicating nearly perfect reproducibility across *** new algorithm represents an accurate and labor-efficient method to quantify bone,cartilage,and fibrous tissue in healing mouse allografts.

关键词： cartilage slide automated healing fibrous Figure automatically sections segmentation quantify

Release models for leaks from high-pressure hydrogen storage systems

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Chinese Science Bulletin 2014年第19期59卷 2302-2308页

作者： Xue-Fang Li David m. christopher Jing-Liang Bi Key Laboratory for Thermal Science and Power Engineering of ministry of Education Tsinghua University

Simulations and analyses of experimental data from leaks from high-pressure hydrogen storage systems will require knowledge of the stagnation state time histories and stream properties exiting the *** analytical ideal-gas model based on the ideal gas state equation and a computer program making use of the NIST standard reference database(REFPROP)were developed to model the entire process of leaks from high-pressurized hydrogen gas *** results obtained by the two methods agree with each other *** the gas behavior departs from the ideal gas properties at high pressures,the actual stagnation pressure and temperature decay more rapidly than with the ideal-gas assumption.

关键词：存储系统高压氢理想气体状态方程泄漏释放模式理想气体模型计算机程序时间历程

Plasma-catalysis: Is it just a question of scale?

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Frontiers of Chemical Science and Engineering 2019年第2期13卷 264-273页

作者： J.christopher Whitehead School of Chemistry The University of ManchesterManchester M13 9PLUK

The issues of describing and understanding the changes in performance that result when a catalyst is placed into plasma are discussed. The different chemical and physical interactions that result and how their combination might produce beneficial results for the plasma-catalytic processing of different gas streams are outlined with particular emphasis being placed on the different range of spatial and temporal scales that must be considered both in experiment and modelling. The focus is on non-thermal plasma where the lack of thermal equilibrium creates a range of temperature scales that must be considered. This contributes in part to a wide range of inhomogeneity in different properties such as species concentrations and electric fields that must be determined experimentally by in situ methods and be incorporated into modelling. It is concluded that plasmacatalysis is best regarded as conventional catalysis perturbed by the presence of a discharge, which modifies its operating conditions, properties and outcomes often in a very localised way. The sometimes used description "plasma-activated catalysis" is an apt one.

关键词： plasma catalysis plasma-activated catalysis non-thermal plasma CO2 conversion

Bulk petroleum geochemistry of shales from the onshore Rio del Rey Basin,Cameroon

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Energy Geoscience 2022年第2期3卷 111-119页

作者： christopher m.Agyingi Noel C.Tangko Emmanuel Eseme Department of Geology University of BueaCameroon P.O.Box 63BueaCameroon Activation Laboratories Ltd AncasterONCanada

Petroleum production in the Rio del Rey Basin,which is an extension of the Niger Delta of Nigeria into Cameroon,has been limited to the Tertiary offshore portion since the late *** to dedlining reserves in this offshore portion,the onshore Cretaceous portion of the basin attracted significant attention in the last *** the present *** from outcrops in the onshore portion of the basin were analyzed to evaluate their potential as source rocks,assess hydrocarbon generation,and highlight their signifcance for *** observations,total organic carbon(TOC)measure-ments,and Rock Eval pyrolysis were used to generate data for these ***-eval S2 values(0.42-3 mg HC/g rock)based on measured present-day TOC values(0.58-2.44 wtx)of the shales studied signify poor to fair source rock potentials,whereas calculated S2 values(1.74-8.19 mg HC/g rock)based on estimated original TOC values(0.67-2.87 wt%)produced fair to good source rocks containing Type Ⅱ/Ⅲ kerogen,which were transformed by maturity to the present-day Type Ⅲ/Ⅳ *** of the samples based on Tmax values varying between 439 and 471℃are equivalent to maturity values ranging between 0.74% R_(r) and 1.32% R_(r), and these represent the peak oil to condensate/wet gas zones of hy-drocarbon *** results demonstrate that mature source rocks are present in the onshore part of the Rio del Rey Basin,and thus,it is suitable for petroleum exploration.

关键词： Shale Rio del Rey Basin Total organic carbon Rock-eval Petroleum geochemistry Cameroon

The ASD that Wouldn’t Go Away:An Unusual Case of ASD Device Failure in a Patient with marfan Syndrome

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Congenital Heart Disease 2021年第2期16卷 183-187页

作者： christopher m.Day Neda mulla Timothy martens Brent m.Gordon Department of Pediatrics Loma Linda University Medical CenterLoma LindaCA 92354USA Division of Pediatric Cardiology Loma Linda University Medical CenterLoma LindaCA 92354USA Division of Cardiothoracic Surgery Loma Linda University Medical CenterLoma LindaCA 92354USA

marfan syndrome patients have connective tissue abnormalities that predispose them to intracardiac defects and postoperative *** present a case of late onset ASD device failure secondary to device movement within the atrial septum in a girl with marfan *** case study suggests that further studies are necessary to determine the optimal device and approach for ASD repair in this patient cohort.

关键词： Congenital heart disease atrial septal defect device closure connective tissue disease marfan syndrome transcatheter intervention

A putative plant organelle RNA recognition protein gene is essential for maize kernel development

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Journal of Integrative Plant Biology 2015年第3期57卷 236-246页

作者： Antony m.Chettoor Gibum Yi Elisa gomez Gregorio Hueros Robert B.meeley Philip W.Becraft Department of Genetics Development and Cell BiologyIowa State University Carnegie Institution of Science Plant Genomics and Breeding Institute Seoul National University Department of Biotechnology and Biomedicine University of AlcalaUniversity Campus Du Pont Pioneer Department of Agronomy Iowa State University

Basal endosperm transfer layer（BETL） cells are responsible for transferring apoplastic solutes from the maternal pedicel into the endosperm,supplying the grain with compounds required for embryo development and storage reserve ***,we analyze the maize（Zea mays L.） empty pericarp6（emp6） mutant,which causes early arrest in grain *** Emp6 tgene function is required independently in both the embryo and *** emp6 mutant causes a notable effect on the differentiation of BETL cells;the extensive cell wall ingrowths that distinguish BETL cells are diminished and BETL marker gene expression is compromised in mutant *** tagging identified the emp6 locus as encoding a putative plant organelle RNA recognition（PORR） protein,1 of 15 PORR family members in *** emp6 transcript is widely detected in plant tissues with highest Researclevels in embryos and developing ***6-green fluorescent protein（GFP） fusion proteins transiently expressed in Nicotiana benthamiana leaves were targeted specifically to *** results suggest that BETL cell differentiation might be particularly energy intensive,or alternatively,that mitochondria might confer a developmental function.

关键词： Empty pericarp endosperm mitochondria RNA processing transfer cell

Impact of dogs with deltamethrin-impregnated collars on prevalence of visceral leishmaniasis

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Infectious Disease modelling 2020年第1期5卷 235-247页

作者： mondal Hasan Zahid christopher m.Kribs University of Texas at Arlington Department of MathematicsArlington76019USA

Leishmaniasis is a vector borne zoonosis which is classified as a neglected tropical *** the three most common forms of the disease,Visceral Leishmaniasis(VL)is the most threatening to human health,causing 20,000 to 30,000 deaths worldwide each *** where VL is mostly endemic have unprotected dogs in community and ***"presence of dogs usually increases VL risk for humans since dogs are the principal reservoir host for the parasite of the *** on this fact,most earlier studies consider culling dogs as a control measure for the spread of VL.A more recent control measure has been the use of deltamethrin-impregnated dog collars(DIDCs)to protect both humans and dogs by putting DIDCs on dogs *** presence of dogs helps to grow the sandfly population faster by offering a more suitable blood-meal *** the other hand,the presence of DIDCs on dogs helps to reduce sandfly population by the lethality of deltamethrin *** study brings an ecological perspective to this public health concern,aiming to understand the impact of an additional host(here,protected dogs)on disease risk to a primary host(here,humans).To answer this question,we compare two different settings:a community without dogs,and a community with dogs protected with *** analysis shows the presence of protected dogs can reduce VL infection risk in ***,this disease risk reduction depends on dogs’tolerance for sandfly bites.

关键词： dogs delta protected

Hypothesized summative anal physiology score correlates but poorly predicts incontinence severity

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World Journal of Gastroenterology 2017年第31期23卷 5732-5738页

作者： christopher J Young Assad Zahid Cherry E Koh Jane m Young Department of Colorectal Surgery University of Sydney RPAH medical Centre Discipline of Surgery University of Sydney Surgical Outcome Research Centre(SOu RCe) Royal Prince Alfred HospitalUniversity of Sydney School of Public health University of Sydney

To explore the relationship between such a construct and an existing continence score. mETHODSA retrospective study of incontinent patients who underwent anal physiology (AP) was performed. AP results and Cleveland Clinic Continence Scores (CCCS) were extracted. An anal physiology score (APS) was developed using maximum resting pressures (mRP), anal canal length (ACL), internal and external sphincter defects and pudendal terminal motor latency. Univariate associations between each variable, APS and CCCS were assessed. multiple regression analyses were performed. RESULTSOf 508 (419 women) patients, 311 had both APS and CCCS measured. Average mRP was 51 mmHg (SD 23.2 mmHg) for men and 39 mmHg (19.2 mmHg) for women. Functional ACL was 1.7 cm for men and 0.7 cm for women. Univariate analyses demonstrated significant associations between CCCS and mRP (P = 0.0002), ACL (P = 0.0006) and pudendal neuropathy (P multiple regression showed that the variables most useful in predicting CCCS were external sphincter defect, pudendal neuropathy and previous pelvic surgery, but only improving the scores predictive ability to 12.5%. CONCLUSIONThis study shows that the ability of AP tests to predict continence scores improves when considered collectively, but that a constructed summation model before and after multiple regression is poor at predicting the variability in continence scores.

关键词： Incontinence Anal physiology Anal canal Anal ultrasound manometry Electromyography

Cirrhotic ascites review: Pathophysiology, diagnosis and management

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World Journal of Hepatology 2013年第5期5卷 251-263页

作者： christopher m moore David H Van Thiel Section of Hepatology Department of MedicineRush University Medical CenterChicagoIL 60612United States

Ascites is a pathologic accumulation of peritoneal fluidcommonly observed in decompensated cirrhotic states. Its causes are multi-factorial, but principally involve significant volume and hormonal dysregulation in the setting of portal hypertension. The diagnosis of ascites is considered in cirrhotic patients given a constellation of clinical and laboratory findings, and ultimately confirmed, with insight into etiology, by imaging and paracentesis procedures. Treatment for ascites is multimodal including dietary sodium restriction, pharmacologic therapies, diagnostic and therapeutic paracentesis, and in certain cases transjugular intra-hepatic portosystemic shunt. Ascites is associated with numerous complications including spontaneous bacterial peritonitis, hepato-hydrothorax and hepatorenal syndrome. Given the complex nature of ascites and associatedcomplications, it is not surprising that it heralds increased morbidity and mortality in cirrhotic patients and increased cost-utilization upon the health-care system. This review will detail the pathophysiology of cirrhotic ascites, common complications derived from it, and pertinent treatment modalities.

关键词： Ascites Cirrhosis Hepato-hydrothorax Hepatorenal syndrome Spontaneous bacterial peritonitis

High-throughput study of the anomalous Hall effect

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npj Computational materials 2023年第1期9卷 767-774页

作者： JakubŽelezný Yuta Yahagi Carles gomez-Olivella Yang Zhang Yan Sun Institute of Physics Czech Academy of SciencesCukrovarnická1016200 Praha 6Czech Republic Department of Applied Physics Tohoku UniversitySendaiMiyagiJapan Department of Physics and Astronomy University of Tennessee KnoxvilleKnoxvilleTN 37996USA min H.Kao Department of Electrical Engineering and Computer Science University of TennesseeKnoxvilleTN 37996USA Shenyang National Laboratory for materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China

Despite its long history,the anomalous Hall continues to attract attention due to its complex origins,its connection to topology,and its use as a probe of magnetic *** this work we investigate the anomalous Hall effect in 2871 ferromagnetic materials using an automatic high-throughput calculation *** analyze general properties of the effect,such as its reliance on spin-orbit coupling strength and *** materials with the largest anomalous Hall effect,we find that symmetry-protected band degeneracies in the non-relativistic electronic structure,such as mirror symmetry-protected nodal lines,are typically responsible for the large ***,we examine the dependence of the anomalous Hall effect on magnetization direction and demonstrate deviations from the commonly assumed expression j^(AHE)~m×E.

关键词： effect symmetry protected