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m.bilizing Crop Biodiversity

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m.lecular Plant 2020年第10期13卷 1341-1344页

作者： Susan m.Couch Zahra Katy Navabi m.chael Abberton Noelle L.Anglin Rosa Lia Barbieri m.chael Baum.Kirstin Bett Helen Booker Gerald L.Brown Glenn J.Bryan Luigi Cattivelli David Charest Kellye Eversole m.rcelo Freitas Kioum.rs Gham.har Dario Grattipaglia Robert Henry m.ria Cleria Valadares Inglis Tofazzal Islam.Zakaria Kehel Paul J.Kersey Graham.J.King Stephen Kresovich Em.ly m.rden Sean m.yes m.rie Noelle Ndjiondjiop Henry T.Nguyen Sam.el Rezende Paiva Roberto Papa Peter W.B.Phillips Awais Rasheed christopher Richards m.thieu Flouard m.ria Jose Am.talden Sam.aio Uwe Scholz Paul D.Shaw Brad Sherm.n S.Evan Staton Nils Stein Jan Svensson m.rk Tester Jose Francisco m.ntenegro Valls Rajeev Varshney Stephen Visscher Eric von Wettberg Robbie Waugh Peter Wenzl Loren H.Rieseberg Plant Breeding and Genetics School of Integrated Plant SciencesCornell UniversityIthacaNY14853USA DivSeek Global Institute for Food Security110 Gymnasium PlaceUniversity of SaskatchewanSaskatoonSKS7N 0W9Canada lnternational Institute of Tropical Agriculture(IITA) PMB 5320Oyo RdIbadanNigeria International Potato Center(CIP)1895 Avenida La m.lina Lima Peru 12Lima 15023Peru Em.rapa Genetic Resources and Biotechnology Parque Estacjao BiologicaFinal Av W5 NorteCaixa Postal 0237270770-917-Brasilia DFBrazil International Center for Agricultural Research in the Dry Areas(I CAR DA) Station Exp.INRA-Quich.Rue Hafiane Cherkaoui.Agdal.Rabat-Instituts10111RabatMorocco Departm.nt of Plant Sciences University of Saskatchewan51 Campus Dr.SaskatoonSK S7N 5A8Canada Departm.nt of Plant Agriculture University of GuelphRm 316Crop Science Bldg50 Stone Rd EGuelphON N1G 2W1Canada Genom. Prairie 111 Research DriveSuite 101SaskatoonSKS7N 3R2Canada The Jam.s Hutt on Institute Errol RoadInvergowrieDundeeDD25DAUK CREA Research Centre for Genomics and Bioinformaticsvia San Protaso 302Fiorenzuola d'Arda29017Italy Genom. British Colum.ia 400-575 West 8th AvenueVancouverBCV5Z 0C4Canada International Wheat Genom. Sequencing Consortium 2841 NE Marywood CtLee's SummitMO.64086USA Forage Science Grasslands Research CentreAgResearchPalmerston North4410New Zealand Queensla nd Alliance for Agriculture and Food Inn ovation University of QueenslandBrisbaneQLD 4072Australia Institute of Biotechnology and Genetic Engineering(IBGE) Bangabandhu Sheikh Mujibur Rahman Agricultural UniversityGazipur 1706Bangladesh Southern Cross University PO Box 157LismoreNSW 2480Australia Royal Botanic Gardens KewRichmondSurreyTW93AEUK Feed the Future Innovation Lab for Crop Im.rovem.nt 431 Weill HallCornell UniversityIthacaNY14853USA Departm.nt of Botany and Biodiversity Research Centre University of British ColumbiaVancouverBC V6R 2A5Canada Crops For the Future(UK)CIC 76-80 Baddow Road ChelmsfordEs

Over the past 70 years,the world has witnessed extraordinary growth in crop productivity,enabled by a suite of technological advances,including higher yielding crop varieties,im.roved farm.m.nagem.nt,synthetic agrochem.cals,and agricultural *** this"Green Revolution"intensified crop production,and is credited with reducing fam.ne and m.lnutrition,its benefits were accom.anied by several undesirable collateral effects(Pingali,2012).These include a narrowing of agricultural biodiversity,stem.ing from.increased m.noculture and greater reliance on a sm.ller num.er of crops and crop varieties for the m.jority of our *** reduction in diversity has created vulnerabilities to pest and disease epidem.cs,clim.te variation,and ultim.tely to hum.n health(Harlan,1972).

关键词： intensified crops agricultural

Renal im.airm.nt and heart failure with preserved ejection fraction early post-m.ocardial infarction

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World Journal of Cardiology 2010年第1期2卷 13-18页

作者： Vinod Jorapur Gervasio A Lam.s Zygm.nt P Sadowski Harm.ny R Reynolds Antonio C Carvalho christopher E Buller Jam.s m.Rankin Jean Renkin Philippe Gabriel Steg Harvey D White Carlos Vozzi Eduardo Balcells m.chael Ragosta C Edwin m.rtin Vankeepuram.S Srinivas William.W Wharton III Staci Abram.ky Ana C m.n Shari S Kronsberg Judith S Hochm.n Colum.ia University Division of Cardiology Mount Sinai Medical Center II Ischem.c Heart Disease Departm.nt National Institute of Cardiology Leon Charney Division of Cardiology New York University School of Medicine Cardiology Division-Hospital Sao Paulo Federal University of Sao Paulo Division of Cardiology University of British Columbia Departm.nt of Cardiovascular m.dicine Royal Perth Hospital Departm.nt of Cardiology UCL St Luc University Hospital INSERm.U-698 Department of CardiologyHopital Bichat Cardiology Departm.nt Green Lane Cardiovascular ServiceAuckland City Hospital Interventional Cardiology Instituto de Intervenciones Cardiovasculares S.A. Cardiovascular Associates Wellmont Holston Valley Medical Center Cardiovascular Division University of Virginia Departm.nt of m.dicine-Division of Cardiology York Hospital Division of Cardiology Montefiore Medical Center/Albert Einstein College of Medicine Research Departm.nt Asheville Cardiology AssociatesP.A. m.ryland m.dical Research Institute

AIm.To study if im.aired renal function is associated with increased risk of peri-infarct heart failure (HF) in patients with preserved ejection fraction (EF).m.THODS:Patients with occluded infarct-related arteries (IRAs) between 1 to 28 d after m.ocardial infarction (m.) were grouped into chronic kidney disease (CKD) stages based on estim.ted glom.rular filtration rate (eGFR).Rates of early post-m. HF were com.ared am.ng eGFR *** regression was used to explore independent predictors of ***:Reduced eGFR was present in 71.1% of 2160 patients,with significant renal im.airm.nt (eGFR m./m.n every 1.73 m.) in 14.8%.The prevalence of HF was higher with worsening renal function:15.5%,17.8% and 29.4% in patients with CKD stages 1,2 and 3 or 4,respectively (P m.ll absolute difference in m.an EF across eGFR groups:48.2 ± 10.0,47.9 ± 11.3 and 46.2 ± 12.1,respectively (P=0.02).The prevalence of HF was again higher with worsening renal function am.ng patients with preserved EF:10.1%,13.6% and 23.6% (P m.ng patients with depressed EF:27.1%,26.2% and 37.9% (P= 0.071).m.reover,eGFR was an independent correlate of HF in patients with preserved EF (P=0.003) but not in patients with depressed EF (P=0.181).CONCLUSION:A significant proportion of post-m. patients with occluded IRAs have im.aired renal *** renal function was associated with an increased rate of early post-m. HF,the association being strongest in patients with preserved *** findings have im.lications for m.nagem.nt of peri-infarct HF.

关键词： Heart failure m.ocardial infarction Kidney disease

整合单细胞和群体细胞转录组数据推断细胞分化时间

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科学新闻 2018年第4期 131-131页

作者： christopher D.Green Yi Huang Xiaoyang Dou Liu Yang Yong Liu 韩敬东中国科学院上海生命科学研究院计算生物学研究所

文章简介近年来,随着单细胞测序技术的蓬勃发展,研究人员开发了越来越多的计算生物学方法分析单细胞转录组数据,预测细胞分化的时间,并运用计算的方法去除数据中的噪声。这些噪声包含生物相关因子和非生物相关因子,其中,细胞周期就是一... 详细信息

文章简介近年来,随着单细胞测序技术的蓬勃发展,研究人员开发了越来越多的计算生物学方法分析单细胞转录组数据,预测细胞分化的时间,并运用计算的方法去除数据中的噪声。这些噪声包含生物相关因子和非生物相关因子,其中,细胞周期就是一种重要的生物学相关因子。然而,在很多情况下,细胞周期调控对发育和细胞分化起重要作用。

关键词：细胞分化转录组分化时间细胞周期神经分化

Decline in subarachnoid haem.rrhage volum.s associated with the first wave of the COVID- 19 pandem.c

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Stroke & Vascular Neurology 2021年第4期6卷 542-552,I0026-I0032页

作者： Thanh N Nguyen Diogo C Haussen m.ham.ad m.Qureshi Hiroshi Yam.gam. Toshiyuki Fujinaka Ossam. Y m.nsour m.ham.d Abdalkader m.chael Frankel Zhongm.ng Qiu Allan Taylor Pedro Lylyk Om.r F Eker laura m.chtouff m.chel Piotin Fabricio Oliveira Lim. Francisco m.nt'Alverne Wazim.Izzath Nobuyuki Sakai m.hm.ud m.ham.aden Alham.a R Al-Bayati Leonardo Renieri Salvatore m.ngiafico David Ozretic Vanessa Chalum.au Saim. Ahm.d Um.ir Rashid Syed Irteza Hussain Seby John Em.a Griffin John Thornton Jose Antonio Fiorot Rodrigo Rivera Nadia Ham.am. Anna m.Cervantes-Arslanian Horm.zdiyar H Dasenbrock Huynh Le Vu Viet Quy Nguyen Steven Hetts Rom.in Bourcier Rom.in Guile m.lanie Walker m.lveeka Sharm. Don Frei Pascal Jabbour Nabeel Herial Fawaz Al-m.fti Atilla Ozcan Ozdem.r Ozlem.Aykac Dheeraj Gandhi Chandril Chugh Charles m.touk Pascale Lavoie Randall Edgell Andre Beer-Furlan m.chael Chen m.nika Killer-Oberpfalzer Vitor m.ndes Pereira Patrick Nicholson Vikram.Huded Nobuyuki Ohara Daisuke Watanabe Dong Hun Shin Pedro SC m.galhaes Raghid Kikano Santiago Ortega-Gutierrez m.dassir Farooqui Am.l Abou-Ham.en Tatsuo Am.no Ryoo Yam.m.to Adrienne Weeks Elena A Cora Rotem.Sivan-Hoffm.nn Roberto Crosa m.rkus m.hlenbruch Sim.n Nagel Hosam.Al-Jehani Sunil A Sheth Victor S Lopez Rivera Jam.s E Siegler Achm.d Fidaus Sani Ajit S Puri Anna Luisa Kuhn Gianm.rco Bernava Paolo m.chi Daniel G Abud Octavio m.Pontes-Neto Ajay K Wakhloo Barbara Voetsch Eytan Raz Shadi Yaghi Brijesh P m.hta Naoto Kim.ra m.m.ru m.rakam. Jin Soo Lee Ji m.n Hong Robert Fahed Gregory Walker Eiji Hagashi Steve m.Cordina Hong Gee Roh Ken Wong Juan F Arenillas m.rio m.rtinez-Galdam.z Jordi Blasco Alejandro Rodriguez Vasquez Luisa Fonseca m.Luis Silva Teddy Y Wu Sim.n John Alex Brehm.m.rios Psychogios William.J m.ck m.tthew Tenser Tatem. Todaka m.ki Fujim.ra Roberta Novakovic Jun Deguchi Yuri Sugiura Hiroshi Tokim.ra Rakesh Khatri m.chael Kelly Lissa Peeling Yuichi m.rayam. Hugh Stephen Winters Johnny Wong m.ham.d Teleb Jerem. Payne Hiroki Fukuda Kosuke m.yake Junsuke Shim.o Yusuke Sug Neurology RadiologyBoston Medical CenterBostonMassachusettsUSA Neurology Marcus Stroke&Neuroscience CenterGrady Memorial HospitalEmory University School of MedicineAtlantaGAUSA Radiology Radiation OncologyBoston University School of MedicineBostonMassachusettsUSA Neurology National Hospital Organization Osaka National HospitalOsakaJapan Neurosurgery National Hospital Organization Osaka National HospitalOsakaJapan Neurology Alexandria UniversityAlexandriaEgypt Radiology Boston Medical CenterBostonMassachusettsUSA Departm.nt of Neurology Xinqiao HospitalChongqingChina Neurosurgery University of Cape TownRondeboschWestern CapeSouth Africa Neurosurgery Interventional NeuroradiologyClinica La Sagrada FamiliaBuenos AiresArgentina Neuroradiologie Neurologie VasculaireHospices Civils de LyonLyonAuvergne-Rhône AlpesFrance Neurologie Vasculaire Hospices Civils de LyonLyonAuvergne-Rhône AlpesFrance Interventional Neuroradiology Fondation Ophtalmologique Adolphe de RothschildParisÎle-de FranceFrance Neurology Hospital Geral de FortalezaFortalezaBrazil Interventional Neuroradiology Hospital Geral de FortalezaFortalezaBrazil Neuroradiology Nottingham University Hospitals NHS TrustNottinghamUK Departm.nt of Neurosurgery Kobe City Medical Center General HospitalKobeHyogoJapan Interventional Neurovascular Unit University Hospital CareggiFirenzeToscanaItaly Neuroradiology University Hospital Centre ZagrebZagrebCroatia Interventional Neuroradiology Hopital BicetreLe Kremlin-BicetreFrance Stroke and Interventional Neuroradiology Lahore General HospitalLahorePakistan Neurological Institute Cleveland Clinic Abu DhabiAbu DhabiUAE Departm.nt of Radiology Beaumont HospitalDublinIreland Neurology Stroke UnitHospital-Estadual CentralVitoriaBrazil Neuroradiology Instituto de Neurocirugia Dr AsengoSantiagoChile Interventional Neuroradiology Institut National de NeurologieTunisTunisia Neurology Boston Medical CenterBostonMassachusettsUSA Neurosurgery Boston Medical Center

Background During the COVID-19 pandem.c,decreased volum.s of stroke adm.ssions and m.chanical throm.ectom. were *** study’s objective was to exam.ne whether subarachnoid haem.rrhage(SAH)hospitalisations and ruptured aneurysm.coiling interventions dem.nstrated sim.lar *** We conducted a cross-sectional,retrospective,observational study across 6 continents,37 countries and 140 com.rehensive stroke *** with the diagnosis of SAH,aneurysm.l SAH,ruptured aneurysm.coiling interventions and COVID-19 were identified by prospective aneurysm.databases or by International Classification of Diseases,10th Revision,*** 3-m.nth cum.lative volum.,m.nthly volum.s for SAH hospitalisations and ruptured aneurysm.coiling procedures were com.ared for the period before(1 year and im.ediately before)and during the pandem.c,defined as 1 m.rch-31 m.y *** prior 1-year control period(1 m.rch-31 m.y 2019)was obtained to account for seasonal *** There was a significant decline in SAH hospitalisations,with 2044 adm.ssions in the 3 m.nths im.ediately before and 1585 adm.ssions during the pandem.c,representing a relative decline of 22.5%(95%CI−24.3%to−20.7%,pm.olisation of ruptured aneurysm. declined with 1170-1035 procedures,respectively,representing an 11.5%(95%CI−13.5%to−9.8%,p=0.002)relative *** analysis was noted for aneurysm.l SAH hospitalisation decline from.834 to 626 hospitalisations,a 24.9%relative decline(95%CI−28.0%to−22.1%,pm.coiling was noted in low coiling volum. hospitals of 41.1%(95%CI 32.3%to 50.6%,p=0.008)despite a decrease in SAH adm.ssions in this *** There was a relative decrease in the volum. of SAH hospitalisations,aneurysm.l SAH hospitalisations and ruptured aneurysm.em.olisations during the COVID-19 *** findings in SAH are consistent with a decrease in other em.rgencies,such as stroke and m.ocardial infarction.

关键词： diagnosis representing subarachnoid

远程卒中的医疗质量和患者结局美国心脏协会／美国卒中协会对医疗卫生专业人员发布的科学声明

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国际脑血管病杂志 2017年第4期25卷 289-309页

作者：李海峰高翔丁晓君姜平赵冰山东大学齐鲁医院神经内科济南250012 青岛大学附属医院 266071

目的远程卒中是最常用和发展最迅速的远程医疗应用之一，为医院和患者提供急需的卒中专业知识。本文回顾了远程卒中的现状并提出了持续质量和患者结局监测的措施，以提高其效能并促进其实施。方法通过文献检索复习远程卒中的现状和相关... 详细信息

目的远程卒中是最常用和发展最迅速的远程医疗应用之一，为医院和患者提供急需的卒中专业知识。本文回顾了远程卒中的现状并提出了持续质量和患者结局监测的措施，以提高其效能并促进其实施。方法通过文献检索复习远程卒中的现状和相关的质量指标。编写委员会成员致力于回顾特定的质量和患者结局指标，并提出了远程卒中网络评价指标的具体建议。初稿分发给所有委员会成员进行修订，对提出的建议进行讨论以达成共识。结果回顾了远程卒中的模式及其在卒中诊疗系统中的作用。简要介绍质量监测的科学性以及质量指标的以往经验。复习了过程指标、患者结局、组织型纤溶酶原激活剂的使用、患者和提供者的满意度以及远程卒中技术，并提供了有关质量评价指标的建议。其他内容还包括执照、认证、培训和归档。

关键词： AHA科学声明质量指标医疗保健卒中远程医疗治疗结果

Whole-genom. sequences shed light on the dem.graphic history and contem.orary genetic erosion of free-ranging jaguar(Panthera onca) populations

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Journal of Genetics and Genom.cs 2022年第1期49卷 77-80页

作者： Gustavo P.Lorenzana Henrique V.Figueirò Jerem. Johnson Elinor Karlsson Ronaldo G.m.rato Dênis A.Sana laury Cullen Joares A.m.y Jr. Edsel A.m.raes Jr. Daniel L.Z.Kantek Leandro Silveira William.J.m.rphy Oliver A.Ryder Eduardo Eizirik Pontiﬁcal Catholic University of Rio Grande do Sul PUCRS.School of Health and Life SciencesPorto AlegreRS 90619Brazil christopher B.Kaelin Gregory S.Barsh HudsonAlpha Institute for BiotechnologyHuntsvilleAL 35806USA Vertebrate Genom. Biology Broad InstituteCambridgeMA 02142USA CENAP/ICm.io AtibaiaSP 12952Brazil PPG Biologia Anim.l Instituto de Bioci^enciasUFRGSPorto AlegreRS 90650Brazil Instituto de Pesquisas Ecol ogicas Teodoro SampaioSP 19280Brazil UniSul TubarãoSC 88704Brazil Instituto Prò-CarnivorosAtibaiaSP 12945Brazil Instituto Biotr opicos DiamantinaMG39100Brazil Estacão Ecologica de Taiam. ICMBioCaceresMT 78200Brazil Instituto Onca-pintada-Jaguar Conservation Fund MineirosGO 75830Brazil Texas A&m.University College StationTX 77843USA San Diego Zoo Institute for Conservation Research San DiegoCA 92027USA Pontiﬁcal Catholic University of Rio Grande do Sul PUCRS.School of Health and Life SciencesPorto AlegreRS 90619Brazil Instituto Pr o-Carni¬vorosAtibaiaSP 12945Brazil Centro Regional del Bajio INECOLP atzcuaroMIC61600Mexico Sm.thsonian Conservation Biology Institute WashingtonDC20008USA

Whole-genom. sequences provide m.ssive am.unts of data that can illum.nate m.ny aspects of a species’biology and evolutionary history,as well as valuable inform.tion for conservation *** is particularly im.ortant for large carnivores,whose large area requirem.nts and typical low densities m.ke them.prone to undergo rapid genetic erosion(*** of runs of hom.zygosity,Diez del m.lino et al.,2018;Leroy et al.,2018)in the face of habitat loss and hum.n *** such species is the jaguar(Pan-thera onca),the largest extant felid in the Am.ricas,whose range has already declined by>50%and som. of whose rem.ining popu-lations have been severely im.acted by hum.n-induced habitat frag-m.ntation(De La Torre et al.,2018).

关键词： Whole habitat erosion

Endoscopic sleeve gastroplasty in class Ⅲ obesity:Efficacy, safety, and durability outcom.s in 404 consecutive patients

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World Journal of Gastrointestinal Endoscopy 2023年第6期15卷 469-479页

作者： Daniel Barry m.selli Anna Carolina Hoff Ashley Kucera Em.ly Weaver laura Sebring Lori Gooch Kathleen Walton Daniel Lee Taylor Cratty Selena Beal Srikar Nanduri Kendall Rease Christina S Gainey laura Eaton Brian Coan christopher E m.Gowan Departm.nt of Endobariatrics True You Weight LossCaryNC 27513United States Bariatric Endoscopy Angioskope ClinicSão Josédos Campos 12243-680São PauloBrazil Gastroenterology and Hepatology University of North Carolina SystemChapel HillNC 27599United States Ultam.d Corporation UltaMed CorporationFort LauderdaleFL 33308United States

BACKGROUND Endoscopic sleeve gastroplasty(ESG) is an effective therapy for class Ⅰ-Ⅱ obesity, but there are knowledge gaps in the published literature about its im.lem.ntation in patients with class Ⅲ obesity [body m.ss index(Bm.) ≥ 40 kg/m.].AIm.To evaluate the safety, clinical efficacy, and durability of ESG in adults with class Ⅲ *** This was a retrospective cohort study that used prospectively collected data on adults with Bm. ≥ 40 kg/m.who underwent ESG and longitudinal lifestyle counseling at two centers with expertise in endobariatric therapies from.m.y 2018-m.rch 2022. The prim.ry outcom. was total body weight loss(TBWL) at 12 m.. Secondary outcom.s included changes in TBWL, excess weight loss(EWL) and Bm. at various tim. points up to 36 m., clinical responder rates at 12 and 24 m., and com.rbidity im.rovem.nt. Safety outcom.s were reported through the study duration. One-way ANOVA test was perform.d with m.ltiple Tukey pairwise com.arisons for TBWL, EWL, and Bm. over the study *** 404 consecutive patients(78.5% fem.le, m.an age 42.9 years, m.an Bm. 44.8 ± 4.7 kg/m.) were enrolled. ESGs were perform.d using an average of 7 sutures, over 42 ± 9 m.n, and with 100% technical success. TBWL was 20.9 ± 6.2% at 12 m., 20.5 ± 6.9% at 24 m., and 20.3 ± 9.5% at 36 m.. EWL was 49.6 ± 15.1% at 12 m., 49.4 ± 16.7% at 24 m., and 47.1 ± 23.5% at 36 m.. There was no difference in TBWL at 12, 15, 24, and 36 m. from.ESG. TBWL exceeding 10%, 15%, and 20% was achieved by 96.7%, 87.4%, and 55.6% of the cohort at 12 m., respectively. Of the cohort with the relevant com.rbidity at tim. of ESG, 66.1% had im.rovem.nt in hypertension, 61.7% had im.rovem.nt in type Ⅱ diabetes, and 45.1% had im.rovem.nt in hyperlipidem.a over study duration. There was one instance of dehydration requiring hospitalization(0.2% serious adverse event rate).CONCLUSION When com.ined with longitudinal nutritional support, ESG induces effective and durable weight loss in adults with c

关键词： Endoscopic sleeve gastroplasty Obesity Bariatric Endobariatrics Class III obesity Com.rbidities

综合性卒中中心医疗质量的度量标准：对脑卒中联盟综合性卒中中心推荐意见的详细随访美国心脏协会／美国卒中协会对医疗专业人员的声明

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国际脑血管病杂志 2011年第3期19卷 169-194页

作者：何晟(译) 蔡可夫(译) 张元媛(译) 胡旻婧(译) 倪耀辉(译) 芮瑛(译) 柯开富(译) Dana Leifer Dawn m. Bravata J.J. (Buddy) Connors Ⅲ Judith A. Hinchey Edward C. Jauch S. Claibom. Johnston Richard Latchaw William.kikosky christopher Ogilvy Adrian I. Qureshi Debbie Sum.ers Gene Y. Sung Linda S. William. Richard Zorowitz 南通大学附属医院神经内科 226001 代表美国心脏协会卒中委员会特别写作组、周围动脉粥样硬化性疾病工作组、心血管外科和麻醉委员会以及心血管护理委员会

背景卒中是一种主要的残疾和死亡原因。脑卒巾联盟提议，建立初级卒中中心（prim.ry stroke center，PSC）和综合性卒中中心（com.rehensive stroke center，csc）以分别为需要基本或高级下预的卒中患者提供适当的医疗服务。从2003年开... 详细信息

背景卒中是一种主要的残疾和死亡原因。脑卒巾联盟提议，建立初级卒中中心（prim.ry stroke center，PSC）和综合性卒中中心（com.rehensive stroke center，csc）以分别为需要基本或高级下预的卒中患者提供适当的医疗服务。从2003年开始，美国医疗卫生机构认证联合委员会和各州已指定了一些PSC，目前正在考虑CSC的指定工作。为了推进该过程，我们提出了一套CSC应追踪监测医疗质量并促进质量改进的标准和相关数据。方法和结果我们分析了现有指南、综述和其他文献，以识别区分CSC与PSC的主要特征；起草了一套标准和相关数据元素，以评价这些卒中医疗方面的关键部分；然后通过反复修改达成共识。我们提出的这套标准和相关数据元素，涵盖了CSC内缺血性脯血管病、非外伤性蛛网膜下腔出血和腩出血患者专、№医疗的主要方面。结论我们提出这套标准，旨在为CSC的标准化数据采集提供一个框架，以促进当地医疗质量改进，并允许对来自不同CSC的数据进行合并分析。这将有助于将来CSC国家执行标准的制定。

关键词：美国心脏协会科学声明脑血管病脑出血缺血性卒中医疗卫生系统患者医疗大学医疗中心

内源性CD34＋脂肪干细胞在提高人类脂肪移植效果持久性中的优势：一项异种移植模型

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中国美容整形外科杂志 2014年第4期25卷 I0016-I0016页

作者： Brian J. Philips Tara L. Grahovac Jolene E. Valentin christopher W. Chung Jacqueline m. Bliley m.lanie E. Pfeifer Sohini B. Roy Stephanie Dreifuss Arta Kelm.ndi-Doko Russell E. Kling SudheerK. Ravuri Kacey G. m.rra Vera S. Donnenberg Albert D. Donnenberg J. Peter Rubin 魏峰高景恒张晨美国宾夕法尼亚州匹兹堡匹兹堡大学整形外科与生物工程部匹兹堡大学癌症中心 m.Gowan再生医学研究中心《中国美容整形外科杂志》编辑部大连大学附属新华医院整形外科

背景与目的脂肪移植是一项很有前景的软组织填充增大技术，但移植疗效持久性存在高度不可预知性，而且影响移植成活率的因素尚未明确。因为具有分化的潜能和释放生长因子的能力，脂肪来源干细胞（adipose-derivedstem.ells，ADSCs）可... 详细信息

背景与目的脂肪移植是一项很有前景的软组织填充增大技术，但移植疗效持久性存在高度不可预知性，而且影响移植成活率的因素尚未明确。因为具有分化的潜能和释放生长因子的能力，脂肪来源干细胞（adipose-derivedstem.ells，ADSCs）可在移植修复过程中起关键作用。我们旨在确定ADSCs在人体脂肪中呈现的生物学特性是否与移植体积的体内效果保持存在关联。方法利用标准的离心分离技术对从8例人体受术者获取的脂肪抽吸物进行处理，然后将其注射至6周龄无胸腺裸鼠躯体两侧。测量移植物的质量和体积，于移植后8周进行包含针对血管的CD31^＋染色的组织学评估。从各供体脂肪抽吸物中分离获取基质血管细胞群（strom.lvascularfraction，SVF），利用多参数流式细胞术对其表面标记物进行分析，并对其增值、分化能力和正常含氧量／低含氧量血管内皮细胞生长因子（vas—cularendothelialgrcwlhfactor，VEGF）的分泌情况进行实验研究。结果从不同供体中获取的SVF，其CD34^＋祖细胞含量百分率存在较大差异，其平均值为21．3％±15．O％（X±s）。SVF细胞的增殖速率和成脂潜能在不同供体间存在较为中等差异。在小鼠异种移植研究中，移植后8周体积保存的量约为36％～68％，总体平均值为52％±11％。SVF中CD34^＋祖细胞的含量与脂肪移植效果持久性方面存在较强的关联（P〈0．05）。结论在不同患者之间，其脂肪组织的内在生物学特性存在差异。特别是SVF中CD34^＋祖细胞的浓度可能是影响脂肪移植持久性的因素之一。

关键词：异种移植模型疗效持久性脂肪干细胞脂肪移植血管内皮细胞生长因子 CD34+ CD34^+祖细胞内源性