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Superior antibody and membrane protein‑specific T‑cell responses to CoronaVac by intradermal versus intramuscular routes in adolescents

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World Journal of Pediatrics 2024年第4期20卷 353-370页

作者： Jaime S.Rosa Duque Samuel M.S.Cheng Carolyn A.Cohen Daniel leung Xiwei Wang Xiaofeng Mu yuet Chung Tsun Ming Lau Manni Wang Wenyue Zhang yanmei Zhang Howard H.W.Wong Leo C.H.Tsang Sara Chaothai Tsz Chun kwan John k.C.Li karl C.k.Chan Leo L.H.Luk Jenson C.H.Ho Wing yan Li Amos M.T.Lee Jennifer H.y.Lam Sau Man Chan Wilfred H.S.Wong Issan y.S.Tam Masashi Mori Sophie A.Valkenburg Malik Peiris Wenwei Tu yu Lung Lau Department of Paediatrics and Adolescent Medicine The University of Hong KongHong KongChina School of Public Health The University of Hong KongHong KongChina HkU‑Pasteur Research Pole School of Public HealthThe University of Hong KongHong KongChina Research Institute for Bioresources and Biotechnology Ishikawa Prefectural UniversityNonoichiJapan Department of Microbiology and Immunology Peter Doherty Institute for Infectionand ImmunityUniversity of MelbourneMelbourneVICAustralia Center for Immunology and Infection C2i Hong KongChina

Background Optimising the immunogenicity of COVID-19 vaccines to improve their protection against disease is *** dosing by intradermal(ID)administration has been shown to be equally immunogenic as intramuscular(IM)administration for several vaccines,but the immunogenicity of ID inactivated whole severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)at the full dose is *** study(NCT04800133)investigated the superiority of antibody and T-cell responses of full-dose CoronaVac by ID over IM administration in *** Participants aged 11–17 years received two doses of IM or ID vaccine,followed by the 3rd dose 13–42 days *** and cellular immunogenicity outcomes were measured post-dose 2(IM-CC versus ID-CC)and post-dose 3(IMCCC versus ID-CCC).Doses 2 and 3 were administered to 173 and 104 adolescents,*** Spike protein(S)immunoglobulin G(IgG),S-receptor-binding domain(RBD)IgG,S IgG Fcγreceptor IIIa(FcγRIIIa)-binding,SNM[sum of individual(S),nucleocapsid protein(N),and membrane protein(M)peptide pool]-specific interleukin-2(IL-2)+CD4^(+),SNM-specific IL-2^(+)CD8^(+),S-specific IL-2^(+)CD8^(+),N-specific IL-2^(+)CD4^(+),N-specific IL-2^(+)CD8^(+)and M-specific IL-2^(+)CD4^(+)responses fulfilled the superior and non-inferior criteria for ID-CC compared to IM-CC,whereas IgG avidity was *** ID-CCC,S-RBD IgG,surrogate virus neutralisation test,90%plaque reduction neutralisation titre(PRNT90),PRNT50,S IgG avidity,S IgG FcγRIIIa-binding,M-specific IL-2^(+)CD4^(+),interferon-γ+CD8^(+)and IL-2^(+)CD8^(+)responses were superior and non-inferior to *** estimated vaccine efficacies were 49%,52%,66%and 79%for IM-CC,ID-CC,IM-CCC and ID-CCC,*** ID groups reported more local,mild adverse *** This is the first study to demonstrate superior antibody and M-specific T-cell responses by ID inactivated SARSCoV-2 vaccination and serves as the basis for future research to improve the

关键词： CoronaVac Coronavirus disease 2019 Immunity Intradermal Vaccine

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Chemical biology investigation of a triple-action,smart-decomposition antimicrobial booster based-combination therapy against“ESkAPE”pathogens

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Science China Chemistry 2024年第9期67卷 3071-3082页

作者： Min Wang Huangsheng Pu yangfan Xu Chenxuan Wu yuanxin Gu Qingyun Cai Guoxing yin Peng yin Chunhui Zhang Wing-leung Wong Muyang Wan yugang Bai Xinxin Feng State key Laboratory of Chem-/Bio-Sensing and Chemometrics Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biologyand School of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China College of Biology Hunan UniversityChangsha 410082China College of Advanced Interdisciplinary Studies&Hunan Provincial key Laboratory of Novel Nano Optoelectronic Information Materials and Devices National University of Defense TechnologyChangsha 410073China Nanhu Laser Laboratory National University of Defense TechnologyChangsha 410073China key Laboratory of Chemical Biology and Traditional Chinese Medicine Research(Ministry of Education) College of Chemistry and Chemical EngineeringHunan Normal UniversityChangsha 410081China State key Laboratory of Chemical Biology and Drug Discovery Department of Applied Biology and Chemical TechnologyThe Hong Kong Polytechnic UniversityHong Kong SAR 999077China Hunan Provincial key Laboratory of Anti-Resistance Microbial Drugs The Third Hospital of Changsha(The Affiliated Changsha Hospital of Hunan University)Changsha 410015China

The global antibiotic resistance crisis necessitates urgent *** innovative approach involves potentiating antibiotics and non-antibiotic drugs with adjuvants or boosters.A major drawback of these membrane-active boosters is their limited biocompatibility,as they struggle to differentiate between prokaryotic and eukaryotic *** study reports the chemical biology investigation of a dual-action oligoamidine(OA1)booster with a glutathione-triggered decomposition ***1,when combined with other antimicrobial molecules,exhibits a triple-targeting mechanism including cell membrane disruption,DNA targeting,and intracellular enzyme *** multi-targeting mechanism not only enhances the in vitro and in vivo eradication of antibiotic-resistant“ESkAPE”pathogens,but also suppresses the development of bacterial ***,OA1 maintains its activity in bacterial cells by creating an oxidative environment,while it quickly decomposes in mammalian cells due to high glutathione *** mechanistic insights and design principles may provide a feasible approach to develop novel antimicrobial agents and effective anti-resistance combination therapies.

关键词： antimicrobial booster oligoamidine membrane disruption DNA targeting triggered degradation anti-resistance

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MicroRNA-based therapeutics for optic neuropathy:opportunities and challenges

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Neural Regeneration Research 2021年第10期16卷 1996-1997页

作者： Heather k.Mak christopher k.S.leung Department of Ophthalmology and Visual Sciences The Chinese University of Hong KongHong Kong Special Administrative RegionChina

Optic nerve degeneration is a major cause of irreversible blindness worldwide with glaucoma being the most common optic neuropathy,affecting approximately 76 million people worldwide in *** optic nerve comprises axons of retinal ganglion cells(RGCs),the output neurons of the inner *** RGCs and axons from degeneration and regenerating RGC axons to preserve and recover vision in patients with progressive optic neuropathy is an unmet *** embryonic neurons,mature neurons of the mammalian central nervous system fail to regenerate their axons following *** age-related loss of axon regenerative capacity of RGCs over time renders vision loss from optic neuropathy *** failure of injured RGCs to regenerate axons is largely attributed to inhibitory molecules in the extrinsic environment and a change in the intrinsic molecular makeup of aging *** studies have demonstrated that RGCs require specific molecular signals for the stimulation of axon growth even without inhibitory molecules in the extrinsic environment,leading successive efforts to focus on uncovering the intrinsic signaling pathways that control axon extension during RGC development.

关键词： neuropathy degeneration stimulation

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Ethanol steam reforming over Ni/ZSM-5 nanosheet for hydrogen production

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Chinese Journal of Chemical Engineering 2024年第3期67卷 247-256页

作者： Porapak Suriya Shanshan Xu Shengzhe Ding Sarayute Chansai yilai Jiao Joseph Hurd Daniel Lee yuxin Zhang christopher Hardacre Prasert Reubroycharoen Xiaolei Fan Department of Chemical Engineering School of EngineeringThe University of ManchesterManchester M139PLUnited Kingdom Program of Petrochemistry and Polymer Science Faculty of ScienceChulalongkorn UniversityBangkok10330Thailand Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China Liaoning Academy of Materials Shenyang 110167China Center of Excellence in Catalysis for Bioenergy and Renewable Chemicals(CBRC) andDepartment of Chemical TechnologyFaculty of ScienceChulalongkorn UniversityBangkok 10330Thailand Nottingham Ningbo China Beacons of Excellence Research and Innovation Institute University of Nottingham Ningbo ChinaNingbo315100China

Compared to reforming reactions using hydrocarbons,ethanol steam reforming(ESR)is a sustainable alternative for hydrogen(H_(2))production since ethanol can be produced sustainably using *** work explores the catalyst design strategies for preparing the Ni supported on ZSM-5 zeolite catalysts to promote ***,two-dimensional ZSM-5 nanosheet and conventional ZSM-5 crystal were used as the catalyst carriers and two synthesis strategies,i.e.,in situ encapsulation and wet impregnation method,were employed to prepare the *** on the comparative characterization of the catalysts and comparative catalytic assessments,it was found that the combination of the in situ encapsulation synthesis and the ZSM-5 nanosheet carrier was the effective strategy to develop catalysts for promoting H_(2) production via ESR due to the improved mass transfer(through the 2-D structure of ZSM-5 nanosheet)and formation of confined small Ni nanoparticles(resulted via the in situ encapsulation synthesis).In addition,the resulting ZSM-5 nanosheet supported Ni catalyst also showed high Ni dispersion and high accessibility to Ni sites by the reactants,being able to improve the activity and stability of catalysts and suppress metal sintering and coking during ESR at high reaction ***,the Ni supported on ZSM-5 nanosheet catalyst prepared by encapsulation showed the stable performance with~88% ethanol conversion and~65% H_(2) yield achieved during a 48-h longevity test at 550-C.

关键词： ZSM-5 nanosheet In situ encapsulation Ni catalyst Ethanol steam reforming Hydrogen production

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Genomics-driven derivatization of the bioactive fungal sesterterpenoid variecolin:Creation of an unnatural analogue with improved anticancer properties

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Acta Pharmaceutica Sinica B 2024年第1期14卷 421-432页

作者： Dexiu yan Jemma Arakelyan Teng Wan Ritvik Raina Tsz ki Chan Dohyun Ahn Vladimir kushnarev Tsz kiu Cheung Ho Ching Chan Inseo Choi Pui yi Ho Feijun Hu yujeong kim Hill Lam Lau ying Lo Law Chi Seng leung Chun yin Tong kai kap Wong Wing Lam yim Nikolay S.karnaukhov Richard y.C.kong Maria V.Babak yudai Matsuda Department of Chemistry City University of Hong KongHong Kong SARChina iGEM Team“VarieCure” City University of Hong KongHong Kong SARChina Department of Biomedical Engineering City University of Hong KongHong Kong SARChina Moscow Clinical Research Center Named After A.S.Loginov Moscow 111123Russian Federation

A biosynthetic gene cluster for the bioactive fungal sesterterpenoids variecolin(1)and variecolactone(2)was identified in Aspergillus aculeatus ATCC *** production of 1 and 2 was achieved in Aspergillus oryzae by expressing the sesterterpene synthase VrcA and the cytochrome P450 ***,the replacement of VrcB with homologous P450s from other fungal terpenoid pathways yielded three new variecolin analogues(5-7).Analysis of the compounds’anticancer activity in vitro and in vivo revealed that although 5 and 1 had comparable activities,5 was associated with significantly reduced toxic side effects in cancer-bearing mice,indicating its potentially broader therapeutic *** study describes the first tests of variecolin and its analogues in animals and demonstrates the utility of synthetic biology for creating molecules with improved biological activities.

关键词： Animal studies Anticancer properties Biosynthesis Natural products Sesterterpenoids Synthetic biology Terpene synthases Variecolin

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光纤裂缝传感器中裂缝宽度与光纤损耗关系分析

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北京理工大学学报 2003年第4期23卷 492-495,532页

作者：江毅 leung k.y.christopher 北京理工大学信息科学技术学院光电工程系北京100081 香港科技大学土木工程系

为了从理论上获得光纤裂缝传感器的性能,简化传感器的设计,用光射线理论分析了多模光纤的弯曲损耗,获得了混凝土裂缝宽度与光功率损耗之间的关系,并编程计算了传感器的裂缝宽度与光纤损耗的关系,光纤与裂缝的夹角对传感器性能的影响,以... 详细信息

为了从理论上获得光纤裂缝传感器的性能,简化传感器的设计,用光射线理论分析了多模光纤的弯曲损耗,获得了混凝土裂缝宽度与光功率损耗之间的关系,并编程计算了传感器的裂缝宽度与光纤损耗的关系,光纤与裂缝的夹角对传感器性能的影响,以及改变光纤的数值孔径对传感器性能的影响.理论分析结果与实验结果吻合.

关键词：光纤传感器损耗混凝土裂缝宽度

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埋入光纤Mach-Zehnder干涉仪检测复合材料梁的分层

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复合材料学报 2004年第1期21卷 129-133页

作者：江毅许颖 christopher k.y.leung 北京理工大学光电工程系北京100081 香港科技大学土木工程系

　将光纤Mach-Zehnder干涉仪的传感臂埋入到复合材料梁的中性层来检测梁的分层。不论梁是连续支撑还是简单支撑,均取得了很好的实验结果。通过用榔头连续下压梁,由光纤干涉仪可以得到一条输出曲线,从这条曲线就可以准确判断梁内部是否... 详细信息

　将光纤Mach-Zehnder干涉仪的传感臂埋入到复合材料梁的中性层来检测梁的分层。不论梁是连续支撑还是简单支撑,均取得了很好的实验结果。通过用榔头连续下压梁,由光纤干涉仪可以得到一条输出曲线,从这条曲线就可以准确判断梁内部是否存在分层,以及分层的位置。

关键词：复合材料分层光纤传感器 Mach-Zehnder干涉仪

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Analytical and Numerical Modelling of FRP Debonding from Concrete Substrate under Pure Shearing

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Journal of Wuhan University of Technology(Materials Science) 2012年第1期27卷 142-148页

作者： PAN Jinlong XU Zhun C k.y.leung LI Zongjin key Laboratory of Concrete and Pre-stressed Concrete Structures of Ministry of Education Southeast UniversityNanjing 210096 Dept.of Civil and Environmental Engineering Hong Kong University of Science and TechnologyHongKongChina

External bonding of fiber reinforced polymer （FRP） composites on the concrete structures has been proved to be an effective and efficient way to strengthen concrete structures. For a FRP strengthened concrete beam, it is usually observed that the failure occurs in the concrete and a thin layer of concrete is attached on the surface of the debonded FRP plate. To study the debond behavior between concrete and FRP composites, an analytical model based on the three-parameter model is developed to study the debonding behavior for the FRP-to-concrete joint under pure shearing. Then, nonlinear FEM analysis is conducted to verify the PrOposed analytical model. The FEM results shows good agreement with the results from the model. Finally, with the analytical model, sensitivity analyses are performed to study the effect of the interracial parameters or the ~eometric parameters on the debondin~ behavior.

关键词： FRP composites debonding behavior analytical model nonlinear FEM analysis

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Methods of Modifying the Brittle Behavior of Cementitious Composites

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Journal of Wuhan University of Technology(Materials Science) 2010年第1期25卷 156-161页

作者：庞超明 leung christopher ky College of Materials Science and Engineering Southeast UniversityJiangsu Key laboratory of Construction Materials Department of Civil and Environmental Engineering Hong Kong University of Science and Technology

We put forward effective methods of increasing the tensile strain of cementitious composites with 2% PVA fiber and high fly ash content. The test results show that curing condition has a significantly effect on the tensile performance. It is approved that the specimens incorporated appropriate volume fraction rubber powder and lightweight aggregate greatly increase the tensile strain of composites at medium-term age, but indefinitely at long-term age. To a certain extent, EVA can limitedly enhance the tensile performance of comentitious composites owing to the formation of polymer membrane and the hindered hydration of cement.

关键词： high-ductility cementitious composites (HDCC) tensile properties high content of fly ash rubber powder light aggregate ethylene vinyl alcohol latex powder

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Study on the wind field and pollutant dispersion in street canyons using a stable numerical method

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Journal of Environmental Sciences 2005年第3期17卷 488-490页

作者： Dennis y.C. leung Department of Mechanical Engineering the University of Hong Kong Hong Kong China

A stable finite element method for the time dependent Navier-Stokes equations was used for studying the wind flow and pollutant dispersion within street canyons. A three-step fractional method was used to solve the velocity field and the pressure field separately from the governing equations. The Streamline Upwind Petrov-Galerkin(SUPG) method was used to get stable numerical results. Numerical oscillation was minimized and satisfactory results can be obtained for flows at high Reynolds numbers. Simulating the flow over a square cylinder within a wide range of Reynolds numbers validates the wind field model. The Strouhal numbers obtained from the numerical simulation had a good agreement with those obtained from experiment. The wind field model developed in the present study is applied to simulate more complex flow phenomena in street canyons with two different building configurations. The results indicated that the flow at rooftop of buildings might not be assumed parallel to the ground as some numerical modelers did. A counter-clockwise rotating vortex may be found in street canyons with an inflow from the left to right. In addition, increasing building height can increase velocity fluctuations in the street canyon under certain circumstances, which facilitate pollutant dispersion. At high Reynolds numbers, the flow regimes in street canyons do not change with inflow velocity.

关键词： finite element method Streamline Upwind Petrov-Galerkin method three-step fractional method

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