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Unusually aggressive primary cloacogenic carcinoma of the vulva: A case report and literature review

Case Reports in Clinical Medicine 2013年第5期2卷 302-305页

作者： Rajni Chibbar k.mberly A. Wood christopher k. giede Anita Agrawal College of Medicine University of Saskatchewan Saskatoon Canada Department of Obstetrics and Gynecology Royal University Hospital Saskatoon Canada Department of Obstetrics and Gynecology University of Saskatchewan Saskatoon Canada Department of Pathology University of Saskatchewan Saskatoon Canada

Vulvar cancer is an uncommon tumor and represents 3%-5% of all female genital tract malignancies. The overall incidence is 1.5/100,000 women. Histopathologically the vast majority (90%) are squamous cell carcinomas. Primary cloacogenic carcinoma of the vulva is extremely rare with less than 20 cases reported in English literature [1]. These tumors are thought to arise from embryonic or ectopic rests of cloacogenic tissue. The majority of these reported cases is relatively indolent cancer, only one case of cloacogenic carcinoma of the vulva reported metastatic spread to the inguinal lymph nodes and none that describe distant metastases. Here we present an aggressive and diagnostically challenging case of cloacogenic carcinoma of the vulva and a review of current literature to date.

关键词： Cloacogenic Vulvar Cancer Metastasis

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A case of k.dney metastasis in vulvar squamous cell carcinoma: A case report and review of literature

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Case Reports in Clinical Medicine 2013年第5期2卷 306-309页

作者： Anita Agrawal k.mberly A. Wood christopher k. giede Rajni Chibbar College of Medicine University of Saskatchewan Saskatoon Canada Department of Obstetrics and Gynecology Royal University Hospital Saskatoon Canada Department of Obstetrics and Gynecology University of Saskatchewan Saskatoon Canada Department of Pathology Royal University Hospital Saskatoon Canada

Vulvar cancer is an uncommon tumor and represents 3%-5% of all female genital tract malignancies. Squamous cell carcinoma (SCC) is the most common carcinoma of the vulva. Distant metastasis of recurrent vulvar squamous cell carcinoma is rare and occurs late in the disease process. We report the first case of k.dney metastasis from a vulvar squamous cell carcinoma in a 68-year-old Caucasian female. On initial presentation she was treated with radical vulvectomy, upper urethrectomy with bilateral inguinal and deep femoral lymph node dissection. She was staged as FIGO stage IVA and also received adjuvant chemo-radiation. She remained in remission for 24 months. Subsequently she was found to have a k.dney tumor and underwent nephrectomy and was diagnosed with metastatic squamous cell carcinoma from the vulva to the k.dney. In cases of recurrent vulvar carcinoma distant metastasis to the bones, breast, and brain is only rarely reported. Metastasis to k.dneys from vulvar carcinoma is exceptionally rare with no reported cases in the literature. Renal metastasis should be considered in the differential diagnosis of k.dney tumor in this group of women.

关键词： Vulva Squamous Cell Carcinoma k.dney Metastasis

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