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Management of gestational diabetes mellitus via nutritional interventions:The relevance of gastric emptying

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World Journal of Diabetes 2024年第7期15卷 1394-1397页

作者： Wei-Kun huang Ryan J Jalleh christopher K Rayner Tong-Zhi Wu Adelaide Medical School and Centre of Research Excellence in Translating Nutritional Science to Good Health The University of AdelaideAdelaide 5000Australia Adelaide Medical School and Centre of Research Excellence in Translating Nutritional Science to Good Health The University of Adelaide and Department of Gastroenterology and HepatologyRoyal Adelaide HospitalAdelaide 5000Australia

Gestational diabetes mellitus(GDM)represents one of the most common medical complications of pregnancy and is important to the well-being of both mothers and offspring in the short and long *** intervention remains the mainstay for the management of *** efficacy of nutritional approaches(*** restriction and small frequent meals)to improving the maternal-neonatal outcomes of GDM was attested to by Chinese population data,discussed in two articles in recent issues of this ***,a specific focus on the relevance of postprandial glycaemic control was *** rather than fasting hyperglycaemia often represents the predominant manifestation of disordered glucose homeostasis in Chinese women with *** is now increasing appreciation that the rate of gastric emptying,which controls the delivery of nutrients for digestion and absorption in the small intestine,is a key determinant of postprandial glycaemia in both health,type 1 and 2 *** remains to be established whether gastric emptying is abnormally rapid in GDM,particularly among Chinese women,thus contributing to a predisposition to postprandial hyperglycaemia,and if so,how this influences the therapeutic response to nutritional *** is essential that we understand the role of gastric emptying in the regulation of postprandial glycaemia during pregnancy and the potential for its modulation by nutritional strategies in order to improve postprandial glycaemic control in GDM.

关键词： Gastric emptying Postprandial glycaemia Diet Nutritional interventions Gestational diabetes mellitus

Antibiotic prophylaxis and infectious complications in patients on peritoneal dialysis undergoing lower gastrointestinal endoscopy

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Gastroenterology Report 2020年第5期8卷 407-409,I0003页

作者： William T.Clarke Venkata R.Satyam David I.Fudman Samantha Zullow Kashika G.Goyal Katerina LByanova christopher huang Joseph D.Feuerstein Division of Gastroenterology Department of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Department of Medicine Boston Medical CenterBoston University School of MedicineBostonMAUSA Present affiliation:Division of Digestive and Liver Diseases Department of Internal MedicineUniversity of Texas Southwestern Medical CenterDallasTXUSA Present affiliation:Division of Gastroenterology and Hepatology New York University Langone Medical CenterNew York University School of MedicineNew YorkNYUSA Department of Medicine Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Section of Gastroenterology Department of MedicineBoston Medical CenterBoston University School of MedicineBostonMAUSA

Introduction Peritoneal dialysis(PD)is widely used for the treatment of endstage renal *** treated with PD have similar outcomes to those treated with hemodialysis[1].However,PDrelated infections including peritonitis have been reported at 1.66 episodes per patient per year[2].One possible source of peritonitis is gastrointestinal(GI)endoscopic *** 2005,the International Society for Peritoneal Dialysis(ISPD)published guidelines suggesting antibiotics be given to PD patients prior to colonoscopy[3].This suggestion was mostly based on expert opinion and a theoretical concern that patients undergoing colonoscopy are at increased risk for enteric peritonitis from bacterial translocation across the bowel *** there is no direct evidence to support this theory,case reports have suggested a risk of transient bacteremia associated with colonoscopy.

关键词：预防性抗生素消化道内镜检查感染性并发症

Geographic context-aware text mining:enhance social media message classification for situational awareness by integrating spatial and temporal features

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International Journal of Digital Earth 2021年第11期14卷 1721-1743页

作者： christopher Scheele Manzhu Yu Qunying huang Spatial Computing and Data Mining Lab Department of GeographyUniversity of Wisconsin-MadisonMadisonWIUSA Department of Geography Pennsylvania State UniversityUniversity ParkPAUSA

To find disaster relevant social media messages,current approaches utilize natural language processing methods or machine learning algorithms relying on text only,which have not been perfected due to the variability and uncertainty in the language used on social media and ignoring the geographic context of the messages when ***,a disaster relevant social media message is highly sensitive to its posting location and ***,limited studies exist to explore what spatial features and the extent of how temporal,and especially spatial features can aid text *** paper proposes a geographic context-aware text mining method to incorporate spatial and temporal information derived from social media and authoritative datasets,along with the text information,for classifying disaster relevant social media *** work designed and demonstrated how diverse types of spatial and temporal features can be derived from spatial data,and then used to enhance text *** deep learning-based method and commonly used machine learning algorithms,assessed the accuracy of the enhanced text-mining *** performance results of different classification models generated by various combinations of textual,spatial,and temporal features indicate that additional spatial and temporal features help improve the overall accuracy of the classification.

关键词： Spatial data science spatially enabled text mining situational awareness deep learning GeoAI spatial features

Pharmacogenomics of EGFR-targeted therapies in non-small cell lung cancer:EGFR and beyond

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Chinese Journal of Cancer 2015年第4期34卷 149-160页

作者： christopher Delaney Samuel Frank R Stephanie huang Biological Sciences Division University of Chicago Department of Medicine University of Chicago The Affiliated Hospital School of MedicineNingbo University

Commonly observed aberrations in epidermal growth factor receptor(EGFR) signaling have led to the development of EGFR-targeted therapies for various cancers,including non-small cell lung cancer(NSCLC).EGFR mutations and overexpression have further been shown to modulate sensitivity to these EGFR-targeted therapies in NSCLC and several other types of ***,it is clear that mutations and/or genetic variations in EGFR alone cannot explain all of the variability in the responses of patients with NSCLC to EGFR-targeted *** instance,in addition to EGFR genotype,genetic variations in other members of the signaling pathway downstream of EGFR or variations in parallel receptor tyrosine kinase(RTK) pathways are now recognized to have a significant impact on the efficacy of certain EGFR-targeted *** this review,we highlight the mutations and genetic variations in such genes downstream of EGFR and in parallel RTK ***,the directional effects of these pharmacogenetic factors are discussed with a focus on two commonly prescribed EGFR inhibitors:cetuximab and *** results of this comprehensive review can be used to optimize the treatment of NSCLC with EGFR ***,they may provide the rationale for the design of subsequent combination therapies that involve the inhibition of EGFR.

关键词：表皮生长因子受体非小细胞肺癌药物基因组学 EGFR 靶向治疗信号传导途径受体酪氨酸激酶遗传变异

Characterisation of dissolved organic matter in stormwater using high-performance size exclusion chromatography

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Journal of Environmental Sciences 2016年第4期28卷 236-245页

作者： Huiping huang christopher W.K.Chow Bo Jin School of Chemical Engineering The University of Adelaide School of Earth and Environmental Sciences The University of Adelaide Australian Water Quality Centre SA Water Corporation

Understanding the complexity of dissolved organic matter（DOM）in stormwater has drawn a lot of interest,since DOM from stormwater causes not only environmental impacts,but also worsens downstream aquatic quality associated with water supply and *** study introduced and employed high-performance size exclusion chromatography（HPSEC）coupled with an ultraviolet–visible（UV–vis）diode array detector to assess changes in stormwater-associated DOM *** DOM was also analysed in relation to storm event characteristics,water quality and spectroscopic *** tools were used to determine the correlations within DOM and water quality *** showed that dissolved organic carbon（DOC）and UV absorbance at 254 nm（UV（254））as conventional DOM parameters were found to be correlated well to the changes in stormwater quality during each of the three storm events *** detector wavelengths（210and 254 nm）and their ratio（A（210）/A（254））were found to provide additional information on the physiochemical properties of stormwater-associated *** study indicated that A（210）/A（254） is an important parameter which could be used to estimate the DOM proportions of functional groups and conjugated carbon *** study provided also an understanding of stormwater quality constituents through assessing variability and sensitivity for various parameters,and the additional information of rainfall characteristics on runoff quality data for a better understanding of parameter correlations and influences.

关键词： Stormwater Dissolved organic matter HPSEC

Hydrolyzed Al(Ⅲ) clusters:Speciation stability of nano-Al_(13)

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Journal of Environmental Sciences 2011年第5期23卷 705-710页

作者： Shuifeng Wang Chihpin huang christopher W K. Chow Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China. E-mail: wgds@*** Institute of Environmental Engineering National Chiao Tung University Hsinchu Taiwan China Australian Water Quality Centre SA Water Corporation 250 Victoria Square Adelaide SA 5000 South Australia

Pure nano-All3 and aggregates at various concentrations were prepared to examine the particle size effect of coagulation with inorganic polymer flocculant. The property and stability of various species formed were characterized using Infrared, 27Al-NMR, photo correlation spectroscopy （PCS）, and Ferron assay. Results showed that concentration and temperature exhibited different roles on the stability of Al13. The quantity of Alb species analyzed by ferron assay in the initial aging period corresponded well with that of Al13, which has been confirmed in a dimension range of 1-2 nm by PCS. Al13 solutions at high concentrations （0.5-2.11 tool/L） were observed to undergo further aggregation with aging. The aggregates with a wide particle size distribution would contribute to the disappeared/decreased Al13 basis on the eTA1-NMR spectrum, whereas a part of Al13 would still remain as Alb. At low concentrations, All3 solution was quite stable at normal temperature, but lost its stability quickly when heating to 90~C.

关键词： nano-All3 clusters inorganic polymer flocculant speciation stability

Introduction to social sensing and big data computing for disaster management

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International Journal of Digital Earth 2019年第11期12卷 1198-1204页

作者： Zhenlong Li Qunying huang christopher T.Emrich Geoinformation and Big Data Research Laboratory Department of GeographyUniversity of South CarolinaColumbiaSCUSA Department of Geography University of Wisconsin-MadisonMadisonWIUSA School of Public Administration and National Center for Integrated Coastal Research University of Central FloridaOrlandoFLUSA

Traditional data collection methods such as remote sensing and field surveying often fail to offer timely information during or immediately following disaster *** sensing enables all citizens to become part of a large sensor network,which is low cost,more comprehensive,and always broadcasting situational awareness ***,data collected with social sensing is often massive,heterogeneous,noisy,unreliable from some aspects,comes in continuous streams,and often lacks geospatial reference ***,these issues represent a grand challenge toward fully leveraging social sensing for emergency management decision making under extreme ***,big data computing methods and technologies such as high-performance computing,deep learning,and multi-source data fusion become critical components of using social sensing to understand the impact of and response to the disaster events in a timely *** special issue captures recent advancements in leveraging social sensing and big data computing for supporting disaster *** analyzed within these papers are some of the promises and pitfalls of social sensing data for disaster relevant information extraction,impact area assessment,population mapping,occurrence patterns,geographical disparities in social media use,and inclusion in larger decision support systems.

关键词： Social media VGI big data natural hazards spatial computing

Adoption of HPAI biosecurity measures： The Chinese broiler industry

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Journal of Integrative Agriculture 2017年第1期16卷 181-189页

作者： huang Ze-ying Adam Loch christopher Findlay WANG Ji-min Institute of Agricultural Economics and Development Chinese Academy of Agricultural Sciences Beijing 100081 P.R.China Centre for Global Food and Resources University of Adelaide Adelaide 5005 South Australia Faculty of the Professions University of Adelaide Adelaide 5005 South Australia

Highly pathogenic avian influenza （HPAI） contamination via wild birds and rodents poses a threat to food security and safety. As chicken meat comprises an increasing proportion of diet in China, it is useful to determine whether broiler farmers are adopting wild bird and rodent controls to minimize the risk of HPAI impacts on food supply. Our study surveyed a cross sectional sample of 331 Chinese broiler farmers in six provinces. We find that only 47% of farmers （mainly farmers with large herds） adopted control measures against wild birds and rodents, while 14% adopted no measures. Farm size was the biggest driver of adoption followed by proportion of farm revenue derived from broiler production. However, southern farmers were at a far greater probability of non-adoption. We suggest that assistance in the form of education/training programs and subsidized traps or baiting controls across smaller producers could help raise of the adoption level toward more effective HPAI control.

关键词： highly pathogenic avian influenza broiler farmers livestock disease biosecurity adoption

Antithrombotic therapy in patients with COVID-19:indications,pharmacotherapy and controversy

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Stroke & Vascular Neurology 2023年第4期8卷 263-265页

作者： David Wang christopher Leo Liping Liu Li huang Lisa huang Yun Lu Department of Neurology Petznick Stroke CenterBarrow Neurological InstitutePhoenixArizonaUSA Department of Medicine/Division of General Internal Medicine/Hospital Medicine Duke UniversityDurhamNorth CarolinaUSA Neurosurgical Intensive Care Unit(NICU) Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases BeijingChina Doctors Medical Center ModestoCaliforniaUSA Chesapeake Regional Medical Center ChesapeakeVirginiaUSA Hennepin Healthcare System and the University of Minnesota MinneapolisMinnesotaUSA

Hypercoagulability associated with COVID-19 infection increases risks for either venous or arterial thrombotic events(ATEs)or both.1 For hospitalised patients with COVID-19,the incidence of venous thromboembolism(VTE)was 4.5%2;the rate among patients with crit-ical illness was 27.9%as compared with those not critically ill(7.1%).The exact mechanism of COVID-19-related thrombotic events is ***,it may partially be related to Virchow triad:alternation of blood flow(stasis),vascular endothelial injury by SARS-CoV 2 virus and alteration of the constituents of the blood including inherited or acquired hypercoagulable ***,it is a challenge to evaluate the thromboembolic risk,select an appropriate antithrombotic agent and decide on the doses and duration of therapy in these *** international and American societies have published clinical guidelines that reviewed evaluation of coagulation abnormalities in patients with COVID-19.3-6 To balance the risk of bleeding and preventing or treating thromboembolic events,a simplified practical summarisation is needed.

关键词： patients thrombotic doses