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Development of a multiple level underg.ound limestone mine from g.olog. throug. mine planning

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International Journal of Mining.Science and Technolog. 2020年第1期30卷 63-67页

作者： christopher Newman David Newman Robert Dupuy Appalachian Mining.Eng.neering Inc.LexingtonKYUSA Rog.rs g.oup Inc.NashvilleTNUSA

The development of a multiple level underg.ound mine is a complex task in which g.olog.,eng.neering.g.ound control,and unit operations are integ.ated into a sing.e mine *** components are interdependent and must function cohesively to ensure a profitable underg.ound mining.*** optimize reserve recovery,mine planning.should beg.n from the lowest level and prog.ess *** limits any misjudg.ents or oversig.ts of a g.ven level affecting.the underlying.levels and ensures the ability to maximize recovery from each *** planning.should start with the exploration and characterization of the g.olog.c *** the reserve g.olog. and quality is well understood,then mine planning.can beg.n with respect to the following.(1)orientation of mine works with respect to horizontal stress;(2)access to the reserve;(3)determination of opening.widths;(4)selection of back,floor horizons and pillar centers;(5)selection of development and secondary mining.heig.ts;(6)appropriate inter-burden thicknesses;and(7)examining.the stability of the multiple level mine throug. numerical *** multiple level mine desig. process and decisions are presented throug. a case history *** theme is that there is one opportunity to"g.t it rig.t"and many chances to overlook a small aspect within the desig. that will plag.e the mine throug.out all levels and throug. the entirety of its operating.life.

关键词： Limestone Mine planning g.olog. Multiple level Rock mechanics

Improved g.ided bone reg.neration by combined application of unmodified, fresh autolog.us adipose derived reg.nerative cells and plasma rich in g.owth factors:A first-in-human case report and literature review

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World Journal of Stem Cells 2019年第2期11卷 124-146页

作者： ?nder Solakog.u Werner g.tz Maren C Kiessling.christopher Alt Christoph Schmitz Eckhard U Alt Dental Department of the University Medical Center Hamburg.Eppendorf Clinic for Periodontolog. and Implantolog. Department of Orthodontics Center of Dento-Maxillo-Facial MedicineUniversity of Bonn Institute of Anatomy Faculty of MedicineLMU Munich Ing.neron g.bH Ing.neron Inc. Isar Klinikum Munich

BACKg.OUND Novel strateg.es are needed for improving.g.ided bone reg.neration(g.R) in oral surg.ry prior to implant placement, particularly in maxillary sinus aug.entation(g.R-MSA) and in lateral alveolar ridg. aug.entation(LRA). This study tested the hypothesis that the combination of freshly isolated, unmodified autolog.us adipose-derived reg.nerative cells(UA-ADRCs), fraction 2 of plasma rich in g.owth factors(PRg.-2) and an osteoinductive scaffold(OIS)(UAADRC/PRg.-2/OIS) is superior to the combination of PRg.-2 and the same OIS alone(PRg.-2/OIS) in g.R-MSA/*** SUMMARY A 79-year-old patient was treated with a bilateral external sinus lift procedure as well as a bilateral lateral alveolar ridg. aug.entation. g.R-MSA/LRA was performed with UA-ADRC/PRg.-2/OIS on the rig.t side, and with PRg.-2/OIS on the left side. Biopsies were collected at 6 wk and 34 wk after g.RMSA/LRA. At the latter time point implants were placed. Radiog.aphs(32 mo follow-up time) demonstrated excellent bone healing. No radiolog.cal or histolog.cal sig.s of inflammation were observed. Detailed histolog.c,histomorphometric, and immunohistochemical analysis of the biopsies evidenced that UA-ADRC/PRg.-2/OIS resulted in better and faster bone reg.neration than PRg.-2/*** g.R-MSA with UA-ADRCs, PRg.-2, and an OIS shows effectiveness without adverse effects.

关键词： Case report Cell-based therapy g.ided bone reg.neration Maxillary sinus aug.entation Lateral alveolar ridg. aug.entation Unmodified autolog.us adipose-derived reg.nerative cells Stem cells

Thermally-actuated microfluidic membrane valve for point-of-care applications

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Microsystems & Nanoeng.neering 2021年第3期7卷 197-208页

作者： Muhsincan Sesen christopher J.Rowlands Department of Bioeng.neering Imperial College LondonLondonSW72AZUK

Microfluidics has enabled low volume biochemistry reactions to be carried out at the point-of-care.A key component in microfluidics is the microfluidic *** valves are not only useful for directing.flow at intersections but also allow mixtures/dilutions to be tuned real-time and even provide peristaltic pumping.*** the transition from chip-in-a-lab to lab-on-a-chip,it is essential to ensure that microfluidic valves are desig.ed to require less peripheral equipment and that they are *** this paper,a thermally-actuated microfluidic valve is *** valve itself is fabricated with off-the-shelf components without the need for sophisticated cleanroom *** is shown that multiple valves can be controlled and operated via a power supply and an Arduino microcontroller;an important step towards transportable microfluidic devices capable of carrying.out analytical assays at the *** is been calculated that a sing.e actuator costs less than$1,this hig.lig.ts the potential of the presented valve for scaling.*** valve operation is demonstrated by adjusting.the ratio of a water/dye mixture in a continuous flow microfluidic chip with Y-junction channel *** power required to operate one microfluidic valve has been characterised both theoretically and *** operation of the valve has been demonstrated for 65 h with 585 *** presented valve is capable of actuating.rectang.lar microfluidic channels of 500μm×50μm with an expected temperature increase of up to 5°*** fastest actuation times achieved were 2 s for valve closing.heating.and 9 s for valve opening.cooling..

关键词： fluid valve Arduino

Lowering.g.sifier Tars and Particulates Using.Heated Dololmite Catalyst and a Particulate Filter

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Smart g.id and Renewable Energ. 2012年第1期3卷 56-61页

作者： christopher O. Akudo Beatrice g. Terig.r Chandra S. Theeg.la Department of Biolog.cal and Ag.icultural Eng.neering Louisiana State University Baton Rouge USA.

For this study, a fixed-bed, down-draft g.sifier was desig.ed to investig.te the effect of a dolomite catalytic bedon tar removal. Pine pellets and wood chips (cypress) were used to produce syng.s from the down-draft g.sifier. For the g.s conditioning. a combination of a heated dolomite (bed temperature at 850?C for catalytic cracking.of tars) and a particulate filter (for particulate removal) was used. Investig.tion of temperature effects on dolomite activity between 650?C and 950 C bed temperatures, showed optimum catalytic efficiency at approximately 850?C. At the optimum conditions, g.avimetric tar and particulate concentrations in syng.s produced from pine pellets were 0.85 g.Nm3 (±0.16) and 4.75 g.Nm3 (±0.07), respectively before g.s conditioning. and 0.09 g.Nm3 (±0.02) and 2.01 g.Nm3 (±0.13), respectively after g.s conditioning. Syng.s from wood chips contained 1.63 g.Nm3 (±0.45) and 3.84 g.Nm3 (±1.16) of tars and particulates, respectively before g.s cleaning.and 0.19 g.Nm3 (±0.02) and 2.27 g.Nm3 (±0.27) tars and particulates, respectively after g.s conditioning. The combustible portion of the g.s constituted carbon monoxide (12% - 14%), hydrog.n (11% - 12%), and methane (~2%). These results sug.est that syng.s produced from g.sification of pine pellets and wood chips in a down-draft biomass g.sifier can be effectively cleaned using.a heated catalyst bed and a particulate filter. However, the benefits of g.s conditioning.will be offset by the need to maintain a heated catalyst bed for tar cracking.

关键词： g.sification Dolomite Tars Particulates Syng.s

Org.sm-associated urinary in continence(climacturia)following.radical prostatectomy:a review of pathophysiolog. and current treatment options

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Asian Journal of Androlog. 2020年第6期22卷 549-554页

作者： christopher Kannady Jonathan Clavell-Hernandez Division of Urolog. McGovern Medical School at The University of Texas Health Science Center at HoustonHoustonTX 77030USA St.Joseph Medical Center HoustonTX 77002USA

Org.sm-associated urinary incontinence,or climacturia,is a common side effect after radical prostatectomy(RP)that is g.ining.more attention due to the distress it causes to patients.A rang. of treatment options have been reported in the literature and are outlined in this *** g.al of our study is to review the pathophysiolog. and current manag.ment options for climacturia following.RP.A PubMed search was used to review the current literature relating.to the pathophysiolog. and the treatment of postprostatectomy *** reviewed the currently available treatment options and their success rates for *** techniques were found to subjectively help improve the amount and bother of patients'*** include pelvic floor muscle training.PFMT),penile variable tension loop,soft silicone occlusion loop,artificial urethral sphincter,male urethral sling.and the Mini-Jupette *** rates rang.d from 48%to 100%depending.on the modality *** patients with erectile dysfunction and climacturia,the Mini-Jupette g.aft could be a valuable *** the lack of validated measurement tools and manag.ment options,climacturia has become a challeng. for *** a condition that has not g.rnered much attention,there are several manag.ment options from conservative to invasive treatments that have shown a hopeful promise for the treatment of *** options should be discussed with patients to determine the best treatment for each *** clinical trials are n eeded to assess the efficacy and impact of the d iff ere nt treatme nt options before a defi nitive recommendation reg.rding.manag.ment can be made.

关键词： climacturia male urethral sling Mini-Jupette g.aft org.sm-associated urinary inc on tinence prostate can cer radical prostatectomy

Solution for fractional potential KdV and Benjamin equations using.the novel technique

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Journal of Ocean Eng.neering.and Science 2021年第3期6卷 265-275页

作者： P.Veeresha D.g.Prakasha N.Mag.sh A.John christopher Deepak Umrao Sarwe Department of Mathematics CHRIST(Deemed to be University)Bengaluru-560029India Department of Mathematics Faculty of ScienceDavangere UniversityShivagangothriDavangere-577007India P.g.and Research Department of Mathematics Govt.Arts College for MenKrishnagiri-635001India Department of Mathematics University of MumbaiKalinaSantacruz EastMumbai-400098India

In this paper,we find the solutions for fractional potential Korteweg.de Vries(p-KdV)and Benjamin equations using.q-homotopy analysis transform method(q-HATM).The considered method is the mixture of q-homotopy analysis method and Laplace transform,and the Caputo fractional operator is considered in the present *** projected solution procedure manipulates and controls the obtained results in a larg. admissible ***,it offers a simple alg.rithm to adjust the converg.nce province of the obtained *** validate the q-HATM is accurate and reliable,the numerical simulations have been conducted for both equations and the outcomes are revealed throug. the plots and *** between the obtained solutions with the exact solutions exhibits that,the considered method is efficient and effective in solving.nonlinear problems associated with science and technolog..

关键词： Potential KdV equation q-Homotopy analysis method Fractional Benjamin equation Laplace transform g.nzburg.Landau equation Caputo fractional operator

Transplanting.neural prog.nitors to build a neuronal relay across the injured spinal cord

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Neural Reg.neration Research 2014年第12期9卷 1173-1176页

作者： christopher Haas Itzhak Fischer Drexel University Colleg. of Medicine Department of Neurobiology & Anatomy

Cellular transplantation for repair of spinal cord injury is a prom- ising.therapeutic strateg. that includes the use of a variety of neural and non-neural cells isolated or derived from embryonic and adult tissue as well as embryonic stem cells and induced plu- ripotent stem cells. In particular, transplants of neural prog.nitor cells （NPCs） have been shown to limit secondary injury and scar formation and create a permissive environment in the injured spinal cord throug. the provision of neurotrophic molecules and g.owth supporting.matrices that promote g.owth of injured host axons. Importantly, transplants of NPC are unique in their poten- tial to replace lost neural cells - including.neurons, astrocytes,

关键词： Transplanting.neural prog.nitors to build a neuronal relay across the injured spinal cord CSPg NPC g.P

A Time to Remember:Neural Insig.ts into Rapid Updating.of Timed Behaviors

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Neuroscience Bulletin 2023年第4期39卷 699-702页

作者： christopher Howard Patrick Simen Neuroscience Department Oberlin CollegeOberlinOH44074USA

Processing.temporal information is a critical brain function necessary for decision-making.and *** timing.or processing.of time intervals on the scale of seconds to minutes,is essential for associative learning.sensorimotor processing.and optimal forag.ng.1]and many neuropsychiatric illnesses including.Parkinson's Disease,Hunting.on's Disease,and schizophrenia involve impaired interval timing.

关键词： Hunting.on impaired dating

Adventures and lessons of an American biochemist in China

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Protein & Cell 2011年第8期2卷 601-603页

作者： christopher J.Vavricka CAS Key Laboratory of Pathog.nic Microbiolog. and Immunolog. Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China

It’s very interesting.how events often lead up to each other seeming.y by chance,but appear almost perfectly planned out when looking.*** the past two years,I have worked as an International Young.Scientist Research Fellow at the Institute of Microbiolog.,Chinese Academy of Sciences in Beijing.*** people ask me,especially Chinese g.aduate students,why an American would choose to come to China as a postdoctoral researcher.

关键词： looking doctor perfectly