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Apples to oranges:environmentally derived,dynamic regulation of serotonin neuron subpopulations in adulthood?

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Neural Regeneration Research 2025年第9期20卷 2596-2597页

作者： christopher J.O’Connell Matthew J.Robson Department of genetics College of MedicineHarvard UniversityBostonMAUSA James L.Winkle College of Pharmacy Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA Neuroscience graduate Program College of MedicineUniversity of CincinnatiCincinnatiOHUSA

Traumatic brain injury(TBI)is a public health problem with an undue economic burden that impacts nearly every age,ethnic,and gender group across the globe(Capizzi et al.,2020).TBIs are often sustained during a dynamic range of exposures to energetic environmental forces and as such outcomes are typically heterogeneous regarding severity and pathology(Capizzi et al.,2020).

关键词： sustained orange dynamic

Comparative analysis of empirical and deep learning models for ionospheric sporadic E layer prediction

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Earth and Planetary Physics 2025年第1期9卷 10-19页

作者： BingKun Yu PengHao Tian XiangHui Xue christopher JScott HaiLun Ye JianFei Wu Wen Yi TingDi Chen XianKang Dou Institute of Deep Space Sciences Deep Space Exploration LaboratoryHefei 230088China CAS Key Laboratory of geospace Environment School of Earth and Space SciencesUniversity of Science and Technology of ChinaHefei 230026China Hefei National Laboratory University of Science and Technology of ChinaHefei 230088China Department of Meteorology University of ReadingReading RG66BBUK

Sporadic E(Es)layers in the ionosphere are characterized by intense plasma irregularities in the E region at altitudes of 90-130 *** they can significantly influence radio communications and navigation systems,accurate forecasting of Es layers is crucial for ensuring the precision and dependability of navigation satellite *** this study,we present Es predictions made by an empirical model and by a deep learning model,and analyze their differences comprehensively by comparing the model predictions to satellite RO measurements and ground-based ionosonde *** deep learning model exhibited significantly better performance,as indicated by its high coefficient of correlation(r=0.87)with RO observations and predictions,than did the empirical model(r=0.53).This study highlights the importance of integrating artificial intelligence technology into ionosphere modelling generally,and into predicting Es layer occurrences and characteristics,in particular.

关键词： ionospheric sporadic E layer radio occultation ionosondes numerical model deep learning model artificial intelligence

mTORC1 signaling:what we still don’t know

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Journal of Molecular Cell Biology 2011年第4期3卷 206-220页

作者： Xuemin Wang christopher g.Proud School of Biological Sciences Life Sciences BuildingUniversity of SouthamptonSouthampton SO171BJUK

The mammalian target of rapamycin(mTOR)is a protein kinase that plays key roles in cellular *** forms complexes with additional *** best-understood one is mTOR complex 1(mTORC1).The regulation and cellular functions of mTORC1 have been the subjects of intense study;despite this,many questions remain to be *** include questions about the actual mechanisms by which mTORC1 signaling is stimulated by hormones and growth factors,which involves the small gTPase Rheb,and by amino acids,which involves other gTPase *** control of Rheb and the mechanism by which it activates mTORC1 remain incompletely *** it has been known for many years that rapamycin interferes with some functions of mTORC1,it is not known how it does this,or why only some functions of mTORC1 are ***1 regulates diverse cellular *** mTORC1 substrates are now known,although in several cases their physiological roles are poorly or incompletely *** the case of several processes,although it is clear that they are regulated by mTORC1,it is not known how mTORC1 does ***,mTORC1 is implicated in ageing,but again it is unclear what mechanisms account for *** the importance of mTORC1 signaling both for cellular functions and in human disease,it is a high priority to gain further insights into the control of mTORC1 signaling and the mechanisms by which it controls cellular functions and animal physiology.

关键词： mTORC1 protein synthesis cell signaling transcription cell growth autophagy metabolism

Modeling the impact of climate change on sediment transport and morphology in coupled watershed-coast systems:A case study using an integrated approach

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International Journal of Sediment Research 2014年第3期29卷 304-315页

作者： Achilleas g.SAMARAS christopher g KOUTITAS Research Fellow CIRI-ECFluid Dynamics Research UnitUniversity of BolognaVia del Lazzaretto 15/5Bologna 40131Italy Department of Civil Engineering Aristotle University of ThessalonikiUniversity Campus

Climate change is an issue of major concern *** impact on the natural and human environment is studied intensively,as the expected shift in climate will be significant in the next few *** experience shows that the effects will be critical in coastal areas,resulting in erosion and inundation phenomena *** addition to that,coastal areas are subject to "pressures" from upstream watersheds in terms of water quality and sediment *** present paper studies the impact of climate change on sediment transport and morphology in the aforementioned coupled *** study regards a sandy coast and its upstream watershed in Chalkidiki,North greece;it is based on:(a)an integrated approach for the quantitative correlation of the two through numerical modeling,developed by the authors,and(b)a calibrated application of the relevant models Soil and Water Assessment Tool(SWAT)and PELNCON-M,applied to the watershed and the coastal zone,*** examined climate change scenarios focus on a shift of the rainfall distribution towards fewer and more extreme rainfall events,and an increased frequency of occurrence of extreme wave *** indicate the significance of climatic pressures in wide-scale sediment dynamics,and are deemed to provide a useful perspective for researchers and policy planners involved in the study of coastal morphology evolution in a changing climate.

关键词： Climate change Sediment transport Coastal morphology Integrated approach Numerical modeling

Neighboring optimal control for periodic tasks for systems with discontinuous dynamics

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Science China(Information Sciences) 2011年第3期54卷 653-663页

作者： ATKESON christopher g. Robotics Institute Carnegie Mellon University

We propose a trajectory-based optimal control method for periodic tasks for systems with discontinuous dynamics. A general method, dynamic programming, suffers from the problem of dimensionality. We use local models of the optimal control law to construct a local controller. We combine a parametric trajectory optimization method and differential dynamic programming (DDP) to find the optimal periodic trajectory in a periodic task. By formulating the optimal control problem with an infinite time horizon, DDP generates time-invariant local models of the optimal control law. For DDP, the value function at dynamics discontinuities is approximated by a second order Taylor series. The utility of the proposed method is evaluated using simu- lated walking control of a five-link biped robot. The results show lower torques and more robustness from the proposed controller than a PD servo controller.

关键词： trajectory optimization differential dynamic programming optimal control biped walking control

Constructing a taxonomy to support multi-document summarization of dissertation abstracts

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2005年第11期6卷 1258-1267页

作者： KHOO christopher S.g. gOH Dion H. Division of Information Studies School of Communication & Information Nanyang Technological University 639798 SingaporeDivision of Information Studies School of Communication & Information Nanyang Technological University 639798 Singapore

This paper reports part of a study to develop a method for automatic multi-document summarization. The current focus is on dissertation abstracts in the field of sociology. The summarization method uses macro-level and micro-level discourse structure to identify important information that can be extracted from dissertation abstracts, and then uses a variable-based framework to integrate and organize extracted information across dissertation abstracts. This framework focuses more on research concepts and their research relationships found in sociology dissertation abstracts and has a hierarchical structure. A taxonomy is constructed to support the summarization process in two ways：（1） helping to identify important concepts and relations expressed in the text, and （2） providing a structure for linking similar concepts in different abstracts. This paper describes the variable-based framework and the summarization process, and then reports the construction of the taxonomy for supporting the summarization process. An example is provided to show how to use the constructed taxonomy to identify important concepts and integrate the concepts extracted from different abstracts.

关键词： Text summarization Automatic multi-document summarization Variable-based framework Digital library

Substrate mediated dissolution of redox active nanoparticles;electron transfer over long distances

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Nano Research 2022年第1期15卷 429-437页

作者： Ruo-Chen Xie christopher Batchelor-McAuley Minjun Yang Richard g.Compton Department of Chemistry Physical and Theoretical Chemistry LaboratoryUniversity of OxfordSouth Parks RoadOxford OXl 3QZUK

Reflective dark field microscopy is used to observe the decrease in the light scattered from Ag nanoparticles immobilised on differing solid *** nanoparticles are exposed to solutions containing halide ions,both at open circuit and under potentiostatic control,leading to the loss of the *** coupling optical and electrochemical techniques the physical origin of this transformation is demonstrated to be the electrochemical dissolution of the metal nanoparticles driven by electron transfer to ultra-trace dissolved *** dissolution kinetics of the surface-supported metal nanoparticles is compared on four substrate materials(i.e.,glass,indium titanium oxide,glassy carbon and platinum)with different electrical *** three conductive substrates catalyse the redox-driven dissolution of Ag nanoparticles with the electrons transferred from the nanoparticles,via the macroscopic electrode to the dioxygen electron acceptor.

关键词： substrate electrocatalysis oxidative dissolution metal nanoparticles optical microscopy electrochemistry

Protecting miners from coal bursts during development above historic mine workings in Harlan County,KY

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International Journal of Mining Science and Technology 2021年第1期31卷 111-116页

作者： christopher Mark Mine Safety and Health Administration PittsburghPA 15236USA

In order to reach a large,untapped reserve of high-quality coal,D8 Cloverlick Mine proposed to mine a corridor nearly 600 m deep beneath the Benham Spur of Black Mountain,Kentucky’s highest peak.D8 Cloverlick Mine was extracting the Owl seam,but the corridor’s route lay approximately 20 m above century-old mine workings in the C–(Darby)*** to the concern,three serious coal bursts had recently occurred in nearby Owl seam *** of the old workings seemed to indicate that the underlying C–seam had been fully ***,two of the coal bursts had occurred above areas where the C–Seam was also shown as mined *** Safety and Health Administration(MSHA)Technical Support therefore investigated the records of past mining to better understand the old mine *** conditions observed in current Owl seam workings were also compared with the maps of the old C–seam *** study concluded that the presence of hazardous underlying remnants could not be ruled *** mitigate the burst risk,D8 Cloverlick Mine adopted a strategy of stress probe drilling.A self-propelled coal drill was used to auger 11.5-m-long,small diameter holes in advance of *** each hole was drilled,the cuttings were measured to detect the presence of highly stressed *** the crossing was successfully completed without incident.

关键词： Coal bursts Underground mining Room-and-pillar Destressing

An updated empirical model for ground control in *** coal mines

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International Journal of Mining Science and Technology 2021年第2期31卷 163-174页

作者： christopher Mark Mine Safety and Health Administration PittsburghPA 15217USA

Multiple seam interactions are a major source of ground instability in several *** methods are well suited for this problem,because while the mechanics multiple seam interactions are very complex and poorly understood,many mining case histories are available for *** study makes use of an updated database that includes 356 multiseam case histories,including 67 unsuccessful *** paper describes in detail the process used to design the study,collect the data,conduct the statistical analysis,and develop the quantitative *** model can be used for mine planning in multiple seam situations,and has been made available as a module within the Analysis of Coal Pillar Stability(ACPS)computer program.

关键词： Underground Coal Multiseam ground control Pillar design Empirical