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The Versatility and Diagnostic Potential of VOC Profiling for Noninfectious Diseases

Biomedical Engineering Frontiers 2023年第1期4卷 274-297页

作者： Micah Oxner Allyson Trang Jhalak Mehta christopher forsyth Barbara Swanson Ali Keshavarzian Abhinav Bhushan Department of Biomedical Engineering Illinois Institute of TechnologyChicagoIL 60616USA Department of Internal Medicine Division of Digestive Diseases and NutritionSection of GastroenterologyRush Medical CollegeChicagoIL 60612USA Department of Adult Health and Gerontological Nursing Rush University College of NursingChicagoIL 60612USA

variety of volatile organic compounds(VOCs)are produced and emitted by the human body every *** identity and concentration of these VOCs reflect an individual’s metabolic *** regarding the production and origin of VOCs,however,has yet to be congruent among the scientific *** review article focuses on the recent investigations of the source and detection of biological VOCs as a potential for noninvasive discrimination between healthy and diseased *** the changes in the components of VOC profiles could provide information regarding the molecular mechanisms behind disease as well as presenting new approaches for personalized screening and *** research has prioritized the study of cancer,resulting in many research articles and reviews being written on the *** review summarizes the information gained about VOC cancer studies over the past 10 years and looks at how this knowledge correlates with and can be expanded to new and upcoming fields of VOC research,including neurodegenerative and other noninfectious *** advances in analytical techniques have allowed for the analysis of VOCs measured in breath,urine,blood,feces,and *** diagnostic approaches founded on sensor-based techniques allow for cheaper and quicker results,and we compare their diagnostic dependability with gas chromatography-and mass spectrometry-based *** future of VOC analysis as a clinical practice and the challenges associated with this transition are also discussed and future research priorities are summarized.

关键词： VOC gained summarized

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Inter-hospital transfers and door-to-balloon times for STEMI: a single centre cohort study

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Journal of Geriatric Cardiology 2020年第6期17卷 321-329页

作者： Renéforsyth Zhong-Hua SUN christopher Reid Rachael Moorin Department of Medical Radiation Sciences Curtin UniversityPerthAustralia School of Public Health NHMRC Centre of Research Excellence in Cardiovascular Outcomes ImprovementPerthAustralia Centre of Research Excellence in Therapeutics Monash UniversityMelbourneAustralia School of Public Health Curtin UniversityPerthAustralia School of Population and Global Health the University of Western AustraliaCrawleyAustralia

Background Key performance indices such as door-to-balloon times have long been recognized as quality metrics in reducing time to care for patients with acute coronary syndromes(ACS). In the situation where patients do not present to a facility capable of 24/7 percutaneous coronary interventions(PCI) delays in time to therapy can exceed the recommendation of 90 min or less. This study aimed to evaluate the impact of transfers on performance indices for patients diagnosed with ST-segment elevation myocardial infarction(STEMI). Methods Over a seven month collection period, all patients presenting with symptoms suggestive of ACS and admitted for PCI were studied. Patients were divided into dichotomous groups of direct presentations or transfers from a secondary non-PCI capable hospital with key times recorded, including symptom-onset, first hospital and PCI-capable hospital arrival and balloon inflation times to evaluate time of treatment for STEMI patients. Results Of the 87 patients diagnosed with STEMI, transferred patients experienced statistically significant delays in symptom-onset to the PCI-capable hospital(PCI-H) arrival(215 vs. 95 min, P < 0.001), symptom-onset to balloon inflation(225 vs. 160 min, P = 0.009) and first hospital arrival to balloon inflation times(106 vs. 56 min, P < 0.001). Only 28%(n = 9) of transferred patients underwent balloon inflation within 90 min from first hospital arrival, while 60%(n = 19) did within 120 min, although all received balloon inflation within 90 min from arrival at the PCI-H. After controlling for confounding factors of socio-economic status, presentation date/time and diagnostic category, transferred patients experienced an average 162% longer delays from symptom-onset to PCI-H door arrival, and 98% longer delays in symptom-onset to balloon inflation;compared to patients who present directly to the PCI-H. No statistically significant differences were noted between transferred and direct patients when measured from PCI-

关键词： Acute coronary syndrome Door-to-balloon times Inter-hospital transfers ST-segment elevation myocardial infarction

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