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exotic and excited-state meson spectroscopy and radiative transitions from lattice QCD

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Chinese Physics C 2010年第9期34卷 1512-1515页

作者： christopher e.Thomas Jefferson Laboratory

We discuss recent progress in extracting the excited meson spectrum and radiative transition form factors from lattice *** mention results in the charmonium sector,including the first lattice QCD calculation of radiative transition rates involving excited charmonium states,highlighting results for high spin and exotic *** present recent results on a highly excited isovector meson spectrum from dynamical anisotropic *** carefully constructed operators we show how the continuum spin of extracted states can be reliably identified and confidently extract excited states,states with exotic quantum numbers and states of high *** spectrum includes the first spin-four state extracted from lattice *** conclude with some comments on future prospects.

关键词： lattice QCD exotics mesons spectroscopy

Clinical variability and molecular heterogeneity inprostate cancer

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Asian Journal of Andrology 2016年第4期18卷 543-548页

作者： Jonathan Shoag christopher e Barbieri Department of Urology NewYork-Presbyterian Hospital Weill Cornell Medical College New York USA Sandra and edward Meyer Cancer Center Weill Cornell Medica College New York USA.

Prostate cancer is a clinically heterogeneous disease, with some men having indolent disease that can safely be observed, while others have aggressive, lethal disease. Over the past decade, researchers have begun to unravel some of the genomic heterogeneity that contributes to these varying clinical phenotypes. Distinct molecular sub-classes of prostate cancer have been identified, and the uniqueness of these sub-classes has been leveraged to predict clinical outcomes, design novel biomarkers for prostate cancer diagnosis, and develop novel therapeutics. Recent work has also elucidated the temporal and spatial heterogeneity of prostate cancer, helping us understand disease pathogenesis, response to therapy, and progression. New genomic techniques have provided us with a window into the remarkable clinical and genomic heterogeneity of prostate cancer, and this new perspective will increasingly impact patient care.

关键词： cell biology eRG genomics molecular heterogeneity prostate cancer sequencing serine peptidase inhibitor, Kazaltype 1 SPOP tumor profiling

The evolution of phenotypic plasticity in fish swimming

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Current Zoology 2016年第5期62卷 475-488页

作者： christopher e. OUFIeRO Katrina R. WHITLOW Department of Biological Sciences Towson University Towson MD 21252 USA

Fish have a remarkable amount of variation in their swimming performance, from within species dif- ferences to diversity among major taxonomic groups. Fish swimming is a complex, integrative phenotype and has the ability to plastically respond to a myriad of environmental changes. The plasticity of fish swimming has been observed on whole-organismal traits such as burst speed or critical swimming speed, as well as underlying phenotypes such as muscle fiber types, kinematics, cardiovascular system, and neuronal processes. Whether the plastic responses of fish swimming are beneficial seems to depend on the environmental variable that is changing. For example, because of the effects of temperature on biochemical processes, alterations of fish swimming in response to tem- perature do not seem to be beneficial. In contrast, changes in fish swimming in response to variation in flow may benefit the fish to maintain position in the water column. In this paper, we examine how this plasticity in fish swimming might evolve, focusing on environmental variables that have received the most attention： temperature, habitat, dissolved oxygen, and carbon dioxide variation. Using examples from previous research, we highlight many of the ways fish swimming can plastic- ally respond to environmental variation and discuss potential avenues of future research aimed at understanding how plasticity of fish swimming might evolve. We consider the direct and indirect ef- fects of environmental variation on swimming performance, including changes in swimming kine- matics and suborganismal traits thought to predict swimming performance. We also discuss the role of the evolution of plasticity in shaping macroevolutionary patterns of diversity in fish swimming.

关键词： environmental variation evolution fish phenotypic plasticity swimming kinematics swimming performance.

Understanding development and ripening of fruit crops in an‘omics’ era

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Horticulture Research 2014年第1期1卷 157-166页

作者： Nigel e Gapper James J Giovannoni christopher B Watkins Department of Horticulture Cornell UniversityIthacaNY 14853USA Boyce Thompson Institute for Plant Research Cornell UniversityIthacaNY 14853USA Plant Soiland Nutrition LaboratoryUS Department of Agriculture/Agriculture Research ServiceIthacaNY 14853USA

Next generation sequencing has revolutionized plant *** only has our understanding of plant metabolism advanced using model systems and modern chromatography,but application of‘omics’-based technology has been widely extended to non-model systems as costs have plummeted and efficiency *** a result,important fundamental questions relating to important horticultural crops are being answered,and novel approaches with application to industry are in *** we review recent research advances on development and ripening of fruit crops,how next generation sequencing approaches are driving this advance and the emerging future landscape.

关键词： crops driving metabolism

ABCD^(2) risk score does not predict the presence of cerebral microemboli in patients with hyper-acute symptomatic critical carotid artery stenosis

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Stroke & Vascular Neurology 2017年第2期2卷 41-46页

作者： Mahmud Saedon Charles e Hutchinson christopher H e Imray Donald R J Singer Warwick Medical School University of WarwickCoventryUK University Hospitals Coventry Warwickshire NHS Trust CoventryUK Fellowship of Postgraduate Medicine LondonUK Yale School of Medicine New HavenConnecticutUSA

Introduction:ABCD^(2) risk score and cerebral microemboli detected by transcranial Doppler(TCD)have been separately shown to the predict risk of recurrent acute *** studied whether ABCD2 risk score predicts cerebral microemboli in patients with hyper-acute symptomatic carotid artery *** and methods:We studied 206 patients presenting within 2 weeks of transient ischaemic attack or minor stroke and found to have critical carotid artery stenosis(≥50% ).86 patients(age 70±1(SeM:years),58 men,83 Caucasian)had evidence of microemboli;72(84% )of these underwent carotid endarterectomy(CeA).120 patients(age 72±1 years,91 men,113 Caucasian)did not have microemboli detected;102(85% )of these underwent *** were analysed using X2 and Mann–Whitney U tests and receiver operating characteristic(ROC)***:140/206(68% :95% CI 61.63 to 74.37)patients with hyper-acute symptomatic critical carotid stenosis had an ABCD2 risk score≥*** was no significant difference in the NICe red flag criterion for early assessment(ABCD^(2) risk score≥4)for patients with cerebral microemboli versus those without microemboli(59/86 vs 81/120 patients:OR 1.05 ABCD2 risk score≥4(95% CI 0.58 to 1.90,p=0.867)).The ABCD2 risk score wasembolising patients and in 39 of 120(31% :95% CI 23 to 39)without cerebral *** adjusting for pre-neurological event antiplatelet treatment(APT),area under the curve(AUC)of ROC for ABCD2 risk score showed no prediction of cerebral microemboli(no pre-event APT,n=57:AUC 0.45(95% CI 0.29 to 0.60,p=0.531);preevent APT,n=147:AUC 0.51(95% CI 0.42 to 0.60,p=0.804)).Conclusions:The ABCD2 score did not predict the presence of cerebral microemboli or carotid disease in over one-quarter of patients with symptomatic critical carotid artery *** the basis of NICe guidelines(refer early if ABCD2≥4),assessment of high stroke risk based on ABCD2 scoring may lead to inappropriate delay in urgent treat

关键词： patients cerebral emboli

Criminal justice in America George F. Cole, christopher e. Smith

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Criminal justice in America George F. Cole, Christopher E. S...

Beyond the RPA and GW methods with adiabatic xc-kernels for accurate ground state and quasiparticle energies

2005年

作者： George F. Cole christopher e. Smith

来源：畅想之星图书光盘版（南... 评论

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npj Computational Materials 2019年第1期5卷 202-224页

作者： Thomas Olsen christopher e.Patrick Jefferson e.Bates Adrienn Ruzsinszky Kristian S.Thygesen Computational Atomic-Scale Materials Design(CAMD) Department of PhysicsTechnical University of DenmarkKongens LyngbyDenmark Department of Physics University of WarwickCoventry CV47ALUK A.R.Smith Department of Chemistry and Fermentation Sciences Appalachian State UniversityBooneNC 28607USA Department of Physics Temple UniversityPhiladelphiaPA 19122USA Center for Nanostructured Graphene(CNG) Department of PhysicsTechnical University of DenmarkKongens LyngbyDenmark

We review the theory and application of adiabatic exchange–correlation(xc)-kernels for ab initio calculations of ground state energies and quasiparticle excitations within the frameworks of the adiabatic connection fluctuation dissipation theorem and Hedin’s equations,*** different xc-kernels,which are all rooted in the homogeneous electron gas,are introduced but hereafter we focus on the specific class of renormalized adiabatic kernels,in particular the rALDA and *** kernels drastically improve the description of short-range correlations as compared to the random phase approximation(RPA),resulting in significantly better correlation *** effect greatly reduces the reliance on error cancellations,which is essential in RPA,and systematically improves covalent bond energies while preserving the good performance of the RPA for dispersive *** quasiparticle energies,the xc-kernels account for vertex corrections that are missing in the GW *** this context,we show that the short-range correlations mainly correct the absolute band positions while the band gap is less affected in agreement with the known good performance of GW for the *** renormalized xc-kernels offer a rigorous extension of the RPA and GW methods with clear improvements in terms of accuracy at little extra computational cost.

关键词： adiabatic kernels quasi

Treatment of hemorrhoids: A survey of surgical practice in Australia and New Zealand

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World Journal of Clinical Cases 2019年第22期7卷 3742-3750页

作者： George e Fowler Javariah Siddiqui Assad Zahid christopher John Young Department of Colorectal Surgery Royal Devon and Exeter NHS Foundation TrustExeter EX25DWUnited Kingdom Department of Colorectal Surgery Royal Prince Alfred HospitalNewtown 2042NSWAustralia

BACKGROUND Hemorrhoidal disease is the most common anorectal *** can be classified as external or internal,according to their relation to the dentate *** hemorrhoids originate below the dentate line and are managed conservatively unless the patient cannot keep the perianal region clean,or they cause significant *** hemorrhoids originate above the dentate line and can be managed according to the graded degree of prolapse,as described by ***,low-grade internal hemorrhoids are effectively treated conservatively,by non-operative measures,while high-grade internal hemorrhoids warrant procedural *** To determine the application of clinical practice guidelines for the current management of hemorrhoids and colorectal surgeon consensus in Australia and New *** An online survey was distributed to 206 colorectal surgeons in Australia and New Zealand using 17 guideline-based hypothetical clinical *** There were 82 respondents(40%)to 17 guideline-based ***(53%)reached consensus,of which only 1(6%)disagreed with the *** was based on low quality evidence for the management of acutely thrombosed external *** were 8 scenarios which showed community equipoise(47%)and they were equally divided for agreeing or disagreeing with the *** topics were based on low and moderate levels of *** included the initial management of grade I internal hemorrhoids,grade III internal hemorrhoids when initial management had failed and the patient had recognised risks factors for septic complications;and finally,the decision-making when considering patient preferences,including a prompt return to work,or minimal post-operative *** Although there are areas of consensus in the management of hemorrhoids,there are many areas of community equipoise which would benefit from further research.

关键词： Hemorrhoids Clinical practice guidelines Survey Consensus

Hypothesized summative anal physiology score correlates but poorly predicts incontinence severity

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World Journal of Gastroenterology 2017年第31期23卷 5732-5738页

作者： christopher J Young Assad Zahid Cherry e Koh Jane M Young Department of Colorectal Surgery University of Sydney RPAH Medical Centre Discipline of Surgery University of Sydney Surgical Outcome Research Centre(SOu RCe) Royal Prince Alfred HospitalUniversity of Sydney School of Public health University of Sydney

To explore the relationship between such a construct and an existing continence score. MeTHODSA retrospective study of incontinent patients who underwent anal physiology (AP) was performed. AP results and Cleveland Clinic Continence Scores (CCCS) were extracted. An anal physiology score (APS) was developed using maximum resting pressures (MRP), anal canal length (ACL), internal and external sphincter defects and pudendal terminal motor latency. Univariate associations between each variable, APS and CCCS were assessed. Multiple regression analyses were performed. ReSULTSOf 508 (419 women) patients, 311 had both APS and CCCS measured. Average MRP was 51 mmHg (SD 23.2 mmHg) for men and 39 mmHg (19.2 mmHg) for women. Functional ACL was 1.7 cm for men and 0.7 cm for women. Univariate analyses demonstrated significant associations between CCCS and MRP (P = 0.0002), ACL (P = 0.0006) and pudendal neuropathy (P e association between APS and CCCS was significant (P ed for only 9.2% of the variability in CCCS. Multiple regression showed that the variables most useful in predicting CCCS were external sphincter defect, pudendal neuropathy and previous pelvic surgery, but only improving the scores predictive ability to 12.5%. CONCLUSIONThis study shows that the ability of AP tests to predict continence scores improves when considered collectively, but that a constructed summation model before and after multiple regression is poor at predicting the variability in continence scores.

关键词： Incontinence Anal physiology Anal canal Anal ultrasound Manometry electromyography