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Antibodies to Nipah or Nipah-like viruses among bats in china's mainland

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Antibodies to Nipah or Nipah-like viruses among bats in Chin...

Antibodies to Nipah or Nipah-like viruses among bats in china's mainland

中国微生物学会《第二届全国农业微生物研究及产业化研讨会》和《第十一届全国杀虫微生物学术研讨会》暨《湖北省暨武汉市微生物学会和内蒙古微生物学会2008年会》

作者： Andrew c.Hickey Jennifer McEachern christopher c.broder State Key Laboratory of Virology Wuhan Institute of VirologyChinese Academy of Sciences Department of Microbiology Uniformed Services UniversityBethesda Maryland 20814USA Yunnan Institute of Endemic Diseases control and Prevention Marine college Shandong University at Weihai college of Life Science University of Guangzhou cSIRO Livestock Industries Australian Animal Health Laboratory and Australian Biosecurity Cooperative Research Center for Emerging Infectious DiseasesGeelongAustralia

Hendra virus(HeV)and Nipah virus(NiV),the only known members of the genus Henipavirus,are two emerging paramyxoviruses highly pathogenic in a variety of vertebrate animals including humans Numerous frugivorous bat spe...

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Antibodies to Nipah or Nipah-like viruses among bats in Chin...

Hendra and Nipah Virus Envelope Glycoproteins and Receptor Interactions

第3届新生病毒性疾病控制学术研讨会

作者： Andrew c.Hickey Jennifer McEachern christopher c.broder Department of Microbiology Uniformed Services UniversityBethesdaMaryland 20814USA cSIRO Livestock Industries Australian Animal Health Laboratory and Australian Biosecurity Cooperative Research Center for Emerging Infectious DiseasesGeelongAustralia.

Hendra virus(HeV) and Nipah virus(NiV),the only known members of the genus Henipavirus,are two emerging paramyxoviruses highly pathogenic in a variety of vertebrate animals including humans Numerous frugivorous bat sp...

Hendra virus(HeV) and Nipah virus(NiV),the only known members of the genus Henipavirus,are two emerging paramyxoviruses highly pathogenic in a variety of vertebrate animals including humans Numerous frugivorous bat species(genus

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Hendra and Nipah Virus Envelope Glycoproteins and Receptor I...

Apples to oranges:environmentally derived,dynamic regulation of serotonin neuron subpopulations in adulthood?

第3届新生病毒性疾病控制学术研讨会

作者： Andrew c.Hickey Kimberly A.Bishop Dimple Khetawat Yee-Peng chan KathadneN.Bossart, Dimiter S.Dimitrov Dimitar B.Nikolov christopher c.broder Department of Microbiology Uniformed Services UniversityBethesdaMaryland 20814USA cSIRO Livestock IndustriesAAHLGeelongVictoria 3220Australia Protein Interactions Group CCRNPCCR and BRPSAIC-FrederickInc.NCINIHFrederickMaryland 21702USA Structural Biology Program Memorial Sloan-Kettering Cancer CenterNew YorkNY 10021USA

Nipah virus(NiV) and Hendra virus(HeV) are the type species of the highly pathogenic paramyxovirus genus *** viruses exhibit a broad species tropism associated with significant morbidity and mortality among a variety of

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Neural Regeneration Research 2025年第9期20卷 2596-2597页

作者： christopher J.O’connell Matthew J.Robson Department of Genetics College of MedicineHarvard UniversityBostonMAUSA James L.Winkle college of Pharmacy Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA Neuroscience Graduate Program College of MedicineUniversity of CincinnatiCincinnatiOHUSA

Traumatic brain injury(TBI)is a public health problem with an undue economic burden that impacts nearly every age,ethnic,and gender group across the globe(capizzi et al.,2020).TBIs are often sustained during a dynamic range of exposures to energetic environmental forces and as such outcomes are typically heterogeneous regarding severity and pathology(capizzi et al.,2020).

关键词： sustained orange dynamic

The Mechanism of Henipavirus Fusion:Examining the Relationships between the Attachment and Fusion Glycoproteins

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Virologica Sinica 2009年第2期24卷 110-120页

作者： Andrew c. Hickey christopher c. broder Department of Microbiology and Immunology Uniformed Services University of the Health Sciences

The henipaviruses,represented by Nipah virus and Hendra virus,are emerging zoonotic viral pathogens responsible for repeated outbreaks associated with high morbidity and mortality in Australia,Southeast Asia,India and Bangladesh. These viruses enter host cells via a class I viral fusion mechanism mediated by their attachment and fusion envelope glycoproteins;efficient membrane fusion requires both these glycoproteins in conjunction with specific virus receptors present on susceptible host cells. The henipavirus attachment glycoprotein interacts with a cellular B class ephrin protein receptor triggering conformational alterations leading to the activation of the viral fusion(F) glycoprotein. The analysis of monoclonal antibody(mAb) reactivity with G has revealed measurable alterations in the antigenic structure of the glycoprotein following its binding interaction with receptor. These observations only appear to occur with full-length native G glycoprotein,which is a tetrameric oligomer,and not with soluble forms of G(sG) ,which are disulfide-linked dimers. Single amino acid mutations in a heptad repeat-like structure within the stalk domain of G can disrupt its association with F and subsequent membrane fusion promotion activity. Notably,these mutants of G also appear to confer a post-receptor bound conformation implicating the stalk domain as an important element in the G glycoprotein's structure and functional relationship with F. Together,these observations suggest fusion is dependent on a specific interaction between the F and G glycoproteins of the henipaviruses. Further,receptor binding induces measurable changes in the G glycoprotein that appear to be greatest in respect to the interactions between the pairs of dimers comprising its native tetrameric structure. These receptor-induced conformational changes may be associated with the G glycoprotein's promotion of the fusion activity of F.

关键词： Hendra virus Nipah virus Henipavirus Paramyxovirus Viral entry

comparative analysis of empirical and deep learning models for ionospheric sporadic E layer prediction

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Earth and Planetary Physics 2025年第1期9卷 10-19页

作者： BingKun Yu PengHao Tian XiangHui Xue christopher JScott HaiLun Ye JianFei Wu Wen Yi TingDi chen XianKang Dou Institute of Deep Space Sciences Deep Space Exploration LaboratoryHefei 230088China cAS Key Laboratory of Geospace Environment School of Earth and Space SciencesUniversity of Science and Technology of ChinaHefei 230026China Hefei National Laboratory University of Science and Technology of ChinaHefei 230088China Department of Meteorology University of ReadingReading RG66BBUK

Sporadic E(Es)layers in the ionosphere are characterized by intense plasma irregularities in the E region at altitudes of 90-130 *** they can significantly influence radio communications and navigation systems,accurate forecasting of Es layers is crucial for ensuring the precision and dependability of navigation satellite *** this study,we present Es predictions made by an empirical model and by a deep learning model,and analyze their differences comprehensively by comparing the model predictions to satellite RO measurements and ground-based ionosonde *** deep learning model exhibited significantly better performance,as indicated by its high coefficient of correlation(r=0.87)with RO observations and predictions,than did the empirical model(r=0.53).This study highlights the importance of integrating artificial intelligence technology into ionosphere modelling generally,and into predicting Es layer occurrences and characteristics,in particular.

关键词： ionospheric sporadic E layer radio occultation ionosondes numerical model deep learning model artificial intelligence

NONDEGENERAcY OF POSITIVE SOLUTIONS TO HOMOGENEOUS SEcOND-ORDER DIFFERENTIAL SYSTEMS AND ITS APPLIcATIONS

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Acta Mathematica Scientia 2009年第2期29卷 435-446页

作者：戴求亿 christopher c. Tisdell Department of Mathematics Hunan Normal University School of Mathematics the University of New South Wales

This article considers the Dirichlet problem of homogeneous and inhomogeneous second-order ordinary differential systems. A nondegeneracy result is proven for positive solutions of homogeneous systems. Sufficient and necessary conditions for the existence of multiple positive solutions for inhomogeneous systems are obtained by making use of the nondegeneracy and uniqueness results of homogeneous systems.

关键词： Second ordinary differential system Dirichlet problem positive solution nondegeneracy multiplicity result

circatidal rhythms of locomotion in the American horseshoe crab Limulus polyphemus: Underlying mechanisms and cues that influence them

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current Zoology 2010年第5期56卷 499-517页

作者： christopher c.cHABOT Winsor H.WATSON Ⅲ Department of Biological Sciences Plymouth State University Department of Biological Sciences University of New Hampshire

While eye sensitivity in the American horseshoe crab Limulus polyphemus has long been known to be under the control of an endogenous circadian clock, only recently has horseshoe crab locomotion been shown to be controlled by a separate clock system. In the laboratory, this system drives clear activity rhythms throughout much of the year, not just during the mating season when horseshoe crabs express clear tidal rhythms in the field. Water temperature is a key factor influencing the expression of these rhythms： at 17~c tidal rhythms are expressed by most animals, while at I l^c expression of circatidal rhythms is rarely seen, and at 4~c rhythms are suppressed. Neither long （16：8 Light：Dark） nor short （8：16） photoperiods modify this behavior at any of these temperatures. Synchronization of these circatidal rhythms can be most readily effeeted by water pressure cycles both in situ and in the lab, while temperature and current cycles play lesser, but possibly contributory, roles. Interestingly, Light：Dark cycles appear to have synchronizing as well as ＂masking＂ effects in some individuals. Evidence that each of two daily bouts of activity are independent suggests that the Limulus circatidal rhythm of locomotion is driven by two （circalunidian） clocks, each with a period of 24.8h. While the anatomical locations of either the circadian clock, that drives fluctuations in visual sensitivity, or the circatidal clock, that controls tidal rhythms of locomotion, are currently unknown, preliminary molecular analyses have shown that a 71 kD protein that reacts with antibodies directed against the Drosophila PERIOD （PER） protein is found in both the pro- tocerebrum and the subesophageal ganglion

关键词： circatidal circadian circalunidian Rhythms Behavior PER Tides Locomotion

High resolution tracking of adult horseshoe crabs Limulus polyphemus in a New Hampshire estuary using fixed array ultrasonic telemetry

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current Zoology 2010年第5期56卷 599-610页

作者： Winsor H.WATSON Ⅲ christopher c.cHABOT Department of Biological Sciences University of New Hampshire Department of Biology Plymouth State University

While several studies have documented the large-scale, seasonal movements of horseshoe crabs, little is known about their fine-scale, daily movement patterns. In this study we used a fixed array ultrasonic telemetry system to track the movements of 12 male and 16 female horseshoe crabs in the Great Bay estuary, New Hampshire. Data were obtained during the mating season, as well as during the remainder of the summer and fall, in the years 2005-2008. During the mating season animals were often, but not always, active during the high tides when they were approaching and leaving the spawning beaches. On average, both males and females approached mating beaches during 33% of the high tides they experienced and they most often made the tran- sition from being inactive to active during the last two hours of an incoming tide. From April-October horseshoe crabs were significantly more active during high tide periods vs low tide periods, with no clear preference for diurnal vs nocturnal activity. After the mating season ended horseshoe crabs continued to move into shallower water at high tide and then return to deeper water at low tide. Observations by ScUBA divers suggest that during these excursions into the mudflats horseshoe crabs were digging pits in the sediment while foraging for food. Thus, the tidal rhythm of activity that has been so well documented during the mating season probably persists into the fall, and primarily involves foraging activities

关键词： Telemetry Tracking Movements Mating Foraging Estuary