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Five-year mortality and coronary heart disease development after normal coronary angiogram

World Journal of Emergency Medicine 2011年第1期2卷 24-29页

作者： Jason t McMullan christopher J Lindsell Andra L Blomkalns Department of Emergency Medicine University of Cincinnati Cincinnati Ohio 670769 USA

BACKGROUND： Previous studies depict low cardiac event and mortality rates in patients with angiographically normal coronary arteries. these studies, however, are limited by small sample sizes, short follow-up intervals, and selection biases. this study was undertaken to determine the natural five-year course of a diverse cohort of subjects with documented normal coronary arteries with respect to coronary heart disease development, revascularization need, and all-cause ***： Consecutive adult patients with angiographically normal coronary arteries were followed up for 5 years through medical record review. Patients with any degree of angiographic abnormality, including minimal luminal irregularity or non-critical stenosis, were excluded. Patients were not excluded based on age, co-morbidities （except cardiac transplant and structural heart disease）, indication for angiogram, or initial hospitalization ***： Normal coronary arteries were found in 182 （31.3%） of 582 patients; 129 met all inclusion criteria. the mean age was （49.1±12.5） years; 47 （36.7%） were male and 75 （58.1%） were caucasian. the most common indication for angiography was cumulative risk factors （60.5%）. Within 5 years of a normal angiogram, 13 of 129 patients died （10.1%; 95 CI 5.7%-16.9%）. Six （40%; 95 CI 19.8% to 64.3%） of 15 patients undergoing repeat angiogram within five years developed new coronary heart disease, with one requiring revascularization. Of traditional risk factors of coronary heart disease, only diabetes was associated with a higher risk of ***： the natural five-year course of a diverse cohort of patients with documented normal coronary arteries suggests that there is significant risk for death and development of coronary heart disease.

关键词： Angiography Coronary disease Mortality Prognosis

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Approaches to identifying drug resistance mechanisms to clinically relevant treatments in childhood rhabdomyosarcoma

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Cancer Drug Resistance 2022年第1期5卷 80-89页

作者： Samson Ghilu christopher L.Morton Angelina V.Vaseva Siyuan Zheng Raushan t.Kurmasheva Peter J.Houghton Department of Molecular Medicine Greehey Children’s Cancer Research InstituteUT HealthSan AntonioTX 78229USA Department of Surgery St.Jude Children’s Research HospitalMemphisTN 38105USA Department of Epidemiology and Biostatistics Greehey Children’s Cancer Research InstituteUT HealthSan AntonioTX 78229USA

Aim:Despite aggressive multiagent protocols,patients with metastatic rhabdomyosarcoma(RMS)have poor *** a recent high-risk trial(ARSt0431),25% of patients failed within the first year,while on therapy and 80% had tumor progression within 24 ***,the mechanisms for tumor resistance are essentially *** we explore the use of preclinical models to develop resistance to complex chemotherapy regimens used in ***:A Single Mouse testing(SMt)protocol was used to evaluate the sensitivity of 34 RMS xenograft models to one cycle of vincristine,actinomycin D,cyclophosphamide(VAC)*** response was determined by caliper measurement,and tumor regression and event-free survival(EFS)were used as endpoints for *** tumors at regrowth were transplanted into recipient mice,and the treatment was repeated until tumors progressed during the treatment period(i.e.,became resistant).At transplant,tumor tissue was stored for biochemical and omics ***:the sensitivity to VAC of 34 RMS models was *** varied from 3 weeks to>20 *** models were classified as having intrinsic resistance,intermediate sensitivity,or high sensitivity to VAC *** to VAC was developed in multiple models after 2-5 cycles of therapy;however,there were examples where sensitivity remained unchanged after 3 cycles of ***:the SMt approach allows for in vivo assessment of drug sensitivity and development of drug resistance in a large number of RMS *** such,it provides a platform for assessing in vivo drug resistance mechanisms at a“population”level,simulating conditions in vivo that lead to clinical *** VAC-resistant models represent“high-risk”tumors that mimic a preclinical phase 2 population and will be valuable for identifying novel agents active against VAC-resistant disease.

关键词： Rhabdomyosarcoma patient-derived xenografts combination therapy intrinsic drug resistance acquired drug resistance

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Orthogonal quantification of soluble inducible t-cell costimulator(ICOS)in healthy and diseased human serum

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Journal of Pharmaceutical Analysis 2022年第2期12卷 317-323页

作者： Kevin McKinski Dean McNulty Francesca Zappacosta Mary Birchler Matt Szapacs christopher Evans Bioanalysis Immunogenicity&BiomarkersGlaxoSmithKlineCollegevillePA19426USA

Inducible t-cell costimulator(ICOS),a homodimeric protein expressed on the surface of activated t-cells,is being investigated as a potential therapeutic target to treat various *** studies have reported aberrant increases in the soluble form of ICOS(sICOS)in human serum in disease-state patients,primarily using commercial ELISA ***,results from our in-house immunoassay did not show these aberrant increases,leading us to speculate that commercial sICOS ELISAs may be prone to *** directly tested that hypothesis and found that one widely used commercial kit yields falsepositives and is prone to human anti-mouse antibody *** then analyzed a panel of healthy,cancer,chronic hepatitis C virus,systemic lupus erythematosus,and diffuse cutaneous systemic sclerosis human serum using our in-house immunoassay and reported the measured sICOS concentrations in these *** even well characterized immunoassay methods are prone to non-specific interference,we also developed a novel sICOS LC-MS/MS method to confirm the *** these orthogonal approaches,we show that sICOS is a low abundance soluble protein that cannot be measured above approximately 20 pg/mL in human serum.

关键词： ICOS Immunoassay LC-MS/MS Biomarker HAMA

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Spontaneous Regression of a Histologically Proven Cutaneous Squamous Cell Carcinoma

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Journal of Cancer therapy 2013年第2期4卷 546-548页

作者： Sweta Sengupta James Arocho t. christopher Windham Florida Hospital Memorial Medical Center Comprehensive Cancer Center Memorial Hospital Daytona Beach USA. Florida Hospital Memorial Medical Center Memorial Hospital Daytona Beach USA Florida State University College of Medicine Tallahassee USA

Introduction: the rate of squamous cell carcinoma spontaneous regression (SR) remains unknown because incidences are rare and underreported. Case Report: We present a case of a 92-year-old Caucasian female who was found to have a 1 cm lesion on her nose. Pathologic evaluation supported the diagnosis of a moderately-differentiated squamous cell carcinoma. the patient refused treatment and returned with no clinical evidence of disease several months later. the lesion spontaneously regressed without excision. Discussion: Frequency of SR of malignancies has been estimated to occur 1 in 80,000 to 100,000 cases [1]. the biologic mechanisms of SR in malignancies remain unclear. Further investigations into the mechanisms of SR may identify potential treatment strategies for cancer.

关键词： Squamous Cell Carcinoma Spontaneous Remission

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Comparison of FAStMAP and <i>B</i><sub>0</sub>Field Map Shimming at 4t: Magnetic Field Mapping Using a Gradient-Echo Pulse Sequence

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Journal of Electromagnetic Analysis and Applications 2020年第8期12卷 115-130页

作者： Mohan Jayatilake christopher t. Sica Rommy Elyan Prasanna Karunanayaka Department of Radiology (Center for NMR Research) Pennsylvania State University College of Medicine Milton S. Hershey Medical Center Hershey Pennsylvania USA Department of Physics University of Cincinnati Cincinnati Ohio USA

Local susceptibility variations result in B0 field inhomogeneities, causing distortions and signal losses in MR imaging. Susceptibility variations become stronger with increasing B0 magnetic field strength. Active shimming is used to generate corrective magnetic fields, which can be used to improve B0 field homogeneity. FAStMAP is an effective shimming technique for computing optimal coil currents, which uses data from six projection directions (or columns): this technique is routinely used for shimming cubic volumes of interest (VOIs). In this paper, we propose several improvements to FAStMAP at 4t. For each shim coil, using a modified 3D gradient-echo pulse sequence, we compute B0 inhomogeneity maps and project them onto eight 1st and 2nd order spherical harmonic functions. this process is repeated for shim currents between -15,000 to 15,000 with increments of 5000 Digital to Analog Converter (DAC) units, and is used to compute the gradient between spherical harmonic coefficients and DAC values for all 8 shim coils—along with the R2 values of linear fits. A method is proposed (based on R2 values) to further refine optimal shim currents in respective coils. We present an analysis that is numerically robust and completely flexible in the selection of the VOIs for shimming. Performance analyses, phantom results, and in vivo results of a human brain are presented, comparing our methods with the FAStMAP method.

关键词： MRI Shimming 4t Higher-Order Shims

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Intracellular signaling mechanisms regulating the activation of human eosinophils by the novel th2 cytokine IL-33:implications for allergic inflammation

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Cellular & Molecular Immunology 2010年第1期7卷 26-34页

作者： Joyce YS Chow Chun K Wong Phyllis FY Cheung christopher WK Lam Department of Chemical Pathology The Chinese University of Hong KongPrince of Wales HospitalShatinNTHong KongChina Macao Institute for Applied Research in Medicine and Health Macao University of Science and Technology FoundationMacaoChina

the novel interleukin(IL)-1 family cytokine IL-33 has been shown to activate t helper 2(th2)lymphocytes,mast cells and basophils to produce an array of proinflammatory cytokines,as well as to mediate blood eosinophilia,IgE secretion and hypertrophy of airway epithelium in *** the present study,we characterized the activation of human eosinophils by IL-33,and investigated the underlying intracellular signaling ***-33 markedly enhanced eosinophil survival and upregulated cell surface expression of the adhesion molecule intercellular adhesion molecule(ICAM)-1 on eosinophils,but it suppressed that of ICAM-3 and *** addition,IL-33 mediates significant release of the proinflammatory cytokine IL-6 and the chemokines CXCL8 and *** found that IL33-mediated enhancement of survival,induction of adhesion molecules,and release of cytokines and chemokines were differentially regulated by activation of the nuclear factor(NF)-KB,p38 mitogen-activated protein kinase(MAPK)and extracellular signal-regulated kinase(ERK)***,we compared the above IL-33 activities with two structurally and functionally related cytokines,IL-1 B and ***-1β,but not IL-18,markedly upregulated cell surface expression of ***-1βand IL-18 also significantly enhanced eosinophil survival,and induced the release of IL-6 and chemokines CXCL8 and CCL2 via the activation of the NF-κB,p38 MAPK and ERK *** efects on the release of IL-6 were also observed in combined treatment withIL-1B,IL-18 and *** together,our findings provide insight into IL-33-mediated activation of eosinophils via differential intracellular signaling cascades in the immunopathogenesis of allergic inflammation.

关键词： allergy cytokines eosinophils signal transduction

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Response of upland rice agronomic parameters to variable water supply

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International Journal of Agricultural and Biological Engineering 2011年第2期4卷 50-58页

作者： christopher O Akinbile Abimbola Y Sangodoyin Department of Agricultural Engineering Federal University of TechnologyAkureNigeria Department of Agricultural and Environmental Engineering University of IbadanNigeria

Rice response to water application is necessary for increased productivity;hence,this study was aimed at establishing the agronomic responses of rice crop to differential water supplies.A two-year dry season experiment was conducted on the research farm of International Institute of tropical Agriculture(IItA),Ibadan,*** upland rice varieties(NERICA 2 and NERICA 4)were planted on a 5 m×5 m plot in a randomized complete block design with four treatments and two replicates based on different water *** scheduling was designed as 100%Et,75%Et,50%Et and 25%Et for the treatments *** parameters such as plant height,root depth,canopy shading(CS),leaf area index(LAI),panicle and tiller configuration,biomass and grain yield in relation to crop water use were obtained and the results were subjected to statistical *** values of highest plant height(89.0 and 100.3 cm),deepest root depth(22.1 and 23.8 cm),panicle diameter(3.9 and 4.5 cm),panicle length(26.1 and 25.7 cm),LAI,3.27 and 3.95,CS,0.22 and 0.99 were obtained for both NERICA 2 and NERICA 4 *** width(1.3 and 1.4 cm),total tillers(14 and 12)and leaf length(36.9 and 38 cm)were also observed for the two varieties *** highest total grain and biomass yields of 1.94 t/ha and 1.95 t/ha were observed in 100%Et treatment for NERICA 2 while the least values of 0.29 t/ha and 1.09 t/ha were observed in 25%Et *** for NERICA 4,the highest values(1.90 t/ha and 2.27 t/ha)were from 100%Et and the least(0.38 t/ha and 2.29 t/ha)in 25%*** result of ANOVA showed significant differences in biomass and grain yield,LAI,CS,plant height and root depth among treatments(Ptressing the domineering influence of water in agronomic response of rice.

关键词： agronomic parameters upland rice water supply irrigation scheduling response rice yield

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Antibiotic prophylaxis and infectious complications in patients on peritoneal dialysis undergoing lower gastrointestinal endoscopy

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Gastroenterology Report 2020年第5期8卷 407-409,I0003页

作者： William t.Clarke Venkata R.Satyam David I.Fudman Samantha Zullow Kashika G.Goyal Katerina LByanova christopher Huang Joseph D.Feuerstein Division of Gastroenterology Department of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Department of Medicine Boston Medical CenterBoston University School of MedicineBostonMAUSA Present affiliation:Division of Digestive and Liver Diseases Department of Internal MedicineUniversity of Texas Southwestern Medical CenterDallasTXUSA Present affiliation:Division of Gastroenterology and Hepatology New York University Langone Medical CenterNew York University School of MedicineNew YorkNYUSA Department of Medicine Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Section of Gastroenterology Department of MedicineBoston Medical CenterBoston University School of MedicineBostonMAUSA

Introduction Peritoneal dialysis(PD)is widely used for the treatment of endstage renal *** treated with PD have similar outcomes to those treated with hemodialysis[1].However,PDrelated infections including peritonitis have been reported at 1.66 episodes per patient per year[2].One possible source of peritonitis is gastrointestinal(GI)endoscopic *** 2005,the International Society for Peritoneal Dialysis(ISPD)published guidelines suggesting antibiotics be given to PD patients prior to colonoscopy[3].this suggestion was mostly based on expert opinion and a theoretical concern that patients undergoing colonoscopy are at increased risk for enteric peritonitis from bacterial translocation across the bowel *** there is no direct evidence to support this theory,case reports have suggested a risk of transient bacteremia associated with colonoscopy.

关键词：预防性抗生素消化道内镜检查感染性并发症

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Identification of optimal contemporary antiemetic prophylaxis for doxorubicin-cyclophosphamide chemotherapy in Chinese cancer patients: post-hoc analysis of 3 prospective studies

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Cancer Biology & Medicine 2021年第3期18卷 825-832页

作者： Winnie Yeo Leung Li thomas KH Lau Kwai t Lai Vicky,tC Chan Kwan H Wong christopher CH Yip Elizabeth Pang Maggie Cheung Vivian Chan Carol CH Kwok Joyce JS Suen Frankie KF Mo Department of Clinical Oncology Prince of Wales HospitalFaculty of MedicineHong Kong Cancer InstituteHong KongChina State Key Laboratory of translational Oncology The Chinese University of Hong KongHong KongChina Department of Clinical Oncology Princess Margaret HospitalHong KongChina

Objective:Chemotherapy-induced nausea and vomiting(CINV)are common with doxorubicin-cyclophosphamide(AC)*** antiemetic regimens incorporate neurokinin-1 receptor antagonist(NK1 RA),5-hydroxytryptamine type-3 receptor antagonist(5 Ht3 RA),corticosteroid,and dopamine *** post-hoc analysis compared results of 3 prospective antiemetic studies conducted among Chinese breast cancer patients who received(neo)adjuvant AC,in order to identify optimal antiemetic ***:A total of 304 patients were included:Group 1,ondansetron/dexamethasone(D1);Group 2,aprepitant/ondansetron/dexamethasone(D1);Group 3,aprepitant/ondansetron/dexamethasone(D1–3);Group 4,aprepitant/ondansetron/dexamethasone(D1–3)/olanzapine;and Group 5,netupitant/palonosetron/dexamethasone(D1–3).Antiemetic efficacies of Groups 3,4,and 5 during cycle 1 of AC were individually compared with Group *** addition,emesis outcomes of patients in Groups 3 and 5,and those of Groups 2 and 3,were ***:When comparing efficacies of a historical doublet(5 Ht3 RA/dexamethasone)with triplet antiemetic regimens(NK1 RA/5 Ht3 RA/dexamethasone)with/without olanzapine,complete response(CR)percentages and quality of life(QOL)in overall phase of cycle 1 AC were compared between Group 1 and the other groups:Group 1 vs.3,41.9%vs.38.3%(P=0.6849);Group 1 vs.4,41.9%vs.65.0%(P=0.0107);and Group 1 vs.5,41.9%vs.60.0%(P=0.0460).Groups 4 and 5 achieved a better *** comparing netupitant-based(Group 3)with aprepitant-based(Group 5)triplet antiemetics,CR percentages were 38.3%vs.60.0%,respectively(P=0.0176);Group 5 achieved a better *** comparing 1 day(Group 2)vs.3 day(Group 3)dexamethasone,CR percentages were 46.8%and 38.3%,respectively(P=0.3459);Group 3 had a worse ***:Aprepitant-containing triplets were non-superior to doublet ***-containing triplets and adding olanzapine to aprepitant-containing triplets were superior to ***/palono

关键词： Netupitant palonosetron aprepitant olanzapine NEPA Asians

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the contribution of fungi to the global economy

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Fungal Diversity 2023年第4期121卷 95-137页

作者： Allen Grace t.Niego christopher Lambert Peter Mortimer Naritsada thongklang Sylvie Rapior Miriam Grosse Hedda Schrey Esteban Charria‑Girón Arttapon Walker Kevin D.Hyde Marc Stadler School of Science Mae Fah Luang UniversityChiang RaiThailand Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang RaiThailand Iloilo Science and technology University La Paz5000 IloiloPhilippines Department Microbial Drugs Helmholtz Centre for Infection ResearchInhoffenstrasse 738124 BrunswickGermany Institute of Microbiology Technische Universitat BraunschweigSpielmannstrase 738106 BrunswickGermany Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunming 650201YunnanPeople’s Republic of China Laboratory of Botany Phytochemistry and MycologyFaculty of PharmacyCS 1449115 Avenue Charles Flahault34093 Montpellier Cedex 5France CEFE CNRSUniv MontpellierEPHEIRDCS 1449115 Avenue Charles Flahault34093 Montpellier Cedex 5France Department of Biology Faculty of ScienceChiang Mai UniversityChiang Mai 50200Thailand Institute for Plant Health Zhongkai University of Agriculture and EngineeringHaizhu DistrictGuangzhou 510225People’s Republic of China

Fungi provide ecological and environmental services to humans, as well as health and nutritional benefits, and are vital to numerousindustries. Fermented food and beverage products from fungi are circulating in the market, generating billions of ***, the highest potential monetary value of fungi is their role in blue carbon trading because of their ability to sequesterlarge amounts of carbon in the soil. there are no conclusive estimates available on the global monetary value of fungi, primarilybecause there are limited data for extrapolation. this study outlines the contribution of fungi to the global economy and providesa first attempt at quantifying the global monetary value of fungi. Our estimate of USD 54.57 trillion provides a starting point thatcan be analysed and improved, highlighting the significance of fungi and providing an appreciation of their value. this paperidentifies the different economically valuable products and services provided by fungi. By giving a monetary value to all importantfungal products, services, and industrial applications underscores their significance in biodiversity and conservation. Furthermore,if the value of fungi is well established, they will be considered in future policies for effective ecosystem management.

关键词： Fungi-based food Medicinal mushrooms Market value Environmental biotechnology

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