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Apples to oranges:environmentally derived,dynamic regulation of serotonin neuron subpopulations in adulthood?

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Neural Regeneration Research 2025年第9期20卷 2596-2597页

作者： christopher J.O’Connell Matthew J.Robson Department of Genetics College of MedicineHarvard UniversityBostonMAUSA James L.Winkle College of Pharmacy Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA Neuroscience Graduate Program College of MedicineUniversity of CincinnatiCincinnatiOHUSA

Traumatic brain injury(TBI)is a public health problem with an undue economic burden that impacts nearly every age,ethnic,and gender group across the globe(Capizzi et al.,2020).TBIs are often sustained during a dynamic range of exposures to energetic environmental forces and as such outcomes are typically heterogeneous regarding severity and pathology(Capizzi et al.,2020).

关键词： sustained orange dynamic

Comparative analysis of empirical and deep learning models for ionospheric sporadic E layer prediction

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Earth and Planetary Physics 2025年第1期9卷 10-19页

作者： BingKun Yu PengHao Tian XiangHui Xue christopher JScott HaiLun Ye JianFei Wu Wen Yi TingDi Chen XianKang Dou Institute of Deep Space Sciences Deep Space Exploration LaboratoryHefei 230088China CAS Key Laboratory of Geospace Environment School of Earth and Space SciencesUniversity of Science and Technology of ChinaHefei 230026China Hefei National Laboratory University of Science and Technology of ChinaHefei 230088China Department of Meteorology University of ReadingReading RG66BBUK

Sporadic E(Es)layers in the ionosphere are characterized by intense plasma irregularities in the E region at altitudes of 90-130 *** they can significantly influence radio communications and navigation systems,accurate forecasting of Es layers is crucial for ensuring the precision and dependability of navigation satellite *** this study,we present Es predictions made by an empirical model and by a deep learning model,and analyze their differences comprehensively by comparing the model predictions to satellite RO measurements and ground-based ionosonde *** deep learning model exhibited significantly better performance,as indicated by its high coefficient of correlation(r=0.87)with RO observations and predictions,than did the empirical model(r=0.53).This study highlights the importance of integrating artificial intelligence technology into ionosphere modelling generally,and into predicting Es layer occurrences and characteristics,in particular.

关键词： ionospheric sporadic E layer radio occultation ionosondes numerical model deep learning model artificial intelligence

Positron Emission Projection Imaging:A technique for concentration field measurements in opaque industrial systems

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Particuology 2024年第11期94卷 1-15页

作者： Roberto Hart-Villamil Jack Sykes Andy Ingram christopher R.K.Windows-Yule Santosh kumar Gupta School of Chemical Engineering University of BirminghamB152TTUK School of Physics and Astronomy University of BirminghamB152TTUK Hindustan Unilever R&D BengaluruKarnataka560066India

A novel Positron Emission Projection Imaging(PEPI)algorithm designed to compute the plane-projected spatial distribution of radiolabelled materials without the need for collimation is *** leveraging improved data efficiency,we have achieved a technique with enhanced spatial resolution and temporal resolution compared to previous PEPI *** of this algorithm was conducted using synthetic data generated from a digital twin of a PET scanner,demonstrating its accuracy for practical *** industrial advantage of this novel algorithm was applied in the imaging of laminar flow mixing within a ploughshare mixer,with the experimental results compared against those obtained from validated computational fluid dynamics(CFD)*** comparison highlights an important use case for PEPI as a robust validation tool for CFD simulations,crucial for enhancing industrial ***,which uses deeply penetrating gamma-photons,is now capable of imaging opaque fluids and solids in industrial *** directions for this work include further algorithmic refinements and expanding its application across various industrial systems,establishing PEPI as a robust tool for in-depth industrial process *** advancements presented here allow for optimized mixer design and enhanced process efficiency,extending the frontiers of tomographic imaging in industrial applications.

关键词： Positron emission projection imaging Positron emission particle tracking Computational fluid dynamics Mixing Ploughshare mixer

Genetic Algorithm Based 7-Level Step-Up Inverter with Reduced Harmonics and Switching Devices

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Intelligent Automation & Soft Computing 2023年第3期35卷 3081-3097页

作者： T.Anand kumar M.Kaliamoorthy I.Gerald christopher Raj Department of EEE Dr.Mahalingam College of Engineering and TechnologyPollachiTamilnaduIndia Department of EEE PSNA College of Engineering and TechnologyDindigulTamilnaduIndia

This paper presents a unique voltage-raising topology for a single-phase seven-level inverter with triple output voltage gain using single input source and two switched *** output voltage has been boosted up to three times the value of input voltage by conﬁguring the switched capacitors in series and parallel combinations which eliminates the use of additional step-up converters and *** selective harmonic elimination(SHE)approach is used to remove the lower-order *** optimal switching angles for SHE is determined using the genetic *** switching angles are com-bined with a level-shifted pulse width modulation(PWM)technique for pulse generation,resulting in reduced total harmonic distortion(THD).A detailed com-parison has been made against other relevant seven-level inverter topologies in terms of the number of switches,drivers,diodes,capacitors,and boosting facil-ities to emphasize the beneﬁts of the proposed *** proposed topology is simulated using MATLAB/SIMULINK and an experimental prototype has been developed to validate the *** Digital Signal Processing(DSP)TMS320F2812 board is used to generate the switching pulses for the proposed technique and the experimental results concur with the simulated model outputs.

关键词： Genetic algorithm multilevel inverter pulse width modulation selective harmonic elimination switched capacitor

Rapid metabolic fingerprinting with the aid of chemometric models to identify authenticity of natural medicines: Turmeric, Ocimum, and Withania somnifera study

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Journal of Pharmaceutical Analysis 2023年第9期13卷 1041-1057页

作者： Samreen Khan Abhishek kumar Rai Anjali Singh Saudan Singh Basant kumar Dubey Raj Kishori Lal Arvind Singh Negi Nicholas Birse Prabodh kumar Trivedi christopher T.Elliott Ratnasekhar Ch Metabolomics Lab Council of Scientific and Industrial Research(CSIR)-Central Institute of Medicinal and Aromatic Plants(CIMAP)Lucknow226015India Department of Crop Production&Protection Council of Scientific and Industrial Research(CSIR)-Central Institute of Medicinal and Aromatic Plants(CIMAP)Lucknow226015India Academy of Council of Scientific and Industrial Research(ACSIR) Ghaziabad201002India Department of Biotechnology Council of Scientific and Industrial Research(CSIR)-Central Institute of Medicinal and Aromatic Plants(CIMAP)Lucknow226015India Genetics and Plant Breeding Department Council of Scientific and Industrial Research(CSIR)-Central Institute of Medicinal and Aromatic Plants(CIMAP)Lucknow226015India Department of Phytochemistry Council of Scientific and Industrial Research(CSIR)-Central Institute of Medicinal and Aromatic Plants(CIMAP)Lucknow226015India School of Biological Sciences Queen's UniversityBelfastBT95DLUK

Herbal medicines are popular natural medicines that have been used for *** use of alternative medicines continues to expand rapidly across the *** World Health Organization suggests that quality assessment of natural medicines is essential for any therapeutic or health care applications,as their therapeutic potential varies between different geographic origins,plant species,and *** of herbal medicines based on a limited number of secondary metabolites is not an ideal *** quality should be considered based on a complete metabolic profile,as their pharmacological activity is not due to a few specific secondary metabolites but rather a larger group of bioactive compounds.A holistic and integrative approach using rapid and nondestructive analytical strategies for the screening of herbal medicines is required for robust *** this study,a rapid and effective quality assessment system for geographical traceability,species,and variety-specific authenticity of the widely used natural medicines turmeric,Ocimum,and Withania somnifera was investigated using Fourier transform near-infrared(FT-NIR)spectroscopy-based metabolic *** different geographical origins of turmeric,five different Ocimum species,and three different varieties of roots and leaves of Withania somnifera were studied with the aid of machine learning *** good discrimination(R^(2)>0.98,Q^(2)>0.97,and accuracy=1.0)with sensitivity and specificity of 100%was achieved using this metabolic fingerprinting *** study demonstrated that FT-NIR-based rapid metabolic fingerprinting can be used as a robust analytical method to authenticate several important medicinal herbs.

关键词： Rapid metabolic fingerprinting Natural medicines FT-NIR Chemometric models

Patterns of cancer recurrence in localized resected hepatocellular carcinoma

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Hepatobiliary & Pancreatic Diseases International 2015年第3期14卷 269-275页

作者： Aryavarta MS kumar Elisha T Fredman christopher Coppa Galal El-Gazzaz Federico N Aucejo May Abdel-Wahab Department of Radiation Oncology 9500 Euclid AveT28 Cleveland ClinicCleveland OH 44195 USA Department of Radiology 9500 Euclid Ave Hb6 Cleveland ClinicCleveland OH 44195 USA Department of Hepato-pancreato-biliary & Transplant Surgery 9500 Euclid Ave A100Cleveland OH 44195 USA

BACKGROUND： Tumor resection in non-metastatic hepato- cellular carcinoma （HCC） patients with adequate liver reserve offers a potential cure, but has a high 5-year recurrence rate. We analyzed the patterns of cancer... 详细信息

关键词： hepatocellular carcinoma patterns of failure partial hepatectomy

Protecting miners from coal bursts during development above historic mine workings in Harlan County,KY

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International Journal of Mining Science and Technology 2021年第1期31卷 111-116页

作者： christopher Mark Mine Safety and Health Administration PittsburghPA 15236USA

In order to reach a large,untapped reserve of high-quality coal,D8 Cloverlick Mine proposed to mine a corridor nearly 600 m deep beneath the Benham Spur of Black Mountain,Kentucky’s highest peak.D8 Cloverlick Mine was extracting the Owl seam,but the corridor’s route lay approximately 20 m above century-old mine workings in the C–(Darby)*** to the concern,three serious coal bursts had recently occurred in nearby Owl seam *** of the old workings seemed to indicate that the underlying C–seam had been fully ***,two of the coal bursts had occurred above areas where the C–Seam was also shown as mined *** Safety and Health Administration(MSHA)Technical Support therefore investigated the records of past mining to better understand the old mine *** conditions observed in current Owl seam workings were also compared with the maps of the old C–seam *** study concluded that the presence of hazardous underlying remnants could not be ruled *** mitigate the burst risk,D8 Cloverlick Mine adopted a strategy of stress probe drilling.A self-propelled coal drill was used to auger 11.5-m-long,small diameter holes in advance of *** each hole was drilled,the cuttings were measured to detect the presence of highly stressed *** the crossing was successfully completed without incident.

关键词： Coal bursts Underground mining Room-and-pillar Destressing

Changes in post-keratoplasty astigmatism after suture removal:refraction vs tomography vs aberrometry

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International Journal of Ophthalmology(English edition) 2021年第11期14卷 1707-1713页

作者： Suraj kumar Chaurasiya Jagadesh C.Reddy Pravin K.Vaddavalli christopher J.Rapuano Brien Holden School of Optometry and Vision Sciences L V Prasad Eye Institute(LVPEI)Hyderabad 500034India Cataract and Refractive Surgery Services The Cornea InstituteL V Prasad Eye Institute(LVPEI)Hyderabad 500034India Comea Service Wills Eye HospitalPhiladelphiaPennsylvania 19107USA

AIM:To analyse the changes in magnitude and orientation of astigmatism after suture removal(SR)in keratoplasty eyes as measured by refraction,tomography,and ***:Twenty-six eyes of 25 patients after optical keratoplasty requiring SR to reduce the astigmatism during the follow-up period were prospectively *** with poor quality topography scans or if there were no sutures in the steepest semi meridian were *** distance visual acuity(CDVA),manifest refraction,corneal tomography and aberrometr y were per formed on all patients before and after ***:The mean age of the patients was 40.8±14.4 *** keratoplasty was performed in 23 eyes(89%)and deep anterior lamellar keratoplasty was done in 3 eyes(11%).There was a statistically significant reduction in the magnitude of refractive,tomographic and aberrometry astigmatism after SR(P<0.001)at 2 h after suture *** mean net reduction of the astigmatism was greater as measured by corneal tomography compared to refractive astigmatism(P<0.05).There was no statistically significant change in refractive astigmatism between 2 h and 2 mo after SR(P=0.55).Vector calculations demonstrated a greater amount of undercorrection in the tomography group and the rotational error was more towards counterclockwise *** monocular log MAR CDVA improved from 0.57 D to 0.49 D after SR(P=0.002).CONCLUSION:The net reduction in the magnitude of astigmatism after SR is greater in the tomography and aberrometry *** one episode of SR,there is no difference in the aberration profile.

关键词： keratoplasty astigmatism suture removal

An updated empirical model for ground control in *** coal mines

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International Journal of Mining Science and Technology 2021年第2期31卷 163-174页

作者： christopher Mark Mine Safety and Health Administration PittsburghPA 15217USA

Multiple seam interactions are a major source of ground instability in several *** methods are well suited for this problem,because while the mechanics multiple seam interactions are very complex and poorly understood,many mining case histories are available for *** study makes use of an updated database that includes 356 multiseam case histories,including 67 unsuccessful *** paper describes in detail the process used to design the study,collect the data,conduct the statistical analysis,and develop the quantitative *** model can be used for mine planning in multiple seam situations,and has been made available as a module within the Analysis of Coal Pillar Stability(ACPS)computer program.

关键词： Underground Coal Multiseam Ground control Pillar design Empirical