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Neural Regeneration Research 2024年第3期19卷 495-496页

作者： Mirjana Antonijevic Patrick Dallemagne christophe.Rochais Normandie University UNICAENCERMNCaenFrance

Brain-derived neurotrophic factor(BDNF)is one of the neurotrophins,a specific polypeptide growth factor,which plays a crucial role in the proliferation,differentiation,survival,and death of neurons and non-neuronal *** is not only essential to maintain the balance between death on one side and survival of neurons on the other,but also it mediates additional higher-order activities such as learning,memory,and *** is initially synthesized as a precursor protein,proBDNF,that can be secreted as it is or it can be cleaved intracellularly by furin and proconvertases,or extracellularly by extracellular proteases such as matrix metalloprotease-9 and matrix metalloprotease-2,or plasmin to give mature BDNF.

关键词： death diseases degenerative

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Lateral ring compression test applied to a small caliber steel jacket:Identification of a constitutive model

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Defence Technology（防务技术） 2024年第6期36卷 133-148页

作者： Yann Coget Yael Demarty christophe.Czarnota Anthony Bracq Jean-sebastien Brest Alexis Rusinek French-German Research Institute of saint-Louis 5 Rue Du General Cassagnou68300 Saint-LouisFrance Laboratoire d'etude des Microstructures et de Mecanique des Materiaux(LeM3) CNRSUniversite de LorraineArts&Metiers ParisTechF-57000 MetzFrance

The evolution of threats and scenarios requires continuous performance improvements of ballistic protections for armed *** a modeling point of view,it is necessary to use sufficiently precise material behavior models to accurately describe the phenomena observed during the impact of a projectile on a protective *** this context,the goal of this paper is to characterize the behavior of a small caliber steel jacket by combining experimental and numerical *** experimental method is based on the lateral compression of ring specimens directly machined from the thin and small *** speeds and temperatures are considered in a quasi-static regime in order to reveal the strain rate and temperature dependencies of the tested *** Finite element Updating Method(FeMU)is *** results are coupled with an inverse optimization method and a finite element numerical model in order to determine the parameters of a constitutive model representative of the jacket *** of the present model are verified against experimental results and a parametric study as well as a discussion on the identified material parameters are *** results indicate that the strain hardening parameter can be neglected and the behavior of the thin steel jacket can be described by a modeling without strain hardening sensitivity.

关键词： Full metal jacket ammunition Lateral ring compression Inverse identification Numerical simulation

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The Knight Of Change

ChinAfrica 2024年第10期16卷 40-41页

作者： christophe.ALeXANDRe 不详

A Nigerian chess player transforms the lives of children through his *** Onakoya is a Nigerian chess player and social activist whose influence extends far beyond the 64 squares of the *** the founder of the Chess in slums initiative,he uses chess as a powerful tool to educate,motivate,and transform the lives of young people in Nigeria’s underprivileged *** work,which began in the slums of Lagos,has garnered international admiration.

关键词： player lives beyond

Design and optimization of piperidinesubstituted thiophene[3,2-d]pyrimidine-based HIV-1 NNRTIs with improved drug resistance and pharmacokinetic profiles

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Acta Pharmaceutica sinica B 2024年第7期14卷 3110-3124页

作者： Yanying sun Zhenzhen Zhou Zhongling shi Fabao Zhao Minghui Xie Zongji Zhuo erik De Clercq christophe.Pannecouqueb Dongwei Kang peng Zhan Xinyong Liu Department of Medicinal Chemistry Key Laboratory of Chemical Biology(Ministry of Education)School of Pharmaceutical SciencesShandong UniversityJinan 250012China Rega Institute for Medical Research Laboratory of Virology and ChemotherapyK.U.LeuvenLeuven B-3000Belgium China-Belgium Collaborative Research Center for Innovative Antiviral Drugs of shandong Province Jinan 250012China

HIV-1 reverse transcriptase(RT)has received great attention as an attractive therapeutic target for acquired immune deficiency syndrome(AIDs),but the inevitable drug resistance and side effects have always been major challenges faced by non-nucleoside reverse transcriptase inhibitors(NNRTIs).This work aimed to identify novel chemotypes of anti-HIV-1 agents with improved drugresistance profiles,reduced toxicity,and excellent druggability.A series of diarylpyrimidine(DAPY)derivatives were prepared via structural modifications of the leads K-5a2 and *** them,15a with dimethylphosphine oxide moiety showed the most prominent antiviral potency against all of the tested viral panel,being 1.6-fold(WT,eC_(50) Z 1.75 nmol/L),3.0-fold(L100I,eC_(50) Z 2.84 nmol/L),2.4-fold(K103N,eC_(50) Z 1.27 nmol/L),3.3-fold(Y181C,eC50 Z 5.38 nmol/L),2.9-fold(Y188L,eC_(50) Z 7.96 nmol/L),2.5-fold(e138K,eC_(50) Z 4.28 nmol/L),4.8-fold(F227L/V106A,eC_(50) Z 3.76 nmol/L)and 5.3-fold(Res056,eC_(50) Z 15.8 nmol/L)more effective than that of the marketed drug *** docking results illustrated the detailed interactions formed by compound 15a and WT,F227L/V106A,and Res056 ***,15a-HCl carried outstanding pharmacokinetic(t1/2 Z 1.32 h,F Z 40.8%)and safety profiles(LD_(50)>2000 mg/kg),which demonstrated that 15a HCl is a potential anti-HIV-1 drug candidate.

关键词： HIV-1 NNRTIs NNIBP structural alert Anti-HIV-1 drug candidate

The germline genetics of mild-to-moderate penetrance:An intriguing role of PRAMe in multiple carcinogenesis

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Genes & Diseases 2024年第3期11卷 7-10页

作者： Diaddin Hamdan Van Tai Nguyen Justine Paris christophe.Leboeuf Morad el Bouchtaoui Marc espie Anne Janin Geraldine Falgarone Melanie Di Benedetto Guithem Bousquet Universite de Paris Cite INSERMUMR_S942MASCOTParis F-75006France Hopital La Porte Verte Versailles F-78004France National Cancer Hospital Cancer Research and Clinical Trials CenterHaNoi100000VietNam AP-HP-Hopital saint Louis Centre de Maladies du SeinParisF-75010France Universite sorbonne Paris Nord Bobigny F-93000France AP-HP-Hopital Avicenne Unite de Medecine AmbulatoireBobigny F-93000France

Germline genetics of high penetrance such as BRCA genes,mutations might be sufficient for carcinogenesis,but this only explains fewer than 10%of *** assume that most cancers are the result of germline mutations of low to moderate penetrance,combined with acquired mutations due to external carcinogenic *** their accumulation over time,aging is associated with an increased risk of multiple cancer development in a given *** decades,germline genetics have been based on familial linkage studies enabling most high-penetrance genes to be *** recently,population-wide studies have led to the identification of considerable numbers of polymorphisms associated with cancer ***,most of them are of unknown functional value,thus limiting their translational application.

关键词： carcinogenesis BRCA linkage

Lighting up aggregate emission of perylene diimide by leveraging polymerization-mediated through-space charge transfer and π-π stacking

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science China Chemistry 2024年

作者： suiying Ye Désirée Füglistaller Tian Tian Anjay Manian sudhir Kumar Celine Nardo Andrew J.Christofferson salvy P.Russo Chih-Jen shih Jean-christophe.Leroux Yinyin Bao Institute of Pharmaceutical sciences Department of Chemistry and Applied Biosciences ETH Zurich Vladimir-Prelog-Weg 3 Institute for Chemical and Bioengineering Department of Chemistry and Applied Biosciences ETH Zurich Vladimir-Prelog-Weg 1-5 ARC Centre of excellence in exciton science School of Science RMIT University school of science STEM College RMIT University

The molecular engineering of fluorescent organic/polymeric materials, specifically those emitting in the deep red to near-infrared spectrum, is vital for advancements in optoelectronics and biomedicine. perylene diimide(PDI), a well-known fluorescent scaffold, offers high thermal and photophysical stability but suffers from fluorescence quenching in solid or aggregate states due to intense π-π interactions. To mitigate this, simple and versatile methods for strong PDI aggregate emission without extensive synthetic demands are highly desirable but still lacking. Here, we report a straightforward strategy to enhance the solid-state emission of PDI by introducing certain degree of through-space charge transfer(TsCT) via controlled radical polymerization,which can efficiently distort the typical face-to-face PDI stacking, enabling greatly enhanced deep red emission. This is achieved by growing electron-donating star-shape styrenic(co)polymers from a multidirectional electron-accepting PDI initiator. The incorporation of polycyclic aromatic monomers further shifted the emission into the near-infrared region, albeit with a reduced intensity. Overall, the emission of the PDI-based TsCT polymers can be systematically manipulated by leveraging the balance between PDI stacking and the TsCT degree, as confirmed by both experimental study and theoretical calculations. Our approach circumvents complex synthetic procedures, offering highly emissive materials with large stokes shifts and showing broad potential for optoelectronic technology.

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Impact of school Canteens on school Retention and Academic performance in the Atlantic Department (Benin)

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Food and Nutrition sciences 2024年第9期15卷 869-879页

作者： Mahunan Léocadie Akpoli Gbèssohèlè Justin Behanzin christophe.Chabi Alphonse sezan Laboratory of Pharmacology and Improved Traditional Medicines (LPMTA) Faculty of Science and Technology (FAST) Department of Animal Physiology University of Abomey Calavi (UAC) Abomey-Calavi Benin

In Benin, obstacles to universal access to primary education persist. In rural areas, enrolment and attendance rates remain low due to several factors. Families living in poverty may not be able to afford to send their children to school;although the government has eliminated primary school fees, parents still have to buy school uniforms and supplies. There is also an opportunity cost associated with sending girls to school, rather than keeping them at home where they can help their mothers with household chores and look after their younger siblings (school canteens in Benin to improve student enrolment and retention in partnership with parents’ associations, 2008). Prior to 2016, the school feeding system was in its infancy, with canteens operated for only three months of the year. However, thanks to determined government reforms, the school canteen system has undergone a profound transformation. The implementation of a UsD 79 million has not only not only increased coverage from coverage from 30% to 75% today, but also set the ambitious target ambitious goal of achieving 100% coverage by the end of 2023 [1]. The aim of this study is to assess the impact of canteens on school retention and children’s academic performance. We conducted a descriptive and analytical diagnostic survey using a questionnaire designed for parents of schoolchildren. Canteens increase and maintain the number of children in our schools, especially when the providers start their activities, in this case those traveling long distances. Almost all the parents surveyed believe that the school canteen has had an impact on their children’s motivation to attend school and class, and consequently on their performance. For example, for all parents surveyed, the school canteen has reduced the risk of children dropping out of school, especially girls (97%), although the difference with boys (95%) remains small and is not statistically significant. What’s more, since the advent of the PNAsI, in the Atla

关键词： school Canteens Impact Atlantic Pnasi Benin

Co-Morbidities Associated with Prematurity in Two Referral Hospitals in Cameroon

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Open Journal of pediatrics 2024年第4期14卷 738-753页

作者： Diomede Noukeu Njinkui Dominique enyama Yolande Djike Fokam Cyrelle O. Mefotse saha Beatrice Moudze Kaptue Charlotte eposse Koube Annick A. Tchouamo sime christophe.Akazong Adjahoung Marthe e. Barla edgar Mandeng Ma Linwa seraphin Nguefack Faculty of Medicine and Pharmaceutical sciences of the University of Dschang Dschang Cameroon Faculty of Health sciences University of Buea Buea Cameroon Faculty of Health sciences University of Mountains Bangangte Cameroon Douala Laquintinie Hospital Douala Cameroon Faculty of Medicine and Pharmaceutical sciences University of Douala Douala Cameroon Douala General Hospital Douala Cameroon Faculty of Medicine and Biomedical sciences University of Yaound I Yaound Cameroon

Introduction: Prematurity is the leading cause of neonatal death in Africa. More than a million children die each year due to co-morbidities related to prematurity. In addition to being one of the causes of neonatal deaths, the health problems associated with prematurity can also lead to severe lifelong impairment in those who survive. Objectives: This paper aims to determine the epidemiology and identify co-morbidities of prematurity in the neonatology units of the Douala General Hospital (DGH) and the Laquintinie Hospital of Douala (LHD). Patients and Methodology: We conducted an analytical retrospective cohort study from January 2015 to January 2018 in the neonatology department of the GDH and the LHD, which are considered reference hospitals for the management of preterm babies in Cameroon. We included all newborns aged less than 37 weeks admitted to the neonatology units of the GDH and the LHD. The descriptive component was based on the analysis of quantitative variables using measures of central tendency. The analytical component was evaluated using spearman correlations and the Chi-square and Fisher tests. simple and multiple logistic regressions measured factors predictive of mortality. The Kaplan Meier survival curve used the Log Rank test and significance at p ≤ 0.05. Results: We recorded 908 preterm newborns in neonatal service and 1,124 preterm deliveries in maternity, representing an incidence of 32.5% in neonatal unit and 10.6% in maternity. 51% of whom were girls, given a sex ratio M/F of 0.9. Hypertension was the main prenatal pathology (9.1%), while premature rupture of membranes: PROM (35.5%) and eclampsia/pre-eclampsia (18.6%) were the most common obstetrical pathologies. 75.9% of deliveries were vaginal with 65.2% being performed in our referral hospitals. Gestational age ranged from 22 to 36 weeks, with a mean of 32.4 weeks. Late preterm birth rate was 53.7%, and birth weight varied between 590 and 3200 g with an average of 1747 ± 479 g. The per

关键词： epidemiology Co-Morbidities Prematurity Douala

Generalisation,symbol specification and map evaluation:feedback from research done at COGIT laboratory,IGN France

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International Journal of Digital earth 2011年第S01期4卷 25-41页

作者： C.Duchenea s.christophe.A.Ruas COGIT Laboratory Institut Geographique NationalSaint-MandeFrance Laboratory of Informatics Grenoble(LIG) J.Fourier UniversityGrenobleFrance

This paper presents an overview of research studies made at the COGIT laboratory of IGN France in the fields of generalisation and symbol specification,particularly considering evaluation *** then discusses how generalisation and symbol specification *** it explores some possible adaptations of the presented works in generalisation and symbol specification to cartography in the context of crisis management.

关键词： automated cartography generalisation evaluation semiotics symbol specification

Thermo-Mechanical Calculation of Printed Circuit Heat exchanger Using Homogenization

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Journal of Thermal science 2022年第6期31卷 2309-2328页

作者： GARNIeR christophe.VINCeNT sébastien LAMAGNeRe Pierre LeJeAIL Yves CACHON Lionel CeA DESIRESNENuclear Technology DepartmentCadarache F-13108 Saint-Paul-Lez-DuranceFrance

The Finite-element Method(FeM) is mainly used to design Compact Heat exchanger structures. However, the narrow channel structures require fine mesh to accurately compute stress and strain. Combined with the dimensions of the overall component, this leads to an excessively large numerical model and therefore long computing time. This is especially true for transient thermal analyses, which require taking into account the full geometry. It is therefore interesting to reduce the size of the mesh. periodic homogenization is an efficient method for achieving this goal. It can be applied to the core of the structure when periodic patterns(identified on basis of the arrangement of the channels) exist. A method based on this technique, with some improvements, is proposed in this paper for thermal loading without internal pressure. In addition to the equivalent Homogenous Medium(eHM) replacing the periodic patterns, some explicit channels are interposed between the eHM and the cover plates. This has two advantages. The first is to smooth the transition of stiffness between the cover plates and the homogenized medium. The second one is to be able to directly compute stress and strain on the most critical channels located in this area. This paper assesses the method’s effectiveness for thermal loadings in order to conduct thermal stress analyses. First, the equivalent elastic constants of the eHM are obtained with a numerical Finite elements Method. Then, two 2D cases using eHM are compared against a 2D explicit model(i.e. explicit geometry for the core channels). These cases are chosen to validate the eHM itself and its effectiveness for a real section of the heat exchanger. Results show very good agreement with a relative difference lower than 1%. In addition, the sensitivity to the number of layers added between the eHM and the cover plates is analysed. It is recommended interposing at least two layers of patterns to obtain converged results for the considered configuration

关键词： compact heat exchanger thermal stress finite element method homogenization

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