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Human Endogenous Retrovirus Type W Envelope from Multiple Sclerosis Demyelinating Lesions Shows Unique Solubility and Antigenic Characteristics

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Virologica Sinica 2021年第5期36卷 1006-1026页

作者： Benjamin Charvet Justine Pierquin Joanna Brunel Rianne Gorter christophe que´tard Branka Horvat Sandra Amor Jacques Portoukalian Herve´Perron GeNeuro Innovation Lyon 69008France CIRI International Center for Infectiology ResearchINSERM U1111CNRS UMR5308University of LyonENS LyonFrance Universite´Claude Bernard Lyon 1 Lyon 69000France Department of Pathology Amsterdam UMCLocation VUMC1007 MB AmsterdamThe Netherlands ProteinSimple Abingdon OX143NBUK Centre for Neuroscience and Trauma Blizard InstituteBarts and London School of Medicine and DentistryQueen Mary University of LondonLondon E12ATUK

In multiple sclerosis(MS),human endogenous retrovirus W family(HERV-W)envelope protein,pHERV-W ENV,limits remyelination and induces microglia-mediated *** better understand its role,we examined the soluble pHERV-W antigen from MS brain lesions detected by specific ***-chemical and antigenic characteristics confirmed differences between pHERV-W ENV and ***-W ENV monomers and trimers remained associated with membranes,while hexamers self-assembled from monomers into a soluble macrostructure involving sulfatides in MS *** hexamers are stabilized by internal hydrophobic bonds and external hydrophilic ***-W studies in MS also suggest that this diffusible antigen may correspond to a previously described highmolecular-weight neurotoxic factor secreted by MS B-cells and thus represents a major agonist in MS *** methods are now needed to identify encoding HERV provirus(es)in affected cells *** properties and origin of MS brain pHERV-W ENV soluble antigen will allow a better understanding of the role of HERVs in MS *** present results anyhow pave the way to an accurate detection of the different forms of pHERV-W ENV antigen with appropriate conditions that remained unseen until now.

关键词： Multiple sclerosis(MS) Brain Antigen HERV-W Envelope Endogenous retrovirus MSRV-ENV Syncytin Demyelination Lipids Glycolipids Sulfatides Oligomer Hexamer

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CD8^(+)CD226^(high)T cells in liver metastases dictate the prognosis of colorectal cancer patients treated with chemotherapy and radical surgery

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Cellular & Molecular Immunology 2023年第4期20卷 365-378页

作者： Julien Viot Syrine Abdeljaoued Angélique Vienot Evan Seffar Laurie Spehner Adeline Bouard Kamal Asgarov Jean-RenéPallandre Elodie Renaude Elodie Klajer ChloéMolimard Franck Monnien Frederic Bibeau Celia Turco Bruno Heyd Paul Peixoto Eric Hervouet Romain Loyon Alexandre Doussot christophe Borg Marie Kroemer Department of Medical Oncology Biotechnology and Immuno-Oncology PlatformUniversity Hospital of BesançonBesançonFrance INSERM EFS BFCUMR1098RIGHTUniversity of Franche-ComtéInteractions Greffon-Hôte-Tumeur/Ingénierie Cellulaire et GéniqueBesançonFrance Department of Pathology University Hospital of BesançonBesançonFrance Department of Surgery University Hospital of BesançonBesançonFrance EPIGENEXP platform University of Bourgogne Franche-ComtéBesançonFrance Department of Pharmacy University Hospital of BesançonBesançonFrance

CD226 has been reported to participate in the rescue of CD8^(+)T cell *** this study,we aimed to assess the prognostic value of CD226 in tumor-inﬁltrating lymphocytes(TILs)derived from colorectal cancer(CRC)liver metastases treated with chemotherapy and radical *** from 43 metastases were isolated and analyzed ex vivo usingﬂow ***155 and CD3 levels in the tumor microenvironment were assessed by *** and validation of biological processes highlighted in this study were performed by bioinformatics analysis of bulk RNA-seq results for 28 CRC liver metastases pretreated with chemotherapy as well as public gene expression ***226 expression contributes to the deﬁnition of the immune context in CRC liver metastases and primary ***226 on CD8^(+)T cells was not speciﬁcally coexpressed with other immune checkpoints,such as PD1,TIGIT,and TIM3,in liver *** Cox regression analysis revealed CD226 expression on CD8^(+)T cells to be an independent prognostic factor(p=0.003),along with CD3 density at invasion margins(p=0.003)and TIGIT expression on CD4^(+)T cells(p=0.019).CD155 was not associated with the prognostic value of *** expression analysis in a validation dataset conﬁrmed the prognostic value of CD226 in CRC liver metastases but not in primary *** of CD226 on CD8^(+)TILs in the liver microenvironment was restored by IL15 ***,CD226 expression on liver metastasis-inﬁltrating CD8^(+)T cells selectively contributes to immune surveillance of CRC liver metastases and has prognostic value for patients undergoing radical surgery.

关键词： CD226 antigen Colorectal Neoplasms Liver metastasis Lymphocytes Tumor-Inﬁltrating

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Relationship between the severity of hepatitis C virus-related liver disease and the presence of Helicobacter species in the liver: A prospective study

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World Journal of Gastroenterology 2006年第45期12卷 7278-7284页

作者： Laurent Castéra Anne Pedeboscq Marcia Rocha Brigitte Le Bail Corinne Asencio Victor de Lédinghen Pierre-Henri Bernard christophe Laurent Marie-Edith Lafon Maylis Capdepont Patrice Couzigou Paulette Bioulac-Sage Charles Balabaud FrancisMégraud Armelle Ménard Service d'Hépato-Gastroentérologie H?pital St-André Bordeaux France Service d'Hépato-Gastroentérologie H?pital Haut Lévêque Pessac France INSERM ERI 10 Laboratoire deBactériologie Université Victor Segalen Bordeaux 2 BordeauxFrance INSERM E0362Groupe de Recherche pour l'étude du Foie Université VictorSegalen Bordeaux 2 Bordeaux France Service d'Anatomie Pathologique H?pital Pellegrin Bordeaux France Service de ChirurgieDigestive H?pital St-André Bordeaux France Laboratoire de Virologie Université VictorSegalen Bordeaux 2 Bordeaux France

AIM: To determine the presence of Helicobacter species DNA in the liver of chronic hepatitis C (CHC) patients with and without cirrhosis as compared to controls, and to identify the bacterial species involved. METHODS: Seventy-nine consecutive patients (HBV and HIV negative) with a liver sample obtained after liver biopsy or hepatic resection were studied: 41 with CHC without cirrhosis, 12 with CHC and cirrhosis, and 26 controls (HCV negative). Polymerase chain reactions (PCRs) targeting Helicobacter 16S rDNA and species- specific were performed on DNA extracted from the liver. A gastric infection with H pylori was determined by serology and confirmed by 13C-urea breath test. RESULTS: Overall, Helicobacter 16S rDNA was found in 16 patients (20.2%). Although positive cases tended to be higher in CHC patients with cirrhosis (41.6%) than in those without cirrhosis (17.0%) or in controls (15.4%), the difference was not statistically significant (P =0.08). H pylori-like DNA was identified in 12 cases and H. pullorum DNA in 2, while 2 cases remained unidenti- fied. Gastric infection with H pylori was found in only 2 of these patients. CONCLUSION: Our results do not confirm the associ- ation of Helicobacter species DNA in the liver of CHC patients with advanced liver disease. The lack of correlation between positive H pylori serology and the presence of H pylori-like DNA in the liver may indicate the presence of a variant of this species.

关键词： Hepatitis C virus Hepatitis Cirrhosis Helicobacter

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