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Diagnostic accuracy of a new point-of-care screening assay for celiac disease

World Journal of Gastroenterology 2013年第31期19卷 5111-5117页

作者： Faiza Benkebil christophe combescure Silvia I Anghel Cécile Besson Duvanel Michela G Schppi Vidymed 1007 Lausanne Switzerland CRC and Division of Clinical Epi-demiology Department of Health and Community MedicineUniversity of Geneva and University Hospitals of Geneva 1007 Geneva Switzerland R and D Department Augurix BioArk 1870 Monthey Switzerland Scientific Officer Augurix BioArk1870 Monthey Switzerland Pediatric Gastroenterology Unit Pediatrics Department Geneva University Hospitals 1211 GenevaSwitzerland

AIM: To determine the diagnostic accuracy of a new point-of-care assay detecting anti-deamidated gliadin peptides in celiac disease(CD) ***: One-hundred-and-twelve patients(age range: 1.8-79.2 years old) with clinical symptoms suggestive of CD and/or first-degree relatives(FDR) of CD patients(n = 66),and confirmed CD on a gluten-free diet(GFD)(n = 46),were prospectively enrolled in the study at Gastroenterology outpatient clinics for adult patients and from the Gastroenterology Consultation Ward at the Pediatric Department of the University Hospital of *** informed consent was obtained from all subjects *** study received approval from the local ethics *** original CD diagnosis had been based on serum-positive IgA anti-tissue transglutaminase enzyme-linked immunosorbent assay(ELISA)(QuantaLite,Inova Diagnostics,San Diego,CA,United States) and on biopsy *** samples from all study participants were tested by the new CD lateral flow immunochromatographic assay(CD-LFIA) device,Simtomax Blood Drop(Augurix SA,BioArk,Monthey,Switzerland) to detect immunoglobulin(Ig)A and IgG antibodies against deamidated gliadin *** diagnostic performance was evaluated using receiver operating characteristic curves with 95%CIs.A cut-off of 2 on the Rann colorimetric scale was used to calculate the device's sensitivity and ***: CD-LFIA was highly accurate in detecting untreated celiac *** the group of patients with CD symptoms and/or FDR,eight new cases of CD were detected by ELISA and *** of these new cases were also correctly identified by *** test yielded four false positive and four false negative *** false positive results were all within the groups with clinical symptoms suggestive of CD and/or FDR,whereas the false negative results were all within the GFD *** test yeld a sensitivity of 78.9%(95%CI: 54.4-93.9) and specificity of 95.7%(95%CI: 89.4-98.8),and the area under

关键词： Celiac disease Deamidated gliadin Total immunoglobulin A Screening Point-of-care assay

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Articulated Estimator Random Field and Geometrical Approach Applied in System Identification

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Journal of Systems Science & Complexity 2018年第5期31卷 1164-1185页

作者： CORBIER christophe Lyon University St-Etienne Jean Monnet University Roanne Technology University Institute

A new point of view of robust statistics based on a geometrical approach is tackled in this paper. Estimation procedures are carried out from a new robust cost function based on a chaining of elementary convex norms. This chain is randomly articulated in order to treat more efficiently natural outliers in data-set. Estimated parameters are considered as random fields and each of them, named articulated estimator random field （AERF） is a manifold or stratum of a stratified space with Riemannian geometry properties, From a high level excursion set, a probability distribution model Mata is presented and a system model validation geometric criterion （SYMOVAGEC） for system model structures Msys based on Rieeian scalar curvatures is proposed. Numerical results are drawn in a context of system identification.

关键词： Articulated robust estimation estimators random field information geometry stratifiedspace system identification.

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Toward the identi?cation and role of structural variations during dog domestication

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National Science Review 2019年第1期6卷 123-124页

作者： christophe Hitte University of Rennes

To date, we know little about the genetic diversity and development mechanisms that, through the process of domestication, have made the modern dog emerge. Following the processes of domestication and a phase of intense artificial selection,dogs became our auxiliaries for hunting, guarding and finally our best friends. The range of phenotypic diversity in dogs today greatly exceeds that of its ancestors, the wolves, making dogs the most morphologically diverse species of terrestrial mammals[1]. To advance these domestication research questions, studies are now focusing on differences in the content, organization and structure of the genome, called structural variations (SV),as a major source of genetic and phenotypic diversity. In addi-

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Late Quaternary clay minerals off Middle Vietnam in the western South China Sea: Implications for source analysis and East Asian monsoon evolution

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Science China Earth Sciences 2007年第11期50卷 1674-1684页

作者： christophe COLIN Laboratoire IDES UMR 8148 CNRS Université de Paris XI Orsay 91405 France

High-resolution clay mineral records combined with oxygen isotopic stratigraphy over the past 450 ka during late Quaternary from Core MD05-2901 off Middle Vietnam in the western South China Sea are re-ported to reconstruct a history of East Asian monsoon evolution. Variations in Illite, chlorite, and kaolinite contents indicate a strong glacial-interglacial cyclicity, while changes in smectite content present a higher frequency cyclicity. The provenance analysis indicates a mixture of individual clay minerals from various sources surrounding the South China Sea. Smectite derived mainly from the Sunda shelf and its major source area of the Indonesian islands. Illite and chlorite originated mainly from the Mekong and Red rivers. Kaolinite was provided mainly by the Pearl River. Spectral analysis of the kaolin-ite/(illite+chlorite) ratio displays a strong eccentricity period of 100 ka, implying the ice sheet-forced win-ter monsoon evolution; whereas higher frequency changes in the smectite content show an ice sheet-forced obliquity period of 41 ka, and precession periods of 23 and 19 ka and a semi-precession period of 13 ka as well, implying the tropical-forced summer monsoon evolution. The winter monsoon evolution is generally in coherence with the glacial-interglacial cyclicity, with intensified winter monsoon winds during glacials and weakened winter monsoon winds during interglacials; whereas the summer monsoon evolution provides an almost linear response to the summer insolation of low latitude in the Northern Hemisphere, with strengthened summer monsoon during higher insolation and weakened summer monsoon during lower insolation. The result suggests that the high-latitude ice sheet and low-latitude tropical factor could drive the late Quaternary evolution of East Asian winter and summer monsoons, respectively, implying their diplex and self-contained forcing mechanism.

关键词： clay minerals,provenance,East Asian monsoon,late Quaternary,Middle Vietnam,South China Sea

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Needs of thermodynamic properties measurements and modeling in the frame of new regulations on refrigerants

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第5期8卷 724-733页

作者： COQUELET christophe RICHON Dominique School of Mines of Paris CEP/TEPCNRS FRE 286135rue Saint HonoréFontainebleau 77305France

In 1987, the Montreal Protocol prohibited the worldwide use and production of chlorofluorocarbons (CFCs) and hydrochlorofluorocarbons (HCFCs) and hydro fluorocarbons (HFCs) were proposed as alternative refrigerants. Unfortunately, HFCs have non negligible global warning potential and therefore new refrigerants must be proposed or old refrigerants must be used associated with HFC. Accurate experimental thermodynamic data and predictive techniques are required for better under-standing of the performance of the newly proposed refrigerants. In this communication, experimental techniques based on either analytic or synthetic methods are first described. Data are reported. Then two newly developed predictive models based on thermodynamic approach with the isofugacity criterion and artificial neural network method are presented. The results can provide better evaluation of refrigerants, especially with the aim of studying global warning effects.

关键词： Refrigerants Experimental apparatus Thermodynamic Modeling Vapor-liquid equilibria (VLE) Phase diagram Density

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Generalized LMMSE Filtering with Out-of-Sequence Observations in Arbitrary Constant Delay

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Chinese Journal of Electronics 2019年第6期28卷 1217-1226页

作者： LEI Ming BAEHR christophe JING Zhongliang School of Aeronautics and Astronautics Shanghai Jiao Tong University Météo-France National Meteorological Research Centre/CNRS

Focusing on the problem of state estimation in the presence of sensor faults and Out-of-sequence measurement(OOSM) observations synchronously, we derive a formulation of Linear minimum mean squared error(LMMSE) filter with the arbitrary time delay of OOSM, the generalization of the present work lies in simultaneous treatment of correlated faults together with OOSMs that arrive at an arbitrary delay in a linear-optimal manner. The approach is demonstrated in a numerical comparison.

关键词： Out-of-sequence measurement(OOSM) Linear minimum mean squared error(LMMSE) Arbitrary time delay Sensor faults Fault-tolerant estimation Multisensor fusion

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A note on the regularity of the holes for permeability property through a perforated domain for the 2D Euler equations:Dedicated to Professor Jean-Yves Chemin on the Occasion of His 60th Birthday

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Science China Mathematics 2019年第6期62卷 1121-1142页

作者： christophe Lacave Chao Wang Institut Fourier Université Grenoble AlpesCNRS School of Mathematical Sciences Peking University

For equations of order two with the Dirichlet boundary condition, as the Laplace problem, the Stokes and the Navier-Stokes systems, perforated domains were only studied when the distance between the holes d_ε is equal to or much larger than the size of the holes ε. Such a diluted porous medium is interesting because it contains some cases where we have a non-negligible effect on the solution when(ε, d_ε) →(0, 0).Smaller distances were avoided for mathematical reasons and for these large distances, the geometry of the holes does not affect or rarely affect the asymptotic result. Very recently, it was shown for the 2D-Euler equations that a porous medium is non-negligible only for inter-holes distances much smaller than the sizes of the *** this result, the boundary regularity of holes plays a crucial role, and the permeability criterion depends on the geometry of the lateral boundary. In this paper, we relax slightly the regularity condition, allowing a corner, and we note that a line of irregular obstacles cannot slow down a perfect fluid in any regime such thatε ln d_ε→ 0.

关键词： ideal fluids homogenization in perforated domains shrinking obstacles and the porous medium domains with corners

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Paleoclimate and Paleoenvironment of Gonghe Basin, Qinghai-Tibet Plateau, During the Lastdeglacial: Weathering, Erosion and Vegetation Cover Affect Clay Mineral Formation

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Acta Geologica Sinica(English Edition) 2014年第2期88卷 647-660页

作者： SUN Qingfeng christophe COLIN Faculty of Geography Northwest Normal University Laboratoire des Interactions et Dynamique des Environnements de Surface (IDES) UMR 8148CNRS Université de Paris-Sud

With the analysis of the sources and formation mechanism of the clay minerals in the sediment core from the Dalianhai lake in the Gonghe Basin,northeastern Tibet-Qinghai Plateau,clay mineral composition proxies,grain-size and carbonate contents have been employed for high-resolution study in order to reconstruct East Asian Summer Monsoon （EASM） over the northeastern Tibet-Qinghai Plateau during the *** study also extended to establish a relationship between vegetation cover changes and erosion during the last 14.5 ka with pollen record and clay mineral ***/kaolinite and smectite/（illite＋chlorite） ratios allow us to assess hydrolysis conditions in lowlands and/or physical erosion process in highlands of the Gonghe *** 12.9 Cal ka BP,both mineralogical ratios show low values indicative of strong physical erosion in the basin with a dominant cold and dry *** 12.9 Cal ka BP,an increase in both mineralogical ratios indicates enhanced chemical weathering in the basin associated with a warm and humid *** beginning of Holocene is characterized by high smectite/（illite＋chlorite） and smectite/kaolinite ratios that is synchronous as with deposition of many peat laminae,implying the best warm and humid conditions specifically between 8.0 to 5.5 Cal ka *** time interval after 5.0 Cai ka BP is characterized by a return to high physical erosion and low chemical weathering with dry climate conditions in the *** variations of clay mineral assemblages with previous pollen results,we observe a rapid response in terms of chemical weathering and physical erosion intensity to a modification of the vegetation cover in the basin.

关键词： clay minerals vegetation Gonghe Basin Tibet-Qinghai Plateau Asian monsoon Holocene

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Predictive-reactive Strategy for Flowshop Rescheduling Problem:Minimizing the Total Weighted Waiting Times and Instability

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Journal of Systems Science and Systems Engineering 2021年第3期30卷 253-275页

作者： Ayoub Tighazoui christophe Sauvey Nathalie Sauer Universitéde Lorraine LGIPMF-57000MetzFrance

Due to the fourth revolution experiencing,referred to as Industry 4.0,many production firms are devoted to integrating new technological tools to their manufacturing *** of them,is rescheduling the tasks on the machines responding to ***,for static scheduling,the efficiency criteria measure the performance of scheduling systems,in dynamic environments,the stability criteria are also used to assess the impact of jobs *** this paper,a new performance measure is investigated for a flowshop rescheduling *** one considers simultaneously the total weighted waiting time as the efficiency criterion,and the total weighted completion time deviation as the stability *** fusion could be a very helpful and significant measure for real life industrial *** disruption types are considered:jobs arrival and jobs ***,a Mixed Integer Linear Programming(MILP)model is developed,as well as an iterative predictive-reactive strategy for dealing with the online *** last,two heuristic methods are proposed and discussed,in terms of solution quality and computing time.

关键词： Rescheduling flowshop predictive-reactive strategy weighted waiting time stability weighted completion time deviation

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Determinationofelasticmodulus of claystone:Nano-/micro-indentation andmeso-compression tests used to investigate impact of alkaline fluid propagation over 18 years

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Journal of Rock Mechanics and Geotechnical Engineering 2017年第3期9卷 129-136页

作者： Danièle Bartier christophe Auvray GeoRessources UMR 7359 Université de Lorraine CNRS CREGU Campus Aiguillettes Vandoeuvre-les-Nancy 54500 France

Micro-mechanical properties of a claystone were tested after undergoing alkaline perturbation on site(Tournemire,CD borehole)for 18 *** a saturated context and outside the excavation disturbed zone(EDZ),the claystone exhibits a 11.6-mm black rim at the cement/paste interface,which shows a different mechanical behaviour from the rest of the *** sets of measurements of elastic modulus were performed using:(i)nano-indentation tests with a constant indentation depth of 2 mm,(ii)microindentation tests with a constant indentation depth of 20 mm,and(iii)meso-compression tests with a constant displacement of 200 *** increase of the modulus of deformability in the black rim is between 15 GPa and 20 GPa according to the ***,an overall decrease of the modulus of deformability from the smallest to the largest scale is observed in each *** view of the mineralogy and petrographic observations,higher values of modulus of deformability in the black rim are related to carbonate content and its *** of cementitious carbonates as inclusions and very thin partings leads to hardening of the claystone.

关键词： Claystone Elastic modulus Nano-indentation Micro-indentation Meso-compression Carbonate Claystone/cement paste contact

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