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Prospective cohort study on facial profile changes in infants with Robin sequence and healthy controls

World Journal of Pediatrics 2024年第6期20卷 581-589页

作者： Cornelia Wiechers Julian Sowula Karen Kreutzer christoph E.schwarz Christina Weismann Michael Krimmel Christian F.Poets Bernd Koos Department of Neonatology Tuebingen University HospitalCalwerstrasse 772076 TuebingenGermany Center for Cleft Lip Palate and Craniofacial MalformationsTuebingen University HospitalTuebingenGermany Department of Orthodontics Tuebingen University HospitalTuebingenGermany Department of Oral and Maxillofacial Surgery Tuebingen University HospitalTuebingenGermany

Background Various conservative and surgical approaches exist to treat Robin sequence(RS),but their effects on facial profile and mandibular catch-up growth are unclear.A functional treatment concept,used in our centre for 25 years,includes an individualized palatal plate with a velo-pharyngeal extension and intensive feeding *** We performed a prospective study to objectively describe facial profiles in infants with RS treated with the above *** with isolated RS were admitted to our tertiary perinatal and national referral centre for craniofacial malformations between May 2018 and Nov *** with RS received 3D-photographs during clinically indicated *** controls were recruited from Dec 2018 to Sep 2019 and received 3D-photographs every 3 *** digitally measured jaw index(JI),defined as alveolar overjet(O)x maxillary arch(U)/mandibular arch(L),and the soft tissue reference points A’-point,Nasion’,B’-point angle(ANB’),describing the relative position of maxilla to mandible,were *** mixed models were used to examine time trajectories in JI and ANB’.Results A total of 2073D images,obtained in 19 infants with RS and 32 controls,were *** and ANB’decreased over time in both groups[for JI−0.18(95%CI−0.25 to−0.10);for ANB’:−0.40°per month[(95%CI−0.48 to−0.32)]]but remained lower in controls[for JI−2.5(95%CI−3.2 to−1.8);for ANB’-1.7°(95%CI−2.4 to−1.0)].Also,the ANB’model showed a significant effect of the interaction term diagnosis x *** Based on longitudinal 3D images,we describe changes in objective parameters of facial profile in infants with and without RS during the first year of *** findings indicate catch-up growth in infants treated for RS.

关键词： Infant Mandibular catch-up growth Pre-epiglottic Baton Plate Robin sequence Three-dimensional photography

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Obesity and its influence on liver dysfunction,morbidity and mortality after liver resection

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Hepatobiliary Surgery and Nutrition 2023年第5期12卷 704-714,I0018页

作者： Stephanie Kampf Michael Sponder Fabian Fitschek Daniel Laxar Martin Bodingbauer Carina Binder Stefan Stremitzer Klaus Kaczirek christoph schwarz Division of Visceral Surgery Department of General SurgeryMedical University of ViennaViennaAustria Division of Cardiology Department of Internal Medicine IIMedical University of ViennaViennaAustria Clinical Institute of Pathology Medical University of ViennaViennaAustria

Background:Obesity and associated steatosis is an increasing health problem *** influence on post-hepatectomy liver failure(PHLF)and after liver resection(LR)is still ***:Patients who underwent LR were investigated and divided into three groups[normal weight:body mass index(BMI)18.5-24.9 kg/m2,overweight:BMI 25.0-29.9 kg/m2,obese:BMI≥30 kg/m2]in this retrospective *** aim of this study was to assess the influence of BMI and nonalcoholic steatohepatitis(NASH)on PHLF and ***:Of 888 included patients,361(40.7%)had normal weight,360(40.5%)were overweight,167(18.8%)were *** age was 62.5 years(IQR,54-69 years).The primary indication for LR was colorectal liver metastases(CLM)(n=366,41.2%).NASH was present in 58(16.1%)of normal weight,84(23.3%)of overweight and 69(41.3%)of obese patients(P<0.001).PHLF occurred in 16.3%in normal weight,15.3%in overweight and 11.4%in obese patients(P=0.32).NASH was not associated with *** was no association between patients’weight and the occurrence of postoperative complications(P=0.45).At multivariable analysis,solely major LR[odds ratio(OR):2.7,95%confidence interval(CI):1.83-4.04;P<0.001]remained a significant predictor for ***:Postoperative complications and PHLF are comparable in normal weight,overweight and obese patients and LRs using modern techniques can be safely performed in these patients.

关键词： Obesity liver resection(LR) post-hepatectomy liver failure(PHLF) morbidity

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Estimated prevalence of Echinococcus multilocularis in rac-coon dogs Nyctereutes procyonoides in northern Branden- burg, Germany

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动物学报：英文版 2011年第5期57卷 655-661页

作者： Sabine schwarz Astrid SUTOR christoph STAUBACH Roswitha MATTIS Kirsten TACKMANN Franz Josef CONRATHS Friedrich-Loeffier-Institut Federal Research Institute for Animal Health Institute of Epidemiology 16868 Wusterhausen Germany

Human alveolar echinococcosis, caused by the larval stage of the small fox tapeworm, is a lethal zoonotic infection if left untreated.E. multilocularisis distributed in the Northern Hemisphere and lives in the small intestines of carnivores, mainly canids. The main definitive host ofE. multilocularisin European countries is the red foxVulpes vulpesand in the last ten years new endemic areas for the parasite in Central Europe have been identified. In some areas, for instance in Germany, the raccoon dogNyctereutes procyonoides- a spreading neozoon - must be regarded as an additional definitive host forE. multilocularis. In 2001 this parasite was found for the first time in raccoon dogs in the Federal State of Brandenburg, Germany. Between 2000 and 2008, 1,252 raccoon dogs from Brandenburg were examined by the Intestinal Scraping Technique. The majority of samples were obtained in five northern counties and all 60 animals that tested positive forE. multiloculariswere located there. The estimated true prevalence calculated by a beta-binomial- model ranged from 6%–12%.

关键词：犬科动物德国估计 RAC 棘球蚴浣熊食肉动物人畜共患病

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The digital Earth Observation Librarian:a data mining approach for large satellite images archives

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Big Earth Data 2020年第3期4卷 265-294页

作者： Mihai Datcu Alexandru-Cosmin Grivei Daniela Espinoza-Molina Corneliu Octavian Dumitru christoph Reck Vlad Manilici Gottfried schwarz German Aerospace Center Remote Sensing Technology InstituteWesslingGermany Research Center for Spatial Information University Politehnica of BucharestBucharestRomania German Remote Sensing Data Center German Aerospace CenterWesslingGermany

Throughout the years,various Earth Observation(EO)satellites have generated huge amounts of *** extraction of latent information in the data repositories is not a trivial *** methodologies and tools,being capable of handling the size,complexity and variety of data,are *** scientists require support for the data manipulation,labeling and information extraction *** paper presents our Earth Observation Image Librarian(EOLib),a modular software framework which offers innovative image data mining capabilities for TerraSAR-X and EO image data,in *** main goal of EOLib is to reduce the time needed to bring information to end-users from Payload Ground Segments(PGS).EOLib is composed of several modules which offer functionalities such as data ingestion,feature extraction from SAR(Synthetic Aperture Radar)data,meta-data extraction,semantic definition of the image content through machine learning and data mining methods,advanced querying of the image archives based on content,meta-data and semantic categories,as well as 3-D visualization of the processed *** is operated by DLR’s(German Aerospace Center’s)Multi-Mission Payload Ground Segment of its Remote Sensing Data Center at Oberpfaffenhofen,Germany.

关键词： Earth observation TerraSAR-X data mining system

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Pyrolytic Recycling of Carbon Fibers from Prepregs and Their Use in Polyamide Composites

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Open Journal of Composite Materials 2020年第4期10卷 92-105页

作者： Stephan schwarz Thomas Höftberger christoph Burgstaller Andreas Hackl Clemens schwarzinger Institute for Chemical Technology of Organic Materials Johannes Kepler University Linz Austria Transfercenter für Kunststoffetechnik Wels Austria Next Generation Elements Feldkirchen Austria

Carbon fibers composites are well-known as high tech materials but are also recognized as a problem after use as they have to be deposited in landfills. Pyrolysis is an attractive process for recycling carbon fibers from used composites as well as offcuts from prepregs. Pyrolysis of carbon fiber composite prepregs is carried out in a pilot plant with a single screw reactor. The pyrolysis products, carbon fibers and pyrolysis vapor are fully characterized. Variation of pyrolysis temperature is carried out to obtain carbon fibers with the best possible surface properties. In order to compare the mechanical properties of the recycled carbon fibers with virgin material, composite materials with polyamide are produced and their properties compared.

关键词： Carbon Fibers Composites Mechanical Properties

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Second-generation direct-acting-antiviral hepatitis C virus treatment: Efficacy, safety, and predictors of SVR12

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World Journal of Gastroenterology 2016年第35期22卷 8050-8059页

作者： christoph R Werner Julia M schwarz Daniel P Egetemeyr Robert Beck Nisar P Malek Ulrich M Lauer christoph P Berg Department of Gastroenterology Hepatology and Infectiology University Hospital Tübingen Institute of Medical Virology University Hospital Tübingen

AIM To gather data on the antiviral efficacy and safety of second generation direct acting antiviral(DAA) treatment with respect to sustained virological response(SVR) 12 wk after conclusion of treatment, and to determine predictors of SVR12 in this *** Two hundred and sixty patients treated with SOF combination partners PR(n = 51), R(n = 10), SMV(n = 30), DCV(n = 81), LDV(n = 73), or 3D(n = 15).144/260 were pre-treated, 89/260 had liver cirrhosis, 56/260 had portal hypertension with platelets < 100/nL, 25/260 had a MELD score ≥ 10 and 17/260 were postliver transplantation patients. 194/260 had HCV GT1, 44/260 HCV *** Two hundred and forty/256(93.7%) patients achieved SVR12(m ITT); 4/260 were lost to follow-up. SVR12 rates for subgroups were: 92% for SOF/DCV, 93% for each SOF/SMV, SOF/PR, 94% for SOF/LDV, 100% for 3D, 94% for pretreated, 87% for liver cirrhosis, 82% for patients with platelets < 100/n L, 88% post-liver transplantation, 95% for GT1 a, 93% for GT1 b, 90% for GT3, 100% for GT2, 4, and 6. 12 patients suffered from relapse, 6 prematurely discontinued treatment, of which 4 died. Negative predictors of SVR12 were a platelet count < 100/nL, MELD score ≥ 10(P < 0.0001), liver cirrhosis(P = 0.005) at baseline. In Interferonfree treatment GT3 had significantly lower SVR rates than GT1(P = 0.016). Side effects were mild. CONCLUSION Excellent SVR12 rates and the favorable side-effect profile of DAA-combination therapy can be well translated into "real-world". Patients with advanced liver disease, signs of portal hypertension, especially with platelets < 100/n L and patients with GT3 are in special need for further research efforts to overcome comparatively higher rates of virological failure.

关键词： Sofosbuvir Simeprevir Ledipasvir 丙肝肝移植持续 virological 反应肝肝硬化副作用抵抗 Daclatasvir

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里昂汇流博物馆

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城市环境设计 2020年第4期126卷 120-133页

作者：沃尔夫·狄·普瑞克斯 christopher Beccone Guy Bébié Lorenz Bürgi Wolfgang Fiel Kai Hellat Robert Haranza Alex Jackson Georg Kolmayr Daniel Kerbler Lucas Kulnig Andreas Mieling Marianna Milioni Daniel Moral Jutta Sch?dler Andrea Sch?ning Mario Schwary Markus schwarz Oliver Tessmann Dionicio Valdez Philipp Vogt Markus Wings christoph Ziegler Patrick Lhomme Francois Texier Philippe Folliasson Etienne Champenois Alexandru Gheorghe Niels Hiller Emanuele Iacono Pierre-Yves Six Sergio Pirrone Duccio Malagamba Raimund Koch

项目大事记/CHRONOLOGY竞赛/Competition:2001初步设计-深化设计/Preliminary Design-Design Development:2002—20041.投标-竞标/Tender-Dialog Competitive:2004—2006第一阶段施工(桩基)/Construction Phase 1:2006—2007停工/Stop of Construction:2007—20092.投标-施工图设计/Tender-Execution Design:2009—2010第二阶段施工/Construction Phase 2:2010—2014竣工/Completion:12/2014

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