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Finding and analysing energy research funding data: The EnArgus system

能源与人工智能(英文) 2021年第3期5卷 18-37页

作者： Leif Oppermann Simon Hirzel Alexander Güldner Karoline Heiwolt Joachim Krassowski Ulrich Schade christoph lange Wolfgang Prinz Cooperation Systems Data Science&AIFraunhofer FITSchloss Birlinghoven 1Sankt Augustin 53757Germany Competence Center Energy Technology and Energy Systems Fraunhofer ISIBreslauer Str.48Karlsruhe 76139Germany Energy Systems Fraunhofer UMSICHTOsterfelder Str.3Oberhausen 46047Germany Information Technology for Command and Control Fraunhofer FKIEFraunhoferstr.20Wachtberg 53343Germany

This paper presents the concept,a system-overview,and the evaluation of EnArgus,the central information system for energy research funding in *** by the German Federal Ministry for Economic Affairs and Energy(BMWi),EnArgus establishes a one-stop information system about all recent and ongoing energy research funding projects in *** ranging from laypersons to experts were surveyed in three workshops to evaluate both the public and expert interfaces of the EnArgus system in comparison to peer *** results showed that the EnArgus system was predominantly evaluated positively by the various *** contributes to making the energy sector more transparent and offers clear advantages for professional use compared to similar *** system’s semantic processing enables more precise hits and better coverage by including semantically related terms in search results;its intelligence makes it fail-safe,rendering it suitable for areas where poor results can have dire *** on an actual real-world system,the paper also provides a roadmap-view of how electronic filing of administrative project data can be semantically enhanced and opened-up to provide the basis for new ways into the data that are key for future breakthrough AI interfaces.

关键词： Energiewende Information System Wiki Ontology Databases Evaluation

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Integration of expression profiles and endo-phenotypes in genetic association studies: A Bayesian approach to determine the path from gene to disease

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Open Journal of Genetics 2013年第3期3卷 216-223页

作者： Sharon M. Lutz Sunita Sharma John E. Hokanson Scott Weiss Benjamin Raby christoph lange Department of Biostatistics Harvard School of Public Health Boston USA Department of Epidemiology University of Colorado at Denver Aurora USA Institute for Genomic Mathematics University of Bonn Bonn Germany The Channing Division of Network Medicine Department of Medicine Bringham and Women’s Hospital Boston USA

In genetic association studies of complex diseases, endo-phenotypes such as expression profiles, epigenetic data, or clinical intermediate-phenotypes provide insight to understand the underlying biological path of the disease. In such situations, in order to establish the path from the gene to the disease, we have to decide whether the gene acts on the disease phenotype primarily through a specific endo-phenotype or whether the gene influences the disease through an unidentified path which is characterized by different intermediate phenotypes. Here, we address the question that a genetic locus, given its effect on an endo-phenotype, influences the trait of interest primarily through the path of the endo-phenotype. We propose a Bayesian approach that can evaluate the genetic association between the genetic locus and the phenotype of interest in the presence of the genetic effect on the endo-phenotype. Using simulation studies, we verify that our approach has the desired properties and compare this approach with a mediation approach. The proposed Bayesian approach is illustrated by an application to genome-wide association study for childhood asthma (CAMP) that contains expression profiles.

关键词： Expression Profiles Endo-Phenotypes Genetic Association Studies Bayesian Hierarchal Model Pathway Mediation

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β肾上腺素受体介导兔心肌缺血后处理保护作用的细胞内机制研究

β肾上腺素受体介导兔心肌缺血后处理保护作用的细胞内机制研究

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第十五次长江流域麻醉学学术年会暨2010年中南六省麻醉学学术年会暨2010年湖北省麻醉学学术年会

作者：高峰 Markus lange Jan Stumpner christoph Blomeyer christopher Lotz Norbert Roewer 田玉科华中科技大学同济医学院附属同济医院麻醉学教研室德国Wurzburg大学医院麻醉科

目的:在前期研究中发现β2肾上腺素受体的激活在心肌缺血后处理(IPOST)的保护作用中发挥了重要作用,但对β2肾上腺素受体的激活后的下游机制尚不清楚。本研究旨在探讨再灌注损伤修复激酶(RISK)通路中磷脂酰肌醇3-激酶

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