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Effects of P301L-TAU on post-translational modifications of microtubules in human iPSC-derived cortical neurons and TAU transgenic mice

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Neural Regeneration Research 2025年第8期20卷 2348-2360页

作者： Mohamed Aghyad Al Kabbani christoph Köhler Hans Zempel Institute of Human Genetics Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany Center for Molecular Medicine Cologne(CMMC) University of CologneCologneGermany Center Anatomy Department ⅡMedical FacultyUniversity of CologneCologneGermany

TAU is a microtubule-associated protein that promotes microtubule assembly and stability in the *** is missorted and aggregated in an array of diseases known as *** are essential for neuronal function and regulated via a complex set of post-translational modifications,changes of which affect microtubule stability and dynamics,microtubule interaction with other proteins and cellular structures,and mediate recruitment of microtubule-severing *** impairment of microtubule dynamics causes neuronal dysfunction,we hypothesize cognitive impairment in human disease to be impacted by impairment of microtubule *** therefore aimed to study the effects of a disease-causing mutation of TAU(P301L)on the levels and localization of microtubule post-translational modifications indicative of microtubule stability and dynamics,to assess whether P301L-TAU causes stability-changing modifications to *** investigate TAU localization,phosphorylation,and effects on tubulin post-translational modifications,we expressed wild-type or P301L-TAU in human MAPT-KO induced pluripotent stem cell-derived neurons(i Neurons)and studied TAU in neurons in the hippocampus of mice transgenic for human P301L-TAU(p R5 mice).Human neurons expressing the longest TAU isoform(2N4R)with the P301L mutation showed increased TAU phosphorylation at the AT8,but not the p-Ser-262 epitope,and increased polyglutamylation and acetylation of microtubules compared with endogenous TAU-expressing neurons.P301L-TAU showed pronounced somatodendritic presence,but also successful axonal enrichment and a similar axodendritic distribution comparable to exogenously expressed 2N4R-wildtype-TAU.P301L-TAU-expressing hippocampal neurons in transgenic mice showed prominent missorting and tauopathy-typical AT8-phosphorylation of TAU and increased polyglutamylation,but reduced acetylation,of microtubules compared with non-transgenic *** sum,P301L-TAU results in changes in micr

关键词： human induced pluripotent stem cell microtubules P301L pR5 mice TAU tauopathy tubulin code

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Ionic thermoelectric materials and devices

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Journal of Energy Chemistry 2021年第10期30卷 88-103,I0003页

作者： Dan Zhao Alois Würger Xavier Crispin Laboratory of Organic Electronics Linkoping UniversityNorrkoping 60247Sweden Univ.Bordeaux&CNRS LOMA(UMR 5798)F-33405 TalenceFrance Wallenberg Wood Science Center ITNLinköping UniversityNorrköpingSweden

The tremendous amount of wasted heat from solar radiation and industry dissipation has motivated the development of thermoelectric concepts that directly convert heat into *** main challenge in practical applications for thermoelectrics is the high cost from both materials and ***,breakthrough progresses in ionic thermoelectrics open up new possibilities to charge energy storage devices when submitted to a temperature *** charging voltage is internally from the ionic Seebeck effect of the electrolyte between two *** electrolytes with high thermoelectric figure of merit are classified as ionic thermoelectric *** ionic thermoelectric materials are composed of abundant elements,and they can generate hundreds of times larger thermal voltage than that of electronic *** emerging thermoelectric category brings new hope to fabricate low cost and large area heat-to-energy conversion devices,and triggers a renewed interest for ionic *** this review,we summarize the state of the art in the new field of ionic thermoelectrics,from the driving force of the ionic thermodiffusion to material and application *** present a general map of ionic thermoelectric materials,discuss the unique characters of each type of the reported electrolytes,and propose potential optimization and future topics of ionic thermoelectrics.

关键词： Electrolytes Soret effect Thermodiffusion Thermal energy conversion

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Achievements and Challenges in European Energy Markets

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Journal of Modern Power Systems and Clean Energy 2023年第3期11卷 698-704页

作者： christoph Weber University of Duisburg-Essen EssenGermany IEEE

The European electricity and gas markets have been deregulated more than two decades *** rather diverse starting points,they have continuously evolved over the years to accommodate with new challenges and to improve *** 2005,these markets have been complemented by the market for emission certificates established by the European Union(EU)emission trading *** partly competing paradigms have thereby shaped the markets and continue to drive their on-going transformation:effective competition,subsidiarity and sustainability.

关键词： Electricity marker Europe carbon pricing market design deregulation decarbonization sustainable energy system

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Rheological properties and concentration evolution of thickened tailings under the coupling effect of compression and shear

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International Journal of Minerals,Metallurgy and Materials 2024年第5期31卷 862-876页

作者： Aixiang Wu Zhenqi Wang Zhuen Ruan Raimund Bürger Shaoyong Wang Yi Mo Key Laboratory of the Ministry of Education of China for High-efficient Mining and Safety of Metal Mines University of Science and Technology BeijingBeijing 100083China Shunde Innovation School University of Science and Technology BeijingFoshan 528399China CI2MA and Departamento de Ingeniería Matemática Facultad de Ciencias Físicas y MatemáticasUniversidad de ConcepciónCasilla 160-CConcepciónChile School of Civil and Resource Engineering University of Science and Technology BeijingBeijing 100083China China Railway Construction Tongguan Investment Co. Ltd.Tongling 244000China

Cemented paste backfill(CPB)is a key technology for green mining in metal mines,in which tailings thickening comprises the primary link of CPB ***,difficult flocculation and substandard concentrations of thickened tailings often *** rheological properties and concentration evolution in the thickened tailings remain ***,traditional indoor thickening experiments have yet to quantitatively characterize their rheological *** experiment of flocculation condition optimization based on the Box-Behnken design(BBD)was performed in the study,and the two response values were investigated:concentration and the mean weighted chord length(MWCL)of ***,optimal flocculation conditions were *** addition,the rheological properties and concentration evolution of different flocculant dosages and ultrafine tailing contents under shear,compression,and compression-shear coupling experimental conditions were tested and *** results show that the shear yield stress under compression and compression-shear coupling increases with the growth of compressive yield stress,while the shear yield stress increases slightly under *** order of shear yield stress from low to high under different thickening conditions is shear,compression,and compression-shear *** compression and compression-shear coupling,the concentration first rapidly increases with the growth of compressive yield stress and then slowly increases,while concentration increases slightly under *** order of concentration from low to high under different thickening conditions is shear,compression,and compression-shear ***,the evolution mechanism of the flocs and drainage channels during the thickening of the thickened tailings under different experimental conditions was revealed.

关键词： thickened tailings compression-shear coupling compressive yield stress shear yield stress concentration

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The evolutionary ecology of symbiont-conferred resistance to parasitoids in aphids

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Insect Science 2014年第3期21卷 251-264页

作者： christoph Vorburger Institute of Integrative Biology ETH Zǖrich Universitātstrasse 16 8092 Zǖdch EAWAG Swiss Federal Institute of Aquatic Science and Technology Uberlandstrasse 133 8600 Dǖbendoàf Switzerland

Aphids may harbor a wide variety of facultative bacterial endosymbionts. These symbionts are transmitted maternally with high fidelity and they show horizontal trans-mission as well, albeit at rates too low to enable infectious spread. Such symbionts need to provide a net fitness benefit to their hosts to persist and spread. Several symbionts haveachieved this by evolving the ability to protect their hosts against parasitoids. Reviewing empirical work and some models, I explore the evolutionary ecology of symbiont-conferredresistance to parasitoids in order to understand how defensive symbiont frequencies are maintained at the intermediate levels observed in aphid populations. I further show thatdefensive symbionts alter the reciprocal selection between aphids and parasitoids by augmenting the heritable variation for resistance, by increasing the genetic specificity of thehost-parasitoid interaction, and by inducing environment-dependent trade-offs. These effects are conducive to very dynamic, symbiont-mediated coevolution that is driven by frequency-dependent selection. Finally I argue that defensive symbionts represent a problem for biological control of pest aphids, and I propose to mitigate this problem byexploiting the parasitoids＇ demonstrated ability to rapidly evolve counteradaptations to symbiont-conferred resistance.

关键词： aphids biological control coevolution genotype × genotype interaction Hamiltonella defensa parasitoid resistance symbiosis

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Effect of variations in the polar and azimuthal angles of coarse particles on the structure of drainage channels in thickened beds

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International Journal of Minerals,Metallurgy and Materials 2023年第12期30卷 2321-2333页

作者： Cuiping Li Gezhong Chen Zhu’en Ruan Raimund Bürger Yuan Gao Hezi Hou Hui Wang Key Laboratory of the Ministry of Education of China for High-efficient Mining and Safety of Metal Mines University of Science and Technology BeijingBeijing 100083China Shunde Innovation School University of Science and Technology BeijingFoshan 528399China CI2MA and Departamento de Ingeniería Matemática Facultad de Ciencias Físicas y MatematicasUniversidad de ConcepcionCasilla 160-CConcepciónChile School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China School of Civil and Resource Engineering University of Science and Technology BeijingBeijing 100083China

The 3D reconstruction and quantitative characterization of drainage channels and coarse tailings particles in a bed were conducted in this *** influence of variations in the azimuthal angle(θ)and polar angle(φ)of coarse particles on drainage channel structure was analyzed,and the drainage mechanism of the bed was *** showed that water discharge in the bed reduced the size of pores and throat channels,increasing slurry *** throat channel structure was a key component of the drainage ***φandθof particles changed predominantly along the length *** changes inφhad a cumulative plugging effect on the drainage channel and increased the difficulty of water *** rake and rod formed a shear ring in the tailings bed with shear,and theθdistribution of particles changed from disorderly to orderly during the rotation *** drainage channel was squeezed during the shearing process with the change inθ,which broke the channel structure,encouraged water discharge in the bed,and facilitated a further increase in slurry *** findings of this work are expected to offer theoretical guidance for preparing high-concentration underflow in the tailings thickening process.

关键词： tailings thickening coarse particle azimuthal angle polar angle drainage channels

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Convergent patterns in multitrophic biodiversity effects on yield across ecosystems

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Science China(Life Sciences) 2023年第11期66卷 2697-2699页

作者： christoph Scherber Leibniz Institute for the Analysis of Biodiversity Change(LIB) Museum KoenigCentre for Biodiversity Monitoring and Conservation ScienceBonn 53113Germany Institute of Evolutionary Biology and Ecology University of BonnBonn 53113Germany

In ecosystems managed for food or fiber production,there is often no space for *** example,intensive cereal monocultures are usually managed towards optimized yields using herbicides,fungicides and *** such systems,biodiversity is essentially unwanted,except maybe when it improves soil health or carbon ***,it has been difficult to convincingly show if and where biodiversity is economically important in intensive production systems.

关键词： ecosystems soil biodiversity

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The pH of the Apoplast： Dynamic Factor with =unctional Impact Under Stress

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Molecular Plant 2017年第11期10卷 1371-1386页

作者： christoph-Martin Geilfus Division of Controlled Environment Horticulture Faculty of Life Sciences Albrecht Daniel Thaer-Institute of Agricultural and Horticultural Sciences Humboldt-University of Berlin Albrecht-Thaer-Weg 1 14195 Berlin Germany

The apoplast is an interconnected compartment with a thin water-film that alkalinizes under stress. This systemic pH increase may be a secondary effect without functional implications, arising from ion movements or proton-pump regulations. On the other hand, there are increasing indications that it is part of a mechanism to withstand stress. Regardless of this controversy, alkalinization of the apoplast has received little attention. The apoplastic pH （PHapo） increases not only during plant-pathogen interactions but also in response to salinity or drought. Not much is known about the mechanisms that cause the leaf apoplast to alkalinize, nor whether, and if so, how functional impact is conveyed. Controversial explanations have been given, and the unusual complexity of pHapo regulation is considered as the primary reason behind this lack of knowledge. A gathering of scattered information revealed that changes in PHapo convey functionality by regulating stomatal aperture via the effects exerted on abscisic acid. Moreover, apoplastic alkalinization may regulate growth under stress, whereas this needs to be verified. In this review, a comprehensive survey about several physiological mechanisms that alkalize the apoplast under stress is given, and the suitability of apoplastic alkalinization as transducing element for the transmission of sensory information is discussed.

关键词： apoplastic fluid alkalinization abscisic acid PM-H^+-ATPase S-Type anion channel malate

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Which species discovers novel food sources first?A camera trap study in a natural environment

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Avian Research 2021年第3期12卷 421-424页

作者： christoph Randler Department of Biology Eberhard Karls University TuebingenAuf der Morgenstelle 2472070 TuebingenGermany

Birds underlie a predation-starvation risk,and foraging should show a diurnal/circadian *** traps were used to study visitation patterns and discovery of a novel food source in woodland birds in SW Germany.A total of 18 species occurred at feeders with nine of them being exploratory *** Tits(Parus major)discovered novel food sources first in most instances,and first discoveries occurred on average at 10:38,while it took 97 h for the first detection of the food *** size was correlated with *** study supports the predation-starva-tion risk hypothesis with discovery of food sources in the morning.

关键词： Camera trap Explorative behaviour Foraging behaviour Novel food source Starvation predation trade-off

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Evaluation of Ultrasound-based Surveillance for Hepatocellular Carcinoma in Patients at Risk:Results From a German Multicenter Retrospective Cohort Study

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Journal of Clinical and Translational Hepatology 2023年第3期11卷 626-637页

作者： Johannes Gillessen Philipp Reuken Peter-Marton Hunyady Matthias Christian Reichert Lucian Lothschütz Fabian Finkelmeier Matthias Nowka Gabriel Allo Fabian Kütting Martin Bürger Dirk Nierhoff Hans-Michael Steffen christoph Schramm University Hospital Cologne Department of Gastroenterology and HepatologyCologneGermany University Hospital Jena Department of Internal Medicine IV-GastroenterologyHepatologyInfectious DiseaseJenaGermany University Hospital Frankfurt Department of Internal Medicine 1-Gastroenterology und HepatologyPulmonology und AllergologyEndocrinologyFrankfurtGermany Department of Medicine II Saarland University Medical CenterHomburgGermany Department of Gastroenterology and Hepatology University Hospital of EssenEssenGermany

Background and Aims:Hepatocellular carcinoma(HCC)surveillance in patients at risk is strongly recommended and usually performed by ultrasound(US)semiannually with or without alfa-fetoprotein(AFP)*** pa-rameters except for surveillance intervals have not been strictly *** aimed to evaluate surveillance success and risk factors for surveillance ***:Patients with≥1 US prior to HCC diagnosis performed at four tertiary referral hospitals in Germany between 2008 and 2019 were retrospectively *** success was defined as HCC detection within Milan ***:Only 47%of 156 patients,median age 63(interquartile range:57-70)years,56%male,and 96%with cirrhosis,received recom-mended surveillance modality and *** fail-ure occurred in 29%and was significantly associated with lower median model for end-stage liver disease(MELD)score odds ratio(OR)1.154,95%confidence interval(CI):1.027-1.297,p=0.025)and HCC localization within right liver lobe(OR:6.083,95%CI:1.303-28.407,p=0.022),but not with AFP≥200μg/*** with surveillance failure had sig-nificantly more intermediate/advanced tumor stages(93%vs.6%,p<0.001),fewer curative treatment options(15%vs.75%,p<0.001)and lower survival at 1 year(54%vs.75%,p=0.041),2 years(32%vs.57%,p=0.019)and 5 years(0%vs.16%,p=0.009).Alcoholic and non-alcoholic fatty liver disease(OR:6.1,95%CI:1.7-21.3,p=0.005)and ascites(OR:3.9,95%CI:1.2-12.6,p=0.021)were in-dependently associated with severe visual limitations on ***:US-based HCC surveillance in patients at risk frequently fails and its failure is associated with unfavorable patient-related *** MELD score and HCC lo-calization within right liver lobe were significantly associated with surveillance failure.

关键词： Hepatocellular carcinoma Surveillance success Screening Ultra-sound.

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