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Sol-gel der.ved B_(2)O_(3)-CaO bor.te bioactive glasses with hemostatic,antibacter.al and pr.-angiogenic activities

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r.gener.tive Biomater.als 2024年第1期3卷 108-118页

作者： Kai Zheng Faina Bider.mahshid monavar. Zhiyan Xu Chr.stina Janko christoph Alexiou Ana m.Beltr.n Aldo r.Boccaccini Jiangsu Pr.vince Engineer.ng r.sear.h Center.of Stomatological Tr.nslational medicine College of StomatologyNanjing Medical UniversityNanjing 210029China Jiangsu Key Labor.tor. of Or.l Diseases Nanjing Medical UniversityNanjing 210029China Institute of Biomater.als University of Erlangen-Nuremberg91058 ErlangenGermany Depar.ment of Oto-r.ino-Lar.ngology Head and Neck SurgerySection of Experimental Oncology and Nanomedicine(SEON)Else Kroener-Fresenius-Stiftung ProfessorshipUniversitaetsklinikum Erlangen91058 ErlangenGermany Depar.amento de Ingenier.ıa y Ciencia de los mater.ales y del Tr.nspor.e Escuela Politecnica

Sol-gel bor.te bioactive glasses(BGs)ar. pr.mising ion-r.leasing biomater.als for.wound healing ***,we r.por. the synthesis of a ser.es of binar. B_(2)O_(3)-CaO bor.te BGs(CaO r.nging fr.m 50 to 90mol%)using a sol-gel-based *** influence of CaO content in B_(2)O_(3)-CaO bor.te BG on mor.hology,str.ctur. and ion r.lease behavior.was investigated in *** dissolution(ion r.lease)and cr.stallization could be obser.ed in bor.te BGs when CaO content incr.ased,while the mor.hology was not significantly alter.d by incr.asing CaO *** r.sults evidenced that the ion r.lease behavior.of bor.te BGs could be tailor.d by tuning the B_(2)O_(3)/CaO molar.*** also evaluated the in vitr. cytotoxicity,hemostatic,antibacter.al and angiogenic activities of bor.te *** was validated for.all bor.te ***,bor.te BGs exhibited composition-dependent hemostatic,antibacter.al and angiogenic ***,higher.contents of Ca in bor.te BGs facilitated hemostatic activity,while higher.contents of B_(2)O_(3) wer. beneficial for.pr.-angiogenic *** synthesized sol-gel-der.ved bor.te BGs ar. pr.mising mater.als for.developing advanced wound healing dr.ssings,given their.fast ion r.lease behavior.and favor.ble hemostatic,antibacter.al and angiogenic activities.

关键词： bor.te glasses sol-gel pr.cessing glass composition wound healing

Inter.eukin-10 gives exhausted chimer.c antigen r.ceptor.CAr.T cells a second br.ath

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Cancer.Communications 2024年第7期44卷 787-790页

作者： christoph Heuser.Loy Leibniz Institute for.Immunother.py Division for Functional Immune Cell ModulationRegensburgGermany

Adoptive cell ther.py(ACT)r.pr.sents a major.pillar.of moder. *** or.synthetically endowed with the ability to r.cognize tumor.associated antigens,tumor.infiltr.ting lymphocytes(TILs)or.T cells engineer.d to tr.nsgenically expr.ss T cell r.ceptor. or.chimer.c antigen r.ceptor.(CAr.)ar. expanded and infused to tumor.patients to lyse tumor.***,despite tr.mendous r.sponse r.tes against liquid tumor.,many patients under.o r.lapses,and tr.atment outcomes in solid tumor. have been disappointing so far.1].The har.h tumor.micr.envir.nment,including nutr.ent depr.vation,acidification,hypoxia,and immunosuppr.ssive signals[2,3],in conjunction with per.istent antigen stimulation tr.gger. a pr.gr.m of exhaustion in T cells(Figur. 1A).Exhausted T cells exhibit r.duced cytotoxicity and minimal pr.lifer.tion potential,physiologically balancing tissue health with contr.l of chr.nic vir.l infection or.of tumor.gr.wth[4,5].Str.tegies to disengage or.r.wir. the“er.oneously”deployed exhaustion pr.gr.m to exploit the full potential of tumor.fighting T cells ar. highly sought after.Figur. 1B).

关键词： Inter.eukin stimulation Figur.

Implementation and validation of a bonded par.icle model to pr.dict r.eological pr.per.ies of viscoelastic mater.als

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Par.icuology 2024年第6期89卷 198-210页

作者： michael mascar. Ar.o mayr.ofer.Stefan r.dl christoph Kloss Institute of Pr.cess and Par.icle Engineer.ng Graz University of TechnologyInffeldgasse 13Graz8010Austria DCS Computing GmbH Industriezeile 35Linz4020Austria

This wor. focuses on implementing a par.icle-based method able to char.cter.ze viscoelastic mater.als whose r.eological pr.per.ies,such as stor.ge modulus G′and loss modulus G″,ar. *** is based on the bonded par.icle model,with the elastic constitutive r.lation her. substituted with a viscoelastic one to captur. time-scale *** Bur.er. model,vastly used in liter.tur. to model viscoelastic systems,is discr.tized and *** test case used for.calibr.tion compr.ses of a cubic lattice,shear.d with a per.odic motion,to mimic the effect of a shear.*** appr.pr.ate filter.ng of the str.ss r.sponse,the r.eological pr.per.ies ar. obtained,highlighting the effect of the lattice geometr.,as well as the par.icle size,on the accur.cy of the ***,the Bur.er. par.meter. ar. calibr.ted by analytically fitting the exper.mental dataset,showing the limitation of the Bur.er. *** micr.-contact par.meter. ar. obtained fr.m the macr. par.meter. thr.ugh appr.pr.ate *** completing a fr.quency sweep,the simulated G′and G″show a r.latively lar.e er.or.ar.und 25%for.G’for.*** this r.ason,a mor. r.bust model,namely the gener.lized maxwell model,has been *** calibr.tion pr.cedur. is per.or.ed in the same fashion as for.the Bur.er. ***,the tangential micr.-contact par.meter. ar. scaled *** nor.al *** scaling par.meter.calledα,is calibr.ted by minimizing the r.ot mean squar. er.or.between simulation and exper.mental data,giving er.or. below 10%in both G′and G″for.a lar.e ***,a full r.ng plate-plate r.eometer.setup is simulated,and the simulation is compar.d with the given exper.mental dataset,again finding a good agr.ement.

关键词： DEm r.eology Numer.cal modeling Viscoelasticity

Spatial impact of digital finance on car.on pr.ductivity

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Geoscience Fr.ntier. 2024年第3期15卷 358-372页

作者： Huaping Sun Tingting Chen christoph Nedopil Wang School of Finance and Economics Jiangsu UniversityZhenjiangChina School of Economics and management University of Science and Technology BeijingBeijingChina Fanhai Inter.ational School of Finance Fudan UniversityShanghaiChina

Low car.on pr.ductivity has been identified as a key dir.ction for.China’s futur. *** an impor.ant dr.ving for.e for.economic gr.wth,the question of whether.digital finance that is r.liant on digital technology can suppor. the development of a low-car.on ur.an economy r.mains *** on the car.on pr.ductivity measur.d by panel data fr.m 201 cities for.the per.od 2011-2020,this study applies the spatial Dubin model and thr.shold r.gr.ssion model to explor. the impact of digital finance on car.on pr.ductivity,yielding the following key ***,the spatial distr.bution heter.geneity of car.on pr.ductivity in China’s easter. r.gion is higher.than that in the wester. r.gion,and both pr.ductivity and digital finance ar. char.cter.zed by high(low)-high(low)dotted spatial ***,digital finance can significantly impr.ve car.on pr.ductivity via two tr.nsmission channels:the human capital and mar.etization *** the same time,digital finance exer.s a spatial spillover.effect on car.on pr.ductivity,and r.sing local digital finance levels will incr.ase car.on pr.ductivity in neighbor.ng *** analysis indicates that the spillover.effect of digital finance in ur.an agglomer.tions and easter. r.gions is mor. ***,fixed-asset investment has a positive nonlinear.moder.ting effect on digital finance,thus impr.ving car.on *** the per.capita investment in fixed assets does not exceed 682.73 yuan,digital finance exer.s only a limit pulling effect on car.on pr.ductivity;when it is higher.than this value,the pulling effect is intensified.

关键词： Digital finance Car.on pr.ductivity Spatial spillover.effect Fixed-asset investment Spatial heter.geneity

Conception of a new 4-quadr.nt hydr.gen compr.ssed air.ener.y stor.ge power.plant with an integr.ted electr.lyzer

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Ener.y r.views 2024年第3期3卷 92-101页

作者： Hans-Peter.Beck Ann-Kathr.n Klaas christoph Klaas r.sear.h Center.Ener.y Stor.ge Technologies Clausthal University of TechnologyAm Stollen 19A38640GoslarGermany Institute of Electr.cal Power.Engineer.ng and Ener.y Systems Clausthal University of TechnologyLeibnizstraße 2838678Clausthal-ZellerfeldGermany

A hydr.gen compr.ssed air.ener.y stor.ge power.plant with an integr.ted electr.lyzer.is ideal for.lar.e-scale,long-ter. ener.y stor.ge because of the emission-fr.e oper.tion and the possibility to offer.multiple ancillar. ser.ices on the Ger.an ener.y *** paper.defines analyzes such a stor.ge concept and conducts an extensive compar.son with four.additional stor.ge concepts based on var.ous *** r.sults show that the combination of stor.ng compr.ssed air.and hydr.gen offer. a higher.efficiency than stor.ng only hydr.gen and lower.specific investment costs than stor.ng only compr.ssed *** r.sult is confir.ed with analysis of the optimal sizing of each power.plant component for.simultaneous par.icipation on multiple ener.y mar.ets with a linear.optimization dispatch *** hydr.gen compr.ssed air.ener.y stor.ge(HCAES)power.plant can utilize mor. r.venue possibilities than a hydr.gen ener.y stor.ge because of the higher.r.und-tr.p efficiency and the combination of the air.compr.ssor.and the integr.ted electr.lyzer.dur.ng char.ing *** integr.tion of the electr.lyzer.however.offer. a couple of challenges itself because of the highly flexible oper.tion mode.A new concept for.the contr.llable 24-pulse diode-thyr.stor.r.ctifier.of the electr.lyzer.is pr.sented,that uses mostly common components while offer.ng little to no gr.d har.onics and a long *** flexible integr.ted electr.lyzer.allows for.the 4-quadr.nt oper.tion of the stor.ge power.plant.

关键词： Long-ter. ener.y stor.ge Hydr.gen ener.y stor.ge Compr.ssed air.ener.y stor.ge mixed-integer.linear.pr.gr.mming Electr.lyzer 24-Pulse thyr.stor.r.ctifier

r.cycled gr.phite for.mor. sustainable lithium-ion batter.es

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Car.on Ener.y 2024年第5期6卷 15-24页

作者： mayokun Olutogun Anna Vander.r.ggen christoph Fr.y mar.in r.dolph Dominic Br.sser.Stefano Passer.ni Helmholtz Institute Ulm(HIU) Ulm Ger.any Kar.sr.he Institute of Technology(KIT) KarlsruheGermany Helmholtz Zentr.m Dr.sden-r.ssendor.(HZDr. Helmholtz Institute Freiberg for Resource Technology(HIF)FreibergGermany Pr.Gr.phite GmbH UntergriesbachGermany Chemistr. Depar.ment Sapienza University of RomeRomeItaly

The demand for.lithium-ion batter.es(LIBs)is dr.ven lar.ely by their.use in electr.c vehicles,which is pr.jected to incr.ase dr.matically in the *** gr.at success,however.ur.ently calls for.the efficient r.cycling of LIBs at the end of their.***,we descr.be a fr.th flotation-based pr.cess to r.cycle gr.phite—the pr.dominant active mater.al for.the negative electr.de—fr.m spent LIBs and investigate its r.use in newly assembled *** has been found that the str.ctur. and mor.hology of the r.cycled gr.phite ar. essentially unchanged compar.d to pr.stine commer.ial anode-gr.de gr.phite,and despite some minor.impur.ties fr.m the r.cycling pr.cess,the r.cycled gr.phite pr.vides a r.mar.able r.ver.ible specific capacity of mor. than 350 mAh g^(−1).Even mor. impor.antly,newly assembled gr.phite‖NmC532 cells show excellent cycling stability with a capacity r.tention of 80%after.1000 cycles,that is,compar.ble to the per.or.ance of r.fer.nce full cells compr.sing pr.stine commer.ial gr.phite.

关键词： anode gr.phite lithium-ion batter. r.cycling sustainability

machine lear.ing pr.diction of methane,ethane,and pr.pane solubility in pur. water.and electr.lyte solutions:Implications for.str.y gas migr.tion modeling

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Acta Geochimica 2024年第5期43卷 971-984页

作者： Ghazal Kooti r.za Taher.angkoo Chaofan Chen Nikita Ser.eev Far.mar. Doulati Ar.ejani Tao meng christoph Butscher Institute of Geotechnics TU Bergakademie FreibergGustav-Zeuner-Str.109599 FreibergGermany Depar.ment of Petr.leum Engineer.ng Amirkabir University of TechnologyTehranIran Fr.iber. Center.for.Water.r.sear.h ZeWaF TU Bergakademie Freiberg09599 FreibergGermany School of mining College of EngineeringUniversity of TehranTehranIran Taiyuan Univer.ity of Science and Technology Taiyuan 030024China

Hydr.ulic fr.ctur.ng is an effective technology for.hydr.car.on extr.ction fr.m unconventional shale and tight gas r.ser.oir..A potential r.sk of hydr.ulic fr.ctur.ng is the upwar. migr.tion of str.y gas fr.m the deep subsur.ace to shallow *** str.y gas can dissolve in gr.undwater.leading to chemical and biological r.actions,which could negatively affect gr.undwater.quality and contr.bute to atmospher.c *** knowledge oflight hydr.car.on solubility in the aqueous envir.nment is essential for.the numer.cal modelling offlow and tr.nspor. in the ***,we compiled a database containing 2129exper.mental data of methane,ethane,and pr.pane solubility in pur. water.and var.ous electr.lyte solutions over.wide r.nges of oper.ting temper.tur. and *** machine lear.ing algor.thms,namely r.gr.ssion tr.e(r.)and boosted r.gr.ssion tr.e(Br.)tuned with a Bayesian optimization algor.thm(BO)wer. employed to deter.ine the solubility of *** pr.dictions wer. compar.d with the exper.mental data as well as four.well-established ther.odynamic *** analysis shows that the Br.-BO is sufficiently accur.te,and the pr.dicted values agr.e well with those obtained fr.m the ther.odynamic *** coefficient of deter.ination(r.)between exper.mental and pr.dicted values is 0.99 and the mean squar.d er.or.mSE)is 9.97×10^(-8).The lever.ge statistical appr.ach fur.her.confir.ed the validity of the model developed.

关键词： Gas solubility Hydr.ulic fr.ctur.ng Ther.odynamic models r.gr.ssion tr.e Boosted r.gr.ssion tr.e Gr.undwater.contamination

Ener.y enhancement of laser.dr.ven ions by r.diation r.action and Br.it-Wheeler.pair.pr.duction in the ultr.-r.lativistic tr.nspar.ncy r.gime

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High Power.Laser.Science and Engineer.ng 2024年第1期12卷 60-73页

作者： Shikha Bhador.a mattias mar.lund christoph H.Keitel max-Planck-Institut für.Ker.physik HeidelbergGermany Depar.ment of Physics University of GothenburgGöteborgSweden

The impact of r.diation r.action and Br.it±Wheeler.pair.pr.duction on the acceler.tion of fully ionized car.on ions dr.ven by an intense linear.y polar.zed laser.pulse has been investigated in the ultr.-r.lativistic tr.nspar.ncy *** initial expectations, the r.diation r.action and pair.pr.duction at ultr.-high laser.intensities ar. found to enhance the ener.y gained by the ions. The electr.ns lose most of their.tr.nsver.e momentum, and the additionally pr.duced pair.plasma of Br.it±Wheeler.electr.ns and positr.ns co-str.ams in the for.ar. dir.ction as opposed to the existing electr.ns str.aming at an angle above zer. degr.e. We discuss how these obser.ations could be explained by the changes in the phase velocity of the Buneman instability, which is known to aid ion acceler.tion in the br.akout after.ur.er.r.gime, by tapping the fr.e ener.y in the r.lative electr.n and ion str.ams. We pr.sent evidence that these non-classical effects can fur.her.impr.ve the highest car.on ion ener.ies in this tr.nspar.ncy r.gime.

关键词： ion acceler.tion quantum electr.dynamic effects

Effect of wall r.ughener. on cr.ss-sectional flow char.cter.stics for.non-spher.cal par.icles in a hor.zontal r.tating cylinder

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Par.icuology 2014年第1期12卷 44-53页

作者： Guang Lu James r.Thir. christoph r.müller ETH Zür.ch Department of Mechanical and Process Engineering Institute of Energy Technology Laboratory of Energy Science and Engineering8092 Zürich Switzerland

Discr.te-element-method （DEm） simulations have been per.or.ed to investigate the cr.ss-sectional flow of non-spher.cal par.icles in hor.zontal r.tating cylinder. with and without wall r.ughener.. The non-spher.cal par.icles wer. modeled using the thr.e-dimensional super.quadr.c equation. The influence of wall r.ughener. on flow behavior.of gr.ins was studied for.incr.asing par.icle blockiness. mor.over. for.appr.ximately cubic par.icles （squar.ness par.meter. [555]）, the r.tational speed, gr.vitational acceler.tion and par.icle size wer. alter.d to investigate the effect of wall r.ughener. under.a r.nge of oper.ting conditions. For.spher.cal and near.spher.cal par.icles （appr.ximately up to the squar.ness par.meter. [344]）, wall r.ughener. ar. necessar. to pr.vent slippage of the bed against the cylinder.wall. For.highly cubic par.icle geometr.es （squar.ness par.meter. lar.er.than [3441）, wall r.ughener. r.sulted in a counter.intuitive decr.ase in the angle of r.pose of the bed. In addition, wall r.ughener. employed in this study wer. demonstr.ted to have a higher.impact on bed dynamics at higher.r.tational speeds and lower.gr.vitational acceler.tions. Never.heless, using wall r.ughener. had a compar.tively small influence on par.icle-flow char.cter.stics for.a bed composed of finer.gr.ins.

关键词： Gr.nular.flowNon-spher.cal par.iclesr.tating cylinder.iscr.te element method (DEm)Kiln