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巨大嵌壁胆囊结石的超声波碎石疗法

放射学实践 1991年第1期6卷 26-29页

作者： christoph D.Becker Robert G.Gibney J.Stephen Fache V.Allen Rowley M.G.McLoughlin Burhenne h.Joachim 武卫国胡仁昭 Departments of Radiology and Urology University of British Columbia and Vancouver General hospital Canada 同济医科大学附属同济医院

当急性胆囊炎患者手术危险性较大或解剖关系不清楚时,可以用胆囊造瘘术代替胆囊切除术,胆囊结石的取出或通过外科手术,或者以后在X线监视下由放射科医生完成,后者使急性炎症期的手术创伤降至最小。我院对36例手术高危的且伴有多种并发... 详细信息

当急性胆囊炎患者手术危险性较大或解剖关系不清楚时,可以用胆囊造瘘术代替胆囊切除术,胆囊结石的取出或通过外科手术,或者以后在X线监视下由放射科医生完成,后者使急性炎症期的手术创伤降至最小。我院对36例手术高危的且伴有多种并发症的老年患者进行了此种卓有成效的治疗。尽管放射科医生用或不伴用机械碎石法在多数病例可取出结石碎片,但是对特别巨大的嵌壁结石的取出还存在着技术上的困难。下面报道的三例此类胆囊结石均采用超声波碎石法成功取出结石。

关键词：胆结石超声波碎石

On attitudes about colorectal cancer screening among gastrointestinal specialists and general practitioners in the Netherlands

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World Journal of Gastroenterology 2006年第32期12卷 5201-5204页

作者： JS Terhaar sive Droste GDN heine ME Craanen h Boot CJJ Mulder Department of Gastroenterology and hepatology VU University Medical Centre AmsterdamThe Netherlands Department of Gastroenterology and hepatology antoni van Leeuwenhoek hospital AmsterdamThe Netherlands

AIM： To find out whether there are differences in attitudes about colorectal cancer （CRC） screening among gastrointestinal （GI） specialists and general practitioners （GPs） and which method is preferred in a national screening program METhODS： Four hundred and twenty Dutch GI specialists in the Netherlands and 400 GPs in Amsterdam were questioned in 2004. Questions included demographics, affiliation, attitude towards screening both for the general population and themselves, methods of screening, family history and individual risk. RESULTS： Eighty-four percent of the GI specialists returned the questionnaire in comparison to 32% of the GPs （P〈0.001）. Among the GI specialists, 92% favoured population screening whereas 51% of GPs supported population screening （P〈0.001）. Of the GI specialists 95% planned to be screened themselves, while 30% of GPs intended to do so （P〈0.001）. Regarding the general population, 72% of the GI specialists preferred colonoscopy as the screening method compared to 27% of the GPs （P〈0.001）. The method preferred for personal screening was colonoscopy in 97% of the GI specialists, while 29% of the GPs favoured colonoscopy （P〈0.001）. CONCLUSION： Screening for CRC is strongly supported by Dutch GI specialists and less by GPs. The major health issue is possibly misjudged by GPs. Since GPs play a crucial role in a successful national screening program, CRC awareness should be realized by increasing knowledge about the incidence and mortality, thus increasing awareness of the need for screening among GPs.

关键词： Colorectal cancer General practitioner Screening Colonoscopy Awareness

德国沃尔夫斯堡汽车城的Level Green-可持续概念展厅

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世界建筑导报 2015年第1期30卷 22-24页

作者： Jan-christoph Stockebrand Uwe Walter Autostadt

可持续利用全球资源的个人责任感,继续在普通消费者的生活中发挥着越来越重要的作用。在此背景下,德国沃尔夫斯堡汽车城委托*** h。建筑师事务所和柏林Art＋ COM新媒体公司联合开发以可持续发展为主题的永久性展厅。LEVELGREEN展厅于200... 详细信息

可持续利用全球资源的个人责任感,继续在普通消费者的生活中发挥着越来越重要的作用。在此背景下,德国沃尔夫斯堡汽车城委托*** h。建筑师事务所和柏林Art＋ COM新媒体公司联合开发以可持续发展为主题的永久性展厅。LEVELGREEN展厅于2009年6月4日开放，占地约1000平方米，出色的诠释了关于可持续性发展的一系列复杂概念，并将其转化为有形展示手段，为用户提供一个获取相关信息的平台。众多相关主题旨在展开该概念的各个方面，同时创造适用不同感知层次参观者的信息环境。

关键词：沃尔夫斯堡汽车城 Level 展厅德国建筑师事务所可持续性发展可持续利用

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拔牙后的组织处理：软组织打孔技术

中国口腔医学继续教育杂志 2005年第4期8卷 16-21页

作者： Ronald E. Jung David W. Siegenthaler christoph h. F. hammerle 乔静（译）欧阳翔英（校）不详北京大学口腔医学院北京海淀区中关村南大街22号100081

这项前瞧性临床研究的目的是分析对拔牙窝内进行软、硬组织移植后软组织在初期阶段的愈合情况。研究对象为需要拔牙（包括切牙、尖牙和前磨牙）和准备种植修复的20位患者。在需要拔除多个牙的患者中，随机选择1颗牙齿纳人研究。在应用... 详细信息

这项前瞧性临床研究的目的是分析对拔牙窝内进行软、硬组织移植后软组织在初期阶段的愈合情况。研究对象为需要拔牙（包括切牙、尖牙和前磨牙）和准备种植修复的20位患者。在需要拔除多个牙的患者中，随机选择1颗牙齿纳人研究。在应用抗生素后，动作轻柔地将患牙拔除，然后在拔牙窝内填人整合了10％胶原基质的去蛋白牛骨矿物质，充满牙槽窝并支撑软组织以防止塌陷。之后再选用直径与拔牙窝相当的活检打孔器。从上腭获取厚度为2～3mm的游离龈，将其移植至拔牙窝的表面，并缝合于拔牙窝周边去上皮的软组织边缘。移植术后1周，平均64.3％的移植面完全整合。35．6％的移植面呈纤维蛋白样，0．1％显示坏死。术后3周和6周，整合的移植面分别增加到92.3％和99．7％。6周后，在4个移植物中平均有0．3％的移植面显示出伤口关闭不全。没有纤维蛋白样结构或组织坏死表现。移植物和邻近组织比色显示平均颜色匹配为ΔE=2．91，低于可分辨口腔内不同颜色的临界阈值3．7。这种软组织打孔技术成功地获得了移植物与局部宿主组织的生物学和美学整合。

关键词：软组织拔牙后打孔组织处理移植术后纤维蛋白组织坏死颜色匹配移植后拔牙窝

New aspects in the pathomechanism and diagnosis of the laryngopharyngeal reflux-clinical impact of laryngeal proton pumps and pharyngeal p h metry in extraesophageal gastroesophageal reflux disease

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World Journal of Gastroenterology 2015年第3期21卷 982-987页

作者： Valentin Becker Romina Drabner Simone Graf christoph Schlag Simon Nennstiel Anna Maria Buchberger Roland M Schmid Dieter Saur Monther Bajbouj Ⅱ.Medizinische Klinik Klinikum rechts der IsarTechnische Universit?t München81675 MünchenGermany hals-Nasen Ohren Klinik Klinikum rechts der IsarTechnische Universit?t München81675 MünchenGermany

AIM:To determine the laryngeal h+K+-ATPase and pharyngeal p h in patients with laryngopharyngeal reflux(LPR)-symptoms as well as to assess the symptom scores during PPI ***:Endoscopy was performed to exclude neoplasia and to collect biopsies from the posterior cricoid area(immunohistochemistry and PCR analysis).Immunohistochemical staining was performed with monoclonal mouse antibodies against human h+K+-*** real-time RT-PCR for each of the h+K+-ATPase subunits was *** p h values were assessed in the aerosolized environment of the oropharynx(Dxp h Catheter) and compared to a subsequently applied combined p h/MII ***:Twenty patients with LPR symptoms were *** only one patient,the laryngeal h+K+-ATPase was verified by immunohistochemical *** another patient,real-time RT-PCR for each h+K+-ATPase subunit was *** out of twenty patients had pathological results in Dxp h,and 6/20 patients had pathological results in p h/*** patients had pathological results in both functional *** out of twenty patients responded to ***:The laryngeal h+K+-ATPase can only be sporadically detected in patients with LPR symptoms and is unlikely to cause the LPR *** hypotheses for the pathomechanism are *** role of pharyngeal p h-metry remains unclearand its use can only be recommended for patients in a research study setting.

关键词： Laryngopharyngeal reflux Proton pump inhibitor Gas

Dynamic changes in O-GlcNAcylation regulate osteoclast differentiation and bone loss via nucleoporin 153

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Bone Research 2022年第4期10卷 799-815页

作者： Yi-Nan Li Chih-Wei Chen Thuong Trinh-Minh honglin Zhu Alexandru-Emil Matei Andrea-hermina Györfi Frederic Kuwert Philipp hubel Xiao Ding Cuong Tran Manh Xiaohan Xu christoph Liebel Vladyslav Fedorchenko Ruifang Liang Kaiyue huang Jens Pfannstiel Min-Chuan huang Neng-Yu Lin Andreas Ramming Georg Schett Jörg h.W.Distler Department of Internal Medicine 3–Rheumatology and Immunology Friedrich Alexander University Erlangen-Nürnberg and Universitätsklinikum ErlangenErlangenGermany Deutsches Zentrum für Immuntherapie Friedrich Alexander University Erlangen-Nuremberg and Universitaetsklinikum ErlangenErlangenGermany Department of Rheumatology Xiangya HospitalCentral South UniversityChangshaHunanChina Core Facility hohenheim University of HohenheimStuttgartGermany Graduate Institute of Anatomy and Cell biology National Taiwan University College of MedicineTaipeiTaiwan

Bone mass is maintained by the balance between osteoclast-induced bone resorption and osteoblast-triggered bone *** inflammatory arthritis such as rheumatoid arthritis(RA),however,increased osteoclast differentiation and activity skew this balance resulting in progressive bone loss.O-GlcNAcylation is a posttranslational modification with attachment of a single O-linkedβ-D-N-acetylglucosamine(O-GlcNAc)residue to serine or threonine residues of target *** O-GlcNAcylation is one of the most common protein modifications,its role in bone homeostasis has not been systematically *** demonstrate that dynamic changes in O-GlcNAcylation are required for *** O-GlcNAcylation promotes osteoclast differentiation during the early stages,whereas its downregulation is required for osteoclast *** the molecular level,O-GlcNAcylation affects several pathways including oxidative phosphorylation and cell-cell ***αfosters the dynamic regulation of O-GlcNAcylation to promote osteoclastogenesis in inflammatory *** pharmaceutical or genetic inhibition of O-GlcNAc transferase(OGT)or O-GlcNAcase(OGA)arrests osteoclast differentiation during early stages of differentiation and during later maturation,respectively,and ameliorates bone loss in experimental *** of NUP153,an O-GlcNAcylation target,has similar effects as OGT inhibition and inhibits *** findings highlight an important role of O-GlcNAcylation in osteoclastogenesis and may offer the potential to therapeutically interfere with pathologic bone resorption.

关键词： osteoclast homeostasis maintained

Kinase function in the gonads of Schistosoma mansoni unravelled by inhibitor and RNAi approaches

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Kinase function in the gonads of Schistosoma mansoni unravel...

Nano-Structured Cu/W Brazing Fillers for Advanced Joining Applications

中国畜牧兽医学会家畜寄生虫学分会第六次代表大会暨第十一次学术研讨会

作者： christoph G.Grevelding Christin Buro Thomas Quack Steffen hahnel Colette Dissous Katia C.Oliveira Sergio Verjovski-Almeida Svenja Beckmann Unite Inserm 547 CIIL-Center for Infection and ImmunityInserm U1019-CNRS UMR 8204Institut PasteurLilleFrance Department of Biochemistry Instituto de QuimicaUniversidade de Sao PauloBrazil

Schistosome biology is characterized by the essential influence of the male on mitoses and differentiation processes in the reproductive organs of the *** pairing-induced sexual maturation leads to egg production causing the pathogenic consequences of *** these correlations are long known,their molecular basis has not been elucidated *** have started to identify and characterise genes coding for signaling proteins and concentrated on cellular tyrosine kinases(CTKs). Among these are members of the Src and Syk families,which are expressed in the reproductive organs of both ***,the transforming growth-factor receptor 1 and the venus kinase receptor 1, which belongs to the class of receptor tyrosine kinases,are expressed in the *** have investigated the physiological effects of chemical inhibitors blocking the activities of specific signaling proteins in adult schistosomes in *** functional assays we investigated pairing-stability,egg production and survival. By confocal laser scanning microscopy the morphological consequences of these approaches were *** two-hybrid(Y2h) cDNA library screenings were performed to identify binding partners of interesting *** specific interactions were confirmed by direct Y2h interaction analyses and/or coimmunoprecipitation *** analyses provided an overview about global gene expression changes upon inhibitor *** was applied to silence specific gene functions and, finally,Xenopus oocyte transfection approaches were combined with germinal vesicle breakdown assays to biochemically study individual *** will be presented that demonstrate the potential of combining these methods to functionally characterize schistosome *** suggest CTKs as promising targets for novel intervention strategies.

关键词：

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材料科学与工程（中英文B版） 2016年第5期6卷 226-230页

作者： Frank Moszner Claudia Cancellieri christoph Becker Mirco Chiodi Jolanta Janczak-Rusch Lars P. h.Jeurgens Empa Swiss Federal Laboratories for Materials Science and Technology Oberlandstrasse 129 CH-8600 Dubendorf Switzerland Institute of Virtual Manufacturing (IvP) ETH Zurich Tannenstrasse 3 CH-8092 Zurich Switzerland

对舒马普坦治疗反应的预测:舒马普坦和那拉曲坦集合患者数据库

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世界核心医学期刊文摘（神经病学分册） 2005年第1期1卷 54-54页

作者： christoph-Diener h. Ferrari M. Mansbach h. 高方 Dept. of Neurology University of Essen Hufelandstr. 55 45147 Essen Germany Dr.

Objective: The efficacy and tolerability profiles of sumatriptan and other 5hT1B/1D agonists (triptans) have been well established. however, the determinants for optimal response to sumatriptan are unknown. The Sumatriptan Naratriptan Aggregate Patient (SNAP) database contains data from 128 clinical trials including 28,407 migraine sufferers treating over 130,000 attacks. The authors analyzed these data to identify factors predicting response (headache relief and pain free response) to sumatriptan. Methods: The authors assessed 24 possible univariate predictors of headache response in 3,706 patients (18 years and older) receiving sumatriptan tablets 100 mg or placebo in a double blind study using recursive partitioning and logistic regression techniques. Results: The authors found seven predictors of headache relief 2 hours postdose. Moderate pain at baseline was the strongest predictor (adjusted p = 3.32× 10- 18), followed by absence of a disability requiring bedrest (adjusted p = 3.11 × 10- 18). Other predictors included absence at baseline of vomiting, pulsating pain, nausea, or photophobia/ phonophobia, and onset of headache during daytime hours. Logistic regression confirmed that treatment with sumatriptan was the strongest predictor of headache relief, with significant baseline covariates being pain severity, level of disability, and presence or absence of vomiting. A similar pattern of results was reported for predictors of pain free response 2 hours after taking sumatriptan. Conclusions: Pretreatment pain seve rity is themost important predicting factor for response to sumatriptan in migraine attacks: the lower baseline severity, the better.

关键词：舒马普坦拉曲递归分区受体激动剂临床试验偏头痛患者痛反应色胺基线水平双盲试验