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ANALYSIS OF MULTI-INDEX MONTE CARLO ESTIMATORS FOR A ZAKAI SPDE

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Journal of Computational Mathematics 2018年第2期36卷 202-236页

作者： christoph Reisinger Zhenru Wang Mathematical Institute University of Oxford Woodstock Road Oxford OX2 6GG UK

In this article, we propose a space-time Multi-Index Monte Carlo （MIMC） estimator for a one-dimensional parabolic stochastic partial differential equation （SPDE） of Zakai type. We compare the complexity with the Multilevel Monte Carlo （MLMC） method of Giles and Reisinger （2012）, and find, by means of Fourier analysis, that the MIMC method：（i） has suboptimal complexity of 0（ε^-21 ｜ogε｜） for a root mean square error （RMSE） z if the same spatial discretisation as in the MLMC method is used; （ii） has a better complexity of 0（ε^-21 ｜ogε｜） if a carefully adapted discretisation is used; （iii） has to be adapted for non-smooth functionals. Numerical tests confirm these findings empirically.

关键词： Parabolic stochastic partial differential equations Multilevel Monte Carlo,Multi-index Monte Carlo Stochastic finite differences Zakai equation.

Influence of rolling friction on single spout fluidized bed simulation

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Particuology 2012年第5期10卷 582-591页

作者： christoph Goniva christoph Kloss Niels G. Deen Johannes A.M.Kuipers Stefan Pirker Christian-Doppler Laboratory on Particulate Flow Modelling Johannes Kepler UniversityLinz Austria DCS Computing GmbH Linz Austria Christian-Doppler Laboratory on Particulate Flow Modelling Johannes Kepler UniversityLinz Austria Department of Chemical Engineering and Chemistry Eindhoven University of TechnologyEindhovenThe Netherlands Department of Chemical Engineering and Chemistry Eindhoven University of TechnologyEindhovenThe Netherlands Christian-Doppler Laboratory on Particulate Flow Modelling Johannes Kepler UniversityLinzAustria Institute of Fluid Mechanics and Heat Transfer Johannes Kepler UniversityLinzAustria

In this paper we study the effect of rolling friction on the dynamics in a single spout fluidized bed using Discrete Element Method （DEM） coupled to Computational Fluid Dynamics （CFD）. In a first step we neglect rolling friction and show that the results delivered by the open source CFD-DEM framework applied in this study agree with previous simulations documented in literature. In a second step we include a rolling friction sub-model in order to investigate the effect of particle non-sphericity. The influence of particle-particle as well as particle-wall rolling friction on the flow in single spout fluidized bed is studied separately. Adequate rolling friction model parameters are obtained using first principle DEM simulations and data from literature. Finally, we demonstrate the importance of correct modelling of rolling friction for coupled CFD-DEM simulations of spout fluidized beds. We show that simulation results can be improved significantly when applying a rolling friction model, and that experimental data from literature obtained with Positron Emission Particle Trackin~ fPEPT） technique can be satisfactorily reoroduced.

关键词： CFD-DEMOpen sourceRolling frictionSpout fluidized bedNon-sphericity

Epigenetic changes of DNA repair genes in cancer

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Journal of Molecular Cell Biology 2011年第1期3卷 51-58页

作者： christoph Lahtz Gerd P.Pfeifer Department of Cancer Biology Beckman Research InstituteCity of HopeDuarteCA 91010USA

‘Every Hour Hurts,The Last One Kills’.That is an old saying about getting *** day,thousands of DNA damaging events take place in each cell of our body,but efficient DNA repair systems have evolved to prevent ***,our DNA repair system and that of most other organisms are not as perfect as that of Deinococcus radiodurans,for example,which is able to repair massive amounts of DNA damage at one *** many instances,accumulation of DNA damage has been linked to cancer,and genetic deficiencies in specific DNA repair genes are associated with tumor-prone *** addition to mutations,which can be either inherited or somatically acquired,epigenetic silencing of DNA repair genes may promote *** review will summarize current knowledge of the epigenetic inactivation of different DNA repair components in human cancer.

关键词： DNA methylation DNA repair epigenetics

Branched side chains improve molecular packing of non-fullerene acceptors

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Science China Chemistry 2021年第9期64卷 1435-1436页

作者： Ning Li christoph J.Brabec Institute of Materials for Electronics and Energy Technology(i-MEET) Friedrich-Alexander University Erlangen-NürnbergMartensstraße 7Erlangen91058Germany Helmholtz-Institute Erlangen-Nürnberg(HI ERN) Immerwahrstraße 2Erlangen91058Germany

As one of the promising emerging photovoltaic technologies(PVs),organic solar cells(OSCs)have received extensive attention from both scientific and industry *** advantages of OSCs,such as low toxicity,high power-toweight ratio,and easy manufacturing and upscaling,guarantee their contribution to versatile applications powered by clean and renewable solar energy,for instance.

关键词： chains packing versatile

Three-dimensional CityGML building models in mobile augmented reality: a smartphone-based pose tracking system

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International Journal of Digital Earth 2021年第1期14卷 32-51页

作者： christoph Blut Jörg Blankenbach Geodetic Institute Department of Computing in Civil Engineering and Geo-Information SystemsRWTH Aachen UniversityAachenGermany

Many augmented reality(AR)systems are developed for entertainment,but AR and particularly mobile AR potentially have more application possibilities in other *** example,in civil engineering or city planning,AR could be used in combination with CityGML building models to enhance some typical workflows in planning,execution and operation processes.A concrete example is the geo-referenced on-site visualization of planned buildings or building parts,to simplify planning processes and optimize the communication between the participating *** of the main challenges for the visualization lies in the pose tracking,*** real-time estimation of the translation and rotation of the mobile device to align the virtual objects with *** this paper,we introduce a proof-of-concept fine-grained mobile AR CityGML-based pose tracking system aimed at the mentioned *** system estimates poses by combining 3D CityGML data with information derived from 2D camera images and an inertial measurement unit and is fully self-sufficient and operates without external *** results of our evaluation show that CityGML and low-cost off-the-shelf mobile devices,such as smartphones,already provide performant and accurate mobile pose tracking for AR in civil engineering and city planning.

关键词： Mobile augmented reality pose tracking CityGML 3D city model Android smartphone

Stratigraphic implications of Sinian-Early Cambrian volcanic ash beds on the Yangtze Platform

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Progress in Natural Science:Materials International 2004年第1期14卷 72-77页

作者： christoph HEUBECK D 12249 Berlin Department of Geological Sciences Freie Universitaet Berlin Germany

Volcanic ash beds from shallow to deep water facies strata of the Sinian Early Cambrian (Meishucunian) on the Yangtze Platform consist of bentonites and tuffites which are readily recognized in the field by their physical features and confirmed by geochemical analyses. Geochemistry suggests that the volcanic ash beds in Meishucunian time are rhyolite and rhyodacite while those in the Qiongzhusian and Sinian are andesite and trachyandesite. The ash beds in the time equivalent strata, even in different areas display rather similar geochemical features, whereas the ash beds in different strata even in the same areas show large chemical difference. The results suggest that these ash beds can be used for intra and extra basinal correlations of the Sinian Early Cambrian interval on the Yangtze Platform. Additionally, these ash beds suggest high potentials for further U Pb dating strategies.

关键词： bentonite tuffite volcanism geochemistry Sinian Cambrian South China

A deterministic method study of the impact of the Pauli principle in double-gate MOSFETs

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Chinese Physics B 2012年第11期21卷 523-527页

作者：赵凯 christoph Jungemann 刘晓彦 Institute of Microelectronics Peking University Chair of Electromagnetic Theory RWTH Aachen University

The Pauli principle is included in a multisubband deterministic solver for two-dimensional devices without approx- imations. The nonlinear Boltzmann equations are treated properly without compromising on accuracy, convergence, or CPU time. The simulation results indicate the significant impact of the Pauli principle on the transport properties of the quasi-2D electron gas, especially for the on state.

关键词： Pauli principle two-dimensional MOSFET degeneracy Fourier harmonics expansion

Interleukin-10 gives exhausted chimeric antigen receptor(CAR)T cells a second breath

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Cancer Communications 2024年第7期44卷 787-790页

作者： christoph Heuser-Loy Leibniz Institute for Immunotherapy Division for Functional Immune Cell ModulationRegensburgGermany

Adoptive cell therapy(ACT)represents a major pillar of modern *** or synthetically endowed with the ability to recognize tumor-associated antigens,tumor-infiltrating lymphocytes(TILs)or T cells engineered to transgenically express T cell receptors or chimeric antigen receptors(CARs)are expanded and infused to tumor patients to lyse tumor ***,despite tremendous response rates against liquid tumors,many patients undergo relapses,and treatment outcomes in solid tumors have been disappointing so far[1].The harsh tumor microenvironment,including nutrient deprivation,acidification,hypoxia,and immunosuppressive signals[2,3],in conjunction with persistent antigen stimulation triggers a program of exhaustion in T cells(Figure 1A).Exhausted T cells exhibit reduced cytotoxicity and minimal proliferation potential,physiologically balancing tissue health with control of chronic viral infection or of tumor growth[4,5].Strategies to disengage or rewire the“erroneously”deployed exhaustion program to exploit the full potential of tumor-fighting T cells are highly sought after(Figure 1B).

关键词： Interleukin stimulation Figure

Alkaline generation and reactions of CF3CHN2

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Science China Chemistry 2019年第8期62卷 923-924页

作者： Nicolai Rosenbaum christoph Zippe Stefan Brase Institute of Organic Chemistry Karlsruhe Institute of TechnologyFritz-Haber- Weg 676131 KarlsruheGermany Institute of Toxicology and Genetics Karlsruhe Institute of TechnologyHermann-von-Helmholtz-Platz I 76344 Eggenstein-LeopoldshafenGermany

Fluorinated organic compounds display significant impact in the fields of agrochemicals, pharmaceuticals and materials science. However, very few fluorine-containing compounds are available from nature, and therefore studies of the distinct effect of fluorine substitution mainly depend on the ease of access to fluorinated scaffolds. Among fluorination strategies, the development and application of fluorinated diazo compounds has provided a convenient and effective method for the construction of various fluorinated structural moieties.

关键词： Alkaline generation reactions of CF3CHN2 fluorination strategies