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Radioembolization for neuroendocrine liver metastases is safe and effective prior to major hepatic resection

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Hepatobiliary Surgery and Nutrition 2020年第3期9卷 312-321页

作者： Florian Bosch Harun Ilhan Vanessa Pfahler Michael Thomas Thomas Knosel Valentin Eibl Sebastian Pratschke Peter Bartenstein Max Seidensticker christoph j.auernhammer Christine Spitzweg Markus O.Guba jens Werner Martin K.Angele Department of General Visceraland Transplant SurgeryLudwig-Maximilians-University MunichMunichGermany Interdisciplinary Center of Neuroendocrine Tumors of the Gastro Entero Pancreatic System Ludwig-Maximilians-University MunichMunichGermany Department of Nuclear Medicine University HospitalLudwig-Maximilians-University MunichMunichGermany Department of Radiology Ludwig-Maximilians-University MunichMunichGermany Institute of Pathology Ludwig-Maximilians-University MunichMunichGermany Department of Internal Medicine 4 Ludwig-Maximilians-University MunichMunichGermany

Background:Radioembolization(RE)is well established in the treatment of neuroendocrine liver *** surgery is rarely performed after RE,although liver resection is the gold standard in the treatment of localized neuroendocrine liver ***,aim of the present study was to evaluate the safety and feasibility of liver resection after RE in a homogenous ***:From a prospective surgical(n=494)and nuclear medical(n=138)database patients with NELM who underwent liver resection and/or RE were *** September 2011 and December 2017 eight patients could be identified who underwent liver resection after RE(mean therapeutic activity of 1,746 Mbq).Overall and progression free survival were evaluated as well as epidemiological and perioperative *** surgical specimens were analyzed for necrosis,fibrosis,inflammation,and ***:The mean hepatic tumor load of patients,who had liver surgery after RE,was 31.4%with a mean Ki-67 proliferation index of 5.9%.The majority of these patients(7/8)received whole liver RE prior to liver resection,which did not increase morbidity and mortality compared to a surgical *** for RE were oncological(6/8)or carcinoid syndrome associated reasons(2/8).Mean overall survival was 25.1 months after RE and subsequent *** necrosis in radioembolized lesions was 29.4%without evidence of fibrosis and inflammation in hepatic ***:This is the first study analyzing the multimodal therapeutic approach of liver resection following whole liver *** treatment algorithm is safe,does not lead to an increased morbidity and is associated with a favorable oncological ***,patient selection remains a key issue.

关键词： Radioembolization(RE) neuroendocrine tumor liver surgery

Aspirin inhibits cell viability and mTOR downstream signaling in gastroenteropancreatic and bronchopulmonary neuroendocrine tumor cells

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World journal of Gastroenterology 2014年第29期20卷 10038-10049页

作者： Matilde Spampatti George Vlotides Gerald Spttl julian Maurer Burkhard Gke christoph j.auernhammer Department of Internal Medicine Ⅱ University-Hospital Campus GrosshadernInterdisciplinary Center of Neuroendocrine Tumours of the GastroEnteroPancreatic System (GEPNET-KUM)Ludwig-Maximilians-University of Munich U.O.C.Gastroenterologia 2 Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico Università degli Studi di Milano

AIM: To investigate the effect of aspirin on neuroendocrine tumor (NET) cell growth and signaling in vitro.

关键词： Neuroendocrine tumors Aspirin Cell Viability Mammalian target of rapamycin protein

Branched side chains improve molecular packing of non-fullerene acceptors

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Science China Chemistry 2021年第9期64卷 1435-1436页

作者： Ning Li christoph j.Brabec Institute of Materials for Electronics and Energy Technology(i-MEET) Friedrich-Alexander University Erlangen-NürnbergMartensstraße 7Erlangen91058Germany Helmholtz-Institute Erlangen-Nürnberg(HI ERN) Immerwahrstraße 2Erlangen91058Germany

As one of the promising emerging photovoltaic technologies(PVs),organic solar cells(OSCs)have received extensive attention from both scientific and industry *** advantages of OSCs,such as low toxicity,high power-toweight ratio,and easy manufacturing and upscaling,guarantee their contribution to versatile applications powered by clean and renewable solar energy,for instance.

关键词： chains packing versatile

Three-dimensional CityGML building models in mobile augmented reality: a smartphone-based pose tracking system

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International journal of Digital Earth 2021年第1期14卷 32-51页

作者： christoph Blut jörg Blankenbach Geodetic Institute Department of Computing in Civil Engineering and Geo-Information SystemsRWTH Aachen UniversityAachenGermany

Many augmented reality(AR)systems are developed for entertainment,but AR and particularly mobile AR potentially have more application possibilities in other *** example,in civil engineering or city planning,AR could be used in combination with CityGML building models to enhance some typical workflows in planning,execution and operation processes.A concrete example is the geo-referenced on-site visualization of planned buildings or building parts,to simplify planning processes and optimize the communication between the participating *** of the main challenges for the visualization lies in the pose tracking,*** real-time estimation of the translation and rotation of the mobile device to align the virtual objects with *** this paper,we introduce a proof-of-concept fine-grained mobile AR CityGML-based pose tracking system aimed at the mentioned *** system estimates poses by combining 3D CityGML data with information derived from 2D camera images and an inertial measurement unit and is fully self-sufficient and operates without external *** results of our evaluation show that CityGML and low-cost off-the-shelf mobile devices,such as smartphones,already provide performant and accurate mobile pose tracking for AR in civil engineering and city planning.

关键词： Mobile augmented reality pose tracking CityGML 3D city model Android smartphone

Stand dynamics of the drought-affected floodplain forests of Araguaia River,Brazilian Amazon

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Forest Ecosystems 2017年第3期4卷 201-210页

作者： jürgen Homeier Dariusz Kurzatkowski christoph Leuschner Plant Ecology Albrecht von Haller Institute for Plant Sciences University of Goettingen

Background： The floodplain forests of Araguaia River, a clear-water river in the southeastern Amazon（Tocantins State, Brazil）, are characterized by seasonal flooding up to 3.5 m height, low nutrient levels in the water, and seasonal drought periods of 4–5 ***： We studied the forest dynamics（tree diameter growth, tree mortality and recruitment） of this unique forest ecosystem over a 5-year period by repeated censuses in 12 permanent plots established along a flooding ***： The cumulative basal area in the plots increased by 0.84（±0.45） m^2·ha^-1·yr^-1（mean ±SD） in the annual y-flooded（AF） plots in lower terrain and by 0.69（±1.00） m^2·ha^-1·yr^-1 in the higher non-annual y flooded（NAF） plots, corresponding to an aboveground biomass increase of 0.81（±0.57） and 0.69（±1.58） Mg·ha^-1·yr^-1 in the AF and NAF plots, indicating a recent carbon sink in the biomass. Mean diameter growth rate was 1.8（±0.44） mm·yr^-1 in the AF and 2.0（±0.56） mm·yr^-1 in the NAF plots（corresponding to a coarse wood production of 1.53（±1.29） and 2.02（±0.52） Mg·ha^-1·yr^-1）,indicating no flooding effect on radial growth. Mean mortality rates in the 5-year period were 1.9（±0.37）·yr^-1 in the AF plots and 1.8（±0.87）%·yr^-1 in the NAF plots with no differences along the flooding gradient. Highest mortalities were registered in the AF plots for the 10–20 cm dbh class（2.4%·yr^-1）, likely as a consequence of flooding,and in the NAF plots for the 40–50 cm dbh class（3.0%·yr^-1）, probably mainly caused by ENSO-related ***： We conclude that these drought-affected tropical floodplain forests have a lower standing biomass and aboveground productivity than central Amazonian floodplain forests in more humid climates, and the imprint of the flooding gradient on stand dynamics is relatively weak, which may result from the lower flooding height and the interaction of flooding with low nutrient supply and periodic drought.

关键词： Amazon Diameter growth Dry season Flooding regime Mortality rate Productivity Tree recruitment

CityGML goes mobile: application of large 3D CityGML models on smartphones

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International journal of Digital Earth 2019年第1期12卷 25-42页

作者： christoph Blut Timothy Blut jörg Blankenbach Department of Computing in Civil Engineering and Geo Information Systems Geodetic InstituteRWTH Aachen UniversityAachenGermany

CityGML,a semantic information model for digital/virtual city models has become quite popular in various *** the data format is still actively under development,it is already supported by different software solutions,especially GIS-based desktop *** systems on the other hand are still neglected,even though the georeferenced objects of CityGML have many application fields,for example,in the currently popular area of location-based Augmented *** this paper we present an independent multi-platform CityGML viewer,its architecture and specific implementation techniques that we use to realize and optimize the process of visualizing CityGML data for use in Augmented *** main focus lies in improving the implementation on mobile devices,such as smartphones,and assessing its usability and performance in comparison to web-based *** to the constrained hardware resources of smartphones,it is a particular challenge to handle complex 3D objects and large virtual worlds as provided by CityGML,not only in terms of memory and storage space,but also with respect to mobile processing units and display sizes.

关键词： CityGML city model android 3D visualization real-time rendering

Asymptomatic pancreatic lesions: New insights and clinical implications

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World journal of Gastroenterology 2012年第33期18卷 4474-4477页

作者： Martin Loos christoph W Michalski jrg Kleeff Department of Surgery Klinikum rechts der Isar Technische Universitt München 81675 München Germany

Despite great efforts in experimental and clinical research, the prognosis of pancreatic cancer (PC) has not changed significantly for decades. Detection of pre-invasive lesions or early-stage PC with small resectable cancers in asymptomatic individuals remains one of the most promising approaches to substantially improve the overall outcome of PC. Therefore, screening programs have been proposed to identify curable lesions especially in individuals with a familial or genetic predisposition for PC. In this regard, Canto et al recently contributed an important article comparing computed tomography, magnetic resonance imaging, and endoscopic ultrasound for the screening of 216 asymptomatic high-risk individuals (HRI). Pancreatic lesions were detected in 92 of 216 asymptomatic HRI (42.6%). The high diagnostic yield in this study raises several questions that need to be answered of which two will be discussed in detail in this commentary: First: which imaging test should be performed? Second and most importantly: what are we doing with incidentally detected pancreatic lesions? Which ones can be observed and which ones need to be resected?

关键词： Pancreatic cancer Early-stage pancreatic cancer Asymptomatic high-risk individuals Preinvasive pancreatic lesions Cystic pancreatic tumors Screening Computed tomography Magnetic resonance imaging Endoscopic ultrasound

Magnetic labeling of primary murine monocytes using very small superparamagnetic iron oxide nanoparticles

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Neural Regeneration Research 2022年第10期17卷 2311-2315页

作者： Martin Pohland christoph Pohland jürgen Kiwit jana Glumm Institute of Cell Biology and Neurobiology Center for AnatomyCharité-Universitätsmedizin BerlinBerlinGermany Department of Neurosurgery Helios Klinikum Berlin BuchBerlinGermany

Due to their very small size,nanoparticles can interact with all cells in the central nervous *** of the most promising nanoparticle subgroups are very small superparamagnetic iron oxide nanoparticles(VSOP)that are citrate coated for electrostatic *** determine their influence on murine blood-derived monocytes,which easily enter the injured central nervous system,we applied VSOP and carboxydextran-coated superparamagnetic iron oxide nanoparticles(Resovist).We assessed their impact on the viability,cytokine,and chemokine secretion,as well as iron uptake of murine blood-derived *** found that(1)the monocytes accumulated VSOP and Resovist,(2)this uptake seemed to be nanoparticle-and time-dependent,(3)the decrease of monocytes viability was treatment-related,(4)VSOP and Resovist incubation did not alter cytokine homeostasis,and(5)overall a 6-hour treatment with 0.75 mM VSOP-R1 was probably sufficient to effectively label monocytes for future *** homeostasis is not altered,it is safe to label blood-derived monocles with *** labeled monocytes can be used to study injured central nervous system sites further,for example with drug-carrying VSOP.

关键词： CD11b,cytokine Ferucarbotran Mac1 MPS MRI Resovist superparamagnetic iron oxide nanoparticles(SPIO) very small superparamagnetic iron oxide nanoparticles(VSOP) viability

Elevated plasma levels of N-terminal pro-brain natriuretic peptide in patients with chronic hepatitis C during interferon-based antiviral therapy

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World journal of Gastroenterology 2006年第36期12卷 5875-5877页

作者： jrg Bojunga christoph Sarrazin Georg Hess Stefan Zeuzem Internal Medicine Ⅱ Saarland University Hospital 66421 Homburg/Saar Germany Roche Diagnostics 68305 Mannheim Germany

AIM: To investigate plasma levels of N-terminal pro-brain natriuretic peptide (NT-proBNP), an established marker of cardiac function, in patients with chronic hepatitis C during interferon-based antiviral therapy. METHODS: Using a sandwich immunoassay, plasma levels of NT-proBNP were determined in 48 patients with chronic hepatitis C at baseline, wk 24 and 48 during antiviral therapy and at wk 72 during ***: Plasma NT-proBNP concentrations were significantly increased (P < 0.05) at wk 24, 48 and 72 compared to the baseline values. NT-proBNP concentrations at baseline and wk 24 were closely correlated (r = 0.8; P < 0.001). At wk 24, 7 (14.6%) patients had NT-proBNP concentrations above 200 ng/L compared to 1 (2%) patient at baseline (P = 0.059). Six of these 7 patients had been treated with high-dose IFN-α induction therapy. In multiple regression analysis, NT-proBNP was not related to other clinical parameters, biochemical parameters of liver disease or virus load and response to ***: Elevated levels of NT-proBNP during and after interferon-based antiviral therapy of chronic hepatitis C may indicate the presence of cardiac dysfunction, which may contribute to the clinical symptoms observed in patients during therapy. Plasma levels of NT-proBNP may be used as a diagnostic tool and for guiding therapy in patients during interferon-based antiviral therapy.

关键词： Hepatitis C N-terminal pro-brain natriuretic peptide Interferon Cardiomyopathy Treatment side effects