检索结果-南通市图书馆

Humanized bone facilitates prostate cancer metastasis and recapitulates therapeutic effects of zoledronic acid in vivo

引用

Bone Research 2019年第4期7卷 388-398页

作者： Marietta Landgraf christoph alahr Alvaro Sanchez-Herrero christoph Meinert Ali Shokoohmand Pamela MPollock Dietmar WHutmacher Abbas Shafiee Jacqui AMcGovern Centre in Regenerative Medicine Institute of Health and Biomedical InnovationQueensland University of TechnologyBrisbaneAustralia School of Biomedical Science Institute of Health and Biomedical InnovationTranslational Research InstituteQueensland University of TechnologyBrisbaneAustralia Australian Research Council(ARC)Training Centre in Additive Biomanufacturing Queensland University of TechnologyBrisbaneAustralia UQ Diamantina Institute Translational Research InstituteThe University of QueenslandBrisbaneQLDAustralia

Advanced prostate cancer(PCa)is known for its high prevalence to metastasize to bone,at which point it is considered *** significant effort,there is no animal model capable of recapitulating the complexity of PCa bone *** humanized mouse model for PCa bone metastasis used in this study aims to provide a platform for the assessment of new drugs by recapitulating the human–human cell interactions relevant for disease development and *** humanized tissueengineered bone construct(hTEBC)was created within NOD-scid IL2rgnull(NSG)mice and was used for the study of experimental PC3-Luc bone *** was confirmed that PC3-Luc cells preferentially grew in the hTEBC compared with murine *** translational potential of the humanized mouse model for PCa bone metastasis was evaluated with two clinically approved osteoprotective therapies,the non-species-specific bisphosphonate zoledronic acid(ZA)or the human-specific antibody Denosumab,both targeting Receptor Activator of Nuclear Factor Kappa-Β***,but not Denosumab,significantly decreased metastases in hTEBCs,but not murine *** results highlight the importance of humanized models for the preclinical research on PCa bone metastasis and indicate the potential of the bioengineered mouse model to closely mimic the metastatic cascade of PCa cells to human ***,it will enable the development of new effective antimetastatic treatments.

关键词： metastasis PC3 drugs

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：